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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6095

FusionGeneSummary for CCT3_GON4L

check button Fusion gene summary
Fusion gene informationFusion gene name: CCT3_GON4L
Fusion gene ID: 6095
HgeneTgene
Gene symbol

CCT3

GON4L

Gene ID

7203

54856

Gene namechaperonin containing TCP1 subunit 3gon-4 like
SynonymsCCT-gamma|CCTG|PIG48|TCP-1-gamma|TRIC5GON-4|GON4|YARP
Cytomap

1q22

1q22

Type of geneprotein-codingprotein-coding
DescriptionT-complex protein 1 subunit gammaT-complex protein 1, gamma subunitTCP1 (t-complex-1) ring complex, polypeptide 5chaperonin containing TCP1, subunit 3 (gamma)hTRiC5GON-4-like protein2610100B20RikYY1AP related proteinYY1AP-related protein1gon-4 homolog
Modification date2018052320180523
UniProtAcc

P49368

Q3T8J9

Ensembl transtripts involved in fusion geneENST00000295688, ENST00000368259, 
ENST00000368261, ENST00000472765, 
ENST00000368256, 
ENST00000437809, 
ENST00000368331, ENST00000271883, 
ENST00000361040, ENST00000471341, 
Fusion gene scores* DoF score16 X 10 X 9=14407 X 6 X 6=252
# samples 178
** MAII scorelog2(17/1440*10)=-3.08246216019197
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCT3 [Title/Abstract] AND GON4L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-HC-8262-01ACCT3chr1

156303338

-GON4Lchr1

155802741

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000295688ENST00000437809CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000295688ENST00000368331CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000295688ENST00000271883CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000295688ENST00000361040CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000295688ENST00000471341CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368259ENST00000437809CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368259ENST00000368331CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368259ENST00000271883CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368259ENST00000361040CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368259ENST00000471341CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368261ENST00000437809CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368261ENST00000368331CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368261ENST00000271883CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368261ENST00000361040CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000368261ENST00000471341CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000472765ENST00000437809CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000472765ENST00000368331CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000472765ENST00000271883CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000472765ENST00000361040CCT3chr1

156303338

-GON4Lchr1

155802741

-
5CDS-intronENST00000472765ENST00000471341CCT3chr1

156303338

-GON4Lchr1

155802741

-
5UTR-intronENST00000368256ENST00000437809CCT3chr1

156303338

-GON4Lchr1

155802741

-
5UTR-intronENST00000368256ENST00000368331CCT3chr1

156303338

-GON4Lchr1

155802741

-
5UTR-intronENST00000368256ENST00000271883CCT3chr1

156303338

-GON4Lchr1

155802741

-
5UTR-intronENST00000368256ENST00000361040CCT3chr1

156303338

-GON4Lchr1

155802741

-
5UTR-intronENST00000368256ENST00000471341CCT3chr1

156303338

-GON4Lchr1

155802741

-

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FusionProtFeatures for CCT3_GON4L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCT3

P49368

GON4L

Q3T8J9

Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCT3_GON4L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCT3_GON4L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCT3SSSCA1, FANCA, RAF1, EIF2B2, PAFAH1B2, PPP4C, CTTNBP2, MOB4, PPP2CA, STK24, STRN, STRN3, PPP2CB, PPP2R2C, IGBP1, TCP1, CDK9, RFWD2, ATG16L1, MAPK6, VHL, WDR82, UBC, MYC, PPP2R2A, PPP2R2B, PPP2R2D, PPP2R4, AGO3, HDAC5, PSMA3, FBXW8, RAD21, SH3BP4, VAV2, SIRT7, ISG15, PSMA2, CUL3, CDK2, XRCC6, INPPL1, UBASH3B, GRB2, EPS15, FBXO6, PACRG, CCT2, CCT5, CCT7, CCT8, CCT6A, CCT4, CCT6B, MARS, PSMA6, PSMA5, NOTCH1, VCP, FN1, VCAM1, ATF2, PEX14, NOS2, CAMKMT, FAM86B2, METTL18, METTL20, METTL21B, METTL21C, METTL23, ITGA4, CFTR, PAN2, CD81, IGSF8, ICAM1, HDAC3, HDAC11, HDAC6, FBXW4, PARK2, ACACA, COPA, EEF1G, LRRC47, PPP4R2, VARS, TRIM28, CDK5, ILK, CDC20, LGALS3BP, NEDD1, TP53, TUBG1, HUWE1, FUS, MIPOL1, CUL7, OBSL1, CCDC8, SUZ12, RNF2, BMI1, CDK13, IKBKE, IRAK1, JAK3, MAPK8, PRKY, PTK6, SGK2, TSSK6, TYK2, WDR76, POC1A, NXF5, TXNDC9, FYCO1, WDR37, WDR83, DCAF5, WDR92, PEX7, GNB5, TSSC1, DDB2, TUBB2B, ACTR1B, SEC31B, TUBAL3, ACTL6A, PNPLA1, TTLL3, TUBA3C, TUBA3E, C17orf102, RPS6KB2, LGALS3, DCAF7, AMBRA1, ARF1, CAD, CANX, CLTC, DNAJA1, DNAJA4, EHD2, ETFA, GTF2I, HSPE1, LDHA, LDHB, PDCL3, PSMC2, SLC25A3, SUCLG2, WARS, CYP27A1, HSP90B1, KPNA4, MCM7, PC, RPN1, STOM, UQCRC2, NTRK1, BTRC, B9D1, MKS1, CETN2, AHSA1, GBA, HDAC1, PDK3, DNAJC7, XRCC3, NSMAF, NIPSNAP1, PRPF4, ACTR2, WRAP53, RFWD3, KIF21A, SEH1L, TUBA1C, ARMC6, GAN, SKI, FBXW7, MCM2, SNW1, CDC5L, ERRFI1, TTC27, CDC73, ZNF746, PPM1J, TUBD1, DCAF12, DTL, WDR70, DCAF13, JMJD4, KLHL33, KDM4B, DCAF10, KLHDC8A, KLHL8, WDR77, WDR46, RAP2C, DCAF4, DNAI2, BUB3, WDR86, ODF1, KLHDC8B, DCAF11, WDTC1, TUBG2, GNB1L, METAP2, DCAF8, ACTR3B, TBL1Y, THOC3, PDCL, WDR34, UTP18, GNB2, GANAB, SMOX, HCFC2, WDR5B, C4orf26, C1orf127, ACTR3, NOL10, MLST8, POC1B, ACTBL2, MAPK15, P4HA2, C11orf70, KLHDC2, CDK11A, TTLL9, STRADB, RPE65, PNPLA5, TUBA1B, DCAF12L2, C11orf54, RBM3, CYLD, TRIM25, G3BP1, BRCA1GON4LDHX16, PNKD, HIST1H2BA, KRAS, HIST1H2BG, CRAMP1L, H2AFX, ASB3, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCT3_GON4L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCCT3P49368DB11638ArtenimolT-complex protein 1 subunit gammasmall moleculeapproved|investigational

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RelatedDiseases for CCT3_GON4L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCT3C0019693HIV Infections1CTD_human
TgeneGON4LC3714756Intellectual Disability1CTD_human