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Fusion gene ID: 6245 |
FusionGeneSummary for CD74_ERBB3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CD74_ERBB3 | Fusion gene ID: 6245 | Hgene | Tgene | Gene symbol | CD74 | ERBB3 | Gene ID | 972 | 2065 |
| Gene name | CD74 molecule | erb-b2 receptor tyrosine kinase 3 | |
| Synonyms | DHLAG|HLADG|II|Ia-GAMMA | ErbB-3|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3 | |
| Cytomap | 5q33.1 | 12q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | HLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated | receptor tyrosine-protein kinase erbB-3human epidermal growth factor receptor 3proto-oncogene-like protein c-ErbB-3tyrosine kinase-type cell surface receptor HER3v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | P04233 | P21860 | |
| Ensembl transtripts involved in fusion gene | ENST00000377795, ENST00000353334, ENST00000524315, ENST00000009530, | ENST00000267101, ENST00000450146, ENST00000415288, ENST00000553131, ENST00000411731, ENST00000549832, | |
| Fusion gene scores | * DoF score | 33 X 31 X 10=10230 | 25 X 8 X 14=2800 |
| # samples | 48 | 25 | |
| ** MAII score | log2(48/10230*10)=-4.41362792902417 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(25/2800*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CD74 [Title/Abstract] AND ERBB3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CD74 | GO:0001516 | prostaglandin biosynthetic process | 12782713 |
| Hgene | CD74 | GO:0001934 | positive regulation of protein phosphorylation | 24942581 |
| Hgene | CD74 | GO:0002792 | negative regulation of peptide secretion | 19849849 |
| Hgene | CD74 | GO:0007165 | signal transduction | 12782713 |
| Hgene | CD74 | GO:0008283 | cell proliferation | 12782713 |
| Hgene | CD74 | GO:0033674 | positive regulation of kinase activity | 24942581 |
| Hgene | CD74 | GO:0043066 | negative regulation of apoptotic process | 12782713 |
| Hgene | CD74 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 24942581 |
| Hgene | CD74 | GO:0043410 | positive regulation of MAPK cascade | 24942581 |
| Hgene | CD74 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 17045821 |
| Hgene | CD74 | GO:0045657 | positive regulation of monocyte differentiation | 24942581 |
| Hgene | CD74 | GO:0045893 | positive regulation of transcription, DNA-templated | 24942581 |
| Hgene | CD74 | GO:0046598 | positive regulation of viral entry into host cell | 24942581 |
| Hgene | CD74 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 17045821 |
| Hgene | CD74 | GO:0051290 | protein heterotetramerization | 24942581 |
| Hgene | CD74 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 17045821|24942581 |
| Tgene | ERBB3 | GO:0007162 | negative regulation of cell adhesion | 7556068 |
| Tgene | ERBB3 | GO:0007165 | signal transduction | 10572067 |
| Tgene | ERBB3 | GO:0009968 | negative regulation of signal transduction | 11389077 |
| Tgene | ERBB3 | GO:0014065 | phosphatidylinositol 3-kinase signaling | 7556068 |
| Tgene | ERBB3 | GO:0042127 | regulation of cell proliferation | 11389077 |
| Tgene | ERBB3 | GO:0051048 | negative regulation of secretion | 10559227 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-DF-A2KR-01A | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000377795 | ENST00000267101 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| 5CDS-intron | ENST00000377795 | ENST00000450146 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| 5CDS-intron | ENST00000377795 | ENST00000415288 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| 5CDS-intron | ENST00000377795 | ENST00000553131 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| 5CDS-intron | ENST00000377795 | ENST00000411731 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| 5CDS-intron | ENST00000377795 | ENST00000549832 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000353334 | ENST00000267101 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000353334 | ENST00000450146 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000353334 | ENST00000415288 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000353334 | ENST00000553131 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000353334 | ENST00000411731 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000353334 | ENST00000549832 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000524315 | ENST00000267101 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000524315 | ENST00000450146 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000524315 | ENST00000415288 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000524315 | ENST00000553131 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000524315 | ENST00000411731 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000524315 | ENST00000549832 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000009530 | ENST00000267101 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000009530 | ENST00000450146 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000009530 | ENST00000415288 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000009530 | ENST00000553131 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000009530 | ENST00000411731 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
| intron-intron | ENST00000009530 | ENST00000549832 | CD74 | chr5 | 149781200 | - | ERBB3 | chr12 | 56492035 | + |
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FusionProtFeatures for CD74_ERBB3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CD74 | ERBB3 |
| Tyrosine-protein kinase that plays an essential role ascell surface receptor for neuregulins. Binds to neuregulin-1(NRG1) and is activated by it; ligand-binding increasesphosphorylation on tyrosine residues and promotes its associationwith the p85 subunit of phosphatidylinositol 3-kinase(PubMed:20682778). May also be activated by CSPG5(PubMed:15358134). {ECO:0000269|PubMed:15358134,ECO:0000269|PubMed:20682778}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CD74_ERBB3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CD74_ERBB3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CD74 | MIF, CD74, APP, HADHA, LAMTOR5, MAP3K1, TM4SF20, COPG1, COPG2, HLA-DPB1, HLA-DQA1, CD44 | ERBB3 | GRB2, PIK3R2, CSK, SHC1, CD82, RGS4, ODF2L, GRB7, PA2G4, EGF, RNF41, NRG1, PIK3R1, IL6ST, PTK6, EGFR, MUC1, NRG2, ERBB2, RPN1, EGR1, ZNF207, HDAC6, LRIG1, MDM2, AKT1, PTPN11, HSP90AA1, NCK2, JAK2, SH2D1A, DAB1, ABL1, HCK, FGFR1, SRC, NCK1, FER, PLCG1, RASA1, TXK, ABL2, ZAP70, SYK, CRK, CRKL, JAK3, VAV2, CHN2, ITK, RIN1, BCAR3, TENC1, TNS3, TNS4, SHC3, PIK3R3, VAV1, VAV3, DAPP1, SH2B3, NEDD4, HLA-DPA1, UQCR10, B3GALTL, PDF, TUBA4A, TUBB8, HLA-A, YBEY, SLC31A1, EIF1AX, SRPK2, HLA-B, SLC25A5, SLC25A6, AIFM1, ANXA2, AP1M2, ATP5A1, B2M, C1QBP, CANX, CDC37, DNAJB11, DNAJA1, TUFM, ERBB3, GFAP, HSPA5, HNRNPH1, HNRNPH2, HNRNPF, HSP90AB1, HSPA8, LGALS3BP, MASP1, PHLDA1, PIK3CA, PIK3CB, PTCD3, RAE1, RPL23, RPS27, RPS27A, RPS27L, MRPS14, MRPS17, MRPS23, MRPS27, MRPS28, S100A10, SSR1, TUBB, ACTA2, ACTB, ACTBL2, POTEKP, ACTC1, ACTG1, ACTG2, ACTA1, HBA1, HBB, HBD, HBE1, HBG1, HBG2, HNRNPH3, HSPA1A, LRPPRC, PON2, POTEE, POTEF, HNRNPA2B1, HNRNPAB, MRPS18B, MRPS22, MRPS25, MRPS26, MRPS34, TUBA1B, PCGF1, DPPA4, NANOG, POU5F1, EPN1, L1CAM, MET, NEDD4L, PTK2B, NDRG1, CDH1, PTPRH, UQCRH, PPM1A, PPM1B, PPM1F, PPM1K, PPM1M, ILKAP, PTPRR, PTPN6, PTPN7, PTPN12, PTPN20B, DUSP14, DUSP18, DUSP19, DUSP21, DUPD1, STYX, PTPDC1, PTEN, TPTE, MTMR1, MTMR2, MTMR6, MTMR8, MTMR9, MTMR10, CDC25C, EYA4, CSPG5, HGS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CD74_ERBB3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CD74_ERBB3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CD74 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Hgene | CD74 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | CD74 | C0162557 | Liver Failure, Acute | 1 | CTD_human |
| Hgene | CD74 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | ERBB3 | C0036341 | Schizophrenia | 3 | PSYGENET |
| Tgene | ERBB3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | ERBB3 | C0011570 | Mental Depression | 1 | PSYGENET |
| Tgene | ERBB3 | C0016978 | gallbladder neoplasm | 1 | CTD_human |
| Tgene | ERBB3 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Tgene | ERBB3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | ERBB3 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | ERBB3 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Tgene | ERBB3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | ERBB3 | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |
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