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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6035

FusionGeneSummary for CCNT2_MTUS1

check button Fusion gene summary
Fusion gene informationFusion gene name: CCNT2_MTUS1
Fusion gene ID: 6035
HgeneTgene
Gene symbol

CCNT2

MTUS1

Gene ID

905

57509

Gene namecyclin T2microtubule associated scaffold protein 1
SynonymsCYCT2ATBP|ATIP|ATIP3|ICIS|MP44|MTSG1
Cytomap

2q21.3

8p22

Type of geneprotein-codingprotein-coding
Descriptioncyclin-T2SDS-stable vimentin-bound DNA fragment HEF42VIM22cyclin T2acyclin T2bsubunit of positive elongation transcription factor bmicrotubule-associated tumor suppressor 1AT2 receptor-binding proteinAT2 receptor-interacting proteinAT2R binding proteinangiotensin-II type 2 receptor-interacting proteinerythroid differentiation-relatedmicrotubule associated tumor suppressor 1mit
Modification date2018052320180523
UniProtAcc

O60583

Q9ULD2

Ensembl transtripts involved in fusion geneENST00000537343, ENST00000295238, 
ENST00000264157, 
ENST00000544260, 
ENST00000381869, ENST00000381861, 
ENST00000262102, ENST00000519263, 
ENST00000400046, ENST00000297488, 
ENST00000518713, ENST00000381862, 
Fusion gene scores* DoF score2 X 2 X 3=123 X 3 X 2=18
# samples 33
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CCNT2 [Title/Abstract] AND MTUS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCCNT2

GO:0019085

early viral transcription

21509660

HgeneCCNT2

GO:0019086

late viral transcription

21509660

HgeneCCNT2

GO:0045944

positive regulation of transcription by RNA polymerase II

15563843


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF828107CCNT2chr2

135697537

+MTUS1chr8

17527797

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000537343ENST00000544260CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000537343ENST00000381869CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000537343ENST00000381861CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000537343ENST00000262102CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000537343ENST00000519263CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000537343ENST00000400046CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000537343ENST00000297488CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000537343ENST00000518713CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000537343ENST00000381862CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000295238ENST00000544260CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000295238ENST00000381869CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000295238ENST00000381861CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000295238ENST00000262102CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000295238ENST00000519263CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000295238ENST00000400046CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000295238ENST00000297488CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000295238ENST00000518713CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000295238ENST00000381862CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000264157ENST00000544260CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000264157ENST00000381869CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000264157ENST00000381861CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000264157ENST00000262102CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000264157ENST00000519263CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000264157ENST00000400046CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000264157ENST00000297488CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000264157ENST00000518713CCNT2chr2

135697537

+MTUS1chr8

17527797

+
intron-intronENST00000264157ENST00000381862CCNT2chr2

135697537

+MTUS1chr8

17527797

+

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FusionProtFeatures for CCNT2_MTUS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCNT2

O60583

MTUS1

Q9ULD2

Regulatory subunit of the cyclin-dependent kinase pair(CDK9/cyclin T) complex, also called positive transcriptionelongation factor B (P-TEFB), which is proposed to facilitate thetransition from abortive to production elongation byphosphorylating the CTD (carboxy-terminal domain) of the largesubunit of RNA polymerase II (RNAP II) (PubMed:9499409,PubMed:15563843). The activity of this complex is regulated bybinding with 7SK snRNA (PubMed:11713533). Plays a role duringmuscle differentiation; P-TEFB complex interacts with MYOD1; thistripartite complex promotes the transcriptional activity of MYOD1through its CDK9-mediated phosphorylation and binds the chromatinof promoters and enhancers of muscle-specific genes; this eventcorrelates with hyperphosphorylation of the CTD domain of RNA polII (By similarity). In addition, enhances MYOD1-dependenttranscription through interaction with PKN1 (PubMed:16331689).Involved in early embryo development (By similarity).{ECO:0000250|UniProtKB:Q7TQK0, ECO:0000269|PubMed:11713533,ECO:0000269|PubMed:15563843, ECO:0000269|PubMed:16331689,ECO:0000269|PubMed:9499409}. (Microbial infection) Promotes transcriptionalactivation of early and late herpes simplex virus 1/HHV-1promoters. {ECO:0000269|PubMed:21509660}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCNT2_MTUS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCNT2_MTUS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCNT2_MTUS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCNT2_MTUS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMTUS1C2239176Liver carcinoma1UNIPROT