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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6065

FusionGeneSummary for CCSER1_BMP2K

check button Fusion gene summary
Fusion gene informationFusion gene name: CCSER1_BMP2K
Fusion gene ID: 6065
HgeneTgene
Gene symbol

CCSER1

BMP2K

Gene ID

401145

55589

Gene namecoiled-coil serine rich protein 1BMP2 inducible kinase
SynonymsFAM190ABIKE|HRIHFB2017
Cytomap

4q22.1

4q21.21

Type of geneprotein-codingprotein-coding
Descriptionserine-rich coiled-coil domain-containing protein 1family with sequence similarity 190, member Aprotein FAM190ABMP-2-inducible protein kinase
Modification date2018051920180523
UniProtAcc

Q9C0I3

Q9NSY1

Ensembl transtripts involved in fusion geneENST00000509176, ENST00000333691, 
ENST00000432775, ENST00000504150, 
ENST00000335016, ENST00000502871, 
Fusion gene scores* DoF score8 X 7 X 4=2243 X 3 X 3=27
# samples 83
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CCSER1 [Title/Abstract] AND BMP2K [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-LT-A5Z6-01ACCSER1chr4

91321280

+BMP2Kchr4

79754736

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000509176ENST00000335016CCSER1chr4

91321280

+BMP2Kchr4

79754736

+
Frame-shiftENST00000509176ENST00000502871CCSER1chr4

91321280

+BMP2Kchr4

79754736

+
Frame-shiftENST00000333691ENST00000335016CCSER1chr4

91321280

+BMP2Kchr4

79754736

+
Frame-shiftENST00000333691ENST00000502871CCSER1chr4

91321280

+BMP2Kchr4

79754736

+
Frame-shiftENST00000432775ENST00000335016CCSER1chr4

91321280

+BMP2Kchr4

79754736

+
Frame-shiftENST00000432775ENST00000502871CCSER1chr4

91321280

+BMP2Kchr4

79754736

+
intron-3CDSENST00000504150ENST00000335016CCSER1chr4

91321280

+BMP2Kchr4

79754736

+
intron-3CDSENST00000504150ENST00000502871CCSER1chr4

91321280

+BMP2Kchr4

79754736

+

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FusionProtFeatures for CCSER1_BMP2K


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCSER1

Q9C0I3

BMP2K

Q9NSY1

May be involved in osteoblast differentiation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCSER1_BMP2K


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCSER1_BMP2K


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCSER1NDEL1, SMYD2, NDE1, CYLDBMP2KKDM5B, TERF1, TERF2, ABL1, EPS15, AP2M1, FN1, SLC25A41, LIMS1, XPO1, CAPZA2, CDK2, CLTB, CLTC, DBN1, FLNA, GAK, GBA, MYH9, PPP1CB, PICALM, IQGAP1, PDLIM7, SEC16A, SYNPO, LIMA1, GTSE1, ANLN, MYO19, MYO18A, AP2S1, CLINT1, REPS1, STAMBP, STAMBPL1, RALBP1, INTS4, RUNDC3A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCSER1_BMP2K


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCSER1_BMP2K


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCSER1C0236736Cocaine-Related Disorders1CTD_human