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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 623

FusionGeneSummary for ACTR2_SORBS2

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTR2_SORBS2
Fusion gene ID: 623
HgeneTgene
Gene symbol

ACTR2

SORBS2

Gene ID

10097

8470

Gene nameARP2 actin related protein 2 homologsorbin and SH3 domain containing 2
SynonymsARP2ARGBP2|PRO0618
Cytomap

2p14

4q35.1

Type of geneprotein-codingprotein-coding
Descriptionactin-related protein 2actin-like protein 2sorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2
Modification date2018051920180523
UniProtAcc

P61160

O94875

Ensembl transtripts involved in fusion geneENST00000260641, ENST00000476840, 
ENST00000542850, ENST00000377982, 
ENST00000448662, ENST00000431808, 
ENST00000284776, ENST00000437304, 
ENST00000319471, ENST00000449407, 
ENST00000355634, ENST00000393528, 
ENST00000418609, ENST00000498125, 
Fusion gene scores* DoF score5 X 5 X 4=10011 X 12 X 7=924
# samples 515
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/924*10)=-2.62293035092018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACTR2 [Title/Abstract] AND SORBS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACTR2

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-J4-8198-01AACTR2chr2

65482828

+SORBS2chr4

186696520

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000260641ENST00000448662ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000260641ENST00000431808ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000260641ENST00000284776ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000260641ENST00000437304ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000260641ENST00000319471ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000260641ENST00000449407ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000260641ENST00000355634ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000260641ENST00000393528ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-intronENST00000260641ENST00000418609ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-intronENST00000260641ENST00000498125ACTR2chr2

65482828

+SORBS2chr4

186696520

-
intron-intronENST00000476840ENST00000448662ACTR2chr2

65482828

+SORBS2chr4

186696520

-
intron-5UTRENST00000476840ENST00000431808ACTR2chr2

65482828

+SORBS2chr4

186696520

-
intron-5UTRENST00000476840ENST00000284776ACTR2chr2

65482828

+SORBS2chr4

186696520

-
intron-5UTRENST00000476840ENST00000437304ACTR2chr2

65482828

+SORBS2chr4

186696520

-
intron-5UTRENST00000476840ENST00000319471ACTR2chr2

65482828

+SORBS2chr4

186696520

-
intron-5UTRENST00000476840ENST00000449407ACTR2chr2

65482828

+SORBS2chr4

186696520

-
intron-5UTRENST00000476840ENST00000355634ACTR2chr2

65482828

+SORBS2chr4

186696520

-
intron-5UTRENST00000476840ENST00000393528ACTR2chr2

65482828

+SORBS2chr4

186696520

-
intron-intronENST00000476840ENST00000418609ACTR2chr2

65482828

+SORBS2chr4

186696520

-
intron-intronENST00000476840ENST00000498125ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-intronENST00000542850ENST00000448662ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000542850ENST00000431808ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000542850ENST00000284776ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000542850ENST00000437304ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000542850ENST00000319471ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000542850ENST00000449407ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000542850ENST00000355634ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000542850ENST00000393528ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-intronENST00000542850ENST00000418609ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-intronENST00000542850ENST00000498125ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-intronENST00000377982ENST00000448662ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000377982ENST00000431808ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000377982ENST00000284776ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000377982ENST00000437304ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000377982ENST00000319471ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000377982ENST00000449407ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000377982ENST00000355634ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-5UTRENST00000377982ENST00000393528ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-intronENST00000377982ENST00000418609ACTR2chr2

65482828

+SORBS2chr4

186696520

-
5CDS-intronENST00000377982ENST00000498125ACTR2chr2

65482828

+SORBS2chr4

186696520

-

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FusionProtFeatures for ACTR2_SORBS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTR2

P61160

SORBS2

O94875

Functions as ATP-binding component of the Arp2/3 complexwhich is involved in regulation of actin polymerization andtogether with an activating nucleation-promoting factor (NPF)mediates the formation of branched actin networks. Seems tocontact the pointed end of the daughter actin filament.{ECO:0000269|PubMed:9000076}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACTR2_SORBS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACTR2_SORBS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACTR2ACTR3B, BAK1, ACTR3, BMP2, CTTN, ESR1, ACTB, UBC, ELAVL1, SIRT7, CUL3, LRRK2, ARPC1B, ARPC4, ARPC5, ARPC2, ARPC3, ARPC1A, ARPC5L, CORO1C, UBE2N, FN1, VCAM1, WASL, ELF5, ANP32B, BAG1, CALR, DHPS, EEF2K, EFTUD1, P3H1, OSGEP, TTLL12, ALAD, CALU, CRTAP, FUBP1, GRPEL1, HIST1H2AB, HSPBP1, KIAA1279, METTL1, NIF3L1, NSUN2, OGT, PANK4, PPME1, PRKACB, RANGAP1, RPA1, RPRD1A, RPRD1B, SH3GL1, SH3GLB1, SRP9, SURF2, TOM1L1, TP53RK, TPD52L2, TPRKB, UFM1, WDR4, ZPR1, CUL7, OBSL1, EGFR, UNK, CAPZA1, CCT5, CORO1A, EFHD2, PSMD7, STXBP1, ARPC4-TTLL3, CAPZA2, CORO1B, FAM98B, NTRK1, KRAS, PCM1, CEP170, CEP128, NIN, SCLT1, EVC2, STIL, XPO1, CCT6A, CFL1, CLTA, CLTB, DAB2, DBN1, DSG2, GSN, ITPR3, MYO6, PPP1R12A, SVIL, TCP1, CCT3, LUZP1, GPRC5A, FLNA, MYH9, PPP1CB, IQGAP1, ATP6AP2, SYNPO, ANLN, MYO5C, MYO19, MYO18A, BASP1, CCT7, CCT4, CCT2, CCT8, COBL, LIMA1, RBM27, METTL3, INF2, PDCL3, CYBRD1, CHURC1, SPECC1, MISP, FBXW7, SNW1, CDC5L, HSD17B10SORBS2YWHAE, SFN, CBL, PTK2B, FLOT1, RPL9, DLGAP4, DLGAP1, VCL, MLLT4, ABL2, ABL1, EGFR, NR1H2, SEMA6A, PALLD, ACTN1, ADAM15, WASF1, PTPN12, BAG3, AKT2, MDM2, YWHAZ, YWHAB, WAS, NCK2, SORBS2, EFS, VPS37C, SH2D4A, ATPAF2, SUZ12, CAPZA2, CLTC, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, MAPRE1, LIMA1, ANLN, MYO18A, FAT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACTR2_SORBS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACTR2_SORBS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACTR2C0036341Schizophrenia1PSYGENET
TgeneSORBS2C0043094Weight Gain1CTD_human