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Fusion gene ID: 6038 |
FusionGeneSummary for CCNYL1_IDH1 |
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Fusion gene information | Fusion gene name: CCNYL1_IDH1 | Fusion gene ID: 6038 | Hgene | Tgene | Gene symbol | CCNYL1 | IDH1 | Gene ID | 151195 | 3417 |
Gene name | cyclin Y like 1 | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | |
Synonyms | - | HEL-216|HEL-S-26|IDCD|IDH|IDP|IDPC|PICD | |
Cytomap | 2q33.3 | 2q34 | |
Type of gene | protein-coding | protein-coding | |
Description | cyclin-Y-like protein 1 | isocitrate dehydrogenase [NADP] cytoplasmicNADP(+)-specific ICDHNADP-dependent isocitrate dehydrogenase, cytosolicNADP-dependent isocitrate dehydrogenase, peroxisomalepididymis luminal protein 216epididymis secretory protein Li 26isocitrate dehydrog | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q8N7R7 | O75874 | |
Ensembl transtripts involved in fusion gene | ENST00000392209, ENST00000420822, ENST00000295414, ENST00000339882, ENST00000468768, | ENST00000345146, ENST00000446179, ENST00000415913, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 3 X 3 X 2=18 |
# samples | 4 | 3 | |
** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CCNYL1 [Title/Abstract] AND IDH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | IDH1 | GO:0006102 | isocitrate metabolic process | 10521434|19935646|20171178 |
Tgene | IDH1 | GO:0006103 | 2-oxoglutarate metabolic process | 19935646 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BC065703 | CCNYL1 | chr2 | 208576841 | + | IDH1 | chr2 | 209104729 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000392209 | ENST00000345146 | CCNYL1 | chr2 | 208576841 | + | IDH1 | chr2 | 209104729 | - |
In-frame | ENST00000392209 | ENST00000446179 | CCNYL1 | chr2 | 208576841 | + | IDH1 | chr2 | 209104729 | - |
In-frame | ENST00000392209 | ENST00000415913 | CCNYL1 | chr2 | 208576841 | + | IDH1 | chr2 | 209104729 | - |
In-frame | ENST00000420822 | ENST00000345146 | CCNYL1 | chr2 | 208576841 | + | IDH1 | chr2 | 209104729 | - |
In-frame | ENST00000420822 | ENST00000446179 | CCNYL1 | chr2 | 208576841 | + | IDH1 | chr2 | 209104729 | - |
In-frame | ENST00000420822 | ENST00000415913 | CCNYL1 | chr2 | 208576841 | + | IDH1 | chr2 | 209104729 | - |
In-frame | ENST00000295414 | ENST00000345146 | CCNYL1 | chr2 | 208576841 | + | IDH1 | chr2 | 209104729 | - |
In-frame | ENST00000295414 | ENST00000446179 | CCNYL1 | chr2 | 208576841 | + | IDH1 | chr2 | 209104729 | - |
In-frame | ENST00000295414 | ENST00000415913 | CCNYL1 | chr2 | 208576841 | + | IDH1 | chr2 | 209104729 | - |
In-frame | ENST00000339882 | ENST00000345146 | CCNYL1 | chr2 | 208576841 | + | IDH1 | chr2 | 209104729 | - |
In-frame | ENST00000339882 | ENST00000446179 | CCNYL1 | chr2 | 208576841 | + | IDH1 | chr2 | 209104729 | - |
In-frame | ENST00000339882 | ENST00000415913 | CCNYL1 | chr2 | 208576841 | + | IDH1 | chr2 | 209104729 | - |
intron-3CDS | ENST00000468768 | ENST00000345146 | CCNYL1 | chr2 | 208576841 | + | IDH1 | chr2 | 209104729 | - |
intron-3CDS | ENST00000468768 | ENST00000446179 | CCNYL1 | chr2 | 208576841 | + | IDH1 | chr2 | 209104729 | - |
intron-3CDS | ENST00000468768 | ENST00000415913 | CCNYL1 | chr2 | 208576841 | + | IDH1 | chr2 | 209104729 | - |
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FusionProtFeatures for CCNYL1_IDH1 |
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Hgene | Tgene |
CCNYL1 | IDH1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >IDH1 | chr2:208576841 | chr2:209104729 | ENST00000345146 | - | 6 | 10 | 310_315 | 283 | 415 | Nucleotide binding | NADP |
Tgene | >IDH1 | chr2:208576841 | chr2:209104729 | ENST00000415913 | - | 6 | 10 | 310_315 | 283 | 415 | Nucleotide binding | NADP |
Tgene | >IDH1 | chr2:208576841 | chr2:209104729 | ENST00000446179 | - | 6 | 10 | 310_315 | 283 | 415 | Nucleotide binding | NADP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >CCNYL1 | chr2:208576841 | chr2:209104729 | ENST00000295414 | + | 1 | 10 | 145_267 | 73 | 360 | Domain | Note=Cyclin N-terminal |
Hgene | >CCNYL1 | chr2:208576841 | chr2:209104729 | ENST00000339882 | + | 1 | 8 | 145_267 | 73 | 309 | Domain | Note=Cyclin N-terminal |
Hgene | >CCNYL1 | chr2:208576841 | chr2:209104729 | ENST00000392209 | + | 2 | 11 | 145_267 | 3 | 290 | Domain | Note=Cyclin N-terminal |
Tgene | IDH1 | chr2:208576841 | chr2:209104729 | ENST00000345146 | - | 6 | 10 | 75_77 | 283 | 415 | Nucleotide binding | NADP |
Tgene | IDH1 | chr2:208576841 | chr2:209104729 | ENST00000415913 | - | 6 | 10 | 75_77 | 283 | 415 | Nucleotide binding | NADP |
Tgene | IDH1 | chr2:208576841 | chr2:209104729 | ENST00000446179 | - | 6 | 10 | 75_77 | 283 | 415 | Nucleotide binding | NADP |
Tgene | IDH1 | chr2:208576841 | chr2:209104729 | ENST00000345146 | - | 6 | 10 | 94_100 | 283 | 415 | Region | Note=Substrate binding |
Tgene | IDH1 | chr2:208576841 | chr2:209104729 | ENST00000415913 | - | 6 | 10 | 94_100 | 283 | 415 | Region | Note=Substrate binding |
Tgene | IDH1 | chr2:208576841 | chr2:209104729 | ENST00000446179 | - | 6 | 10 | 94_100 | 283 | 415 | Region | Note=Substrate binding |
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FusionGeneSequence for CCNYL1_IDH1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CCNYL1_IDH1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CCNYL1 | MOV10, NXF1, CDK16, BCAN, HOXB5, TAS2R7, FYTTD1, TMEM185A, WEE1, CKAP5, RTEL1, CCNY, GJB7, S100A7A, IVL, TREX2, HIST2H3PS2, DUSP22, CIR1, PPL, EVPL, FGB, BIRC2, SERPINB4, SERPINB5, TRIM29, SERPINB2, FGG, PKP3, SPPL2B, SBSN, POF1B, CAPG, CALML5, A2ML1, S100A8, RAB3IP | IDH1 | ZHX1, ELAVL1, SLC2A4, CDK2, ASF1B, AK1, MDH2, AK2, PEX5, ADSS, GLRX3, HSPE1, ANXA6, C12orf10, CBX3, CHMP4A, DCK, EFHD2, FDPS, GOT1, NME1, OXCT1, RANBP1, SBDS, THOP1, UBE2H, NME1-NME2, PTMS, RBBP7, RCN1, SUGT1, TALDO1, MOV10, NXF1, CAB39, DAZAP1, FAM49B, HSD17B4, ARF4, ETHE1, IDH2, IDH3A, IDH3B, IDH3G, TKT, LTA4H, PCBP1, PHB2, NTRK1, IDH1, CDH1, AGGF1, DKK3, CRACR2B, FAM131A, FHL2, FIGNL1, LAX1, NUP62, PRDM14, TMOD4, UBL7 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CCNYL1_IDH1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCNYL1_IDH1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IDH1 | C0017638 | Glioma | 4 | CTD_human |
Tgene | IDH1 | C0014084 | Enchondromatosis | 2 | CTD_human;HPO;ORPHANET |
Tgene | IDH1 | C0936248 | Chondroma | 2 | CTD_human |
Tgene | IDH1 | C0018916 | Hemangioma | 1 | CTD_human |
Tgene | IDH1 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Tgene | IDH1 | C0023487 | Acute Promyelocytic Leukemia | 1 | CTD_human |
Tgene | IDH1 | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
Tgene | IDH1 | C0028945 | oligodendroglioma | 1 | CTD_human |
Tgene | IDH1 | C0206698 | Cholangiocarcinoma | 1 | CTD_human |
Tgene | IDH1 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
Tgene | IDH1 | C2239176 | Liver carcinoma | 1 | CTD_human |