|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 6109 |
FusionGeneSummary for CCT4_BIRC6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCT4_BIRC6 | Fusion gene ID: 6109 | Hgene | Tgene | Gene symbol | CCT4 | BIRC6 | Gene ID | 10575 | 57448 |
| Gene name | chaperonin containing TCP1 subunit 4 | baculoviral IAP repeat containing 6 | |
| Synonyms | CCT-DELTA|Cctd|SRB | APOLLON|BRUCE | |
| Cytomap | 2p15 | 2p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | T-complex protein 1 subunit deltaTCP-1-deltachaperonin containing TCP1, subunit 4 (delta)chaperonin containing t-complex polypeptide 1, delta subunitstimulator of TAR RNA-binding | baculoviral IAP repeat-containing protein 6BIR repeat-containing ubiquitin-conjugating enzymeRING-type E3 ubiquitin transferase BIRC6ubiquitin-conjugating BIR-domain enzyme apollon | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P50991 | Q9NR09 | |
| Ensembl transtripts involved in fusion gene | ENST00000394440, ENST00000461540, ENST00000544079, ENST00000544185, ENST00000538252, | ENST00000421745, | |
| Fusion gene scores | * DoF score | 4 X 5 X 2=40 | 17 X 11 X 13=2431 |
| # samples | 5 | 23 | |
| ** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(23/2431*10)=-3.40184412708435 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CCT4 [Title/Abstract] AND BIRC6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-L5-A8NE-01A | CCT4 | chr2 | 62107421 | - | BIRC6 | chr2 | 32756422 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000394440 | ENST00000421745 | CCT4 | chr2 | 62107421 | - | BIRC6 | chr2 | 32756422 | + |
| intron-3CDS | ENST00000461540 | ENST00000421745 | CCT4 | chr2 | 62107421 | - | BIRC6 | chr2 | 32756422 | + |
| In-frame | ENST00000544079 | ENST00000421745 | CCT4 | chr2 | 62107421 | - | BIRC6 | chr2 | 32756422 | + |
| intron-3CDS | ENST00000544185 | ENST00000421745 | CCT4 | chr2 | 62107421 | - | BIRC6 | chr2 | 32756422 | + |
| Frame-shift | ENST00000538252 | ENST00000421745 | CCT4 | chr2 | 62107421 | - | BIRC6 | chr2 | 32756422 | + |
Top |
FusionProtFeatures for CCT4_BIRC6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCT4 | BIRC6 |
| Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}. | Anti-apoptotic protein which can regulate cell death bycontrolling caspases and by acting as an E3 ubiquitin-proteinligase. Has an unusual ubiquitin conjugation system in that itcould combine in a single polypeptide, ubiquitin conjugating (E2)with ubiquitin ligase (E3) activity, forming a chimeric E2/E3ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Actsas an inhibitor of CASP3, CASP7 and CASP9. Important regulator forthe final stages of cytokinesis. Crucial for normal vesicletargeting to the site of abscission, but also for the integrity ofthe midbody and the midbody ring, and its striking ubiquitinmodification. {ECO:0000269|PubMed:14765125,ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >BIRC6 | chr2:62107421 | chr2:32756422 | ENST00000421745 | + | 59 | 74 | 4576_4704 | 4031 | 4858 | Region | Note=Ubiquitin-conjugating |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | BIRC6 | chr2:62107421 | chr2:32756422 | ENST00000421745 | + | 59 | 74 | 1660_1668 | 4031 | 4858 | Compositional bias | Note=Poly-Ala |
| Tgene | BIRC6 | chr2:62107421 | chr2:32756422 | ENST00000421745 | + | 59 | 74 | 30_36 | 4031 | 4858 | Compositional bias | Note=Poly-Ala |
| Tgene | BIRC6 | chr2:62107421 | chr2:32756422 | ENST00000421745 | + | 59 | 74 | 284_358 | 4031 | 4858 | Repeat | Note=BIR |
Top |
FusionGeneSequence for CCT4_BIRC6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CCT4_ENST00000394440_chr2_62107421_-_BIRC6_ENST00000421745_chr2_32756422_+_953aa MPENVAPRSGATAGAAGGRGKGAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARM LVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKDHGDLLASCPEDEALTPGDECMDGILDESLLETCPIQSPLQVFAGMGGLALIAE RLPMLYPEVIQQVSAPVVTSTTQEKPKDSDQFEWVTIEQSGELVYEAPETVAAEPPPIKSAVQTMSPIPAHSLAAFGLFLRLPGYAEVLL KERKHAQCLLRLVLGVTDDGEGSHILQSPSANVLPTLPFHVLRSLFSTTPLTTDDGVLLRRMALEIGALHLILVCLSALSHHSPRVPNSS VNQTEPQVSSSHNPTSTEEQQLYWAKGTGFGTGSTASGWDVEQALTKQRLEEEHVTCLLQVLASYINPVSSAVNGEAQSSHETRGQNSNA LPSVLLELLSQSCLIPAMSSYLRNDSVLDMARHVPLYRALLELLRAIASCAAMVPLLLPLSTENGEEEEEQSECQTSVGTLLAKMKTCVD TYTNRLRSKRENVKTGVKPDASDQEPEGLTLLVPDIQKTAEIVYAATTSLRQANQEKKLGEYSKKAAMKPKPLSVLKSLEEKYVAVMKKL QFDTFEMVSEDEDGKLGFKVNYHYMSQVKNANDANSAARARRLAQEAVTLSTSLPLSSSSSVFVRCDEERLDIMKVLITGPADTPYANGC FEFDVYFPQDYPSSPPLVNLETTGGHSVRFNPNLYNDGKVCLSILNTWHGRPEEKWNPQTSSFLQVLVSVQSLILVAEPYFNEPGYERSR GTPSGTQSSREYDGNIRQATVKWAMLEQIRNPSPCFKEVIHKHFYLKRVEIMAQCEEWIADIQQYSSDKRVGRTMSHHAAALKRHTAQLR >In-frame_CCT4_ENST00000544079_chr2_62107421_-_BIRC6_ENST00000421745_chr2_32756422_+_923aa MPENVAPRSGATAGAAGGRGKGAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMLVELSKAQDIEAGDGTTSVVIIAGSLLDSC TKLLQKDHGDLLASCPEDEALTPGDECMDGILDESLLETCPIQSPLQVFAGMGGLALIAERLPMLYPEVIQQVSAPVVTSTTQEKPKDSD QFEWVTIEQSGELVYEAPETVAAEPPPIKSAVQTMSPIPAHSLAAFGLFLRLPGYAEVLLKERKHAQCLLRLVLGVTDDGEGSHILQSPS ANVLPTLPFHVLRSLFSTTPLTTDDGVLLRRMALEIGALHLILVCLSALSHHSPRVPNSSVNQTEPQVSSSHNPTSTEEQQLYWAKGTGF GTGSTASGWDVEQALTKQRLEEEHVTCLLQVLASYINPVSSAVNGEAQSSHETRGQNSNALPSVLLELLSQSCLIPAMSSYLRNDSVLDM ARHVPLYRALLELLRAIASCAAMVPLLLPLSTENGEEEEEQSECQTSVGTLLAKMKTCVDTYTNRLRSKRENVKTGVKPDASDQEPEGLT LLVPDIQKTAEIVYAATTSLRQANQEKKLGEYSKKAAMKPKPLSVLKSLEEKYVAVMKKLQFDTFEMVSEDEDGKLGFKVNYHYMSQVKN ANDANSAARARRLAQEAVTLSTSLPLSSSSSVFVRCDEERLDIMKVLITGPADTPYANGCFEFDVYFPQDYPSSPPLVNLETTGGHSVRF NPNLYNDGKVCLSILNTWHGRPEEKWNPQTSSFLQVLVSVQSLILVAEPYFNEPGYERSRGTPSGTQSSREYDGNIRQATVKWAMLEQIR NPSPCFKEVIHKHFYLKRVEIMAQCEEWIADIQQYSSDKRVGRTMSHHAAALKRHTAQLREELLKLPCPEGLDPDTDDAPEVCRATTGAE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CCT4_ENST00000394440_chr2_62107421_-_BIRC6_ENST00000421745_chr2_32756422_+_2859nt ATGCCCGAGAATGTGGCACCCCGGAGCGGGGCGACTGCCGGGGCTGCCGGCGGCCGCGGGAAAGGCGCCTATCAGGACCGCGACAAGCCA GCCCAGATCCGCTTCAGCAACATTTCCGCCGCCAAAGCGGTTGCTGATGCTATTAGAACAAGCCTTGGACCAAAAGGAATGGATAAAATG ATTCAAGATGGAAAAGGTGATGTAACCATTACAAATGATGGTGCTACCATTCTGAAACAAATGCAAGTATTACATCCAGCAGCCAGAATG CTGGTGGAGCTGTCTAAGGCTCAAGATATAGAAGCAGGAGATGGCACCACATCAGTAGTCATCATTGCTGGCTCCCTCTTAGATTCTTGT ACCAAGCTTCTTCAGAAAGATCATGGAGACTTACTTGCTAGCTGTCCAGAAGATGAGGCTCTCACTCCAGGTGATGAATGCATGGATGGG ATACTGGATGAATCTTTGCTTGAAACCTGTCCAATTCAGTCACCATTACAAGTTTTTGCAGGAATGGGTGGACTGGCTCTTATTGCTGAA AGACTACCCATGCTATATCCAGAAGTAATTCAACAGGTGAGTGCTCCAGTTGTAACATCTACCACTCAGGAAAAGCCGAAGGATAGCGAT CAGTTTGAATGGGTGACCATTGAACAGTCAGGGGAGTTAGTTTATGAAGCACCAGAAACTGTTGCGGCTGAACCTCCACCTATCAAGTCA GCAGTACAGACCATGTCTCCCATACCTGCCCATTCTTTGGCTGCTTTTGGATTATTTCTTCGTCTTCCGGGCTATGCGGAAGTGCTACTG AAAGAGAGAAAACATGCCCAGTGCCTTCTTCGATTGGTATTGGGAGTGACAGATGATGGAGAAGGAAGTCATATTCTTCAATCTCCATCA GCCAATGTGCTTCCAACCCTTCCTTTCCACGTCCTTCGTAGCTTGTTTAGCACTACACCTTTGACAACTGATGATGGTGTACTTCTAAGG CGGATGGCATTGGAAATTGGAGCCTTACACCTCATTCTTGTCTGTCTCTCTGCTTTGAGCCACCATTCCCCACGAGTTCCAAACTCTAGC GTGAATCAAACTGAGCCACAGGTGTCAAGCTCTCATAACCCTACATCAACAGAAGAACAACAGTTATATTGGGCCAAAGGGACTGGCTTT GGAACAGGCTCTACAGCTTCTGGGTGGGATGTGGAACAAGCCTTAACTAAGCAAAGGCTGGAAGAGGAACATGTTACCTGCCTTCTGCAG GTTCTTGCCAGTTACATAAATCCCGTCAGTAGTGCGGTAAATGGAGAAGCTCAGTCATCTCATGAGACTAGAGGGCAGAACAGTAATGCC CTTCCTTCTGTACTTCTCGAGCTTCTCAGTCAGTCCTGCCTCATCCCAGCCATGTCATCTTATCTACGAAATGATTCAGTTCTGGACATG GCAAGACATGTGCCACTCTATCGGGCACTGCTGGAATTGCTTCGGGCCATTGCTTCTTGTGCTGCCATGGTGCCCCTATTGTTGCCCCTT TCTACAGAGAACGGTGAAGAGGAAGAAGAACAGTCAGAATGTCAAACTTCTGTTGGTACATTGTTAGCCAAAATGAAGACCTGTGTTGAT ACCTATACCAACCGTTTAAGATCTAAAAGGGAAAATGTTAAAACAGGAGTAAAACCAGATGCGTCTGATCAAGAACCAGAAGGACTTACT CTTTTGGTACCAGACATCCAAAAGACTGCTGAGATAGTTTATGCAGCCACCACCAGTTTGCGGCAAGCAAATCAGGAAAAAAAACTGGGT GAATACTCCAAGAAGGCGGCTATGAAACCCAAACCTTTGTCAGTATTAAAGTCACTTGAAGAAAAATATGTGGCTGTTATGAAGAAATTA CAGTTTGATACGTTTGAAATGGTTTCTGAAGATGAAGATGGGAAATTGGGATTTAAAGTAAATTACCACTACATGTCTCAGGTGAAAAAT GCTAATGATGCGAACAGTGCTGCCAGAGCTCGCCGCCTTGCCCAGGAAGCTGTGACGCTTTCAACCTCACTGCCTCTGTCTTCATCCTCT AGTGTGTTTGTACGCTGTGATGAGGAGCGACTTGATATCATGAAGGTTCTAATAACTGGTCCAGCGGACACCCCTTATGCAAATGGCTGC TTTGAGTTTGATGTGTATTTTCCTCAAGATTATCCCAGTTCACCCCCTCTTGTGAATCTAGAGACAACTGGTGGTCATAGCGTGCGATTC AATCCAAACCTTTATAATGATGGCAAGGTTTGTTTAAGCATCTTAAACACGTGGCATGGAAGACCAGAAGAGAAGTGGAATCCTCAGACC TCAAGCTTTTTGCAAGTGTTGGTGTCTGTCCAGTCCCTTATATTAGTAGCTGAGCCTTATTTTAATGAACCGGGATATGAACGGTCTAGA GGCACTCCCAGTGGCACACAGAGTTCTCGAGAATATGATGGAAACATTCGACAAGCAACAGTTAAGTGGGCAATGCTAGAACAAATCAGA AACCCTTCACCATGTTTTAAAGAGGTAATACACAAACATTTTTACTTGAAAAGAGTTGAGATAATGGCCCAATGTGAGGAGTGGATTGCG GATATCCAGCAGTACAGCAGTGATAAGCGGGTAGGCAGGACTATGTCTCACCATGCAGCAGCTCTCAAGCGTCACACTGCTCAGCTCCGC GAAGAGTTGCTGAAACTTCCCTGCCCTGAAGGCTTGGATCCTGACACTGACGATGCCCCAGAGGTGTGCAGAGCCACAACAGGTGCTGAG >In-frame_CCT4_ENST00000544079_chr2_62107421_-_BIRC6_ENST00000421745_chr2_32756422_+_2769nt ATGCCCGAGAATGTGGCACCCCGGAGCGGGGCGACTGCCGGGGCTGCCGGCGGCCGCGGGAAAGGCGCCTATCAGGACCGCGACAAGCCA GCCCAGATCCGCTTCAGCAACATTTCCGCCGCCAAAGCGGTTGCTGATGCTATTAGAACAAGCCTTGGACCAAAAGGAATGGATAAAATG CTGGTGGAGCTGTCTAAGGCTCAAGATATAGAAGCAGGAGATGGCACCACATCAGTAGTCATCATTGCTGGCTCCCTCTTAGATTCTTGT ACCAAGCTTCTTCAGAAAGATCATGGAGACTTACTTGCTAGCTGTCCAGAAGATGAGGCTCTCACTCCAGGTGATGAATGCATGGATGGG ATACTGGATGAATCTTTGCTTGAAACCTGTCCAATTCAGTCACCATTACAAGTTTTTGCAGGAATGGGTGGACTGGCTCTTATTGCTGAA AGACTACCCATGCTATATCCAGAAGTAATTCAACAGGTGAGTGCTCCAGTTGTAACATCTACCACTCAGGAAAAGCCGAAGGATAGCGAT CAGTTTGAATGGGTGACCATTGAACAGTCAGGGGAGTTAGTTTATGAAGCACCAGAAACTGTTGCGGCTGAACCTCCACCTATCAAGTCA GCAGTACAGACCATGTCTCCCATACCTGCCCATTCTTTGGCTGCTTTTGGATTATTTCTTCGTCTTCCGGGCTATGCGGAAGTGCTACTG AAAGAGAGAAAACATGCCCAGTGCCTTCTTCGATTGGTATTGGGAGTGACAGATGATGGAGAAGGAAGTCATATTCTTCAATCTCCATCA GCCAATGTGCTTCCAACCCTTCCTTTCCACGTCCTTCGTAGCTTGTTTAGCACTACACCTTTGACAACTGATGATGGTGTACTTCTAAGG CGGATGGCATTGGAAATTGGAGCCTTACACCTCATTCTTGTCTGTCTCTCTGCTTTGAGCCACCATTCCCCACGAGTTCCAAACTCTAGC GTGAATCAAACTGAGCCACAGGTGTCAAGCTCTCATAACCCTACATCAACAGAAGAACAACAGTTATATTGGGCCAAAGGGACTGGCTTT GGAACAGGCTCTACAGCTTCTGGGTGGGATGTGGAACAAGCCTTAACTAAGCAAAGGCTGGAAGAGGAACATGTTACCTGCCTTCTGCAG GTTCTTGCCAGTTACATAAATCCCGTCAGTAGTGCGGTAAATGGAGAAGCTCAGTCATCTCATGAGACTAGAGGGCAGAACAGTAATGCC CTTCCTTCTGTACTTCTCGAGCTTCTCAGTCAGTCCTGCCTCATCCCAGCCATGTCATCTTATCTACGAAATGATTCAGTTCTGGACATG GCAAGACATGTGCCACTCTATCGGGCACTGCTGGAATTGCTTCGGGCCATTGCTTCTTGTGCTGCCATGGTGCCCCTATTGTTGCCCCTT TCTACAGAGAACGGTGAAGAGGAAGAAGAACAGTCAGAATGTCAAACTTCTGTTGGTACATTGTTAGCCAAAATGAAGACCTGTGTTGAT ACCTATACCAACCGTTTAAGATCTAAAAGGGAAAATGTTAAAACAGGAGTAAAACCAGATGCGTCTGATCAAGAACCAGAAGGACTTACT CTTTTGGTACCAGACATCCAAAAGACTGCTGAGATAGTTTATGCAGCCACCACCAGTTTGCGGCAAGCAAATCAGGAAAAAAAACTGGGT GAATACTCCAAGAAGGCGGCTATGAAACCCAAACCTTTGTCAGTATTAAAGTCACTTGAAGAAAAATATGTGGCTGTTATGAAGAAATTA CAGTTTGATACGTTTGAAATGGTTTCTGAAGATGAAGATGGGAAATTGGGATTTAAAGTAAATTACCACTACATGTCTCAGGTGAAAAAT GCTAATGATGCGAACAGTGCTGCCAGAGCTCGCCGCCTTGCCCAGGAAGCTGTGACGCTTTCAACCTCACTGCCTCTGTCTTCATCCTCT AGTGTGTTTGTACGCTGTGATGAGGAGCGACTTGATATCATGAAGGTTCTAATAACTGGTCCAGCGGACACCCCTTATGCAAATGGCTGC TTTGAGTTTGATGTGTATTTTCCTCAAGATTATCCCAGTTCACCCCCTCTTGTGAATCTAGAGACAACTGGTGGTCATAGCGTGCGATTC AATCCAAACCTTTATAATGATGGCAAGGTTTGTTTAAGCATCTTAAACACGTGGCATGGAAGACCAGAAGAGAAGTGGAATCCTCAGACC TCAAGCTTTTTGCAAGTGTTGGTGTCTGTCCAGTCCCTTATATTAGTAGCTGAGCCTTATTTTAATGAACCGGGATATGAACGGTCTAGA GGCACTCCCAGTGGCACACAGAGTTCTCGAGAATATGATGGAAACATTCGACAAGCAACAGTTAAGTGGGCAATGCTAGAACAAATCAGA AACCCTTCACCATGTTTTAAAGAGGTAATACACAAACATTTTTACTTGAAAAGAGTTGAGATAATGGCCCAATGTGAGGAGTGGATTGCG GATATCCAGCAGTACAGCAGTGATAAGCGGGTAGGCAGGACTATGTCTCACCATGCAGCAGCTCTCAAGCGTCACACTGCTCAGCTCCGC GAAGAGTTGCTGAAACTTCCCTGCCCTGAAGGCTTGGATCCTGACACTGACGATGCCCCAGAGGTGTGCAGAGCCACAACAGGTGCTGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CCT4_ENST00000394440_chr2_62107421_-_BIRC6_ENST00000421745_chr2_32756422_+_4151nt GCGTAAAGGTTCCCCCGGCGCTCTTCACCCACAGCGCCCCGGGCGTACAATCTCGCCAGCCCGGAGCCCACCGCACGCATCCTCCTCGCC CGGCGCGCAGCGGACAGCCTCCTACGTCACGCCAGCGCCGCGCGGCAAGGAAGGCCCCCTTCTCCGCCTCCGCCTCCTCCCGACGCCGGC GCCGCTTTCTGGAAGGTTCGTGAAGGCAGTGAGGGCTTACCGTTATTACACTGCGGCCGGCCAGAATCCGGGTCCATCCGTCCTTCCCGA GCCAACCCAGACACAGCGGAGTTTGCCATGCCCGAGAATGTGGCACCCCGGAGCGGGGCGACTGCCGGGGCTGCCGGCGGCCGCGGGAAA GGCGCCTATCAGGACCGCGACAAGCCAGCCCAGATCCGCTTCAGCAACATTTCCGCCGCCAAAGCGGTTGCTGATGCTATTAGAACAAGC CTTGGACCAAAAGGAATGGATAAAATGATTCAAGATGGAAAAGGTGATGTAACCATTACAAATGATGGTGCTACCATTCTGAAACAAATG CAAGTATTACATCCAGCAGCCAGAATGCTGGTGGAGCTGTCTAAGGCTCAAGATATAGAAGCAGGAGATGGCACCACATCAGTAGTCATC ATTGCTGGCTCCCTCTTAGATTCTTGTACCAAGCTTCTTCAGAAAGATCATGGAGACTTACTTGCTAGCTGTCCAGAAGATGAGGCTCTC ACTCCAGGTGATGAATGCATGGATGGGATACTGGATGAATCTTTGCTTGAAACCTGTCCAATTCAGTCACCATTACAAGTTTTTGCAGGA ATGGGTGGACTGGCTCTTATTGCTGAAAGACTACCCATGCTATATCCAGAAGTAATTCAACAGGTGAGTGCTCCAGTTGTAACATCTACC ACTCAGGAAAAGCCGAAGGATAGCGATCAGTTTGAATGGGTGACCATTGAACAGTCAGGGGAGTTAGTTTATGAAGCACCAGAAACTGTT GCGGCTGAACCTCCACCTATCAAGTCAGCAGTACAGACCATGTCTCCCATACCTGCCCATTCTTTGGCTGCTTTTGGATTATTTCTTCGT CTTCCGGGCTATGCGGAAGTGCTACTGAAAGAGAGAAAACATGCCCAGTGCCTTCTTCGATTGGTATTGGGAGTGACAGATGATGGAGAA GGAAGTCATATTCTTCAATCTCCATCAGCCAATGTGCTTCCAACCCTTCCTTTCCACGTCCTTCGTAGCTTGTTTAGCACTACACCTTTG ACAACTGATGATGGTGTACTTCTAAGGCGGATGGCATTGGAAATTGGAGCCTTACACCTCATTCTTGTCTGTCTCTCTGCTTTGAGCCAC CATTCCCCACGAGTTCCAAACTCTAGCGTGAATCAAACTGAGCCACAGGTGTCAAGCTCTCATAACCCTACATCAACAGAAGAACAACAG TTATATTGGGCCAAAGGGACTGGCTTTGGAACAGGCTCTACAGCTTCTGGGTGGGATGTGGAACAAGCCTTAACTAAGCAAAGGCTGGAA GAGGAACATGTTACCTGCCTTCTGCAGGTTCTTGCCAGTTACATAAATCCCGTCAGTAGTGCGGTAAATGGAGAAGCTCAGTCATCTCAT GAGACTAGAGGGCAGAACAGTAATGCCCTTCCTTCTGTACTTCTCGAGCTTCTCAGTCAGTCCTGCCTCATCCCAGCCATGTCATCTTAT CTACGAAATGATTCAGTTCTGGACATGGCAAGACATGTGCCACTCTATCGGGCACTGCTGGAATTGCTTCGGGCCATTGCTTCTTGTGCT GCCATGGTGCCCCTATTGTTGCCCCTTTCTACAGAGAACGGTGAAGAGGAAGAAGAACAGTCAGAATGTCAAACTTCTGTTGGTACATTG TTAGCCAAAATGAAGACCTGTGTTGATACCTATACCAACCGTTTAAGATCTAAAAGGGAAAATGTTAAAACAGGAGTAAAACCAGATGCG TCTGATCAAGAACCAGAAGGACTTACTCTTTTGGTACCAGACATCCAAAAGACTGCTGAGATAGTTTATGCAGCCACCACCAGTTTGCGG CAAGCAAATCAGGAAAAAAAACTGGGTGAATACTCCAAGAAGGCGGCTATGAAACCCAAACCTTTGTCAGTATTAAAGTCACTTGAAGAA AAATATGTGGCTGTTATGAAGAAATTACAGTTTGATACGTTTGAAATGGTTTCTGAAGATGAAGATGGGAAATTGGGATTTAAAGTAAAT TACCACTACATGTCTCAGGTGAAAAATGCTAATGATGCGAACAGTGCTGCCAGAGCTCGCCGCCTTGCCCAGGAAGCTGTGACGCTTTCA ACCTCACTGCCTCTGTCTTCATCCTCTAGTGTGTTTGTACGCTGTGATGAGGAGCGACTTGATATCATGAAGGTTCTAATAACTGGTCCA GCGGACACCCCTTATGCAAATGGCTGCTTTGAGTTTGATGTGTATTTTCCTCAAGATTATCCCAGTTCACCCCCTCTTGTGAATCTAGAG ACAACTGGTGGTCATAGCGTGCGATTCAATCCAAACCTTTATAATGATGGCAAGGTTTGTTTAAGCATCTTAAACACGTGGCATGGAAGA CCAGAAGAGAAGTGGAATCCTCAGACCTCAAGCTTTTTGCAAGTGTTGGTGTCTGTCCAGTCCCTTATATTAGTAGCTGAGCCTTATTTT AATGAACCGGGATATGAACGGTCTAGAGGCACTCCCAGTGGCACACAGAGTTCTCGAGAATATGATGGAAACATTCGACAAGCAACAGTT AAGTGGGCAATGCTAGAACAAATCAGAAACCCTTCACCATGTTTTAAAGAGGTAATACACAAACATTTTTACTTGAAAAGAGTTGAGATA ATGGCCCAATGTGAGGAGTGGATTGCGGATATCCAGCAGTACAGCAGTGATAAGCGGGTAGGCAGGACTATGTCTCACCATGCAGCAGCT CTCAAGCGTCACACTGCTCAGCTCCGCGAAGAGTTGCTGAAACTTCCCTGCCCTGAAGGCTTGGATCCTGACACTGACGATGCCCCAGAG GTGTGCAGAGCCACAACAGGTGCTGAGGAGACTCTAATGCATGATCAGGTTAAACCCAGCAGCAGCAAAGAACTCCCCAGTGACTTCCAG TTATGAGCTGCATTGATGTGGACTTCATAGACACAAAGGCTTCGAAGCACAAGCCAAATATGTCAATATTTGTATGTAAGAAACTAATTA TGTAATAGGTAATGAAACTGAAACTATACTATGCCCTTAAGGAGATCCAGTTTAATTCAAGGTGATCTTTTATTTACCTGTACAGGAGTG TAAACTTTTTTGTGCTTTTATTTTTCAATTGTGAGAACCACTGATTGGTATGTTCAACAAATTTGTGTATACAAAGAAATGGATAAATCA CTGCTATATAAGGGAAACTACCTTAGGAAAGAATGTTTACTGAATGTTTATTTTATTTTATTTTTTTTTTACTATAGAGTGAGGGGTTGT TAACAAAGAATATATATTGGTCATTCTTACAACTACTATTTAAAGTCAGCAACTTTTCACTGAATTTGATAGATTTTATGTTTGGCCATA TCTTCATGCTCACATTTGATTTCTGAAGACCTCCTACATACACTTCAATAAAAGTTAAATGGACATACTCCCTCTTTTTTGATTTACTGG TACATTTTTAAAATAATAAATCTGCCATAAAATGCATTATATCTGGAGACTTGCACTTGTATGGATGAATTTATTACATTCAACATATTT AATTTTATGCCTTCTAATTCTAAGATGCAGAAAAAAATAAATGAACATGATTTTATTCTATGCCAACATTTGGGCCTCTGAATGTATCTG TTATTTGAATTTAAGTATTTGAAAAGGAATGGTCAATTTGAAAGTCATTCTAAACTGATTTTTTTTTTCTAAAGGGCTCCTTTTTTCCTG GACTATGTGGTTTTATGACTAAAGTCACATGTATGTATTAAACATTGAGGCTCTGTAGAGGAGAGAGGATGTACCTCTCTGGTGCTGTTA CAGTACATTCTGTACCTGCCATACAGGCTCATTTTCATGCAAATTCTTCCTAGAGCCAAATAAATAAAGACTTAGGTGAATTAGTATGTC >In-frame_CCT4_ENST00000544079_chr2_62107421_-_BIRC6_ENST00000421745_chr2_32756422_+_3913nt CTTCTCCGCCTCCGCCTCCTCCCGACGCCGGCGCCGCTTTCTGGAAGGTTCGTGAAGGCAGTGAGGGCTTACCGTTATTACACTGCGGCC GGCCAGAATCCGGGTCCATCCGTCCTTCCCGAGCCAACCCAGACACAGCGGAGTTTGCCATGCCCGAGAATGTGGCACCCCGGAGCGGGG CGACTGCCGGGGCTGCCGGCGGCCGCGGGAAAGGCGCCTATCAGGACCGCGACAAGCCAGCCCAGATCCGCTTCAGCAACATTTCCGCCG CCAAAGCGGTTGCTGATGCTATTAGAACAAGCCTTGGACCAAAAGGAATGGATAAAATGCTGGTGGAGCTGTCTAAGGCTCAAGATATAG AAGCAGGAGATGGCACCACATCAGTAGTCATCATTGCTGGCTCCCTCTTAGATTCTTGTACCAAGCTTCTTCAGAAAGATCATGGAGACT TACTTGCTAGCTGTCCAGAAGATGAGGCTCTCACTCCAGGTGATGAATGCATGGATGGGATACTGGATGAATCTTTGCTTGAAACCTGTC CAATTCAGTCACCATTACAAGTTTTTGCAGGAATGGGTGGACTGGCTCTTATTGCTGAAAGACTACCCATGCTATATCCAGAAGTAATTC AACAGGTGAGTGCTCCAGTTGTAACATCTACCACTCAGGAAAAGCCGAAGGATAGCGATCAGTTTGAATGGGTGACCATTGAACAGTCAG GGGAGTTAGTTTATGAAGCACCAGAAACTGTTGCGGCTGAACCTCCACCTATCAAGTCAGCAGTACAGACCATGTCTCCCATACCTGCCC ATTCTTTGGCTGCTTTTGGATTATTTCTTCGTCTTCCGGGCTATGCGGAAGTGCTACTGAAAGAGAGAAAACATGCCCAGTGCCTTCTTC GATTGGTATTGGGAGTGACAGATGATGGAGAAGGAAGTCATATTCTTCAATCTCCATCAGCCAATGTGCTTCCAACCCTTCCTTTCCACG TCCTTCGTAGCTTGTTTAGCACTACACCTTTGACAACTGATGATGGTGTACTTCTAAGGCGGATGGCATTGGAAATTGGAGCCTTACACC TCATTCTTGTCTGTCTCTCTGCTTTGAGCCACCATTCCCCACGAGTTCCAAACTCTAGCGTGAATCAAACTGAGCCACAGGTGTCAAGCT CTCATAACCCTACATCAACAGAAGAACAACAGTTATATTGGGCCAAAGGGACTGGCTTTGGAACAGGCTCTACAGCTTCTGGGTGGGATG TGGAACAAGCCTTAACTAAGCAAAGGCTGGAAGAGGAACATGTTACCTGCCTTCTGCAGGTTCTTGCCAGTTACATAAATCCCGTCAGTA GTGCGGTAAATGGAGAAGCTCAGTCATCTCATGAGACTAGAGGGCAGAACAGTAATGCCCTTCCTTCTGTACTTCTCGAGCTTCTCAGTC AGTCCTGCCTCATCCCAGCCATGTCATCTTATCTACGAAATGATTCAGTTCTGGACATGGCAAGACATGTGCCACTCTATCGGGCACTGC TGGAATTGCTTCGGGCCATTGCTTCTTGTGCTGCCATGGTGCCCCTATTGTTGCCCCTTTCTACAGAGAACGGTGAAGAGGAAGAAGAAC AGTCAGAATGTCAAACTTCTGTTGGTACATTGTTAGCCAAAATGAAGACCTGTGTTGATACCTATACCAACCGTTTAAGATCTAAAAGGG AAAATGTTAAAACAGGAGTAAAACCAGATGCGTCTGATCAAGAACCAGAAGGACTTACTCTTTTGGTACCAGACATCCAAAAGACTGCTG AGATAGTTTATGCAGCCACCACCAGTTTGCGGCAAGCAAATCAGGAAAAAAAACTGGGTGAATACTCCAAGAAGGCGGCTATGAAACCCA AACCTTTGTCAGTATTAAAGTCACTTGAAGAAAAATATGTGGCTGTTATGAAGAAATTACAGTTTGATACGTTTGAAATGGTTTCTGAAG ATGAAGATGGGAAATTGGGATTTAAAGTAAATTACCACTACATGTCTCAGGTGAAAAATGCTAATGATGCGAACAGTGCTGCCAGAGCTC GCCGCCTTGCCCAGGAAGCTGTGACGCTTTCAACCTCACTGCCTCTGTCTTCATCCTCTAGTGTGTTTGTACGCTGTGATGAGGAGCGAC TTGATATCATGAAGGTTCTAATAACTGGTCCAGCGGACACCCCTTATGCAAATGGCTGCTTTGAGTTTGATGTGTATTTTCCTCAAGATT ATCCCAGTTCACCCCCTCTTGTGAATCTAGAGACAACTGGTGGTCATAGCGTGCGATTCAATCCAAACCTTTATAATGATGGCAAGGTTT GTTTAAGCATCTTAAACACGTGGCATGGAAGACCAGAAGAGAAGTGGAATCCTCAGACCTCAAGCTTTTTGCAAGTGTTGGTGTCTGTCC AGTCCCTTATATTAGTAGCTGAGCCTTATTTTAATGAACCGGGATATGAACGGTCTAGAGGCACTCCCAGTGGCACACAGAGTTCTCGAG AATATGATGGAAACATTCGACAAGCAACAGTTAAGTGGGCAATGCTAGAACAAATCAGAAACCCTTCACCATGTTTTAAAGAGGTAATAC ACAAACATTTTTACTTGAAAAGAGTTGAGATAATGGCCCAATGTGAGGAGTGGATTGCGGATATCCAGCAGTACAGCAGTGATAAGCGGG TAGGCAGGACTATGTCTCACCATGCAGCAGCTCTCAAGCGTCACACTGCTCAGCTCCGCGAAGAGTTGCTGAAACTTCCCTGCCCTGAAG GCTTGGATCCTGACACTGACGATGCCCCAGAGGTGTGCAGAGCCACAACAGGTGCTGAGGAGACTCTAATGCATGATCAGGTTAAACCCA GCAGCAGCAAAGAACTCCCCAGTGACTTCCAGTTATGAGCTGCATTGATGTGGACTTCATAGACACAAAGGCTTCGAAGCACAAGCCAAA TATGTCAATATTTGTATGTAAGAAACTAATTATGTAATAGGTAATGAAACTGAAACTATACTATGCCCTTAAGGAGATCCAGTTTAATTC AAGGTGATCTTTTATTTACCTGTACAGGAGTGTAAACTTTTTTGTGCTTTTATTTTTCAATTGTGAGAACCACTGATTGGTATGTTCAAC AAATTTGTGTATACAAAGAAATGGATAAATCACTGCTATATAAGGGAAACTACCTTAGGAAAGAATGTTTACTGAATGTTTATTTTATTT TATTTTTTTTTTACTATAGAGTGAGGGGTTGTTAACAAAGAATATATATTGGTCATTCTTACAACTACTATTTAAAGTCAGCAACTTTTC ACTGAATTTGATAGATTTTATGTTTGGCCATATCTTCATGCTCACATTTGATTTCTGAAGACCTCCTACATACACTTCAATAAAAGTTAA ATGGACATACTCCCTCTTTTTTGATTTACTGGTACATTTTTAAAATAATAAATCTGCCATAAAATGCATTATATCTGGAGACTTGCACTT GTATGGATGAATTTATTACATTCAACATATTTAATTTTATGCCTTCTAATTCTAAGATGCAGAAAAAAATAAATGAACATGATTTTATTC TATGCCAACATTTGGGCCTCTGAATGTATCTGTTATTTGAATTTAAGTATTTGAAAAGGAATGGTCAATTTGAAAGTCATTCTAAACTGA TTTTTTTTTTCTAAAGGGCTCCTTTTTTCCTGGACTATGTGGTTTTATGACTAAAGTCACATGTATGTATTAAACATTGAGGCTCTGTAG AGGAGAGAGGATGTACCTCTCTGGTGCTGTTACAGTACATTCTGTACCTGCCATACAGGCTCATTTTCATGCAAATTCTTCCTAGAGCCA |
Top |
FusionGenePPI for CCT4_BIRC6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CCT4 | PPP4C, PPP2CA, STK24, STRN, STRN3, PPP2CB, PPP2R2C, IGBP1, TCP1, ACTA2, ACTA1, MEPCE, HNRNPH1, GPN1, CDK9, RFWD2, MYC, PPP2R2A, PPP2R2B, PPP2R2D, PPP2R4, HDAC5, PSMA3, RPS6KA1, PCK1, VHL, ISG15, FBXO25, CUL3, CUL5, CDK2, CUL1, COPS5, GRB2, PACRG, CCT2, CCT6A, CCT3, CCT7, CCT5, CCT8, CCT6B, RPSA, P4HB, PSMA6, SSR1, G6PD, XPO1, TXNL1, SMURF1, VCP, CFAP52, FN1, VCAM1, ATF2, PEX14, PPP5C, NOS2, FAM86B2, METTL18, METTL21B, ITGA4, CFTR, PAN2, CD81, IGSF8, ICAM1, HDAC3, HDAC11, FBXW4, FBXO6, PRPF40A, USP9X, VARS, VRK2, CDK5, ILK, UBC, STAU1, CDC20, LGALS3BP, NEDD1, TP53, TUBG1, HUWE1, FUS, CUL7, IKBKE, IRAK1, JAK3, MAPK8, PTK6, SGK2, TSSK6, TYK2, WDR76, POC1A, TXNDC9, WDR83, PEX7, ACTR1B, SEC31B, ACTL6A, TTLL3, CDK15, RPS6KB2, DCAF7, AMBRA1, UNK, CANX, CAD, DNAJA2, EHD2, MCM7, SLC25A3, DNAJA4, HSPE1, KIAA0368, PDCL3, PSMC2, NTRK1, BTRC, B9D1, MKS1, CETN2, AHSA1, CDK1, DDB2, HDAC1, PDK3, NSMAF, NIPSNAP1, PRPF4, BUB3, ACTR2, FGFR1OP2, WRAP53, RFWD3, KIF21A, MYO19, SEH1L, TUBA1C, ARMC6, GAN, CRY1, CRY2, ALKBH3, MCM2, SNW1, CDC5L, TTC27, NLE1, CDC73, ZNF746, FLCN, PPM1J, KLHL33, KLHDC8A, KDM4B, ACTR3B, RAP2C, WDR86, THOC3, DCAF11, DCAF10, DCAF8, WDR77, TUBG2, WDTC1, WDR5B, HCFC2, TBL1Y, PDDC1, WDR34, DNAI2, PNPLA5, WDR37, POC1B, GNB2, TUBA1B, ODF1, ACTBL2, CDK11A, ACTR3, ASTN2, GANAB, RBM3, CYLD, WDR92, TRIM25, BRCA1 | BIRC6 | RNF41, KIF23, USP8, DIABLO, CASP9, HTRA2, UBC, VAV2, SIRT7, CASP3, CASP7, BIRC6, CASP8, UBE2D1, CSNK2A1, RASSF2, EPS15L1, GBF1, CCNA2, CDC27, ANAPC11, TEX35, PRSS45, RTBDN, C3orf20, WDR4, DFNA5, FAM175B, CA11, FIGF, MOS, HERC2, CHIA, CLEC11A, INTS4P2, TBC1D22A, FAM58A, MCPH1, TP53, UNK, RPGR, KIF22, LLGL2, PLK1, MYH13, SSH3, AGRP, ANGPTL3, UGGT2, AKAP9, DCAF12, FERMT2, PSMC5, MGST3, CCDC22, OSBPL2, ADAMTS4, HEY1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CCT4_BIRC6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CCT4_BIRC6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|