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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 6189

FusionGeneSummary for CD44_SLC1A2

check button Fusion gene summary
Fusion gene informationFusion gene name: CD44_SLC1A2
Fusion gene ID: 6189
HgeneTgene
Gene symbol

CD44

SLC1A2

Gene ID

960

6506

Gene nameCD44 molecule (Indian blood group)solute carrier family 1 member 2
SynonymsCDW44|CSPG8|ECMR-III|HCELL|HUTCH-I|IN|LHR|MC56|MDU2|MDU3|MIC4|Pgp1EAAT2|EIEE41|GLT-1|HBGT
Cytomap

11p13

11p13

Type of geneprotein-codingprotein-coding
DescriptionCD44 antigenGP90 lymphocyte homing/adhesion receptorHermes antigencell surface glycoprotein CD44chondroitin sulfate proteoglycan 8epicanextracellular matrix receptor IIIhematopoietic cell E- and L-selectin ligandheparan sulfate proteoglycanhomingexcitatory amino acid transporter 2excitotoxic amino acid transporter 2glutamate/aspartate transporter IIsodium-dependent glutamate/aspartate transporter 2solute carrier family 1 (glial high affinity glutamate transporter), member 2
Modification date2018052720180519
UniProtAcc

P16070

P43004

Ensembl transtripts involved in fusion geneENST00000263398, ENST00000526025, 
ENST00000449691, ENST00000360158, 
ENST00000415148, ENST00000437706, 
ENST00000433354, ENST00000428726, 
ENST00000526669, ENST00000433892, 
ENST00000278386, ENST00000434472, 
ENST00000352818, ENST00000528922, 
ENST00000278379, ENST00000395750, 
ENST00000395753, ENST00000606205, 
ENST00000479543, 
Fusion gene scores* DoF score11 X 10 X 7=7709 X 8 X 5=360
# samples 1411
** MAII scorelog2(14/770*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD44 [Title/Abstract] AND SLC1A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD44

GO:0030214

hyaluronan catabolic process

17170110

HgeneCD44

GO:0033138

positive regulation of peptidyl-serine phosphorylation

17045821

HgeneCD44

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

17045821

HgeneCD44

GO:0044344

cellular response to fibroblast growth factor stimulus

19577615

HgeneCD44

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

17045821

HgeneCD44

GO:0070374

positive regulation of ERK1 and ERK2 cascade

17045821

HgeneCD44

GO:1902166

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

17045821

TgeneSLC1A2

GO:0015813

L-glutamate transmembrane transport

26690923

TgeneSLC1A2

GO:0070207

protein homotrimerization

15265858|15483603

TgeneSLC1A2

GO:0070779

D-aspartate import across plasma membrane

7521911

TgeneSLC1A2

GO:0098712

L-glutamate import across plasma membrane

7521911|15265858|26690923


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-B7-5818-01ACD44chr11

35243279

+SLC1A2chr11

35339063

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000263398ENST00000278379CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000263398ENST00000395750CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000263398ENST00000395753CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000263398ENST00000606205CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-intronENST00000263398ENST00000479543CD44chr11

35243279

+SLC1A2chr11

35339063

-
intron-3CDSENST00000526025ENST00000278379CD44chr11

35243279

+SLC1A2chr11

35339063

-
intron-5UTRENST00000526025ENST00000395750CD44chr11

35243279

+SLC1A2chr11

35339063

-
intron-5UTRENST00000526025ENST00000395753CD44chr11

35243279

+SLC1A2chr11

35339063

-
intron-5UTRENST00000526025ENST00000606205CD44chr11

35243279

+SLC1A2chr11

35339063

-
intron-intronENST00000526025ENST00000479543CD44chr11

35243279

+SLC1A2chr11

35339063

-
In-frameENST00000449691ENST00000278379CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000449691ENST00000395750CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000449691ENST00000395753CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000449691ENST00000606205CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-intronENST00000449691ENST00000479543CD44chr11

35243279

+SLC1A2chr11

35339063

-
In-frameENST00000360158ENST00000278379CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000360158ENST00000395750CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000360158ENST00000395753CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000360158ENST00000606205CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-intronENST00000360158ENST00000479543CD44chr11

35243279

+SLC1A2chr11

35339063

-
In-frameENST00000415148ENST00000278379CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000415148ENST00000395750CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000415148ENST00000395753CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000415148ENST00000606205CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-intronENST00000415148ENST00000479543CD44chr11

35243279

+SLC1A2chr11

35339063

-
In-frameENST00000437706ENST00000278379CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000437706ENST00000395750CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000437706ENST00000395753CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000437706ENST00000606205CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-intronENST00000437706ENST00000479543CD44chr11

35243279

+SLC1A2chr11

35339063

-
In-frameENST00000433354ENST00000278379CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000433354ENST00000395750CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000433354ENST00000395753CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000433354ENST00000606205CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-intronENST00000433354ENST00000479543CD44chr11

35243279

+SLC1A2chr11

35339063

-
In-frameENST00000428726ENST00000278379CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000428726ENST00000395750CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000428726ENST00000395753CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000428726ENST00000606205CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-intronENST00000428726ENST00000479543CD44chr11

35243279

+SLC1A2chr11

35339063

-
In-frameENST00000526669ENST00000278379CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000526669ENST00000395750CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000526669ENST00000395753CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000526669ENST00000606205CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-intronENST00000526669ENST00000479543CD44chr11

35243279

+SLC1A2chr11

35339063

-
In-frameENST00000433892ENST00000278379CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000433892ENST00000395750CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000433892ENST00000395753CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000433892ENST00000606205CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-intronENST00000433892ENST00000479543CD44chr11

35243279

+SLC1A2chr11

35339063

-
Frame-shiftENST00000278386ENST00000278379CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000278386ENST00000395750CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000278386ENST00000395753CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000278386ENST00000606205CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-intronENST00000278386ENST00000479543CD44chr11

35243279

+SLC1A2chr11

35339063

-
In-frameENST00000434472ENST00000278379CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000434472ENST00000395750CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000434472ENST00000395753CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000434472ENST00000606205CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-intronENST00000434472ENST00000479543CD44chr11

35243279

+SLC1A2chr11

35339063

-
In-frameENST00000352818ENST00000278379CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000352818ENST00000395750CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000352818ENST00000395753CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-5UTRENST00000352818ENST00000606205CD44chr11

35243279

+SLC1A2chr11

35339063

-
5CDS-intronENST00000352818ENST00000479543CD44chr11

35243279

+SLC1A2chr11

35339063

-
intron-3CDSENST00000528922ENST00000278379CD44chr11

35243279

+SLC1A2chr11

35339063

-
intron-5UTRENST00000528922ENST00000395750CD44chr11

35243279

+SLC1A2chr11

35339063

-
intron-5UTRENST00000528922ENST00000395753CD44chr11

35243279

+SLC1A2chr11

35339063

-
intron-5UTRENST00000528922ENST00000606205CD44chr11

35243279

+SLC1A2chr11

35339063

-
intron-intronENST00000528922ENST00000479543CD44chr11

35243279

+SLC1A2chr11

35339063

-

Top

FusionProtFeatures for CD44_SLC1A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD44

P16070

SLC1A2

P43004

Sodium-dependent, high-affinity amino acid transporterthat mediates the uptake of L-glutamate and also L-aspartate andD-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858,PubMed:26690923). Functions as a symporter that transports oneamino acid molecule together with two or three Na(+) ions and oneproton, in parallel with the counter-transport of one K(+) ion(PubMed:14506254). Mediates Cl(-) flux that is not coupled toamino acid transport; this avoids the accumulation of negativecharges due to aspartate and Na(+) symport (PubMed:14506254).Essential for the rapid removal of released glutamate from thesynaptic cleft, and for terminating the postsynaptic action ofglutamate (By similarity). {ECO:0000250|UniProtKB:P43006,ECO:0000269|PubMed:15265858, ECO:0000269|PubMed:26690923,ECO:0000269|PubMed:7521911}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD44chr11:35243279chr11:35339063ENST00000263398+89150_158293362Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35243279chr11:35339063ENST00000352818+78150_158272341Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35243279chr11:35339063ENST00000360158+910150_158328397Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35243279chr11:35339063ENST00000415148+1617150_158631700Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35243279chr11:35339063ENST00000428726+1718150_158674743Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35243279chr11:35339063ENST00000433892+1112150_158425494Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35243279chr11:35339063ENST00000434472+910150_158361430Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35243279chr11:35339063ENST00000437706+1617150_158606675Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35243279chr11:35339063ENST00000449691+1617150_158631700Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35243279chr11:35339063ENST00000263398+8932_120293362DomainLink
HgeneCD44chr11:35243279chr11:35339063ENST00000352818+7832_120272341DomainLink
HgeneCD44chr11:35243279chr11:35339063ENST00000360158+91032_120328397DomainLink
HgeneCD44chr11:35243279chr11:35339063ENST00000415148+161732_120631700DomainLink
HgeneCD44chr11:35243279chr11:35339063ENST00000428726+171832_120674743DomainLink
HgeneCD44chr11:35243279chr11:35339063ENST00000433892+111232_120425494DomainLink
HgeneCD44chr11:35243279chr11:35339063ENST00000434472+91032_120361430DomainLink
HgeneCD44chr11:35243279chr11:35339063ENST00000437706+161732_120606675DomainLink
HgeneCD44chr11:35243279chr11:35339063ENST00000449691+161732_120631700DomainLink
HgeneCD44chr11:35243279chr11:35339063ENST00000428726+1718224_649674743RegionNote=Stem
HgeneCD44chr11:35243279chr11:35339063ENST00000428726+171821_649674743Topological domainExtracellular
HgeneCD44chr11:35243279chr11:35339063ENST00000428726+1718650_670674743TransmembraneHelical
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011345_3755575IntramembraneDiscontinuously helical
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011425_4585575IntramembraneDiscontinuously helical
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112345_375-4566IntramembraneDiscontinuously helical
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112425_458-4566IntramembraneDiscontinuously helical
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112345_375-4566IntramembraneDiscontinuously helical
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112425_458-4566IntramembraneDiscontinuously helical
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011362_3645575RegionAspartate binding
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011442_4465575RegionAspartate binding
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112362_364-4566RegionAspartate binding
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112442_446-4566RegionAspartate binding
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112362_364-4566RegionAspartate binding
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112442_446-4566RegionAspartate binding
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011109_1205575Topological domainCytoplasmic
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011143_2355575Topological domainExtracellular
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011260_2685575Topological domainCytoplasmic
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011297_3175575Topological domainExtracellular
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011340_3445575Topological domainCytoplasmic
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011376_3845575Topological domainCytoplasmic
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011412_4245575Topological domainExtracellular
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011459_4715575Topological domainExtracellular
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011494_5745575Topological domainCytoplasmic
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-01165_875575Topological domainExtracellular
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112109_120-4566Topological domainCytoplasmic
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112143_235-4566Topological domainExtracellular
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-1121_44-4566Topological domainCytoplasmic
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112260_268-4566Topological domainCytoplasmic
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112297_317-4566Topological domainExtracellular
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112340_344-4566Topological domainCytoplasmic
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112376_384-4566Topological domainCytoplasmic
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112412_424-4566Topological domainExtracellular
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112459_471-4566Topological domainExtracellular
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112494_574-4566Topological domainCytoplasmic
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-11265_87-4566Topological domainExtracellular
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112109_120-4566Topological domainCytoplasmic
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112143_235-4566Topological domainExtracellular
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-1121_44-4566Topological domainCytoplasmic
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112260_268-4566Topological domainCytoplasmic
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112297_317-4566Topological domainExtracellular
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112340_344-4566Topological domainCytoplasmic
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112376_384-4566Topological domainCytoplasmic
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112412_424-4566Topological domainExtracellular
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112459_471-4566Topological domainExtracellular
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112494_574-4566Topological domainCytoplasmic
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-11265_87-4566Topological domainExtracellular
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011121_1425575TransmembraneHelical
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011236_2595575TransmembraneHelical%3B Name%3D4
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011269_2965575TransmembraneHelical%3B Name%3D5
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011318_3395575TransmembraneHelical%3B Name%3D6
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011385_4115575TransmembraneHelical%3B Name%3D7
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-01145_645575TransmembraneHelical
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-011472_4935575TransmembraneHelical%3B Name%3D8
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-01188_1085575TransmembraneHelical
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112121_142-4566TransmembraneHelical
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112236_259-4566TransmembraneHelical%3B Name%3D4
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112269_296-4566TransmembraneHelical%3B Name%3D5
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112318_339-4566TransmembraneHelical%3B Name%3D6
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112385_411-4566TransmembraneHelical%3B Name%3D7
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-11245_64-4566TransmembraneHelical
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-112472_493-4566TransmembraneHelical%3B Name%3D8
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395750-11288_108-4566TransmembraneHelical
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112121_142-4566TransmembraneHelical
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112236_259-4566TransmembraneHelical%3B Name%3D4
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112269_296-4566TransmembraneHelical%3B Name%3D5
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112318_339-4566TransmembraneHelical%3B Name%3D6
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112385_411-4566TransmembraneHelical%3B Name%3D7
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-11245_64-4566TransmembraneHelical
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-112472_493-4566TransmembraneHelical%3B Name%3D8
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000395753-11288_108-4566TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD44chr11:35243279chr11:35339063ENST00000278386+34150_15887140Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35243279chr11:35339063ENST00000278386+3432_12087140DomainLink
HgeneCD44chr11:35243279chr11:35339063ENST00000263398+89224_649293362RegionNote=Stem
HgeneCD44chr11:35243279chr11:35339063ENST00000278386+34224_64987140RegionNote=Stem
HgeneCD44chr11:35243279chr11:35339063ENST00000352818+78224_649272341RegionNote=Stem
HgeneCD44chr11:35243279chr11:35339063ENST00000360158+910224_649328397RegionNote=Stem
HgeneCD44chr11:35243279chr11:35339063ENST00000415148+1617224_649631700RegionNote=Stem
HgeneCD44chr11:35243279chr11:35339063ENST00000433892+1112224_649425494RegionNote=Stem
HgeneCD44chr11:35243279chr11:35339063ENST00000434472+910224_649361430RegionNote=Stem
HgeneCD44chr11:35243279chr11:35339063ENST00000437706+1617224_649606675RegionNote=Stem
HgeneCD44chr11:35243279chr11:35339063ENST00000449691+1617224_649631700RegionNote=Stem
HgeneCD44chr11:35243279chr11:35339063ENST00000263398+8921_649293362Topological domainExtracellular
HgeneCD44chr11:35243279chr11:35339063ENST00000263398+89671_742293362Topological domainCytoplasmic
HgeneCD44chr11:35243279chr11:35339063ENST00000278386+3421_64987140Topological domainExtracellular
HgeneCD44chr11:35243279chr11:35339063ENST00000278386+34671_74287140Topological domainCytoplasmic
HgeneCD44chr11:35243279chr11:35339063ENST00000352818+7821_649272341Topological domainExtracellular
HgeneCD44chr11:35243279chr11:35339063ENST00000352818+78671_742272341Topological domainCytoplasmic
HgeneCD44chr11:35243279chr11:35339063ENST00000360158+91021_649328397Topological domainExtracellular
HgeneCD44chr11:35243279chr11:35339063ENST00000360158+910671_742328397Topological domainCytoplasmic
HgeneCD44chr11:35243279chr11:35339063ENST00000415148+161721_649631700Topological domainExtracellular
HgeneCD44chr11:35243279chr11:35339063ENST00000415148+1617671_742631700Topological domainCytoplasmic
HgeneCD44chr11:35243279chr11:35339063ENST00000428726+1718671_742674743Topological domainCytoplasmic
HgeneCD44chr11:35243279chr11:35339063ENST00000433892+111221_649425494Topological domainExtracellular
HgeneCD44chr11:35243279chr11:35339063ENST00000433892+1112671_742425494Topological domainCytoplasmic
HgeneCD44chr11:35243279chr11:35339063ENST00000434472+91021_649361430Topological domainExtracellular
HgeneCD44chr11:35243279chr11:35339063ENST00000434472+910671_742361430Topological domainCytoplasmic
HgeneCD44chr11:35243279chr11:35339063ENST00000437706+161721_649606675Topological domainExtracellular
HgeneCD44chr11:35243279chr11:35339063ENST00000437706+1617671_742606675Topological domainCytoplasmic
HgeneCD44chr11:35243279chr11:35339063ENST00000449691+161721_649631700Topological domainExtracellular
HgeneCD44chr11:35243279chr11:35339063ENST00000449691+1617671_742631700Topological domainCytoplasmic
HgeneCD44chr11:35243279chr11:35339063ENST00000263398+89650_670293362TransmembraneHelical
HgeneCD44chr11:35243279chr11:35339063ENST00000278386+34650_67087140TransmembraneHelical
HgeneCD44chr11:35243279chr11:35339063ENST00000352818+78650_670272341TransmembraneHelical
HgeneCD44chr11:35243279chr11:35339063ENST00000360158+910650_670328397TransmembraneHelical
HgeneCD44chr11:35243279chr11:35339063ENST00000415148+1617650_670631700TransmembraneHelical
HgeneCD44chr11:35243279chr11:35339063ENST00000433892+1112650_670425494TransmembraneHelical
HgeneCD44chr11:35243279chr11:35339063ENST00000434472+910650_670361430TransmembraneHelical
HgeneCD44chr11:35243279chr11:35339063ENST00000437706+1617650_670606675TransmembraneHelical
HgeneCD44chr11:35243279chr11:35339063ENST00000449691+1617650_670631700TransmembraneHelical
TgeneSLC1A2chr11:35243279chr11:35339063ENST00000278379-0111_445575Topological domainCytoplasmic


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FusionGeneSequence for CD44_SLC1A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CD44_SLC1A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CD44ARHGEF1, COL14A1, LCK, IGFBP3, MMP7, ERBB4, TIAM1, TGFBR1, VAV2, FN1, EGFR, ERBB2, HBEGF, EZR, VCAN, SRC, PTPRC, FYN, MSN, NF2, ELAVL1, PRKCZ, ITGB1, FLOT2, CAV1, EP300, STAT3, SLC3A2, IQGAP1, FMNL1, ATF2, ANK1, VHL, BAG1, DPP8, ABCE1, AIM1, DBN1, FLNA, MYH9, DYNLL1, SYNPO, LIMA1, MYO19, SQSTM1, CHERP, PHRF1, CDC73, CD44, FGFR1, CTDSPL, GMEB2, FGF2, GMEB1, DHRS2, METTL8, FAM115C, SLC39A9, AMPD2, SNX33, CAMKV, ATG9A, PRDM10, C17orf80, SNX18, FGFR2, FGFRL1, VANGL1, PARP2, TEFM, LAMA3, MTCH2, HADHB, CLCN7, XAB2, GTF3C2, CDC40, GTF3C3, AQR, GTF3C1, GTF3C6, HADHA, TMEM160, OSBPL8, CDC5L, TNPO2, PRKCI, LEMD3, LGALS1, RBM22, VANGL2, MBOAT7, ISY1, GBAS, TRIM25, CD74SLC1A2AJUBA, GRB2, PML, MAPT, RPL17, RPL23A, RPL32, RPL38, RPL5, RPL3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CD44_SLC1A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCD44P16070DB08818Hyaluronic acidCD44 antigensmall moleculeapproved|vet_approved
TgeneSLC1A2P43004DB00142Glutamic AcidExcitatory amino acid transporter 2small moleculeapproved|nutraceutical

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RelatedDiseases for CD44_SLC1A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD44C0023487Acute Promyelocytic Leukemia2CTD_human
HgeneCD44C0011616Contact Dermatitis1CTD_human
HgeneCD44C0017661IGA Glomerulonephritis1CTD_human
HgeneCD44C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneCD44C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneCD44C0027627Neoplasm Metastasis1CTD_human
HgeneCD44C0027746Nerve Degeneration1CTD_human
HgeneCD44C0030297Pancreatic Neoplasm1CTD_human
HgeneCD44C0037274Dermatologic disorders1CTD_human
HgeneCD44C0038356Stomach Neoplasms1CTD_human
HgeneCD44C0042900Vitiligo1CTD_human
HgeneCD44C0311375Arsenic Poisoning1CTD_human
HgeneCD44C2609414Acute kidney injury1CTD_human
TgeneSLC1A2C0005586Bipolar Disorder4PSYGENET
TgeneSLC1A2C0036341Schizophrenia4PSYGENET
TgeneSLC1A2C0001973Alcoholic Intoxication, Chronic3PSYGENET
TgeneSLC1A2C0011570Mental Depression3PSYGENET
TgeneSLC1A2C0011581Depressive disorder3PSYGENET
TgeneSLC1A2C0002736Amyotrophic Lateral Sclerosis1CTD_human
TgeneSLC1A2C0014544Epilepsy1CTD_human
TgeneSLC1A2C0027746Nerve Degeneration1CTD_human
TgeneSLC1A2C0038356Stomach Neoplasms1CTD_human
TgeneSLC1A2C0236736Cocaine-Related Disorders1CTD_human
TgeneSLC1A2C0525045Mood Disorders1PSYGENET