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Fusion gene ID: 6065 |
FusionGeneSummary for CCSER1_BMP2K |
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Fusion gene information | Fusion gene name: CCSER1_BMP2K | Fusion gene ID: 6065 | Hgene | Tgene | Gene symbol | CCSER1 | BMP2K | Gene ID | 401145 | 55589 |
Gene name | coiled-coil serine rich protein 1 | BMP2 inducible kinase | |
Synonyms | FAM190A | BIKE|HRIHFB2017 | |
Cytomap | 4q22.1 | 4q21.21 | |
Type of gene | protein-coding | protein-coding | |
Description | serine-rich coiled-coil domain-containing protein 1family with sequence similarity 190, member Aprotein FAM190A | BMP-2-inducible protein kinase | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9C0I3 | Q9NSY1 | |
Ensembl transtripts involved in fusion gene | ENST00000509176, ENST00000333691, ENST00000432775, ENST00000504150, | ENST00000335016, ENST00000502871, | |
Fusion gene scores | * DoF score | 8 X 7 X 4=224 | 3 X 3 X 3=27 |
# samples | 8 | 3 | |
** MAII score | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CCSER1 [Title/Abstract] AND BMP2K [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BLCA | TCGA-LT-A5Z6-01A | CCSER1 | chr4 | 91321280 | + | BMP2K | chr4 | 79754736 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000509176 | ENST00000335016 | CCSER1 | chr4 | 91321280 | + | BMP2K | chr4 | 79754736 | + |
Frame-shift | ENST00000509176 | ENST00000502871 | CCSER1 | chr4 | 91321280 | + | BMP2K | chr4 | 79754736 | + |
Frame-shift | ENST00000333691 | ENST00000335016 | CCSER1 | chr4 | 91321280 | + | BMP2K | chr4 | 79754736 | + |
Frame-shift | ENST00000333691 | ENST00000502871 | CCSER1 | chr4 | 91321280 | + | BMP2K | chr4 | 79754736 | + |
Frame-shift | ENST00000432775 | ENST00000335016 | CCSER1 | chr4 | 91321280 | + | BMP2K | chr4 | 79754736 | + |
Frame-shift | ENST00000432775 | ENST00000502871 | CCSER1 | chr4 | 91321280 | + | BMP2K | chr4 | 79754736 | + |
intron-3CDS | ENST00000504150 | ENST00000335016 | CCSER1 | chr4 | 91321280 | + | BMP2K | chr4 | 79754736 | + |
intron-3CDS | ENST00000504150 | ENST00000502871 | CCSER1 | chr4 | 91321280 | + | BMP2K | chr4 | 79754736 | + |
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FusionProtFeatures for CCSER1_BMP2K |
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Hgene | Tgene |
CCSER1 | BMP2K |
May be involved in osteoblast differentiation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CCSER1_BMP2K |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CCSER1_BMP2K |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CCSER1 | NDEL1, SMYD2, NDE1, CYLD | BMP2K | KDM5B, TERF1, TERF2, ABL1, EPS15, AP2M1, FN1, SLC25A41, LIMS1, XPO1, CAPZA2, CDK2, CLTB, CLTC, DBN1, FLNA, GAK, GBA, MYH9, PPP1CB, PICALM, IQGAP1, PDLIM7, SEC16A, SYNPO, LIMA1, GTSE1, ANLN, MYO19, MYO18A, AP2S1, CLINT1, REPS1, STAMBP, STAMBPL1, RALBP1, INTS4, RUNDC3A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CCSER1_BMP2K |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCSER1_BMP2K |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CCSER1 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |