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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6038

FusionGeneSummary for CCNYL1_IDH1

check button Fusion gene summary
Fusion gene informationFusion gene name: CCNYL1_IDH1
Fusion gene ID: 6038
HgeneTgene
Gene symbol

CCNYL1

IDH1

Gene ID

151195

3417

Gene namecyclin Y like 1isocitrate dehydrogenase (NADP(+)) 1, cytosolic
Synonyms-HEL-216|HEL-S-26|IDCD|IDH|IDP|IDPC|PICD
Cytomap

2q33.3

2q34

Type of geneprotein-codingprotein-coding
Descriptioncyclin-Y-like protein 1isocitrate dehydrogenase [NADP] cytoplasmicNADP(+)-specific ICDHNADP-dependent isocitrate dehydrogenase, cytosolicNADP-dependent isocitrate dehydrogenase, peroxisomalepididymis luminal protein 216epididymis secretory protein Li 26isocitrate dehydrog
Modification date2018052320180527
UniProtAcc

Q8N7R7

O75874

Ensembl transtripts involved in fusion geneENST00000392209, ENST00000420822, 
ENST00000295414, ENST00000339882, 
ENST00000468768, 
ENST00000345146, 
ENST00000446179, ENST00000415913, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 3 X 2=18
# samples 43
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CCNYL1 [Title/Abstract] AND IDH1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIDH1

GO:0006102

isocitrate metabolic process

10521434|19935646|20171178

TgeneIDH1

GO:0006103

2-oxoglutarate metabolic process

19935646


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC065703CCNYL1chr2

208576841

+IDH1chr2

209104729

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000392209ENST00000345146CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000392209ENST00000446179CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000392209ENST00000415913CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000420822ENST00000345146CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000420822ENST00000446179CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000420822ENST00000415913CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000295414ENST00000345146CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000295414ENST00000446179CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000295414ENST00000415913CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000339882ENST00000345146CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000339882ENST00000446179CCNYL1chr2

208576841

+IDH1chr2

209104729

-
In-frameENST00000339882ENST00000415913CCNYL1chr2

208576841

+IDH1chr2

209104729

-
intron-3CDSENST00000468768ENST00000345146CCNYL1chr2

208576841

+IDH1chr2

209104729

-
intron-3CDSENST00000468768ENST00000446179CCNYL1chr2

208576841

+IDH1chr2

209104729

-
intron-3CDSENST00000468768ENST00000415913CCNYL1chr2

208576841

+IDH1chr2

209104729

-

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FusionProtFeatures for CCNYL1_IDH1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCNYL1

Q8N7R7

IDH1

O75874


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIDH1chr2:208576841chr2:209104729ENST00000345146-610310_315283415Nucleotide bindingNADP
TgeneIDH1chr2:208576841chr2:209104729ENST00000415913-610310_315283415Nucleotide bindingNADP
TgeneIDH1chr2:208576841chr2:209104729ENST00000446179-610310_315283415Nucleotide bindingNADP

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCNYL1chr2:208576841chr2:209104729ENST00000295414+110145_26773360DomainNote=Cyclin N-terminal
HgeneCCNYL1chr2:208576841chr2:209104729ENST00000339882+18145_26773309DomainNote=Cyclin N-terminal
HgeneCCNYL1chr2:208576841chr2:209104729ENST00000392209+211145_2673290DomainNote=Cyclin N-terminal
TgeneIDH1chr2:208576841chr2:209104729ENST00000345146-61075_77283415Nucleotide bindingNADP
TgeneIDH1chr2:208576841chr2:209104729ENST00000415913-61075_77283415Nucleotide bindingNADP
TgeneIDH1chr2:208576841chr2:209104729ENST00000446179-61075_77283415Nucleotide bindingNADP
TgeneIDH1chr2:208576841chr2:209104729ENST00000345146-61094_100283415RegionNote=Substrate binding
TgeneIDH1chr2:208576841chr2:209104729ENST00000415913-61094_100283415RegionNote=Substrate binding
TgeneIDH1chr2:208576841chr2:209104729ENST00000446179-61094_100283415RegionNote=Substrate binding


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FusionGeneSequence for CCNYL1_IDH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCNYL1_IDH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCNYL1MOV10, NXF1, CDK16, BCAN, HOXB5, TAS2R7, FYTTD1, TMEM185A, WEE1, CKAP5, RTEL1, CCNY, GJB7, S100A7A, IVL, TREX2, HIST2H3PS2, DUSP22, CIR1, PPL, EVPL, FGB, BIRC2, SERPINB4, SERPINB5, TRIM29, SERPINB2, FGG, PKP3, SPPL2B, SBSN, POF1B, CAPG, CALML5, A2ML1, S100A8, RAB3IPIDH1ZHX1, ELAVL1, SLC2A4, CDK2, ASF1B, AK1, MDH2, AK2, PEX5, ADSS, GLRX3, HSPE1, ANXA6, C12orf10, CBX3, CHMP4A, DCK, EFHD2, FDPS, GOT1, NME1, OXCT1, RANBP1, SBDS, THOP1, UBE2H, NME1-NME2, PTMS, RBBP7, RCN1, SUGT1, TALDO1, MOV10, NXF1, CAB39, DAZAP1, FAM49B, HSD17B4, ARF4, ETHE1, IDH2, IDH3A, IDH3B, IDH3G, TKT, LTA4H, PCBP1, PHB2, NTRK1, IDH1, CDH1, AGGF1, DKK3, CRACR2B, FAM131A, FHL2, FIGNL1, LAX1, NUP62, PRDM14, TMOD4, UBL7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCNYL1_IDH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCNYL1_IDH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIDH1C0017638Glioma4CTD_human
TgeneIDH1C0014084Enchondromatosis2CTD_human;HPO;ORPHANET
TgeneIDH1C0936248Chondroma2CTD_human
TgeneIDH1C0018916Hemangioma1CTD_human
TgeneIDH1C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneIDH1C0023487Acute Promyelocytic Leukemia1CTD_human
TgeneIDH1C0027643Neoplasm Recurrence, Local1CTD_human
TgeneIDH1C0028945oligodendroglioma1CTD_human
TgeneIDH1C0206698Cholangiocarcinoma1CTD_human
TgeneIDH1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneIDH1C2239176Liver carcinoma1CTD_human