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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6068

FusionGeneSummary for CCSER1_CTBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: CCSER1_CTBP2
Fusion gene ID: 6068
HgeneTgene
Gene symbol

CCSER1

CTBP2

Gene ID

401145

1488

Gene namecoiled-coil serine rich protein 1C-terminal binding protein 2
SynonymsFAM190A-
Cytomap

4q22.1

10q26.13

Type of geneprotein-codingprotein-coding
Descriptionserine-rich coiled-coil domain-containing protein 1family with sequence similarity 190, member Aprotein FAM190AC-terminal-binding protein 2ribeye
Modification date2018051920180524
UniProtAcc

Q9C0I3

P56545

Ensembl transtripts involved in fusion geneENST00000509176, ENST00000333691, 
ENST00000432775, ENST00000504150, 
ENST00000337195, ENST00000531469, 
ENST00000494626, ENST00000411419, 
ENST00000476817, ENST00000309035, 
ENST00000334808, 
Fusion gene scores* DoF score8 X 7 X 4=2245 X 5 X 3=75
# samples 87
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCSER1 [Title/Abstract] AND CTBP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF514170CCSER1chr4

92256104

+CTBP2chr10

126725276

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000509176ENST00000337195CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000509176ENST00000531469CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000509176ENST00000494626CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000509176ENST00000411419CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000509176ENST00000476817CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000509176ENST00000309035CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000509176ENST00000334808CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000333691ENST00000337195CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000333691ENST00000531469CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000333691ENST00000494626CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000333691ENST00000411419CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000333691ENST00000476817CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000333691ENST00000309035CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000333691ENST00000334808CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000432775ENST00000337195CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000432775ENST00000531469CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000432775ENST00000494626CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000432775ENST00000411419CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000432775ENST00000476817CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000432775ENST00000309035CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000432775ENST00000334808CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000504150ENST00000337195CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000504150ENST00000531469CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000504150ENST00000494626CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000504150ENST00000411419CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000504150ENST00000476817CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000504150ENST00000309035CCSER1chr4

92256104

+CTBP2chr10

126725276

+
intron-intronENST00000504150ENST00000334808CCSER1chr4

92256104

+CTBP2chr10

126725276

+

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FusionProtFeatures for CCSER1_CTBP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCSER1

Q9C0I3

CTBP2

P56545


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCSER1_CTBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCSER1_CTBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCSER1_CTBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCSER1_CTBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCSER1C0236736Cocaine-Related Disorders1CTD_human
TgeneCTBP2C0033578Prostatic Neoplasms1CTD_human