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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5982

FusionGeneSummary for CCNC_ERVW-1

check button Fusion gene summary
Fusion gene informationFusion gene name: CCNC_ERVW-1
Fusion gene ID: 5982
HgeneTgene
Gene symbol

CCNC

ERVW-1

Gene ID

892

30816

Gene namecyclin Cendogenous retrovirus group W member 1, envelope
SynonymsCycC|SRB11|hSRB11ENV|ENVW|ERVWE1|HERV-7q|HERV-W-ENV|HERV7Q|HERVW|HERVWENV
Cytomap

6q16.2

7q21.2

Type of geneprotein-codingprotein-coding
Descriptioncyclin-CSRB11 homologsyncytin-1HERV-7q envelope proteinHERV-W Env glycoproteinHERV-W envelope proteinHERV-W_7q21.2 provirus ancestral Env polyproteinHERV-tryptophan envelope proteinendogenous retroviral family W, env(C7), member 1endogenous retrovirus group W member 1
Modification date2018052520180329
UniProtAcc

P24863

Q9UQF0

Ensembl transtripts involved in fusion geneENST00000520429, ENST00000369220, 
ENST00000520371, ENST00000523799, 
ENST00000523985, ENST00000518714, 
ENST00000521017, ENST00000482541, 
ENST00000604270, ENST00000603053, 
ENST00000493463, 
Fusion gene scores* DoF score3 X 1 X 2=62 X 2 X 2=8
# samples 32
** MAII scorelog2(3/6*10)=2.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: CCNC [Title/Abstract] AND ERVW-1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneERVW-1

GO:0000768

syncytium formation by plasma membrane fusion

14557543

TgeneERVW-1

GO:0006949

syncytium formation

23492904

TgeneERVW-1

GO:0045026

plasma membrane fusion

14557543


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-HB-A3YV-01ACCNCchr6

100016372

-ERVW-1chr7

92098259

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000520429ENST00000604270CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5CDS-5UTRENST00000520429ENST00000603053CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5CDS-5UTRENST00000520429ENST00000493463CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5CDS-5UTRENST00000369220ENST00000604270CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5CDS-5UTRENST00000369220ENST00000603053CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5CDS-5UTRENST00000369220ENST00000493463CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5CDS-5UTRENST00000520371ENST00000604270CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5CDS-5UTRENST00000520371ENST00000603053CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5CDS-5UTRENST00000520371ENST00000493463CCNCchr6

100016372

-ERVW-1chr7

92098259

-
intron-5UTRENST00000523799ENST00000604270CCNCchr6

100016372

-ERVW-1chr7

92098259

-
intron-5UTRENST00000523799ENST00000603053CCNCchr6

100016372

-ERVW-1chr7

92098259

-
intron-5UTRENST00000523799ENST00000493463CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5UTR-5UTRENST00000523985ENST00000604270CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5UTR-5UTRENST00000523985ENST00000603053CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5UTR-5UTRENST00000523985ENST00000493463CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5CDS-5UTRENST00000518714ENST00000604270CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5CDS-5UTRENST00000518714ENST00000603053CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5CDS-5UTRENST00000518714ENST00000493463CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5UTR-5UTRENST00000521017ENST00000604270CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5UTR-5UTRENST00000521017ENST00000603053CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5UTR-5UTRENST00000521017ENST00000493463CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5CDS-5UTRENST00000482541ENST00000604270CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5CDS-5UTRENST00000482541ENST00000603053CCNCchr6

100016372

-ERVW-1chr7

92098259

-
5CDS-5UTRENST00000482541ENST00000493463CCNCchr6

100016372

-ERVW-1chr7

92098259

-

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FusionProtFeatures for CCNC_ERVW-1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCNC

P24863

ERVW-1

Q9UQF0

Component of the Mediator complex, a coactivatorinvolved in regulated gene transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. Binds to and activates cyclin-dependentkinase CDK8 that phosphorylates the CTD (C-terminal domain) of thelarge subunit of RNA polymerase II (RNAp II), which may inhibitthe formation of a transcription initiation complex.{ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:8700522}. This endogenous retroviral envelope protein has retainedits original fusogenic properties and participates in trophoblastfusion and the formation of a syncytium during placentamorphogenesis. May induce fusion through binding of SLC1A4 andSLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).{ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:12050356,ECO:0000269|PubMed:23492904}. Endogenous envelope proteins may have kept, lost ormodified their original function during evolution. Retroviralenvelope proteins mediate receptor recognition and membrane fusionduring early infection. The surface protein (SU) mediates receptorrecognition, while the transmembrane protein (TM) acts as a classI viral fusion protein. The protein may have at least 3conformational states: pre-fusion native state, pre-hairpinintermediate state, and post-fusion hairpin state. During viraland target cell membrane fusion, the coiled coil regions (heptadrepeats) assume a trimer-of-hairpins structure, positioning thefusion peptide in close proximity to the C-terminal region of theectodomain. The formation of this structure appears to driveapposition and subsequent fusion of membranes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCNC_ERVW-1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCNC_ERVW-1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCNCMED10, MED29, MED19, MED28, CDK8, CREBBP, MCM2, ESR1, ESR2, MED12, MED1, MED18, ZC3H13, SOCS2, CISH, GTF2F1, FBXW7, MED26, RB1, CDK3, ERCC3, CCNH, MED6, TP63, CDK19, CRX, GOLGA2, KRT13, KRT15, KRT31, MEOX2, MGST3, NEFL, ZNF18, TADA3, PUF60, MBIP, TRIM39, PBXIP1, NMNAT1, LZTS2, GLYR1, FOXP2, PNMA5, DYDC1, MED7, SPEN, MED13, MED27, MED31, MED13L, MED14, MED12L, MED16, MED23, MED15, MED4, MED17, MED22, MED24, MED20, MED21, MED30, MED8, HSPB1, GPC4, LZIC, MED9, MED25, MED11, TRIM25ERVW-1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCNC_ERVW-1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCNC_ERVW-1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneERVW-1C0036341Schizophrenia2PSYGENET
TgeneERVW-1C0005586Bipolar Disorder1PSYGENET