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Fusion gene ID: 6170 |
FusionGeneSummary for CD34_DBN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CD34_DBN1 | Fusion gene ID: 6170 | Hgene | Tgene | Gene symbol | CD34 | DBN1 | Gene ID | 947 | 1627 |
| Gene name | CD34 molecule | drebrin 1 | |
| Synonyms | - | D0S117E | |
| Cytomap | 1q32.2 | 5q35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | hematopoietic progenitor cell antigen CD34CD34 antigen | drebrindevelopmentally-regulated brain proteindrebrin Adrebrin Edrebrin E2 | |
| Modification date | 20180523 | 20180525 | |
| UniProtAcc | P28906 | Q16643 | |
| Ensembl transtripts involved in fusion gene | ENST00000485761, ENST00000367036, ENST00000310833, ENST00000356522, ENST00000537704, | ENST00000309007, ENST00000292385, ENST00000393565, ENST00000393563, ENST00000512501, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 8 X 7 X 6=336 |
| # samples | 5 | 9 | |
| ** MAII score | log2(5/16*10)=1.64385618977472 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CD34 [Title/Abstract] AND DBN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CD34 | GO:0001894 | tissue homeostasis | 12939361 |
| Hgene | CD34 | GO:0001935 | endothelial cell proliferation | 21835908 |
| Hgene | CD34 | GO:0008217 | regulation of blood pressure | 17505307 |
| Hgene | CD34 | GO:0030195 | negative regulation of blood coagulation | 17505307 |
| Hgene | CD34 | GO:0032720 | negative regulation of tumor necrosis factor production | 17505307 |
| Hgene | CD34 | GO:0032733 | positive regulation of interleukin-10 production | 17505307 |
| Hgene | CD34 | GO:0038001 | paracrine signaling | 21835908 |
| Hgene | CD34 | GO:0042482 | positive regulation of odontogenesis | 12939361 |
| Hgene | CD34 | GO:0045019 | negative regulation of nitric oxide biosynthetic process | 17505307 |
| Hgene | CD34 | GO:0045766 | positive regulation of angiogenesis | 12939361|21835908 |
| Hgene | CD34 | GO:0071636 | positive regulation of transforming growth factor beta production | 17505307 |
| Hgene | CD34 | GO:0071657 | positive regulation of granulocyte colony-stimulating factor production | 9815891 |
| Hgene | CD34 | GO:0071971 | extracellular exosome assembly | 21835908 |
| Hgene | CD34 | GO:0098609 | cell-cell adhesion | 15249540 |
| Hgene | CD34 | GO:1900035 | negative regulation of cellular response to heat | 17505307 |
| Hgene | CD34 | GO:1900038 | negative regulation of cellular response to hypoxia | 17505307 |
| Hgene | CD34 | GO:1900168 | positive regulation of glial cell-derived neurotrophic factor secretion | 17505307 |
| Hgene | CD34 | GO:1901215 | negative regulation of neuron death | 17505307 |
| Hgene | CD34 | GO:2001214 | positive regulation of vasculogenesis | 12939361 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW351462 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + | ||
| ChiTaRS3.1 | AW351463 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000485761 | ENST00000309007 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000485761 | ENST00000292385 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000485761 | ENST00000393565 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000485761 | ENST00000393563 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000485761 | ENST00000512501 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000367036 | ENST00000309007 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000367036 | ENST00000292385 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000367036 | ENST00000393565 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000367036 | ENST00000393563 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000367036 | ENST00000512501 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000310833 | ENST00000309007 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000310833 | ENST00000292385 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000310833 | ENST00000393565 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000310833 | ENST00000393563 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000310833 | ENST00000512501 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000356522 | ENST00000309007 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000356522 | ENST00000292385 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000356522 | ENST00000393565 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000356522 | ENST00000393563 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000356522 | ENST00000512501 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000537704 | ENST00000309007 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000537704 | ENST00000292385 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000537704 | ENST00000393565 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000537704 | ENST00000393563 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
| intron-3CDS | ENST00000537704 | ENST00000512501 | CD34 | chr1 | 208061080 | - | DBN1 | chr5 | 176887485 | + |
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FusionProtFeatures for CD34_DBN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CD34 | DBN1 |
| Possible adhesion molecule with a role in earlyhematopoiesis by mediating the attachment of stem cells to thebone marrow extracellular matrix or directly to stromal cells.Could act as a scaffold for the attachment of lineage specificglycans, allowing stem cells to bind to lectins expressed bystromal cells or other marrow components. Presents carbohydrateligands to selectins. | Drebrins might play some role in cell migration,extension of neuronal processes and plasticity of dendrites.Required for actin polymerization at immunological synapses (IS)and for CXCR4 recruitment to IS. {ECO:0000269|PubMed:20215400}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CD34_DBN1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CD34_DBN1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CD34_DBN1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CD34_DBN1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CD34 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Hgene | CD34 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Hgene | CD34 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Hgene | CD34 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| Hgene | CD34 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Tgene | DBN1 | C0036341 | Schizophrenia | 3 | PSYGENET |
| Tgene | DBN1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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