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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5932

FusionGeneSummary for CCDC91_FRY

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC91_FRY
Fusion gene ID: 5932
HgeneTgene
Gene symbol

CCDC91

FRY

Gene ID

55297

10129

Gene namecoiled-coil domain containing 91FRY microtubule binding protein
SynonymsHSD8|p5613CDNA73|214K23.2|C13orf14|CG003|bA207N4.2|bA37E23.1
Cytomap

12p11.22

13q13.1

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 91GGA-binding partnerp56 accessory proteinprotein furry homologWUGSC:H_2G3A.1furry homolog
Modification date2018052320180523
UniProtAcc

Q7Z6B0

Q5TBA9

Ensembl transtripts involved in fusion geneENST00000539107, ENST00000545336, 
ENST00000381256, ENST00000381259, 
ENST00000540401, ENST00000306172, 
ENST00000380250, ENST00000463566, 
ENST00000542859, ENST00000380217, 
Fusion gene scores* DoF score11 X 8 X 7=6162 X 2 X 2=8
# samples 112
** MAII scorelog2(11/616*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: CCDC91 [Title/Abstract] AND FRY [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW897460CCDC91chr12

28702997

+FRYchr13

32794482

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000539107ENST00000380250CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000539107ENST00000463566CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000539107ENST00000542859CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000539107ENST00000380217CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000545336ENST00000380250CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000545336ENST00000463566CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000545336ENST00000542859CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000545336ENST00000380217CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000381256ENST00000380250CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000381256ENST00000463566CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000381256ENST00000542859CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000381256ENST00000380217CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000381259ENST00000380250CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000381259ENST00000463566CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000381259ENST00000542859CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000381259ENST00000380217CCDC91chr12

28702997

+FRYchr13

32794482

+
intron-intronENST00000540401ENST00000380250CCDC91chr12

28702997

+FRYchr13

32794482

+
intron-intronENST00000540401ENST00000463566CCDC91chr12

28702997

+FRYchr13

32794482

+
intron-intronENST00000540401ENST00000542859CCDC91chr12

28702997

+FRYchr13

32794482

+
intron-intronENST00000540401ENST00000380217CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000306172ENST00000380250CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000306172ENST00000463566CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000306172ENST00000542859CCDC91chr12

28702997

+FRYchr13

32794482

+
3UTR-intronENST00000306172ENST00000380217CCDC91chr12

28702997

+FRYchr13

32794482

+

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FusionProtFeatures for CCDC91_FRY


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC91

Q7Z6B0

FRY

Q5TBA9

Involved in the regulation of membrane traffic throughthe trans-Golgi network (TGN). Functions in close cooperation withthe GGAs in the sorting of hydrolases to lysosomes.{ECO:0000269|PubMed:17596511}. Plays a crucial role in the structural integrity ofmitotic centrosomes and in the maintenance of spindle bipolarityby promoting PLK1 activity at the spindle poles in early mitosis.May function as a scaffold promoting the interaction between AURKAand PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.{ECO:0000269|PubMed:22753416}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCDC91_FRY


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCDC91_FRY


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCDC91_FRY


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCDC91_FRY


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCDC91C0236969Substance-Related Disorders1CTD_human
TgeneFRYC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneFRYC3714756Intellectual Disability1CTD_human