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Fusion gene ID: 6240 |
FusionGeneSummary for CD74_CD40 |
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Fusion gene information | Fusion gene name: CD74_CD40 | Fusion gene ID: 6240 | Hgene | Tgene | Gene symbol | CD74 | CD40 | Gene ID | 972 | 958 |
Gene name | CD74 molecule | CD40 molecule | |
Synonyms | DHLAG|HLADG|II|Ia-GAMMA | Bp50|CDW40|TNFRSF5|p50 | |
Cytomap | 5q33.1 | 20q13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | HLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated | tumor necrosis factor receptor superfamily member 5B cell surface antigen CD40B cell-associated moleculeCD40 molecule, TNF receptor superfamily member 5CD40L receptor | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | P04233 | P25942 | |
Ensembl transtripts involved in fusion gene | ENST00000377795, ENST00000353334, ENST00000524315, ENST00000009530, | ENST00000372285, ENST00000372276, ENST00000489304, | |
Fusion gene scores | * DoF score | 33 X 31 X 10=10230 | 3 X 1 X 3=9 |
# samples | 48 | 3 | |
** MAII score | log2(48/10230*10)=-4.41362792902417 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CD74 [Title/Abstract] AND CD40 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CD74 | GO:0001516 | prostaglandin biosynthetic process | 12782713 |
Hgene | CD74 | GO:0001934 | positive regulation of protein phosphorylation | 24942581 |
Hgene | CD74 | GO:0002792 | negative regulation of peptide secretion | 19849849 |
Hgene | CD74 | GO:0007165 | signal transduction | 12782713 |
Hgene | CD74 | GO:0008283 | cell proliferation | 12782713 |
Hgene | CD74 | GO:0033674 | positive regulation of kinase activity | 24942581 |
Hgene | CD74 | GO:0043066 | negative regulation of apoptotic process | 12782713 |
Hgene | CD74 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 24942581 |
Hgene | CD74 | GO:0043410 | positive regulation of MAPK cascade | 24942581 |
Hgene | CD74 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 17045821 |
Hgene | CD74 | GO:0045657 | positive regulation of monocyte differentiation | 24942581 |
Hgene | CD74 | GO:0045893 | positive regulation of transcription, DNA-templated | 24942581 |
Hgene | CD74 | GO:0046598 | positive regulation of viral entry into host cell | 24942581 |
Hgene | CD74 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 17045821 |
Hgene | CD74 | GO:0051290 | protein heterotetramerization | 24942581 |
Hgene | CD74 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 17045821|24942581 |
Tgene | CD40 | GO:2000353 | positive regulation of endothelial cell apoptotic process | 12885753 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-XF-A9T5-01A | CD74 | chr5 | 149781200 | - | CD40 | chr20 | 44754189 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000377795 | ENST00000372285 | CD74 | chr5 | 149781200 | - | CD40 | chr20 | 44754189 | + |
5CDS-intron | ENST00000377795 | ENST00000372276 | CD74 | chr5 | 149781200 | - | CD40 | chr20 | 44754189 | + |
5CDS-intron | ENST00000377795 | ENST00000489304 | CD74 | chr5 | 149781200 | - | CD40 | chr20 | 44754189 | + |
intron-intron | ENST00000353334 | ENST00000372285 | CD74 | chr5 | 149781200 | - | CD40 | chr20 | 44754189 | + |
intron-intron | ENST00000353334 | ENST00000372276 | CD74 | chr5 | 149781200 | - | CD40 | chr20 | 44754189 | + |
intron-intron | ENST00000353334 | ENST00000489304 | CD74 | chr5 | 149781200 | - | CD40 | chr20 | 44754189 | + |
intron-intron | ENST00000524315 | ENST00000372285 | CD74 | chr5 | 149781200 | - | CD40 | chr20 | 44754189 | + |
intron-intron | ENST00000524315 | ENST00000372276 | CD74 | chr5 | 149781200 | - | CD40 | chr20 | 44754189 | + |
intron-intron | ENST00000524315 | ENST00000489304 | CD74 | chr5 | 149781200 | - | CD40 | chr20 | 44754189 | + |
intron-intron | ENST00000009530 | ENST00000372285 | CD74 | chr5 | 149781200 | - | CD40 | chr20 | 44754189 | + |
intron-intron | ENST00000009530 | ENST00000372276 | CD74 | chr5 | 149781200 | - | CD40 | chr20 | 44754189 | + |
intron-intron | ENST00000009530 | ENST00000489304 | CD74 | chr5 | 149781200 | - | CD40 | chr20 | 44754189 | + |
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FusionProtFeatures for CD74_CD40 |
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Hgene | Tgene |
CD74 | CD40 |
Receptor for TNFSF5/CD40LG. Transduces TRAF6- andMAP3K8-mediated signals that activate ERK in macrophages and Bcells, leading to induction of immunoglobulin secretion. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CD74_CD40 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CD74_CD40 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CD74 | MIF, CD74, APP, HADHA, LAMTOR5, MAP3K1, TM4SF20, COPG1, COPG2, HLA-DPB1, HLA-DQA1, CD44 | CD40 | UGGT1, CALR, SGK1, USP15, RFC5, ERP44, POLR2H, SLC30A7, TXN, DDX3X, RNF219, SLC39A7, FBL, NCOA6, RIPK2, TRAF2, TRAF3, TRAF5, TRAF6, TDP2, MS4A1, TRAF3IP2, XRCC6, XRCC5, HSPA4, TANK, TRAF1, BIRC2, TRAF4, PIK3CA, CBL, MAP3K8, IL4R, BAG3, CD40LG, PIK3R1, FAF1, CHUK, DIABLO, CD40, IKBKB, RNF31, HTRA2, TMEM173 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CD74_CD40 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CD74_CD40 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CD74 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Hgene | CD74 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | CD74 | C0162557 | Liver Failure, Acute | 1 | CTD_human |
Hgene | CD74 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | CD40 | C0003873 | Rheumatoid Arthritis | 3 | CTD_human |
Tgene | CD40 | C0026691 | Mucocutaneous Lymph Node Syndrome | 2 | CTD_human |
Tgene | CD40 | C1720957 | Hyper-IgM Immunodeficiency Syndrome, Type 3 | 2 | ORPHANET;UNIPROT |
Tgene | CD40 | C0026769 | Multiple Sclerosis | 1 | CTD_human |
Tgene | CD40 | C0038220 | Status Epilepticus | 1 | CTD_human |
Tgene | CD40 | C1458155 | Mammary Neoplasms | 1 | CTD_human |