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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6171

FusionGeneSummary for CD34_DEPDC1B

check button Fusion gene summary
Fusion gene informationFusion gene name: CD34_DEPDC1B
Fusion gene ID: 6171
HgeneTgene
Gene symbol

CD34

DEPDC1B

Gene ID

947

55789

Gene nameCD34 moleculeDEP domain containing 1B
Synonyms-BRCC3|XTP1
Cytomap

1q32.2

5q12.1

Type of geneprotein-codingprotein-coding
Descriptionhematopoietic progenitor cell antigen CD34CD34 antigenDEP domain-containing protein 1BHBV X-transactivated gene 8 proteinHBV XAg-transactivated protein 8HBxAg transactivated protein 1breast cancer cell 3
Modification date2018052320180523
UniProtAcc

P28906

Q8WUY9

Ensembl transtripts involved in fusion geneENST00000485761, ENST00000367036, 
ENST00000310833, ENST00000356522, 
ENST00000537704, 
ENST00000265036, 
ENST00000453022, ENST00000545085, 
ENST00000509006, 
Fusion gene scores* DoF score4 X 4 X 1=162 X 4 X 4=32
# samples 58
** MAII scorelog2(5/16*10)=1.64385618977472
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/32*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CD34 [Title/Abstract] AND DEPDC1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD34

GO:0001894

tissue homeostasis

12939361

HgeneCD34

GO:0001935

endothelial cell proliferation

21835908

HgeneCD34

GO:0008217

regulation of blood pressure

17505307

HgeneCD34

GO:0030195

negative regulation of blood coagulation

17505307

HgeneCD34

GO:0032720

negative regulation of tumor necrosis factor production

17505307

HgeneCD34

GO:0032733

positive regulation of interleukin-10 production

17505307

HgeneCD34

GO:0038001

paracrine signaling

21835908

HgeneCD34

GO:0042482

positive regulation of odontogenesis

12939361

HgeneCD34

GO:0045019

negative regulation of nitric oxide biosynthetic process

17505307

HgeneCD34

GO:0045766

positive regulation of angiogenesis

12939361|21835908

HgeneCD34

GO:0071636

positive regulation of transforming growth factor beta production

17505307

HgeneCD34

GO:0071657

positive regulation of granulocyte colony-stimulating factor production

9815891

HgeneCD34

GO:0071971

extracellular exosome assembly

21835908

HgeneCD34

GO:0098609

cell-cell adhesion

15249540

HgeneCD34

GO:1900035

negative regulation of cellular response to heat

17505307

HgeneCD34

GO:1900038

negative regulation of cellular response to hypoxia

17505307

HgeneCD34

GO:1900168

positive regulation of glial cell-derived neurotrophic factor secretion

17505307

HgeneCD34

GO:1901215

negative regulation of neuron death

17505307

HgeneCD34

GO:2001214

positive regulation of vasculogenesis

12939361


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI394178CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000485761ENST00000265036CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000485761ENST00000453022CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000485761ENST00000545085CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000485761ENST00000509006CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000367036ENST00000265036CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000367036ENST00000453022CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000367036ENST00000545085CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000367036ENST00000509006CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000310833ENST00000265036CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000310833ENST00000453022CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000310833ENST00000545085CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000310833ENST00000509006CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000356522ENST00000265036CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000356522ENST00000453022CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000356522ENST00000545085CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000356522ENST00000509006CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000537704ENST00000265036CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000537704ENST00000453022CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000537704ENST00000545085CD34chr1

208060067

+DEPDC1Bchr5

59895934

+
intron-intronENST00000537704ENST00000509006CD34chr1

208060067

+DEPDC1Bchr5

59895934

+

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FusionProtFeatures for CD34_DEPDC1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD34

P28906

DEPDC1B

Q8WUY9

Possible adhesion molecule with a role in earlyhematopoiesis by mediating the attachment of stem cells to thebone marrow extracellular matrix or directly to stromal cells.Could act as a scaffold for the attachment of lineage specificglycans, allowing stem cells to bind to lectins expressed bystromal cells or other marrow components. Presents carbohydrateligands to selectins.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CD34_DEPDC1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CD34_DEPDC1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CD34_DEPDC1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CD34_DEPDC1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD34C0007621Neoplastic Cell Transformation1CTD_human
HgeneCD34C0033975Psychotic Disorders1PSYGENET
HgeneCD34C0041696Unipolar Depression1PSYGENET
HgeneCD34C0349204Nonorganic psychosis1PSYGENET
HgeneCD34C1269683Major Depressive Disorder1PSYGENET