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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6205

FusionGeneSummary for CD55_NEK2

check button Fusion gene summary
Fusion gene informationFusion gene name: CD55_NEK2
Fusion gene ID: 6205
HgeneTgene
Gene symbol

CD55

NEK2

Gene ID

1604

4751

Gene nameCD55 molecule (Cromer blood group)NIMA related kinase 2
SynonymsCHAPLE|CR|CROM|DAF|TCHsPK21|NEK2A|NLK1|PPP1R111|RP67
Cytomap

1q32.2

1q32.3

Type of geneprotein-codingprotein-coding
Descriptioncomplement decay-accelerating factorCD55 antigenCD55 molecule, decay accelerating factor for complement (Cromer blood group)Cromer blood group antigenserine/threonine-protein kinase Nek2NIMA (never in mitosis gene a)-related kinase 2nimA-like protein kinase 1nimA-related protein kinase 2protein phosphatase 1, regulatory subunit 111
Modification date2018051920180527
UniProtAcc

P08174

P51955

Ensembl transtripts involved in fusion geneENST00000367064, ENST00000367063, 
ENST00000391921, ENST00000367067, 
ENST00000314754, ENST00000391920, 
ENST00000367062, ENST00000367065, 
ENST00000465534, 		ENST00000366999, 
ENST00000540251, ENST00000462283, 
ENST00000366998, 
Fusion gene scores* DoF score6 X 3 X 5=902 X 2 X 2=8
# samples 72
** MAII scorelog2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: CD55 [Title/Abstract] AND NEK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD55

GO:0007204

positive regulation of cytosolic calcium ion concentration

8223854

HgeneCD55

GO:0031664

regulation of lipopolysaccharide-mediated signaling pathway

12731067

HgeneCD55

GO:0035743

CD4-positive, alpha-beta T cell cytokine production

16818763

HgeneCD55

GO:0045916

negative regulation of complement activation

6211481

HgeneCD55

GO:2000516

positive regulation of CD4-positive, alpha-beta T cell activation

16818763

HgeneCD55

GO:2000563

positive regulation of CD4-positive, alpha-beta T cell proliferation

16818763

TgeneNEK2

GO:0006468

protein phosphorylation

21076410

TgeneNEK2

GO:0007059

chromosome segregation

14978040

TgeneNEK2

GO:0046777

protein autophosphorylation

17626005

TgeneNEK2

GO:0051299

centrosome separation

18086858


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-D9-A1JW-06ACD55chr1

207512762

+NEK2chr1

211836994

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000367064ENST00000366999CD55chr1

207512762

+NEK2chr1

211836994

-
Frame-shiftENST00000367064ENST00000540251CD55chr1

207512762

+NEK2chr1

211836994

-
5CDS-intronENST00000367064ENST00000462283CD55chr1

207512762

+NEK2chr1

211836994

-
5CDS-intronENST00000367064ENST00000366998CD55chr1

207512762

+NEK2chr1

211836994

-
Frame-shiftENST00000367063ENST00000366999CD55chr1

207512762

+NEK2chr1

211836994

-
Frame-shiftENST00000367063ENST00000540251CD55chr1

207512762

+NEK2chr1

211836994

-
5CDS-intronENST00000367063ENST00000462283CD55chr1

207512762

+NEK2chr1

211836994

-
5CDS-intronENST00000367063ENST00000366998CD55chr1

207512762

+NEK2chr1

211836994

-
Frame-shiftENST00000391921ENST00000366999CD55chr1

207512762

+NEK2chr1

211836994

-
Frame-shiftENST00000391921ENST00000540251CD55chr1

207512762

+NEK2chr1

211836994

-
5CDS-intronENST00000391921ENST00000462283CD55chr1

207512762

+NEK2chr1

211836994

-
5CDS-intronENST00000391921ENST00000366998CD55chr1

207512762

+NEK2chr1

211836994

-
3UTR-3CDSENST00000367067ENST00000366999CD55chr1

207512762

+NEK2chr1

211836994

-
3UTR-3CDSENST00000367067ENST00000540251CD55chr1

207512762

+NEK2chr1

211836994

-
3UTR-intronENST00000367067ENST00000462283CD55chr1

207512762

+NEK2chr1

211836994

-
3UTR-intronENST00000367067ENST00000366998CD55chr1

207512762

+NEK2chr1

211836994

-
Frame-shiftENST00000314754ENST00000366999CD55chr1

207512762

+NEK2chr1

211836994

-
Frame-shiftENST00000314754ENST00000540251CD55chr1

207512762

+NEK2chr1

211836994

-
5CDS-intronENST00000314754ENST00000462283CD55chr1

207512762

+NEK2chr1

211836994

-
5CDS-intronENST00000314754ENST00000366998CD55chr1

207512762

+NEK2chr1

211836994

-
Frame-shiftENST00000391920ENST00000366999CD55chr1

207512762

+NEK2chr1

211836994

-
Frame-shiftENST00000391920ENST00000540251CD55chr1

207512762

+NEK2chr1

211836994

-
5CDS-intronENST00000391920ENST00000462283CD55chr1

207512762

+NEK2chr1

211836994

-
5CDS-intronENST00000391920ENST00000366998CD55chr1

207512762

+NEK2chr1

211836994

-
Frame-shiftENST00000367062ENST00000366999CD55chr1

207512762

+NEK2chr1

211836994

-
Frame-shiftENST00000367062ENST00000540251CD55chr1

207512762

+NEK2chr1

211836994

-
5CDS-intronENST00000367062ENST00000462283CD55chr1

207512762

+NEK2chr1

211836994

-
5CDS-intronENST00000367062ENST00000366998CD55chr1

207512762

+NEK2chr1

211836994

-
Frame-shiftENST00000367065ENST00000366999CD55chr1

207512762

+NEK2chr1

211836994

-
Frame-shiftENST00000367065ENST00000540251CD55chr1

207512762

+NEK2chr1

211836994

-
5CDS-intronENST00000367065ENST00000462283CD55chr1

207512762

+NEK2chr1

211836994

-
5CDS-intronENST00000367065ENST00000366998CD55chr1

207512762

+NEK2chr1

211836994

-
3UTR-3CDSENST00000465534ENST00000366999CD55chr1

207512762

+NEK2chr1

211836994

-
3UTR-3CDSENST00000465534ENST00000540251CD55chr1

207512762

+NEK2chr1

211836994

-
3UTR-intronENST00000465534ENST00000462283CD55chr1

207512762

+NEK2chr1

211836994

-
3UTR-intronENST00000465534ENST00000366998CD55chr1

207512762

+NEK2chr1

211836994

-

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FusionProtFeatures for CD55_NEK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD55

P08174

NEK2

P51955

Protein kinase which is involved in the control ofcentrosome separation and bipolar spindle formation in mitoticcells and chromatin condensation in meiotic cells. Regulatescentrosome separation (essential for the formation of bipolarspindles and high-fidelity chromosome separation) byphosphorylating centrosomal proteins such as CROCC, CEP250 andNINL, resulting in their displacement from the centrosomes.Regulates kinetochore microtubule attachment stability in mitosisvia phosphorylation of NDC80. Involved in regulation of mitoticcheckpoint protein complex via phosphorylation of CDC20 andMAD2L1. Plays an active role in chromatin condensation during thefirst meiotic division through phosphorylation of HMGA2.Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential forlocalization of MAD2L1 to kinetochore and MAPK1 and NPM1 to thecentrosome. Phosphorylates CEP68 and CNTLN directly or indirectly(PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotesCEP68 dissociation from the centrosome and its degradation at theonset of mitosis (PubMed:25704143). Involved in the regulation ofcentrosome disjunction (PubMed:26220856).{ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871,ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203,ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141,ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005,ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113,ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410,ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143,ECO:0000269|PubMed:26220856}. Isoform 1: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}. Isoform 2: Not present in the nucleolus and, in contrastto isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CD55_NEK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CD55_NEK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CD55CD55, NDUFB7, MPV17, MAN2A1, RAB31, PTCD3, SLC2A1, MRPL4, GNAI3, INF2, ZMPSTE24, PTRH2, S100A10, SYNJ2BP, TIMM50, SLC12A4, NDUFS7, ATP6V1E1, SLC25A24, PICALM, CHI3L1, C6orf120, LCK, C2, TRIM25NEK2MAPK1, NEK2, CEP250, NDC80, CLEC4C, PPP1R2, PDE4DIP, TCF25, IMMT, TPM3, EIF4A2, MCC, IFT140, GIT1, CCDC85A, EDRF1, SPTBN4, CHGA, DCTN1, PPP1CA, MYC, CDC27, CSN2, CHEK1, PPP1CC, CDC20, VCP, CTNNB1, ANAPC4, FZR1, ODF2, CDC23, CDC16, ANAPC15, CFAP97, MAD2L1, BUB1B, PARK2, SMURF1, BFSP2, C16orf87, DTD1, DPP9, FANCA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CD55_NEK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCD55P08174DB00446ChloramphenicolComplement decay-accelerating factorsmall moleculeapproved|vet_approved

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RelatedDiseases for CD55_NEK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD55C0014175Endometriosis1CTD_human
HgeneCD55C0236733Amphetamine-Related Disorders1CTD_human