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Fusion gene ID: 6245 |
FusionGeneSummary for CD74_ERBB3 |
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Fusion gene information | Fusion gene name: CD74_ERBB3 | Fusion gene ID: 6245 | Hgene | Tgene | Gene symbol | CD74 | ERBB3 | Gene ID | 972 | 2065 |
Gene name | CD74 molecule | erb-b2 receptor tyrosine kinase 3 | |
Synonyms | DHLAG|HLADG|II|Ia-GAMMA | ErbB-3|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3 | |
Cytomap | 5q33.1 | 12q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | HLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated | receptor tyrosine-protein kinase erbB-3human epidermal growth factor receptor 3proto-oncogene-like protein c-ErbB-3tyrosine kinase-type cell surface receptor HER3v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 | |
Modification date | 20180522 | 20180527 | |
UniProtAcc | P04233 | P21860 | |
Ensembl transtripts involved in fusion gene | ENST00000377795, ENST00000353334, ENST00000524315, ENST00000009530, | ENST00000267101, ENST00000450146, ENST00000415288, ENST00000553131, ENST00000411731, ENST00000549832, | |
Fusion gene scores | * DoF score | 33 X 31 X 10=10230 | 25 X 8 X 14=2800 |
# samples | 48 | 25 | |
** MAII score | log2(48/10230*10)=-4.41362792902417 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(25/2800*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CD74 [Title/Abstract] AND ERBB3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CD74 | GO:0001516 | prostaglandin biosynthetic process | 12782713 |
Hgene | CD74 | GO:0001934 | positive regulation of protein phosphorylation | 24942581 |
Hgene | CD74 | GO:0002792 | negative regulation of peptide secretion | 19849849 |
Hgene | CD74 | GO:0007165 | signal transduction | 12782713 |
Hgene | CD74 | GO:0008283 | cell proliferation | 12782713 |
Hgene | CD74 | GO:0033674 | positive regulation of kinase activity | 24942581 |
Hgene | CD74 | GO:0043066 | negative regulation of apoptotic process | 12782713 |
Hgene | CD74 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 24942581 |
Hgene | CD74 | GO:0043410 | positive regulation of MAPK cascade | 24942581 |
Hgene | CD74 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 17045821 |
Hgene | CD74 | GO:0045657 | positive regulation of monocyte differentiation | 24942581 |
Hgene | CD74 | GO:0045893 | positive regulation of transcription, DNA-templated | 24942581 |
Hgene | CD74 | GO:0046598 | positive regulation of viral entry into host cell | 24942581 |
Hgene | CD74 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 17045821 |
Hgene | CD74 | GO:0051290 | protein heterotetramerization | 24942581 |
Hgene | CD74 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 17045821|24942581 |
Tgene | ERBB3 | GO:0007162 | negative regulation of cell adhesion | 7556068 |
Tgene | ERBB3 | GO:0007165 | signal transduction | 10572067 |
Tgene | ERBB3 | GO:0009968 | negative regulation of signal transduction | 11389077 |
Tgene | ERBB3 | GO:0014065 | phosphatidylinositol 3-kinase signaling | 7556068 |
Tgene | ERBB3 | GO:0042127 | regulation of cell proliferation | 11389077 |
Tgene | ERBB3 | GO:0051048 | negative regulation of secretion | 10559227 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCEC | TCGA-DF-A2KR-01A | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000377795 | ENST00000267101 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
5CDS-intron | ENST00000377795 | ENST00000450146 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
5CDS-intron | ENST00000377795 | ENST00000415288 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
5CDS-intron | ENST00000377795 | ENST00000553131 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
5CDS-intron | ENST00000377795 | ENST00000411731 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
5CDS-intron | ENST00000377795 | ENST00000549832 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000353334 | ENST00000267101 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000353334 | ENST00000450146 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000353334 | ENST00000415288 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000353334 | ENST00000553131 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000353334 | ENST00000411731 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000353334 | ENST00000549832 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000524315 | ENST00000267101 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000524315 | ENST00000450146 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000524315 | ENST00000415288 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000524315 | ENST00000553131 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000524315 | ENST00000411731 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000524315 | ENST00000549832 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000009530 | ENST00000267101 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000009530 | ENST00000450146 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000009530 | ENST00000415288 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000009530 | ENST00000553131 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000009530 | ENST00000411731 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000009530 | ENST00000549832 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
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FusionProtFeatures for CD74_ERBB3 |
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Hgene | Tgene |
CD74 | ERBB3 |
Tyrosine-protein kinase that plays an essential role ascell surface receptor for neuregulins. Binds to neuregulin-1(NRG1) and is activated by it; ligand-binding increasesphosphorylation on tyrosine residues and promotes its associationwith the p85 subunit of phosphatidylinositol 3-kinase(PubMed:20682778). May also be activated by CSPG5(PubMed:15358134). {ECO:0000269|PubMed:15358134,ECO:0000269|PubMed:20682778}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CD74_ERBB3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CD74_ERBB3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CD74 | MIF, CD74, APP, HADHA, LAMTOR5, MAP3K1, TM4SF20, COPG1, COPG2, HLA-DPB1, HLA-DQA1, CD44 | ERBB3 | GRB2, PIK3R2, CSK, SHC1, CD82, RGS4, ODF2L, GRB7, PA2G4, EGF, RNF41, NRG1, PIK3R1, IL6ST, PTK6, EGFR, MUC1, NRG2, ERBB2, RPN1, EGR1, ZNF207, HDAC6, LRIG1, MDM2, AKT1, PTPN11, HSP90AA1, NCK2, JAK2, SH2D1A, DAB1, ABL1, HCK, FGFR1, SRC, NCK1, FER, PLCG1, RASA1, TXK, ABL2, ZAP70, SYK, CRK, CRKL, JAK3, VAV2, CHN2, ITK, RIN1, BCAR3, TENC1, TNS3, TNS4, SHC3, PIK3R3, VAV1, VAV3, DAPP1, SH2B3, NEDD4, HLA-DPA1, UQCR10, B3GALTL, PDF, TUBA4A, TUBB8, HLA-A, YBEY, SLC31A1, EIF1AX, SRPK2, HLA-B, SLC25A5, SLC25A6, AIFM1, ANXA2, AP1M2, ATP5A1, B2M, C1QBP, CANX, CDC37, DNAJB11, DNAJA1, TUFM, ERBB3, GFAP, HSPA5, HNRNPH1, HNRNPH2, HNRNPF, HSP90AB1, HSPA8, LGALS3BP, MASP1, PHLDA1, PIK3CA, PIK3CB, PTCD3, RAE1, RPL23, RPS27, RPS27A, RPS27L, MRPS14, MRPS17, MRPS23, MRPS27, MRPS28, S100A10, SSR1, TUBB, ACTA2, ACTB, ACTBL2, POTEKP, ACTC1, ACTG1, ACTG2, ACTA1, HBA1, HBB, HBD, HBE1, HBG1, HBG2, HNRNPH3, HSPA1A, LRPPRC, PON2, POTEE, POTEF, HNRNPA2B1, HNRNPAB, MRPS18B, MRPS22, MRPS25, MRPS26, MRPS34, TUBA1B, PCGF1, DPPA4, NANOG, POU5F1, EPN1, L1CAM, MET, NEDD4L, PTK2B, NDRG1, CDH1, PTPRH, UQCRH, PPM1A, PPM1B, PPM1F, PPM1K, PPM1M, ILKAP, PTPRR, PTPN6, PTPN7, PTPN12, PTPN20B, DUSP14, DUSP18, DUSP19, DUSP21, DUPD1, STYX, PTPDC1, PTEN, TPTE, MTMR1, MTMR2, MTMR6, MTMR8, MTMR9, MTMR10, CDC25C, EYA4, CSPG5, HGS |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CD74_ERBB3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CD74_ERBB3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CD74 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Hgene | CD74 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | CD74 | C0162557 | Liver Failure, Acute | 1 | CTD_human |
Hgene | CD74 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | ERBB3 | C0036341 | Schizophrenia | 3 | PSYGENET |
Tgene | ERBB3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | ERBB3 | C0011570 | Mental Depression | 1 | PSYGENET |
Tgene | ERBB3 | C0016978 | gallbladder neoplasm | 1 | CTD_human |
Tgene | ERBB3 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | ERBB3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | ERBB3 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | ERBB3 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Tgene | ERBB3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | ERBB3 | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |