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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 610

FusionGeneSummary for ACTR10_MKX

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTR10_MKX
Fusion gene ID: 610
HgeneTgene
Gene symbol

ACTR10

MKX

Gene ID

55860

283078

Gene nameactin related protein 10 homologmohawk homeobox
SynonymsACTR11|Arp10|Arp11|HARP11C10orf48|IFRX|IRXL1
Cytomap

14q23.1

10p12.1

Type of geneprotein-codingprotein-coding
Descriptionactin-related protein 10actin-related protein 11homeobox protein MohawkIroquois family related homeodomain proteiniroquois homeobox protein-like 1
Modification date2018052220180519
UniProtAcc

Q9NZ32

Q8IYA7

Ensembl transtripts involved in fusion geneENST00000254286, ENST00000419761, 
ENST00000375790, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: ACTR10 [Title/Abstract] AND MKX [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-FX-A76Y-01AACTR10chr14

58667012

+MKXchr10

27964483

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000254286ENST00000419761ACTR10chr14

58667012

+MKXchr10

27964483

-
Frame-shitENST00000254286ENST00000375790ACTR10chr14

58667012

+MKXchr10

27964483

-

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FusionProtFeatures for ACTR10_MKX


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTR10

Q9NZ32

MKX

Q8IYA7

May act as a morphogenetic regulator of cell adhesion.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACTR10_MKX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACTR10_MKX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACTR10DCTN4, ACTR1A, ACTR1B, DCTN2, DCTN3, LMNB1, RABEP1, NAGK, CSPP1, ORC6, C9orf24, CAPZA2, GPS2, CA10, LOC554223, DCTN1, KIF11, MYO19, DUSP13, DCTN6, KLHL2, DEFB127, UQCRH, RIC8A, PDGFD, MIS18A, C16orf45, RPS19BP1, C1orf106, RHOC, MAPK8IP3, NEXN, CCDC120, NGEF, BCL7C, ACTBL2MKXHDAC1, SIN3A, TBP, GTF2A1, GTF2B, ELAVL1, HSP90AA1, TBL1X, TBL1XR1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACTR10_MKX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACTR10_MKX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource