![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 6243 |
FusionGeneSummary for CD74_DDX27 |
![]() |
Fusion gene information | Fusion gene name: CD74_DDX27 | Fusion gene ID: 6243 | Hgene | Tgene | Gene symbol | CD74 | DDX27 | Gene ID | 972 | 55661 |
Gene name | CD74 molecule | DEAD-box helicase 27 | |
Synonyms | DHLAG|HLADG|II|Ia-GAMMA | DRS1|Drs1p|HSPC259|PP3241|RHLP|dJ686N3.1 | |
Cytomap | 5q33.1 | 20q13.13 | |
Type of gene | protein-coding | protein-coding | |
Description | HLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated | probable ATP-dependent RNA helicase DDX27DEAD (Asp-Glu-Ala-Asp) box polypeptide 27DEAD box protein 27DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 27Deficiency of ribosomal subunits protein 1 homologRNA helicase-like protein | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | P04233 | Q96GQ7 | |
Ensembl transtripts involved in fusion gene | ENST00000377795, ENST00000353334, ENST00000524315, ENST00000009530, | ENST00000484427, ENST00000371764, | |
Fusion gene scores | * DoF score | 33 X 31 X 10=10230 | 35 X 5 X 20=3500 |
# samples | 48 | 38 | |
** MAII score | log2(48/10230*10)=-4.41362792902417 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(38/3500*10)=-3.20328359838874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CD74 [Title/Abstract] AND DDX27 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CD74 | GO:0001516 | prostaglandin biosynthetic process | 12782713 |
Hgene | CD74 | GO:0001934 | positive regulation of protein phosphorylation | 24942581 |
Hgene | CD74 | GO:0002792 | negative regulation of peptide secretion | 19849849 |
Hgene | CD74 | GO:0007165 | signal transduction | 12782713 |
Hgene | CD74 | GO:0008283 | cell proliferation | 12782713 |
Hgene | CD74 | GO:0033674 | positive regulation of kinase activity | 24942581 |
Hgene | CD74 | GO:0043066 | negative regulation of apoptotic process | 12782713 |
Hgene | CD74 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 24942581 |
Hgene | CD74 | GO:0043410 | positive regulation of MAPK cascade | 24942581 |
Hgene | CD74 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 17045821 |
Hgene | CD74 | GO:0045657 | positive regulation of monocyte differentiation | 24942581 |
Hgene | CD74 | GO:0045893 | positive regulation of transcription, DNA-templated | 24942581 |
Hgene | CD74 | GO:0046598 | positive regulation of viral entry into host cell | 24942581 |
Hgene | CD74 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 17045821 |
Hgene | CD74 | GO:0051290 | protein heterotetramerization | 24942581 |
Hgene | CD74 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 17045821|24942581 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | CHOL | TCGA-W5-AA2H-01A | CD74 | chr5 | 149781200 | - | DDX27 | chr20 | 47849303 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000377795 | ENST00000484427 | CD74 | chr5 | 149781200 | - | DDX27 | chr20 | 47849303 | + |
5CDS-intron | ENST00000377795 | ENST00000371764 | CD74 | chr5 | 149781200 | - | DDX27 | chr20 | 47849303 | + |
intron-intron | ENST00000353334 | ENST00000484427 | CD74 | chr5 | 149781200 | - | DDX27 | chr20 | 47849303 | + |
intron-intron | ENST00000353334 | ENST00000371764 | CD74 | chr5 | 149781200 | - | DDX27 | chr20 | 47849303 | + |
intron-intron | ENST00000524315 | ENST00000484427 | CD74 | chr5 | 149781200 | - | DDX27 | chr20 | 47849303 | + |
intron-intron | ENST00000524315 | ENST00000371764 | CD74 | chr5 | 149781200 | - | DDX27 | chr20 | 47849303 | + |
intron-intron | ENST00000009530 | ENST00000484427 | CD74 | chr5 | 149781200 | - | DDX27 | chr20 | 47849303 | + |
intron-intron | ENST00000009530 | ENST00000371764 | CD74 | chr5 | 149781200 | - | DDX27 | chr20 | 47849303 | + |
Top |
FusionProtFeatures for CD74_DDX27 |
![]() |
Hgene | Tgene |
CD74 | DDX27 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CD74_DDX27 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CD74_DDX27 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CD74 | MIF, CD74, APP, HADHA, LAMTOR5, MAP3K1, TM4SF20, COPG1, COPG2, HLA-DPB1, HLA-DQA1, CD44 | DDX27 | ARRB2, ARRB1, LYAR, PPP1R16A, YWHAG, SIRT7, API5, ESR1, HDAC11, TARBP2, STAU1, CUL7, OBSL1, EED, RNF2, HIST1H1A, NOL12, RPL10A, RPL14, RPL8, NIFK, NPM1, RPS8, PRR11, NTRK1, DCAF13, DDX24, EIF6, FBL, FTSJ3, KIAA0020, KRR1, NOP56, NOP58, RPL18A, RPL23, RPL31, RRP15, DKC1, PES1, RBBP6, RBM19, RBM34, RPL5, RPL9, RUVBL1, SRP68, SRP72, SSB, UTP14A, IFI16, HNRNPU, RPL10, ZNFX1, MCM5, BOP1, WDR12, SENP3, ZNF746, CDC14B, RPL37A, RPL30, MAK16, DGCR8, RPL18, WDR46, HIST1H1T, GLTSCR2, CNBP, RRP8, GPATCH4, ZC3HAV1, ZNF71, PPAN, SYNCRIP, ZNF692, HIST1H1E, NR3C1, TRIM25, MTF1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CD74_DDX27 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CD74_DDX27 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CD74 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Hgene | CD74 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | CD74 | C0162557 | Liver Failure, Acute | 1 | CTD_human |
Hgene | CD74 | C1458155 | Mammary Neoplasms | 1 | CTD_human |