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Fusion gene ID: 6057 |
FusionGeneSummary for CCPG1_DNAJB11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCPG1_DNAJB11 | Fusion gene ID: 6057 | Hgene | Tgene | Gene symbol | CCPG1 | DNAJB11 | Gene ID | 9236 | 51726 |
| Gene name | cell cycle progression 1 | DnaJ heat shock protein family (Hsp40) member B11 | |
| Synonyms | CPR8 | ABBP-2|ABBP2|DJ9|Dj-9|EDJ|ERdj3|ERj3|ERj3p|PRO1080|UNQ537 | |
| Cytomap | 15q21.3 | 3q27.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cell cycle progression protein 1cell cycle progression restoration protein 8 | dnaJ homolog subfamily B member 11APOBEC1-binding protein 2DnaJ (Hsp40) homolog, subfamily B, member 11DnaJ protein 9ER-associated DNAJ protein 3ER-associated Hsp40 co-chaperoneER-resident protein ERdj3PWP1-interacting protein 4endoplasmic reticul | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9ULG6 | Q9UBS4 | |
| Ensembl transtripts involved in fusion gene | ENST00000563294, ENST00000442196, ENST00000310958, ENST00000425574, ENST00000569205, | ENST00000439351, ENST00000265028, ENST00000538831, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 2 X 2 X 1=4 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: CCPG1 [Title/Abstract] AND DNAJB11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DNAJB11 | GO:0032781 | positive regulation of ATPase activity | 20335166 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE925161 | CCPG1 | chr15 | 55652573 | - | DNAJB11 | chr3 | 186301734 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000563294 | ENST00000439351 | CCPG1 | chr15 | 55652573 | - | DNAJB11 | chr3 | 186301734 | + |
| intron-3CDS | ENST00000563294 | ENST00000265028 | CCPG1 | chr15 | 55652573 | - | DNAJB11 | chr3 | 186301734 | + |
| intron-intron | ENST00000563294 | ENST00000538831 | CCPG1 | chr15 | 55652573 | - | DNAJB11 | chr3 | 186301734 | + |
| intron-3CDS | ENST00000442196 | ENST00000439351 | CCPG1 | chr15 | 55652573 | - | DNAJB11 | chr3 | 186301734 | + |
| intron-3CDS | ENST00000442196 | ENST00000265028 | CCPG1 | chr15 | 55652573 | - | DNAJB11 | chr3 | 186301734 | + |
| intron-intron | ENST00000442196 | ENST00000538831 | CCPG1 | chr15 | 55652573 | - | DNAJB11 | chr3 | 186301734 | + |
| intron-3CDS | ENST00000310958 | ENST00000439351 | CCPG1 | chr15 | 55652573 | - | DNAJB11 | chr3 | 186301734 | + |
| intron-3CDS | ENST00000310958 | ENST00000265028 | CCPG1 | chr15 | 55652573 | - | DNAJB11 | chr3 | 186301734 | + |
| intron-intron | ENST00000310958 | ENST00000538831 | CCPG1 | chr15 | 55652573 | - | DNAJB11 | chr3 | 186301734 | + |
| intron-3CDS | ENST00000425574 | ENST00000439351 | CCPG1 | chr15 | 55652573 | - | DNAJB11 | chr3 | 186301734 | + |
| intron-3CDS | ENST00000425574 | ENST00000265028 | CCPG1 | chr15 | 55652573 | - | DNAJB11 | chr3 | 186301734 | + |
| intron-intron | ENST00000425574 | ENST00000538831 | CCPG1 | chr15 | 55652573 | - | DNAJB11 | chr3 | 186301734 | + |
| intron-3CDS | ENST00000569205 | ENST00000439351 | CCPG1 | chr15 | 55652573 | - | DNAJB11 | chr3 | 186301734 | + |
| intron-3CDS | ENST00000569205 | ENST00000265028 | CCPG1 | chr15 | 55652573 | - | DNAJB11 | chr3 | 186301734 | + |
| intron-intron | ENST00000569205 | ENST00000538831 | CCPG1 | chr15 | 55652573 | - | DNAJB11 | chr3 | 186301734 | + |
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FusionProtFeatures for CCPG1_DNAJB11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCPG1 | DNAJB11 |
| Serves as a co-chaperone for HSPA5. Binds directly toboth unfolded proteins that are substrates for ERAD and nascentunfolded peptide chains, but dissociates from the HSPA5-unfoldedprotein complex before folding is completed. May help recruitingHSPA5 and other chaperones to the substrate. Stimulates HSPA5ATPase activity. {ECO:0000269|PubMed:10827079,ECO:0000269|PubMed:15525676}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CCPG1_DNAJB11 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CCPG1_DNAJB11 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CCPG1_DNAJB11 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCPG1_DNAJB11 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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