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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 62

FusionGeneSummary for AASDH_KIAA1211

check button Fusion gene summary
Fusion gene informationFusion gene name: AASDH_KIAA1211
Fusion gene ID: 62
HgeneTgene
Gene symbol

AASDH

KIAA1211

Gene ID

132949

57482

Gene nameaminoadipate-semialdehyde dehydrogenaseKIAA1211
SynonymsACSF4|LYS2|NRPS1098|NRPS998-
Cytomap

4q12

4q12

Type of geneprotein-codingprotein-coding
Descriptionbeta-alanine-activating enzyme2-aminoadipic 6-semialdehyde dehydrogenaseacyl-CoA synthetase family member 4non-ribosomal peptide synthetase 1098non-ribosomal peptide synthetase 998uncharacterized protein KIAA1211
Modification date2018051920180519
UniProtAcc

Q4L235

Q6ZU35

Ensembl transtripts involved in fusion geneENST00000513376, ENST00000205214, 
ENST00000434343, ENST00000451613, 
ENST00000602986, ENST00000502617, 
ENST00000510762, 		ENST00000264229, 
ENST00000541073, ENST00000504228, 
ENST00000505410, 
Fusion gene scores* DoF score5 X 5 X 3=756 X 4 X 4=96
# samples 56
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AASDH [Title/Abstract] AND KIAA1211 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA411740AASDHchr4

57253528

-KIAA1211chr4

57189543

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000513376ENST00000264229AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000513376ENST00000541073AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000513376ENST00000504228AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-intronENST00000513376ENST00000505410AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000205214ENST00000264229AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000205214ENST00000541073AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000205214ENST00000504228AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-intronENST00000205214ENST00000505410AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000434343ENST00000264229AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000434343ENST00000541073AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000434343ENST00000504228AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-intronENST00000434343ENST00000505410AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000451613ENST00000264229AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000451613ENST00000541073AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000451613ENST00000504228AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-intronENST00000451613ENST00000505410AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000602986ENST00000264229AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000602986ENST00000541073AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000602986ENST00000504228AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-intronENST00000602986ENST00000505410AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000502617ENST00000264229AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000502617ENST00000541073AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000502617ENST00000504228AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-intronENST00000502617ENST00000505410AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000510762ENST00000264229AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000510762ENST00000541073AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-3CDSENST00000510762ENST00000504228AASDHchr4

57253528

-KIAA1211chr4

57189543

+
5UTR-intronENST00000510762ENST00000505410AASDHchr4

57253528

-KIAA1211chr4

57189543

+

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FusionProtFeatures for AASDH_KIAA1211


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AASDH

Q4L235

KIAA1211

Q6ZU35


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AASDH_KIAA1211


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AASDH_KIAA1211


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AASDHGPSM2, EGFR, RNF113A, GORASP1, TKTKIAA1211UBC, CAPZA2, NTRK1, FLNA, MYO19, MYO18A, GLI1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AASDH_KIAA1211


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AASDH_KIAA1211


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource