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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5983

FusionGeneSummary for CCNC_FAM201A

check button Fusion gene summary
Fusion gene informationFusion gene name: CCNC_FAM201A
Fusion gene ID: 5983
HgeneTgene
Gene symbol

CCNC

FAM201A

Gene ID

892

158228

Gene namecyclin Cfamily with sequence similarity 201 member A
SynonymsCycC|SRB11|hSRB11C9orf122
Cytomap

6q16.2

9p13.1

Type of geneprotein-codingncRNA
Descriptioncyclin-CSRB11 homolog-
Modification date2018052520180329
UniProtAcc

P24863

Ensembl transtripts involved in fusion geneENST00000520429, ENST00000369220, 
ENST00000520371, ENST00000523799, 
ENST00000523985, ENST00000518714, 
ENST00000521017, ENST00000482541, 
ENST00000471864, ENST00000484285, 
ENST00000377680, 
Fusion gene scores* DoF score3 X 1 X 2=63 X 1 X 3=9
# samples 33
** MAII scorelog2(3/6*10)=2.32192809488736log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CCNC [Title/Abstract] AND FAM201A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCHOLTCGA-YR-A95A-01ACCNCchr6

100016372

-FAM201Achr9

38621829

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000520429ENST00000471864CCNCchr6

100016372

-FAM201Achr9

38621829

+
5CDS-3UTRENST00000520429ENST00000484285CCNCchr6

100016372

-FAM201Achr9

38621829

+
5CDS-3UTRENST00000520429ENST00000377680CCNCchr6

100016372

-FAM201Achr9

38621829

+
5CDS-3UTRENST00000369220ENST00000471864CCNCchr6

100016372

-FAM201Achr9

38621829

+
5CDS-3UTRENST00000369220ENST00000484285CCNCchr6

100016372

-FAM201Achr9

38621829

+
5CDS-3UTRENST00000369220ENST00000377680CCNCchr6

100016372

-FAM201Achr9

38621829

+
5CDS-3UTRENST00000520371ENST00000471864CCNCchr6

100016372

-FAM201Achr9

38621829

+
5CDS-3UTRENST00000520371ENST00000484285CCNCchr6

100016372

-FAM201Achr9

38621829

+
5CDS-3UTRENST00000520371ENST00000377680CCNCchr6

100016372

-FAM201Achr9

38621829

+
intron-3UTRENST00000523799ENST00000471864CCNCchr6

100016372

-FAM201Achr9

38621829

+
intron-3UTRENST00000523799ENST00000484285CCNCchr6

100016372

-FAM201Achr9

38621829

+
intron-3UTRENST00000523799ENST00000377680CCNCchr6

100016372

-FAM201Achr9

38621829

+
5UTR-3UTRENST00000523985ENST00000471864CCNCchr6

100016372

-FAM201Achr9

38621829

+
5UTR-3UTRENST00000523985ENST00000484285CCNCchr6

100016372

-FAM201Achr9

38621829

+
5UTR-3UTRENST00000523985ENST00000377680CCNCchr6

100016372

-FAM201Achr9

38621829

+
5CDS-3UTRENST00000518714ENST00000471864CCNCchr6

100016372

-FAM201Achr9

38621829

+
5CDS-3UTRENST00000518714ENST00000484285CCNCchr6

100016372

-FAM201Achr9

38621829

+
5CDS-3UTRENST00000518714ENST00000377680CCNCchr6

100016372

-FAM201Achr9

38621829

+
5UTR-3UTRENST00000521017ENST00000471864CCNCchr6

100016372

-FAM201Achr9

38621829

+
5UTR-3UTRENST00000521017ENST00000484285CCNCchr6

100016372

-FAM201Achr9

38621829

+
5UTR-3UTRENST00000521017ENST00000377680CCNCchr6

100016372

-FAM201Achr9

38621829

+
5CDS-3UTRENST00000482541ENST00000471864CCNCchr6

100016372

-FAM201Achr9

38621829

+
5CDS-3UTRENST00000482541ENST00000484285CCNCchr6

100016372

-FAM201Achr9

38621829

+
5CDS-3UTRENST00000482541ENST00000377680CCNCchr6

100016372

-FAM201Achr9

38621829

+

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FusionProtFeatures for CCNC_FAM201A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCNC

P24863

FAM201A

Component of the Mediator complex, a coactivatorinvolved in regulated gene transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. Binds to and activates cyclin-dependentkinase CDK8 that phosphorylates the CTD (C-terminal domain) of thelarge subunit of RNA polymerase II (RNAp II), which may inhibitthe formation of a transcription initiation complex.{ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:8700522}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCNC_FAM201A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCNC_FAM201A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCNCMED10, MED29, MED19, MED28, CDK8, CREBBP, MCM2, ESR1, ESR2, MED12, MED1, MED18, ZC3H13, SOCS2, CISH, GTF2F1, FBXW7, MED26, RB1, CDK3, ERCC3, CCNH, MED6, TP63, CDK19, CRX, GOLGA2, KRT13, KRT15, KRT31, MEOX2, MGST3, NEFL, ZNF18, TADA3, PUF60, MBIP, TRIM39, PBXIP1, NMNAT1, LZTS2, GLYR1, FOXP2, PNMA5, DYDC1, MED7, SPEN, MED13, MED27, MED31, MED13L, MED14, MED12L, MED16, MED23, MED15, MED4, MED17, MED22, MED24, MED20, MED21, MED30, MED8, HSPB1, GPC4, LZIC, MED9, MED25, MED11, TRIM25FAM201A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCNC_FAM201A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCNC_FAM201A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource