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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6253

FusionGeneSummary for CD74_NR6A1

check button Fusion gene summary
Fusion gene informationFusion gene name: CD74_NR6A1
Fusion gene ID: 6253
HgeneTgene
Gene symbol

CD74

NR6A1

Gene ID

972

2649

Gene nameCD74 moleculenuclear receptor subfamily 6 group A member 1
SynonymsDHLAG|HLADG|II|Ia-GAMMACT150|GCNF|GCNF1|NR61|RTR|hGCNF|hRTR
Cytomap

5q33.1

9q33.3

Type of geneprotein-codingprotein-coding
DescriptionHLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated nuclear receptor subfamily 6 group A member 1germ cell nuclear factor variant 1retinoic acid receptor-related testis-associated receptorretinoid receptor-related testis-specific receptor
Modification date2018052220180523
UniProtAcc

P04233

Q15406

Ensembl transtripts involved in fusion geneENST00000377795, ENST00000353334, 
ENST00000524315, ENST00000009530, 
ENST00000487099, ENST00000373584, 
ENST00000416460, ENST00000344523, 
Fusion gene scores* DoF score33 X 31 X 10=102306 X 5 X 4=120
# samples 486
** MAII scorelog2(48/10230*10)=-4.41362792902417
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD74 [Title/Abstract] AND NR6A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD74

GO:0001516

prostaglandin biosynthetic process

12782713

HgeneCD74

GO:0001934

positive regulation of protein phosphorylation

24942581

HgeneCD74

GO:0002792

negative regulation of peptide secretion

19849849

HgeneCD74

GO:0007165

signal transduction

12782713

HgeneCD74

GO:0008283

cell proliferation

12782713

HgeneCD74

GO:0033674

positive regulation of kinase activity

24942581

HgeneCD74

GO:0043066

negative regulation of apoptotic process

12782713

HgeneCD74

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

24942581

HgeneCD74

GO:0043410

positive regulation of MAPK cascade

24942581

HgeneCD74

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

17045821

HgeneCD74

GO:0045657

positive regulation of monocyte differentiation

24942581

HgeneCD74

GO:0045893

positive regulation of transcription, DNA-templated

24942581

HgeneCD74

GO:0046598

positive regulation of viral entry into host cell

24942581

HgeneCD74

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

17045821

HgeneCD74

GO:0051290

protein heterotetramerization

24942581

HgeneCD74

GO:0070374

positive regulation of ERK1 and ERK2 cascade

17045821|24942581


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1U64876CD74chr5

149792319

+NR6A1chr9

127533473

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000377795ENST00000487099CD74chr5

149792319

+NR6A1chr9

127533473

-
intron-5UTRENST00000377795ENST00000373584CD74chr5

149792319

+NR6A1chr9

127533473

-
intron-5UTRENST00000377795ENST00000416460CD74chr5

149792319

+NR6A1chr9

127533473

-
intron-5UTRENST00000377795ENST00000344523CD74chr5

149792319

+NR6A1chr9

127533473

-
intron-5UTRENST00000353334ENST00000487099CD74chr5

149792319

+NR6A1chr9

127533473

-
intron-5UTRENST00000353334ENST00000373584CD74chr5

149792319

+NR6A1chr9

127533473

-
intron-5UTRENST00000353334ENST00000416460CD74chr5

149792319

+NR6A1chr9

127533473

-
intron-5UTRENST00000353334ENST00000344523CD74chr5

149792319

+NR6A1chr9

127533473

-
intron-5UTRENST00000524315ENST00000487099CD74chr5

149792319

+NR6A1chr9

127533473

-
intron-5UTRENST00000524315ENST00000373584CD74chr5

149792319

+NR6A1chr9

127533473

-
intron-5UTRENST00000524315ENST00000416460CD74chr5

149792319

+NR6A1chr9

127533473

-
intron-5UTRENST00000524315ENST00000344523CD74chr5

149792319

+NR6A1chr9

127533473

-
intron-5UTRENST00000009530ENST00000487099CD74chr5

149792319

+NR6A1chr9

127533473

-
intron-5UTRENST00000009530ENST00000373584CD74chr5

149792319

+NR6A1chr9

127533473

-
intron-5UTRENST00000009530ENST00000416460CD74chr5

149792319

+NR6A1chr9

127533473

-
intron-5UTRENST00000009530ENST00000344523CD74chr5

149792319

+NR6A1chr9

127533473

-

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FusionProtFeatures for CD74_NR6A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD74

P04233

NR6A1

Q15406

Orphan nuclear receptor. Binds to a response elementcontaining the sequence 5'-TCAAGGTCA-3'. May be involved in theregulation of gene expression in germ cell development duringgametogenesis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CD74_NR6A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CD74_NR6A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CD74_NR6A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CD74_NR6A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD74C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneCD74C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCD74C0162557Liver Failure, Acute1CTD_human
HgeneCD74C1458155Mammary Neoplasms1CTD_human