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Fusion gene ID: 6035 |
FusionGeneSummary for CCNT2_MTUS1 |
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Fusion gene information | Fusion gene name: CCNT2_MTUS1 | Fusion gene ID: 6035 | Hgene | Tgene | Gene symbol | CCNT2 | MTUS1 | Gene ID | 905 | 57509 |
Gene name | cyclin T2 | microtubule associated scaffold protein 1 | |
Synonyms | CYCT2 | ATBP|ATIP|ATIP3|ICIS|MP44|MTSG1 | |
Cytomap | 2q21.3 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | cyclin-T2SDS-stable vimentin-bound DNA fragment HEF42VIM22cyclin T2acyclin T2bsubunit of positive elongation transcription factor b | microtubule-associated tumor suppressor 1AT2 receptor-binding proteinAT2 receptor-interacting proteinAT2R binding proteinangiotensin-II type 2 receptor-interacting proteinerythroid differentiation-relatedmicrotubule associated tumor suppressor 1mit | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O60583 | Q9ULD2 | |
Ensembl transtripts involved in fusion gene | ENST00000537343, ENST00000295238, ENST00000264157, | ENST00000544260, ENST00000381869, ENST00000381861, ENST00000262102, ENST00000519263, ENST00000400046, ENST00000297488, ENST00000518713, ENST00000381862, | |
Fusion gene scores | * DoF score | 2 X 2 X 3=12 | 3 X 3 X 2=18 |
# samples | 3 | 3 | |
** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CCNT2 [Title/Abstract] AND MTUS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CCNT2 | GO:0019085 | early viral transcription | 21509660 |
Hgene | CCNT2 | GO:0019086 | late viral transcription | 21509660 |
Hgene | CCNT2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15563843 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF828107 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000537343 | ENST00000544260 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000537343 | ENST00000381869 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000537343 | ENST00000381861 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000537343 | ENST00000262102 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000537343 | ENST00000519263 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000537343 | ENST00000400046 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000537343 | ENST00000297488 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000537343 | ENST00000518713 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000537343 | ENST00000381862 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000295238 | ENST00000544260 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000295238 | ENST00000381869 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000295238 | ENST00000381861 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000295238 | ENST00000262102 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000295238 | ENST00000519263 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000295238 | ENST00000400046 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000295238 | ENST00000297488 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000295238 | ENST00000518713 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000295238 | ENST00000381862 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000264157 | ENST00000544260 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000264157 | ENST00000381869 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000264157 | ENST00000381861 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000264157 | ENST00000262102 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000264157 | ENST00000519263 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000264157 | ENST00000400046 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000264157 | ENST00000297488 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000264157 | ENST00000518713 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
intron-intron | ENST00000264157 | ENST00000381862 | CCNT2 | chr2 | 135697537 | + | MTUS1 | chr8 | 17527797 | + |
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FusionProtFeatures for CCNT2_MTUS1 |
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Hgene | Tgene |
CCNT2 | MTUS1 |
Regulatory subunit of the cyclin-dependent kinase pair(CDK9/cyclin T) complex, also called positive transcriptionelongation factor B (P-TEFB), which is proposed to facilitate thetransition from abortive to production elongation byphosphorylating the CTD (carboxy-terminal domain) of the largesubunit of RNA polymerase II (RNAP II) (PubMed:9499409,PubMed:15563843). The activity of this complex is regulated bybinding with 7SK snRNA (PubMed:11713533). Plays a role duringmuscle differentiation; P-TEFB complex interacts with MYOD1; thistripartite complex promotes the transcriptional activity of MYOD1through its CDK9-mediated phosphorylation and binds the chromatinof promoters and enhancers of muscle-specific genes; this eventcorrelates with hyperphosphorylation of the CTD domain of RNA polII (By similarity). In addition, enhances MYOD1-dependenttranscription through interaction with PKN1 (PubMed:16331689).Involved in early embryo development (By similarity).{ECO:0000250|UniProtKB:Q7TQK0, ECO:0000269|PubMed:11713533,ECO:0000269|PubMed:15563843, ECO:0000269|PubMed:16331689,ECO:0000269|PubMed:9499409}. (Microbial infection) Promotes transcriptionalactivation of early and late herpes simplex virus 1/HHV-1promoters. {ECO:0000269|PubMed:21509660}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CCNT2_MTUS1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CCNT2_MTUS1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CCNT2_MTUS1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCNT2_MTUS1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MTUS1 | C2239176 | Liver carcinoma | 1 | UNIPROT |