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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6124

FusionGeneSummary for CD101_SEC31A

check button Fusion gene summary
Fusion gene informationFusion gene name: CD101_SEC31A
Fusion gene ID: 6124
HgeneTgene
Gene symbol

CD101

SEC31A

Gene ID

9398

22872

Gene nameCD101 moleculeSEC31 homolog A, COPII coat complex component
SynonymsEWI-101|IGSF2|V7ABP125|ABP130|HSPC275|HSPC334|SEC31L1
Cytomap

1p13.1

4q21.22

Type of geneprotein-codingprotein-coding
Descriptionimmunoglobulin superfamily member 2cell surface glycoprotein V7glu-Trp-Ile EWI motif-containing protein 101leukocyte surface proteinprotein transport protein Sec31ASEC31 homolog A, COPII coating complex componentSEC31-like protein 1SEC31-related protein Aweb1-like proteinyeast Sec31p homolog
Modification date2018052320180523
UniProtAcc

Q93033

O94979

Ensembl transtripts involved in fusion geneENST00000256652, ENST00000369470, 
ENST00000467588, 		ENST00000348405, 
ENST00000513858, ENST00000395310, 
ENST00000443462, ENST00000509142, 
ENST00000326950, ENST00000432794, 
ENST00000311785, ENST00000448323, 
ENST00000505472, ENST00000500777, 
ENST00000508502, ENST00000355196, 
ENST00000264405, ENST00000505984, 
ENST00000508479, ENST00000436790, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 8 X 4=256
# samples 19
** MAII scorelog2(1/1*10)=3.32192809488736log2(9/256*10)=-1.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD101 [Title/Abstract] AND SEC31A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSEC31A

GO:0051592

response to calcium ion

17196169

TgeneSEC31A

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF824998CD101chr1

117576519

-SEC31Achr4

83740102

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000256652ENST00000348405CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000256652ENST00000513858CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000256652ENST00000395310CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000256652ENST00000443462CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000256652ENST00000509142CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000256652ENST00000326950CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000256652ENST00000432794CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000256652ENST00000311785CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000256652ENST00000448323CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000256652ENST00000505472CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000256652ENST00000500777CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-intronENST00000256652ENST00000508502CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-intronENST00000256652ENST00000355196CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-intronENST00000256652ENST00000264405CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-intronENST00000256652ENST00000505984CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-intronENST00000256652ENST00000508479CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-intronENST00000256652ENST00000436790CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000369470ENST00000348405CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000369470ENST00000513858CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000369470ENST00000395310CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000369470ENST00000443462CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000369470ENST00000509142CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000369470ENST00000326950CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000369470ENST00000432794CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000369470ENST00000311785CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000369470ENST00000448323CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000369470ENST00000505472CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-3UTRENST00000369470ENST00000500777CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-intronENST00000369470ENST00000508502CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-intronENST00000369470ENST00000355196CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-intronENST00000369470ENST00000264405CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-intronENST00000369470ENST00000505984CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-intronENST00000369470ENST00000508479CD101chr1

117576519

-SEC31Achr4

83740102

+
5CDS-intronENST00000369470ENST00000436790CD101chr1

117576519

-SEC31Achr4

83740102

+
3UTR-3UTRENST00000467588ENST00000348405CD101chr1

117576519

-SEC31Achr4

83740102

+
3UTR-3UTRENST00000467588ENST00000513858CD101chr1

117576519

-SEC31Achr4

83740102

+
3UTR-3UTRENST00000467588ENST00000395310CD101chr1

117576519

-SEC31Achr4

83740102

+
3UTR-3UTRENST00000467588ENST00000443462CD101chr1

117576519

-SEC31Achr4

83740102

+
3UTR-3UTRENST00000467588ENST00000509142CD101chr1

117576519

-SEC31Achr4

83740102

+
3UTR-3UTRENST00000467588ENST00000326950CD101chr1

117576519

-SEC31Achr4

83740102

+
3UTR-3UTRENST00000467588ENST00000432794CD101chr1

117576519

-SEC31Achr4

83740102

+
3UTR-3UTRENST00000467588ENST00000311785CD101chr1

117576519

-SEC31Achr4

83740102

+
3UTR-3UTRENST00000467588ENST00000448323CD101chr1

117576519

-SEC31Achr4

83740102

+
3UTR-3UTRENST00000467588ENST00000505472CD101chr1

117576519

-SEC31Achr4

83740102

+
3UTR-3UTRENST00000467588ENST00000500777CD101chr1

117576519

-SEC31Achr4

83740102

+
3UTR-intronENST00000467588ENST00000508502CD101chr1

117576519

-SEC31Achr4

83740102

+
3UTR-intronENST00000467588ENST00000355196CD101chr1

117576519

-SEC31Achr4

83740102

+
3UTR-intronENST00000467588ENST00000264405CD101chr1

117576519

-SEC31Achr4

83740102

+
3UTR-intronENST00000467588ENST00000505984CD101chr1

117576519

-SEC31Achr4

83740102

+
3UTR-intronENST00000467588ENST00000508479CD101chr1

117576519

-SEC31Achr4

83740102

+
3UTR-intronENST00000467588ENST00000436790CD101chr1

117576519

-SEC31Achr4

83740102

+

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FusionProtFeatures for CD101_SEC31A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD101

Q93033

SEC31A

O94979

Plays a role as inhibitor of T-cells proliferationinduced by CD3. Inhibits expression of IL2RA on activated T-cellsand secretion of IL2. Inhibits tyrosine kinases that are requiredfor IL2 production and cellular proliferation. Inhibitsphospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nucleartranslocation of nuclear factor of activated T-cell to thenucleus. Plays a role in the inhibition of T-cell proliferationvia IL10 secretion by cutaneous dendritic cells. May be a markerof CD4(+) CD56(+) leukemic tumor cells.{ECO:0000269|PubMed:11093127, ECO:0000269|PubMed:15737213,ECO:0000269|PubMed:7722299, ECO:0000269|PubMed:9233604,ECO:0000269|PubMed:9389317, ECO:0000269|PubMed:9647226}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CD101_SEC31A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CD101_SEC31A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CD101_SEC31A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CD101_SEC31A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSEC31AC0079744Diffuse Large B-Cell Lymphoma1CTD_human