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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6016

FusionGeneSummary for CCNG2_SLC4A4

check button Fusion gene summary
Fusion gene informationFusion gene name: CCNG2_SLC4A4
Fusion gene ID: 6016
HgeneTgene
Gene symbol

CCNG2

SLC4A4

Gene ID

901

8671

Gene namecyclin G2solute carrier family 4 member 4
Synonyms-HNBC1|KNBC|NBC1|NBC2|NBCe1-A|SLC4A5|hhNMC|kNBC1|pNBC
Cytomap

4q21.1

4q13.3

Type of geneprotein-codingprotein-coding
Descriptioncyclin-G2electrogenic sodium bicarbonate cotransporter 1Na(+)/HCO3(-) cotransportersodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas)solute carrier family 4 (sodium bicarbonate cotransporter
Modification date2018052320180523
UniProtAcc

Q16589

Q9Y6R1

Ensembl transtripts involved in fusion geneENST00000497512, ENST00000316355, 
ENST00000354403, ENST00000502280, 
ENST00000395640, ENST00000509972, 
ENST00000264485, ENST00000425175, 
ENST00000351898, ENST00000340595, 
ENST00000514331, ENST00000512686, 
Fusion gene scores* DoF score1 X 1 X 1=110 X 8 X 5=400
# samples 111
** MAII scorelog2(1/1*10)=3.32192809488736log2(11/400*10)=-1.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCNG2 [Title/Abstract] AND SLC4A4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC4A4

GO:0006814

sodium ion transport

16769890


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-CH-5751-01ACCNG2chr4

78085632

+SLC4A4chr4

72102293

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000497512ENST00000264485CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
3UTR-5UTRENST00000497512ENST00000425175CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
3UTR-5UTRENST00000497512ENST00000351898CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
3UTR-intronENST00000497512ENST00000340595CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
3UTR-intronENST00000497512ENST00000514331CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
3UTR-intronENST00000497512ENST00000512686CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-5UTRENST00000316355ENST00000264485CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-5UTRENST00000316355ENST00000425175CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-5UTRENST00000316355ENST00000351898CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-intronENST00000316355ENST00000340595CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-intronENST00000316355ENST00000514331CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-intronENST00000316355ENST00000512686CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-5UTRENST00000354403ENST00000264485CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-5UTRENST00000354403ENST00000425175CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-5UTRENST00000354403ENST00000351898CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-intronENST00000354403ENST00000340595CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-intronENST00000354403ENST00000514331CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-intronENST00000354403ENST00000512686CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-5UTRENST00000502280ENST00000264485CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-5UTRENST00000502280ENST00000425175CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-5UTRENST00000502280ENST00000351898CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-intronENST00000502280ENST00000340595CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-intronENST00000502280ENST00000514331CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-intronENST00000502280ENST00000512686CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-5UTRENST00000395640ENST00000264485CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-5UTRENST00000395640ENST00000425175CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-5UTRENST00000395640ENST00000351898CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-intronENST00000395640ENST00000340595CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-intronENST00000395640ENST00000514331CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-intronENST00000395640ENST00000512686CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-5UTRENST00000509972ENST00000264485CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-5UTRENST00000509972ENST00000425175CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-5UTRENST00000509972ENST00000351898CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-intronENST00000509972ENST00000340595CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-intronENST00000509972ENST00000514331CCNG2chr4

78085632

+SLC4A4chr4

72102293

+
5CDS-intronENST00000509972ENST00000512686CCNG2chr4

78085632

+SLC4A4chr4

72102293

+

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FusionProtFeatures for CCNG2_SLC4A4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCNG2

Q16589

SLC4A4

Q9Y6R1

May play a role in growth regulation and in negativeregulation of cell cycle progression.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCNG2_SLC4A4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCNG2_SLC4A4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCNG2PPP2R5B, PPP2R5C, PPP2CA, SKP1, SKP2, NRIP2, FAM208B, EFHC2, PPP2R5D, NME2, PPP2R5ESLC4A4SREBF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCNG2_SLC4A4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCNG2_SLC4A4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSLC4A4C1970309Renal Tubular Acidosis, Proximal, With Ocular Abnormalities And Mental Retardation3CTD_human;ORPHANET;UNIPROT
TgeneSLC4A4C0001126Renal tubular acidosis1CTD_human
TgeneSLC4A4C0008073Developmental Disabilities1CTD_human
TgeneSLC4A4C0010038Corneal Opacity1CTD_human
TgeneSLC4A4C0017601Glaucoma1CTD_human;HPO
TgeneSLC4A4C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneSLC4A4C0086543Cataract1CTD_human;HPO