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Fusion gene ID: 6251 |
FusionGeneSummary for CD74_NGB |
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Fusion gene information | Fusion gene name: CD74_NGB | Fusion gene ID: 6251 | Hgene | Tgene | Gene symbol | CD74 | NGB | Gene ID | 972 | 58157 |
Gene name | CD74 molecule | neuroglobin | |
Synonyms | DHLAG|HLADG|II|Ia-GAMMA | - | |
Cytomap | 5q33.1 | 14q24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | HLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated | neuroglobin | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | P04233 | Q9NPG2 | |
Ensembl transtripts involved in fusion gene | ENST00000377795, ENST00000353334, ENST00000524315, ENST00000009530, | ENST00000298352, | |
Fusion gene scores | * DoF score | 33 X 31 X 10=10230 | 1 X 1 X 1=1 |
# samples | 48 | 1 | |
** MAII score | log2(48/10230*10)=-4.41362792902417 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: CD74 [Title/Abstract] AND NGB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CD74 | GO:0001516 | prostaglandin biosynthetic process | 12782713 |
Hgene | CD74 | GO:0001934 | positive regulation of protein phosphorylation | 24942581 |
Hgene | CD74 | GO:0002792 | negative regulation of peptide secretion | 19849849 |
Hgene | CD74 | GO:0007165 | signal transduction | 12782713 |
Hgene | CD74 | GO:0008283 | cell proliferation | 12782713 |
Hgene | CD74 | GO:0033674 | positive regulation of kinase activity | 24942581 |
Hgene | CD74 | GO:0043066 | negative regulation of apoptotic process | 12782713 |
Hgene | CD74 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 24942581 |
Hgene | CD74 | GO:0043410 | positive regulation of MAPK cascade | 24942581 |
Hgene | CD74 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 17045821 |
Hgene | CD74 | GO:0045657 | positive regulation of monocyte differentiation | 24942581 |
Hgene | CD74 | GO:0045893 | positive regulation of transcription, DNA-templated | 24942581 |
Hgene | CD74 | GO:0046598 | positive regulation of viral entry into host cell | 24942581 |
Hgene | CD74 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 17045821 |
Hgene | CD74 | GO:0051290 | protein heterotetramerization | 24942581 |
Hgene | CD74 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 17045821|24942581 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | K01144 | CD74 | chr5 | 149781300 | - | NGB | chr14 | 77736137 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000377795 | ENST00000298352 | CD74 | chr5 | 149781300 | - | NGB | chr14 | 77736137 | + |
intron-intron | ENST00000353334 | ENST00000298352 | CD74 | chr5 | 149781300 | - | NGB | chr14 | 77736137 | + |
intron-intron | ENST00000524315 | ENST00000298352 | CD74 | chr5 | 149781300 | - | NGB | chr14 | 77736137 | + |
intron-intron | ENST00000009530 | ENST00000298352 | CD74 | chr5 | 149781300 | - | NGB | chr14 | 77736137 | + |
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FusionProtFeatures for CD74_NGB |
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Hgene | Tgene |
CD74 | NGB |
Involved in oxygen transport in the brain.Hexacoordinate globin, displaying competitive binding of oxygen orthe distal His residue to the iron atom. Not capable ofpenetrating cell membranes. The deoxygenated form exhibits nitritereductase activity inhibiting cellular respiration via NO-bindingto cytochrome c oxidase. Involved in neuroprotection duringoxidative stress. May exert its anti-apoptotic activity by actingto reset the trigger level of mitochondrial cytochrome c releasenecessary to commit the cells to apoptosis.{ECO:0000269|PubMed:11029004, ECO:0000269|PubMed:11473128,ECO:0000269|PubMed:18416560, ECO:0000269|PubMed:21190290,ECO:0000269|PubMed:21296891}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CD74_NGB |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CD74_NGB |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CD74_NGB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CD74_NGB |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CD74 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Hgene | CD74 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | CD74 | C0162557 | Liver Failure, Acute | 1 | CTD_human |
Hgene | CD74 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | NGB | C0751870 | Heredodegenerative Disorders, Nervous System | 1 | CTD_human |