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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 591

FusionGeneSummary for ACTN4_FTO

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTN4_FTO
Fusion gene ID: 591
HgeneTgene
Gene symbol

ACTN4

FTO

Gene ID

81

79068

Gene nameactinin alpha 4FTO, alpha-ketoglutarate dependent dioxygenase
SynonymsACTININ-4|FSGS|FSGS1ALKBH9|BMIQ14|GDFD
Cytomap

19q13.2

16q12.2

Type of geneprotein-codingprotein-coding
Descriptionalpha-actinin-4focal segmental glomerulosclerosis 1non-muscle alpha-actinin 4alpha-ketoglutarate-dependent dioxygenase FTOAlkB homolog 9fat mass and obesity associatedfat mass and obesity-associated protein
Modification date2018052220180527
UniProtAcc

O43707

Q9C0B1

Ensembl transtripts involved in fusion geneENST00000252699, ENST00000424234, 
ENST00000390009, ENST00000497637, 
ENST00000471389, ENST00000394647, 
ENST00000431610, ENST00000460382, 
ENST00000463855, ENST00000472835, 
Fusion gene scores* DoF score28 X 17 X 13=61888 X 4 X 6=192
# samples 307
** MAII scorelog2(30/6188*10)=-4.36643879095316
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/192*10)=-1.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACTN4 [Title/Abstract] AND FTO [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACTN4

GO:0035357

peroxisome proliferator activated receptor signaling pathway

22351778

HgeneACTN4

GO:0048384

retinoic acid receptor signaling pathway

22351778

HgeneACTN4

GO:0051272

positive regulation of cellular component movement

9508771

TgeneFTO

GO:0006307

DNA dealkylation involved in DNA repair

18775698|20376003

TgeneFTO

GO:0035552

oxidative single-stranded DNA demethylation

18775698|20376003

TgeneFTO

GO:0035553

oxidative single-stranded RNA demethylation

18775698|22002720

TgeneFTO

GO:0042245

RNA repair

18775698

TgeneFTO

GO:0070989

oxidative demethylation

18775698

TgeneFTO

GO:0080111

DNA demethylation

18775698


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E2-A150-01AACTN4chr19

39138547

+FTOchr16

53844052

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000252699ENST00000471389ACTN4chr19

39138547

+FTOchr16

53844052

+
5CDS-5UTRENST00000252699ENST00000394647ACTN4chr19

39138547

+FTOchr16

53844052

+
5CDS-intronENST00000252699ENST00000431610ACTN4chr19

39138547

+FTOchr16

53844052

+
5CDS-intronENST00000252699ENST00000460382ACTN4chr19

39138547

+FTOchr16

53844052

+
5CDS-intronENST00000252699ENST00000463855ACTN4chr19

39138547

+FTOchr16

53844052

+
5CDS-intronENST00000252699ENST00000472835ACTN4chr19

39138547

+FTOchr16

53844052

+
In-frameENST00000424234ENST00000471389ACTN4chr19

39138547

+FTOchr16

53844052

+
5CDS-5UTRENST00000424234ENST00000394647ACTN4chr19

39138547

+FTOchr16

53844052

+
5CDS-intronENST00000424234ENST00000431610ACTN4chr19

39138547

+FTOchr16

53844052

+
5CDS-intronENST00000424234ENST00000460382ACTN4chr19

39138547

+FTOchr16

53844052

+
5CDS-intronENST00000424234ENST00000463855ACTN4chr19

39138547

+FTOchr16

53844052

+
5CDS-intronENST00000424234ENST00000472835ACTN4chr19

39138547

+FTOchr16

53844052

+
In-frameENST00000390009ENST00000471389ACTN4chr19

39138547

+FTOchr16

53844052

+
5CDS-5UTRENST00000390009ENST00000394647ACTN4chr19

39138547

+FTOchr16

53844052

+
5CDS-intronENST00000390009ENST00000431610ACTN4chr19

39138547

+FTOchr16

53844052

+
5CDS-intronENST00000390009ENST00000460382ACTN4chr19

39138547

+FTOchr16

53844052

+
5CDS-intronENST00000390009ENST00000463855ACTN4chr19

39138547

+FTOchr16

53844052

+
5CDS-intronENST00000390009ENST00000472835ACTN4chr19

39138547

+FTOchr16

53844052

+
intron-3CDSENST00000497637ENST00000471389ACTN4chr19

39138547

+FTOchr16

53844052

+
intron-5UTRENST00000497637ENST00000394647ACTN4chr19

39138547

+FTOchr16

53844052

+
intron-intronENST00000497637ENST00000431610ACTN4chr19

39138547

+FTOchr16

53844052

+
intron-intronENST00000497637ENST00000460382ACTN4chr19

39138547

+FTOchr16

53844052

+
intron-intronENST00000497637ENST00000463855ACTN4chr19

39138547

+FTOchr16

53844052

+
intron-intronENST00000497637ENST00000472835ACTN4chr19

39138547

+FTOchr16

53844052

+

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FusionProtFeatures for ACTN4_FTO


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTN4

O43707

FTO

Q9C0B1

F-actin cross-linking protein which is thought to anchoractin to a variety of intracellular structures. This is a bundlingprotein (Probable). Probably involved in vesicular trafficking viaits association with the CART complex. The CART complex isnecessary for efficient transferrin receptor recycling but not forEGFR degradation (PubMed:15772161). Involved in tight junctionassembly in epithelial cells probably through interaction withMICALL2. Links MICALL2 to the actin cytoskeleton and recruits itto the tight junctions (By similarity). May also function as atranscriptional coactivator, stimulating transcription mediated bythe nuclear hormone receptors PPARG and RARA (PubMed:22351778).{ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161,ECO:0000269|PubMed:22351778, ECO:0000305|PubMed:9508771}. Dioxygenase that repairs alkylated DNA and RNA byoxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylaseactivity towards single-stranded DNA containing 1-methyladenine or3-methylcytosine (PubMed:18775698, PubMed:20376003). Specificallydemethylates N(6)-methyladenosine (m6A) RNA, the most prevalentinternal modification of messenger RNA (mRNA) in higher eukaryotes(PubMed:22002720, PubMed:26458103). Has no activity towards 1-methylguanine. Has no detectable activity towards double-strandedDNA. Requires molecular oxygen, alpha-ketoglutarate and iron.Contributes to the regulation of the global metabolic rate, energyexpenditure and energy homeostasis. Contributes to the regulationof body size and body fat accumulation (PubMed:18775698,PubMed:20376003). In particular, it is involved in the regulationof thermogenesis and the control of adipocyte differentiation intobrown or white fat cells (PubMed:26287746).{ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003,ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:26287746,ECO:0000269|PubMed:26458103}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTN4chr19:39138547chr16:53844052ENST00000252699+12119_2654912Compositional biasPoly-Gly
HgeneACTN4chr19:39138547chr16:53844052ENST00000390009+11419_2654693Compositional biasPoly-Gly
TgeneFTOchr19:39138547chr16:53844052ENST00000431610+05213_224-55107RegionNote=Loop L1%3B predicted to block binding of double-stranded DNA or RNA
TgeneFTOchr19:39138547chr16:53844052ENST00000431610+05231_234-55107RegionNote=Substrate binding
TgeneFTOchr19:39138547chr16:53844052ENST00000431610+05316_318-55107RegionNote=Alpha-ketoglutarate binding
TgeneFTOchr19:39138547chr16:53844052ENST00000431610+0532_327-55107RegionNote=Fe2OG dioxygenase domain
TgeneFTOchr19:39138547chr16:53844052ENST00000460382+04213_224-42107RegionNote=Loop L1%3B predicted to block binding of double-stranded DNA or RNA
TgeneFTOchr19:39138547chr16:53844052ENST00000460382+04231_234-42107RegionNote=Substrate binding
TgeneFTOchr19:39138547chr16:53844052ENST00000460382+04316_318-42107RegionNote=Alpha-ketoglutarate binding
TgeneFTOchr19:39138547chr16:53844052ENST00000460382+0432_327-42107RegionNote=Fe2OG dioxygenase domain
TgeneFTOchr19:39138547chr16:53844052ENST00000463855+03213_224-42128RegionNote=Loop L1%3B predicted to block binding of double-stranded DNA or RNA
TgeneFTOchr19:39138547chr16:53844052ENST00000463855+03231_234-42128RegionNote=Substrate binding
TgeneFTOchr19:39138547chr16:53844052ENST00000463855+03316_318-42128RegionNote=Alpha-ketoglutarate binding
TgeneFTOchr19:39138547chr16:53844052ENST00000463855+0332_327-42128RegionNote=Fe2OG dioxygenase domain
TgeneFTOchr19:39138547chr16:53844052ENST00000471389+09213_22415506RegionNote=Loop L1%3B predicted to block binding of double-stranded DNA or RNA
TgeneFTOchr19:39138547chr16:53844052ENST00000471389+09231_23415506RegionNote=Substrate binding
TgeneFTOchr19:39138547chr16:53844052ENST00000471389+09316_31815506RegionNote=Alpha-ketoglutarate binding
TgeneFTOchr19:39138547chr16:53844052ENST00000471389+0932_32715506RegionNote=Fe2OG dioxygenase domain

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTN4chr19:39138547chr16:53844052ENST00000252699+121778_78954912Calcium binding1
HgeneACTN4chr19:39138547chr16:53844052ENST00000252699+121819_83054912Calcium binding2
HgeneACTN4chr19:39138547chr16:53844052ENST00000390009+114778_78954693Calcium binding1
HgeneACTN4chr19:39138547chr16:53844052ENST00000390009+114819_83054693Calcium binding2
HgeneACTN4chr19:39138547chr16:53844052ENST00000252699+121163_26954912DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr16:53844052ENST00000252699+12150_15454912DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr16:53844052ENST00000252699+121765_80054912DomainEF-hand 1
HgeneACTN4chr19:39138547chr16:53844052ENST00000252699+121806_84154912DomainEF-hand 2
HgeneACTN4chr19:39138547chr16:53844052ENST00000390009+114163_26954693DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr16:53844052ENST00000390009+11450_15454693DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr16:53844052ENST00000390009+114765_80054693DomainEF-hand 1
HgeneACTN4chr19:39138547chr16:53844052ENST00000390009+114806_84154693DomainEF-hand 2
HgeneACTN4chr19:39138547chr16:53844052ENST00000252699+12184_8854912MotifLXXLL motif
HgeneACTN4chr19:39138547chr16:53844052ENST00000390009+11484_8854693MotifLXXLL motif
HgeneACTN4chr19:39138547chr16:53844052ENST00000252699+121177_19254912RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr16:53844052ENST00000252699+1211_26954912RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr16:53844052ENST00000390009+114177_19254693RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr16:53844052ENST00000390009+1141_26954693RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr16:53844052ENST00000252699+121293_40354912RepeatSpectrin 1
HgeneACTN4chr19:39138547chr16:53844052ENST00000252699+121413_51854912RepeatSpectrin 2
HgeneACTN4chr19:39138547chr16:53844052ENST00000252699+121528_63954912RepeatSpectrin 3
HgeneACTN4chr19:39138547chr16:53844052ENST00000252699+121649_75254912RepeatSpectrin 4
HgeneACTN4chr19:39138547chr16:53844052ENST00000390009+114293_40354693RepeatSpectrin 1
HgeneACTN4chr19:39138547chr16:53844052ENST00000390009+114413_51854693RepeatSpectrin 2
HgeneACTN4chr19:39138547chr16:53844052ENST00000390009+114528_63954693RepeatSpectrin 3
HgeneACTN4chr19:39138547chr16:53844052ENST00000390009+114649_75254693RepeatSpectrin 4


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FusionGeneSequence for ACTN4_FTO


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ACTN4_ENST00000252699_chr19_39138547_+_FTO_ENST00000471389_chr16_53844052_+_545aa
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKKLRLLEELEDTWLPTLTPKDDEFTQQWQLKTPKLIL
REASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLK
LNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPTFGMGKMAVSWH
HDENLVDRSAVAVYSTSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCTFMLDDLNATHQHCVLAGSQPRFSSTH
RVAECSTGTLDTILQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKME
GVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQLL

>In-frame_ACTN4_ENST00000424234_chr19_39138547_+_FTO_ENST00000471389_chr16_53844052_+_545aa
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKKLRLLEELEDTWLPTLTPKDDEFTQQWQLKTPKLIL
REASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLK
LNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPTFGMGKMAVSWH
HDENLVDRSAVAVYSTSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCTFMLDDLNATHQHCVLAGSQPRFSSTH
RVAECSTGTLDTILQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKME
GVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQLL

>In-frame_ACTN4_ENST00000390009_chr19_39138547_+_FTO_ENST00000471389_chr16_53844052_+_545aa
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKKLRLLEELEDTWLPTLTPKDDEFTQQWQLKTPKLIL
REASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLK
LNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPTFGMGKMAVSWH
HDENLVDRSAVAVYSTSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCTFMLDDLNATHQHCVLAGSQPRFSSTH
RVAECSTGTLDTILQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKME
GVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQLL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ACTN4_ENST00000252699_chr19_39138547_+_FTO_ENST00000471389_chr16_53844052_+_1635nt
ATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGAC
TACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGAAACTGAGGCTTCTTGAA
GAGCTTGAAGACACTTGGCTCCCTTATCTGACCCCCAAAGATGATGAATTCTATCAGCAGTGGCAGCTGAAATATCCTAAACTAATTCTC
CGAGAAGCCAGCAGTGTATCTGAGGAGCTCCATAAAGAGGTTCAAGAAGCCTTTCTCACACTGCACAAGCATGGCTGCTTATTTCGGGAC
CTGGTTAGGATCCAAGGCAAAGATCTGCTCACTCCGGTATCTCGCATCCTCATTGGTAATCCAGGCTGCACCTACAAGTACCTGAACACC
AGGCTCTTTACGGTCCCCTGGCCAGTGAAAGGGTCTAATATAAAACACACCGAGGCTGAAATAGCCGCTGCTTGTGAGACCTTCCTCAAG
CTCAATGACTACCTGCAGATAGAAACCATCCAGGCTTTGGAAGAACTTGCTGCCAAAGAGAAGGCTAATGAGGATGCTGTGCCATTGTGT
ATGTCTGCAGATTTCCCCAGGGTTGGGATGGGTTCATCCTACAACGGACAAGATGAAGTGGACATTAAGAGCAGAGCAGCATACAACGTA
ACTTTGCTGAATTTCATGGATCCTCAGAAAATGCCATACCTGAAAGAGGAACCTTATTTTGGCATGGGGAAAATGGCAGTGAGCTGGCAT
CATGATGAAAATCTGGTGGACAGGTCAGCGGTGGCAGTGTACAGTTATAGCTGTGAAGGCCCTGAAGAGGAAAGTGAGGATGACTCTCAT
CTCGAAGGCAGGGATCCTGATATTTGGCATGTTGGTTTTAAGATCTCATGGGACATAGAGACACCTGGTTTGGCGATACCCCTTCACCAA
GGAGACTGCTATTTCATGCTTGATGATCTCAATGCCACCCACCAACACTGTGTTTTGGCCGGTTCACAACCTCGGTTTAGTTCCACCCAC
CGAGTGGCAGAGTGCTCAACAGGAACCTTGGATTATATTTTACAACGCTGTCAGTTGGCTCTGCAGAATGTCTGTGACGATGTGGACAAT
GATGATGTCTCTTTGAAATCCTTTGAGCCTGCAGTTTTGAAACAAGGAGAAGAAATTCATAATGAGGTCGAGTTTGAGTGGCTGAGGCAG
TTTTGGTTTCAAGGCAATCGATACAGAAAGTGCACTGACTGGTGGTGTCAACCCATGGCTCAACTGGAAGCACTGTGGAAGAAGATGGAG
GGTGTGACAAATGCTGTGCTTCATGAAGTTAAAAGAGAGGGGCTCCCCGTGGAACAAAGGAATGAAATCTTGACTGCCATCCTTGCCTCG
CTCACTGCACGCCAGAACCTGAGGAGAGAATGGCATGCCAGGTGCCAGTCACGAATTGCCCGAACATTACCTGCTGATCAGAAGCCAGAA
TGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCACAGACATCGTTTCAGAACTCAGAGGTCAGCTTCTG

>In-frame_ACTN4_ENST00000424234_chr19_39138547_+_FTO_ENST00000471389_chr16_53844052_+_1635nt
ATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGAC
TACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGAAACTGAGGCTTCTTGAA
GAGCTTGAAGACACTTGGCTCCCTTATCTGACCCCCAAAGATGATGAATTCTATCAGCAGTGGCAGCTGAAATATCCTAAACTAATTCTC
CGAGAAGCCAGCAGTGTATCTGAGGAGCTCCATAAAGAGGTTCAAGAAGCCTTTCTCACACTGCACAAGCATGGCTGCTTATTTCGGGAC
CTGGTTAGGATCCAAGGCAAAGATCTGCTCACTCCGGTATCTCGCATCCTCATTGGTAATCCAGGCTGCACCTACAAGTACCTGAACACC
AGGCTCTTTACGGTCCCCTGGCCAGTGAAAGGGTCTAATATAAAACACACCGAGGCTGAAATAGCCGCTGCTTGTGAGACCTTCCTCAAG
CTCAATGACTACCTGCAGATAGAAACCATCCAGGCTTTGGAAGAACTTGCTGCCAAAGAGAAGGCTAATGAGGATGCTGTGCCATTGTGT
ATGTCTGCAGATTTCCCCAGGGTTGGGATGGGTTCATCCTACAACGGACAAGATGAAGTGGACATTAAGAGCAGAGCAGCATACAACGTA
ACTTTGCTGAATTTCATGGATCCTCAGAAAATGCCATACCTGAAAGAGGAACCTTATTTTGGCATGGGGAAAATGGCAGTGAGCTGGCAT
CATGATGAAAATCTGGTGGACAGGTCAGCGGTGGCAGTGTACAGTTATAGCTGTGAAGGCCCTGAAGAGGAAAGTGAGGATGACTCTCAT
CTCGAAGGCAGGGATCCTGATATTTGGCATGTTGGTTTTAAGATCTCATGGGACATAGAGACACCTGGTTTGGCGATACCCCTTCACCAA
GGAGACTGCTATTTCATGCTTGATGATCTCAATGCCACCCACCAACACTGTGTTTTGGCCGGTTCACAACCTCGGTTTAGTTCCACCCAC
CGAGTGGCAGAGTGCTCAACAGGAACCTTGGATTATATTTTACAACGCTGTCAGTTGGCTCTGCAGAATGTCTGTGACGATGTGGACAAT
GATGATGTCTCTTTGAAATCCTTTGAGCCTGCAGTTTTGAAACAAGGAGAAGAAATTCATAATGAGGTCGAGTTTGAGTGGCTGAGGCAG
TTTTGGTTTCAAGGCAATCGATACAGAAAGTGCACTGACTGGTGGTGTCAACCCATGGCTCAACTGGAAGCACTGTGGAAGAAGATGGAG
GGTGTGACAAATGCTGTGCTTCATGAAGTTAAAAGAGAGGGGCTCCCCGTGGAACAAAGGAATGAAATCTTGACTGCCATCCTTGCCTCG
CTCACTGCACGCCAGAACCTGAGGAGAGAATGGCATGCCAGGTGCCAGTCACGAATTGCCCGAACATTACCTGCTGATCAGAAGCCAGAA
TGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCACAGACATCGTTTCAGAACTCAGAGGTCAGCTTCTG

>In-frame_ACTN4_ENST00000390009_chr19_39138547_+_FTO_ENST00000471389_chr16_53844052_+_1635nt
ATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGAC
TACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGAAACTGAGGCTTCTTGAA
GAGCTTGAAGACACTTGGCTCCCTTATCTGACCCCCAAAGATGATGAATTCTATCAGCAGTGGCAGCTGAAATATCCTAAACTAATTCTC
CGAGAAGCCAGCAGTGTATCTGAGGAGCTCCATAAAGAGGTTCAAGAAGCCTTTCTCACACTGCACAAGCATGGCTGCTTATTTCGGGAC
CTGGTTAGGATCCAAGGCAAAGATCTGCTCACTCCGGTATCTCGCATCCTCATTGGTAATCCAGGCTGCACCTACAAGTACCTGAACACC
AGGCTCTTTACGGTCCCCTGGCCAGTGAAAGGGTCTAATATAAAACACACCGAGGCTGAAATAGCCGCTGCTTGTGAGACCTTCCTCAAG
CTCAATGACTACCTGCAGATAGAAACCATCCAGGCTTTGGAAGAACTTGCTGCCAAAGAGAAGGCTAATGAGGATGCTGTGCCATTGTGT
ATGTCTGCAGATTTCCCCAGGGTTGGGATGGGTTCATCCTACAACGGACAAGATGAAGTGGACATTAAGAGCAGAGCAGCATACAACGTA
ACTTTGCTGAATTTCATGGATCCTCAGAAAATGCCATACCTGAAAGAGGAACCTTATTTTGGCATGGGGAAAATGGCAGTGAGCTGGCAT
CATGATGAAAATCTGGTGGACAGGTCAGCGGTGGCAGTGTACAGTTATAGCTGTGAAGGCCCTGAAGAGGAAAGTGAGGATGACTCTCAT
CTCGAAGGCAGGGATCCTGATATTTGGCATGTTGGTTTTAAGATCTCATGGGACATAGAGACACCTGGTTTGGCGATACCCCTTCACCAA
GGAGACTGCTATTTCATGCTTGATGATCTCAATGCCACCCACCAACACTGTGTTTTGGCCGGTTCACAACCTCGGTTTAGTTCCACCCAC
CGAGTGGCAGAGTGCTCAACAGGAACCTTGGATTATATTTTACAACGCTGTCAGTTGGCTCTGCAGAATGTCTGTGACGATGTGGACAAT
GATGATGTCTCTTTGAAATCCTTTGAGCCTGCAGTTTTGAAACAAGGAGAAGAAATTCATAATGAGGTCGAGTTTGAGTGGCTGAGGCAG
TTTTGGTTTCAAGGCAATCGATACAGAAAGTGCACTGACTGGTGGTGTCAACCCATGGCTCAACTGGAAGCACTGTGGAAGAAGATGGAG
GGTGTGACAAATGCTGTGCTTCATGAAGTTAAAAGAGAGGGGCTCCCCGTGGAACAAAGGAATGAAATCTTGACTGCCATCCTTGCCTCG
CTCACTGCACGCCAGAACCTGAGGAGAGAATGGCATGCCAGGTGCCAGTCACGAATTGCCCGAACATTACCTGCTGATCAGAAGCCAGAA
TGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCACAGACATCGTTTCAGAACTCAGAGGTCAGCTTCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_ACTN4_ENST00000252699_chr19_39138547_+_FTO_ENST00000471389_chr16_53844052_+_11737nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGAAACTGAGGCTTCTTGAAGAGCTTGAAGACAC
TTGGCTCCCTTATCTGACCCCCAAAGATGATGAATTCTATCAGCAGTGGCAGCTGAAATATCCTAAACTAATTCTCCGAGAAGCCAGCAG
TGTATCTGAGGAGCTCCATAAAGAGGTTCAAGAAGCCTTTCTCACACTGCACAAGCATGGCTGCTTATTTCGGGACCTGGTTAGGATCCA
AGGCAAAGATCTGCTCACTCCGGTATCTCGCATCCTCATTGGTAATCCAGGCTGCACCTACAAGTACCTGAACACCAGGCTCTTTACGGT
CCCCTGGCCAGTGAAAGGGTCTAATATAAAACACACCGAGGCTGAAATAGCCGCTGCTTGTGAGACCTTCCTCAAGCTCAATGACTACCT
GCAGATAGAAACCATCCAGGCTTTGGAAGAACTTGCTGCCAAAGAGAAGGCTAATGAGGATGCTGTGCCATTGTGTATGTCTGCAGATTT
CCCCAGGGTTGGGATGGGTTCATCCTACAACGGACAAGATGAAGTGGACATTAAGAGCAGAGCAGCATACAACGTAACTTTGCTGAATTT
CATGGATCCTCAGAAAATGCCATACCTGAAAGAGGAACCTTATTTTGGCATGGGGAAAATGGCAGTGAGCTGGCATCATGATGAAAATCT
GGTGGACAGGTCAGCGGTGGCAGTGTACAGTTATAGCTGTGAAGGCCCTGAAGAGGAAAGTGAGGATGACTCTCATCTCGAAGGCAGGGA
TCCTGATATTTGGCATGTTGGTTTTAAGATCTCATGGGACATAGAGACACCTGGTTTGGCGATACCCCTTCACCAAGGAGACTGCTATTT
CATGCTTGATGATCTCAATGCCACCCACCAACACTGTGTTTTGGCCGGTTCACAACCTCGGTTTAGTTCCACCCACCGAGTGGCAGAGTG
CTCAACAGGAACCTTGGATTATATTTTACAACGCTGTCAGTTGGCTCTGCAGAATGTCTGTGACGATGTGGACAATGATGATGTCTCTTT
GAAATCCTTTGAGCCTGCAGTTTTGAAACAAGGAGAAGAAATTCATAATGAGGTCGAGTTTGAGTGGCTGAGGCAGTTTTGGTTTCAAGG
CAATCGATACAGAAAGTGCACTGACTGGTGGTGTCAACCCATGGCTCAACTGGAAGCACTGTGGAAGAAGATGGAGGGTGTGACAAATGC
TGTGCTTCATGAAGTTAAAAGAGAGGGGCTCCCCGTGGAACAAAGGAATGAAATCTTGACTGCCATCCTTGCCTCGCTCACTGCACGCCA
GAACCTGAGGAGAGAATGGCATGCCAGGTGCCAGTCACGAATTGCCCGAACATTACCTGCTGATCAGAAGCCAGAATGTCGGCCATACTG
GGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCACAGACATCGTTTCAGAACTCAGAGGTCAGCTTCTGGAAGCAAAACCCTA
GAAGGAGCACAAGTCTCAGGCGGAGGAGAAAAAGAGATCGGCTTTTCTCCTCCAACGTTGTCATGGGCTTAAGCAAGAGCAGTGGAGACT
TCTCTTGGCCCCTAGATTGTAGCACCCGGGTCCCAATCCAAAACAGCTAGGAAATGGTGCCCATGAAGTTTTAAATGTTTTAAAATGACC
CTGTGTTATAGTCTGATTTGGTGTTAAACAGGACCTTCTTCCCCCAAAATTGTTCAGATTATAAAATGTGAGCCATTCAGCCCCCAAGGT
CCAGGGCAGGCGACAGGAACGAGCCCAGCGTGTGACAAAGCCTAACCTACTTTCCTCTTTCCCAAGCTTTTTCAGAGACTCTGGAGTGGA
CCCAGCCCTCTGGGGAAAGACAGAACTTAGAGACATCCCAGTTACTCACCACACCCATAGTGCTGTCCAATATGGTAGCCACTAGCTAGC
TGTGGCTACTTCAATTTAAATTCAGTTTTAATTTTAATTAAAAATGCAGCTCTTCAGTCGCCCTGGCCACATTTCAAGTGCTTAACAGCC
TCATGTGGCTAGTGACTGCTGTATTGGACGGTACAGATATGGAACATTTTCATCATCGAAGAAAGTCCTATTGGACAACACTTCTATAAA
AAGTTTGAGAGCAGGAATTCTCATTTCCATTCGTCTGTAGCTTCTATCCCCAAAGGCAAAGAAACTAAAAGAGAAATGACTCATTGAAGA
TTGGCCTCTTTCCTTTCTCTAAGACAAACCTAAGTAAAAGCCTGAGCTTTGAGTCCTATGCTCAGCACACGGGAAGGAGATGTTAATAAT
TAAAATAAAGTTGATATCCTGTCTTTAGGGAGTTCCCTTGATCTCTTGAAAGAGACACAGCCCCATTTACATTATTTCGTGGATTTCACC
AGCATAGTATAGTTTTTTTCTGTAAGTCCCTCATTCTTATGTAATAACAGGTGGAACTGAGGTTTGAAGAACCTCAGTGGCCCATCCTGA
TGACATTGGAGACTCAAAGAGACAAGAGAGAGTAGGGTTTAAAACCTGAGCTTTAAGACTCCCACTAGCTTCGTGTCCTTTGGCATGTTA
ACGTGCCTCAGTTTCCTCATCTGTATAATGGGGATATATGAAAGGCACCAGTCCTAAGGTGAACATTAAGTGAGATGATTCTAGTTACAG
ACTTAGAACAATTTCCAGCACATAGTTAAATATCCAGGAAATTCTGGTACTGTTATGTGTGGGTGAGCTGACCTGGATGTAGATGTTTTC
CTCTCTCTTGCTGACCCCTCCGCCAGTTTTGTCTTGTGATGCCATTAACACATCTCTCCCTTTCTGACCTGGCTCCTGCCCATTGGTGTC
CCAAGAAATCGTGAGAATAGTTAGCCCCCCGTCTCCCCAGCCTGTTGCTTTCTCGTGTAGTTGTTCACAGTAGTTGAGAAGTTGAAGAGC
TTTTGCCTATTGAAGGTGCACTGAGAATAAACTCTTTCCTGCCACCAGAATTGCAGTGGTTCACGGCCTGCACTCATTCCCATGAATGCA
GTTAATAGCCACAGAAATGTCACATTAAGCAAAGCAGCCAGGGTCTCATCGTGTTGAGACTCGAGTCTCTCAGACCTTGGATTCATTCCC
TGGTGTCTTTGAGCCTCAGTTTCCTCATTGGTAAAAGAGAAGTGAAGCAGTGTCTCACAGGGTCATTACAGAGATTAAATGAAATAAATG
AAATAACATAGACCAGGAGGGCGTGGTGTTTAAAAGTCACAGATGGGGCACCCTCGGGCCATCCAGCCCAGTGTTTTCTTTAGCCCCTAT
GATGTTCATTTTTTGTTATATCCCATTAGGTGCCCATATTTAAAAATTGGGAGATTTCACATAAAATTAAAAGGTCTGCATTTTCTTTTT
TCTTTTCTTTTTTTTTTTTTTTGAGACACAGTCTCACTCTGTCACCAGGCTAGAGTGCAGTGGCACGATCTCAGCTCACTGCAACCTCTG
CCTCCCAGGTTCAAGTAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACGTGCCACCACGCCCAGCTAATTTTTGTATT
TTTAGCAGAGATGGGGTTTCACCACATTGGCCAGGATGGTCTCGATCTCAACCTCGTGATCCACCCACCTCGGTCTCCCAAAGCGCTGGG
ATTACAGGCGTGAGCCACCGCGCCAAGCCAAGGTCTGCATTTTTCTTTAGAACTCAGAACACCCAATAGTCCTAGGCCCCCATCCTCGCA
TGGCAGCAAGCTAAATAAGCATCTTCCCACTGCGAGTTGGGGCATGACCCAGCCTATGGTTTGCCATACTCCCTCTTTTTCTCCGTTTTT
TCATTAATTGTGAACCTGACCTGCATCACCCTTTCATGTCAGTGCTCTCCAAACCTGCTTGCTTGCACCCCTCTAGTCGAAATATTTTGT
GCTTACCCCAATATATGTGTGTGACTATTGAACTCTATTCGTAGACTGCTTGTACTAATGTCATTTGCATCATAAAATATTCATATCCAA
TAAACATATTAAAAGGATGAGATAAGAAACCGAGAGATTTTGCTGTTTTTTTCCTTTTGCATGGATGAGCCAGCTTCACTGTCCTGGGTG
GGGCCCAGGTGGAATTAGTTCTCAAAGTCCTCCAGGTGGAGTCAGGGAATGTGCAACAGGGTTGGAGAAATCACTACTTTAAGTGAATCC
GAAAGGTGAGATCACATTTGCTCTAAAGAAATGGTGATCCCAGCACTTTGGGAGGCTGAGGCAGCAGATCACTGGAGGTCAGGAGTTCGA
GACCAGCCTGGCCAACACGGTGAAACCCCGTCTCTACTGAAAACACAAAAATTAGCTGGGTGTGGTGGTGTGTGCCTGTAATCCCAGCTA
CTCGGGAGGCTGAGGCAGGCAAATCGCTTGGCCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACTCCAGCCTGGGCCA
CGGAGCGAGAGAAGAAAGAAATGGTGACTTTCATTGATCATGTGTTTGAGGATTTCATGTGCTCTCCAGGGAGGTTTCAGGTGGGTAGAA
GGAGGTGGGCAAGACCCAATAAAAAAGCAGCTGGTGCGGGCAATGACAATGAACTCGTATCCTGCAGGGTCAAAGGAAGGCTTGCTTCTG
CTGTGAATTGGAGAAGGACTTTCCTGGAAGCACAGGCCCAGAAATCGCACCCTTCTCCCCATGTGTGCGGATAAGGGACCACTTCCATCA
GCAGCAGCCCCCTCCTGCTTTCCTGCCAGTCCTCCCTGTGGTCCCAGGTCTCTTGAGAAAAGTGATCTAAGAGATCCCTTTGCAATGAGG
TGCTACTGACTGCCCTACCTCCCTCCCTTCCTCCCATGAATGTTTCTTGGTGCTGACCACAGCCTCAGCAATGAGGCAAGCCTGGGGACC
CAAGACAGATCTCTGCCTCCCAGGCTAGTGGATGCCCTGGGATATGTAGTCACCAAAATAGGAACTTACCCCATAGTGGGGAAATAGACA
GTAAGCAGCAAATCAATAACAAGAGTGTTCCAGATGGTTGTAAGTGCCAGGAAGGGAACCAACTGGGAGAGGGACAAGAGGAGATGGTGA
CTGACCAAGGGGACCTTGATCAGGCTGTGGGGAAGGGAGGTGGTTGGGAAGAGCTTCCCAGGAAAGGGGACGGCGGGCCCAGGCAGGAGA
GCCTTGGGAGGGGGTGCCCAAGGAAGGAAAAGGGCCCTGAGCCTGAAGCCGAGAAGACCAGGAGGGGAGAAGGGGAGATGTAGGGCAGAG
CAGACGGGAGCCGCTCGGGTTTTATTCCACACACCCCAGGAAGCATGAGAGGGTTTCAAGCAGCAAGGGCATGGAAGTAACTTGGTGAGA
TATTTTTATGCATTAGATCATCGCTCTATCTGGATTCCAGAGGGTCTCTGAGAGAGCAAACAGCTTAATCCAAAGGAGCGGCTTTCCAAC
TGGGAATGTCCCCCTGGCTGGGTGAGATCTCAAGATGGCCTGCGGCCCCTCTAGATTGCCTGCCTACAGAGTTCACTCTAAACAGCCCCT
CCCCTCCACACCCCAGCAGATCCATTCCTGACGCCCTCACTGGCAGGCTCCAGCCCCACAGAGCTTTCTAGACATAAAAGAGCAGGGTCA
TGGCATCATTGGTGACACAATTTTAGTAATAAGCTTCAAAACCCATCACTCCACTGAATCCAGGGATGCCAGAATTGAGAGTCCATAGGA
CCCGTTTAACGGATCCCACATTCAGTAGACGGTTTTTTGTATGCTTCGAGGGAAGGAAGGTATTTTCAAATGCAACTTCTTTTTTTTTTT
TCTTGCTCTAGTTAGGGCTGATTTTACCACTGGGCAAATTGCATACATTTGGATCCATGCCACGCTAAAAACTGTTTATTTTGGAGATCT
GTCAGAGGCAAGCACATGGAAGACAAGGGGATTCTGGTTTGAAAAGGCAATTCTCATCCAGACAGATTCAGATGGAGAGGAGCGGTGTGG
ATTAAAATGCGCCGAAGTGGTAATGCCGTTTATCCCGTTTGCCTTTGTTACTCTGTGATTAAATGGTATTTTTAATTAAGTTTCATTGGG
AGCCATAGGTATCGCGGTGGTGAAATCAATTTGACAACCATAAAGGGGAGAGACGGCACAGGCGTGTTGTGATGATTGCGGCTGTAGGGA
AAGCCGGGCAGCTTGCAGAGGATGGGTGGGAGGAGGGGAAGCCGGCTAAGAATGACTTCCTGCAAGACAGCAAGGGCACCCCTGGGCCAC
TGCTGTGTTTGGGAGGCAGGTTTTGGGGGTTGTCAGAAGGCATTCACCTGGTTCTCTCGCTCACCTGAGACACCCGATAGATTCCTGGAA
ACTCCAGGAAAGTATCTGAAGATCTGGTTCTCCATTCTCTCTTATTAACAAGGAGAACCACAAGTGCCCCCCAGATCCCGGCTAGAAGGA
CCAGACAGCTTTCCACCCCGGTTCCCAGGCAGCCCTGCTCCCATAGTCCTGTGTCCCATCGGCCCCATGCTCCCAGGACAGTCCTAATTC
CCACCTCTCAGAACCTTGTCAGCCAAGTTCTTCCTGCTCTCTGGCCCAAATCCTCCTCCTACATTGGAAACTGAGCCTCTCTGCATCCTC
TGCTCTTTCTATCCCGCTGTCATTCATCAGATTTTCCAAATCTTTGGATTCCTGAGTGGCAGAAGAGGTTTTCTGAGTTTAAGTTCTGAT
TCTGTGTGTGATTCTCACTCTACCACCTCTTCAAACCTTTGTTGTCTTATCTACAAAATAGAATAGTAGTAATCCATCACCTAAGGTTGT
TGTGAAGGTTCAATAAGTTAATGCGTATTTAAAATGCCTCCCACAGTACCTGACATATACTGGGCTTCAGTGAGGTACTAGCTATTATTA
TTAACCAAGTTTCCTGTGGTAACAGTTGTAGCTTTGTGACTGGGCCAAATCACTTAACCCCTCTGCGCTCCAGTCTTTGTTTCTATAATG
GGGATGATGATAATGCCTAGCTCATTGGATTGTTCTGTCCCCTACGATCAGCCATGTTAAGTGATTCATATCATGTCTGGTACTTAAAAA
TCACGCCACGCATGTACATTATTATGATGAAAAATATGATCCGTGATATCCTGACCAAAATATTAAAGGGACTAAAGATAGCTGTGGCTT
GTTCAAGAAGAATATTGTGTCACTATCCCATATATTATCCCATTTGCTCTTCACAGCTTCCATTTTTCGCTAGGCGGATGGCATGGAACT
TTTTATAAATGAGATATTATGAAAAATGATGTTTTAGGACTCTCATTTCTACAGTGGGAGTAGGTCACCCATTGCAATTTTGGATTTGCT
TAAAAAAATTCTTGCCATCACCTTCTAATGGATGATCTGTGTACAACAATTGTTTATTGACTCTGAATGTCTAAGTACCAGGGTCAGTCT
ATTTCAAGGGGAGGGAAGCATTAATTAACCTCCAGCATTAGATTCAGTGATTCTTTTCCAATGATGCAGTTCATGACTTTGCTCGCATTT
ACTTTTCATCAATCCTGAAAGAATTGAGGTAAAATAGTTCCTCTGCACATGTGTGTCAAGCTAAATGGATAACAGCAGATACAGATCTGT
TTGCCTGTCTGCACTTGCCTTTAGACAAAATTCATCAATTTTACAAAAGCCACTGACTAAACATGGCACCAATACAAATGAAGCACTTCT
AGCAGGCGGAGATTCCCTTTGTTTCTGATCTGGTAAATGCGGTAGTTTCCTGCTGAGAGATGGGAAGTGCTGGCCTAGGACAGCAAGGTG
CCCTACAGGTGGGGCCAAAAGGGTCAAGACCGTTCTACAGGAAGTTTAGGAGAAGTTCAATGGTTCCAGATCCTGTGTGCTTCGGGTAAT
TCTGACCCTCTTCATTAGTGATAATGGCATGAAGCTCTTTCACACAGTCTTTTTTTTTTTTCTTTTTTTTTTTCAGACAGGGTCTCACCC
TGTCACGTAGGCTGGAGTGCAGTGGTGAGATCACGGCTCACTGCAGCCTCGACTTCATGGGCTCAAGCGATTCTCCTGCCTCAGCCTCCT
AAGTAGTCGGGATCATAGGCACTTGCCACCACATCCGGCTAATTTTTTTGTAGAGACAGGATTTCACCACATTACACAGGCTGGTTTCAA
ACTCCGAGGCTCAAGTGATCTGCCTGCATCGGCCTCCCAAAGCGCTGAGATTACAAGCGTGAGCCACTACGCCTTGCCCTCCACACAGCC
TTGCTTGGTGTTAAAGATTAAACAAAGACCACAGGTGATCACTGTCTTCGTGGTGCCAGTTTCAAGGGCACCCTTCTTCCCTTCCCAGCC
TCCGAGAGAAGGAGAGAGGGTCCACAAGCCAGATCCATCCCCATCCACACAGGTAAAACCACGACTGTGCAGCTAGCAGGTGGAGATAAC
ATTTGGAAAAAGGCTTTGTAAATGCTAAAGTCCTACTCAAGTCCAAGGGAGAGAAATTATTATTATTCGTTTTGTGAAACCAATTTAGTT
TGGCTGGGTAATGGAAGAATTTCTACATACATTCATTACTTCTGATCAGGCAAGACCAGTCTGACACAGGAACAGTCTATGGCTCACTCT
TAAAGCCACAGCAGGCTGCCAGGGCTTGGAGAAATAGAAACCTCTCTTGCACAAGAATAGTCTCAATGAATCATGTTAAGGCCTCTTTAG
GTTTTTCAGACTCCATGCACCCTGTGGAAACTGCCTTTCTTGAGTAGAGGTACGTTCAGCACTTCATAAAATAATCTTGGAGCCTCCAGA
CACACGGATGGAGGAGCATGATTTCATTTGTTTCTTTGCAAAACTGCTGTCCCCAACTGAAAAACCTGATTATCCTTTCAAATAGGGAAT
TCGGCTTTCCACGTTGGAACCAGAACAGTTAACCTTCAAACCCCCAAGGCTTGCAAGAGATGAATCAGTTTCTCAGACAGCCAAAGCCGT
GGCTTATAACTCATCCAACCCAGAAAACTGGACCGCTGGTCACCTTCCTTCCCCCTGCCCCCAACTCTGCAGACAGAGGTTTCCCGTTGA
TTATGCCTTGATTAGAGTCAGGAGAGAAGCAAACCAGGTATATAGGATTCCATTATCCTTCCCTCCTCTGCTCCCAACCAGGGTCACGCT
GAGAGGGATCTCGGTGAACATGTGAACAATCAAGCCATGTTTACCATGGACGTTTAGTTTTCTTTTCTCAAAATCAAAACAGAGTTTAGT
AGGCAGCGTATTTCATACATGCCCCTTGATCAATGGAATGATCTGTCAGAAGCCATTAAAGCCCCCATTAGCTTGAATGCATTCAAAGCT
AAACTATTGGATCATTTAAGGGCTGCAGTGATTGTTTTTAATATACCGTACATTGATTTCTCCCTGTGAGCAGCAACATAAGTTTGAAAC
TAACTGTGTATGACTAAGGCTCCATTTGCTGTCTCCAACCCTCTGTGAGAAGCATGGTTTCACTTCGACCAGAAATGTCTGTGTATAGTT
TTCAAAGAGATGCAGACCCTGTTCGATTTCCCAAGATTTAGACTGGGTCGGGTTGTTATTTCTTTTTTCCCTGAGCTTTCTCCCATTTCT
TTGTGCCCATTAAGTGAGCTGTGCGTGCAGAATGGGAGAGGCATCCCTGCCAAGGACTTCAAGTGAAAGGCGGTGGGAGAAATTGTTCTG
AAAGCATGAAGCCCAGCTGAGGCCAAAATCAAAGTGAATTTGACAGCCTTGGGCCAGCAAAACTCTGTACCCAGCAGAAAACAATAGATG
TGTGGCTGTGTCAGGGGCATCCTCACTGGGACATAGCTTGGGGAGCTGAAGGTACCTTGGAAGGGCCAGATGAGGAAGCTAGCCAAGGCC
ACAGGCCTTCCTTTGACTGCCATATTGCCAGCTCTTCATAGTATTGACTCTTCAGTCTTAGCCAACACACACTTGTTGATTCCTTCCGGA
ATGTCAGACTCTGCTAGCAACACAAGGTCCCTGTCCTCAAAATCCTATTCTTAATCAGCATTTCTAATTTCTGCCCTTTGCTCATTTTAA
TACAGAGCCTGAGGATAGGAGAGCAGCGTGGTGAAAGAAGCAATAGTTACCACATTTGCAAAGGCACATACCCCAAAGAGAAGTTTTTAA
TATGTCACACCCATATTTTATAGATGGGGCAATGGAAGTCCAGATGGGAGAAGTTATTTCAGGTGAATTATAGAAACTGGATTTCAAGTT
TCTGATAAGTATTGAATTTGGGAAGGCTGTGAACATTCTTGAGCCCCCCTCCCAAGTTCACCTTCAACATCCTAAAGCAGGTTGAAGAGG
AAGATGGTTCCAGGTCACTTACAAGAACAGGAACAGCCCCTCCCTCCAAATTTGAGCCCAGAAAGGAGAACCTTTGTTACTCTAGAAAAC
AGTGTGTGTGCTATTGTTTTCTCCATAGGTCACAAACATCCACAAGATATTGGTGATTTTACATATTATTAGAGCCACTGAAATTTATGA
TGCAGGATATTAACGTCAAAGAGGCCAAGATGCATCATTCAGAACACTGGCAGGTCAAGCAGAAACCACCGTAGTAAAATTGAAAGCTGG
AGTCAGCAAAGTATAGCCCACAGCCAAATCTGGCCCATCCCCTGTTCTTATAAAGTTTTATTGGAACGCAGCCATGCTCATCGGTTTATG
TATTATCTATGGCTGTTTCCAACTACAGTGGCAGAGCTGAATAGTTGCAAAGGACCATAGGGCTATCAAAGCCCCAAATAGTCATTGTCT
GACCCTTCATAGAAAAATTTTGCTGAACTGTAGTCTAGCTCCAAGGATTGTTGTATCACCTGTGATCGTGCCTATTAAGCAATTAACGTC
ATGTCTAGTACTTAGTAATGACTCAGCATGTATCAATTACGATGATAAATATTATCATGGCATCCAAACCAAAATACTCATGCCAACATC
TCTCTGTACAGAAACATGGAAAAAGAGCGATGCTATTAAGGAGGAAAATGGAGCCAGGAGCAAAACCTAAGGCTATTTCTGAACTAAAGA
GGCCTGAATAAGGTAGTGAAAGGACCAGGGAAAGCCTTCCCACGGGGATGGAGAGCCACCTCCTCCCCGGCTTTCTGGTTCAGATGTCTT
GTCTCAACAGACGGCAGATTCGCAGGGAAGCAGGCCGAGCCTGATCTTTTCTCCGCTAGAACTGCTCAACAGGTGAAGAATCTTTTTCCA
GCACTCCTGAGCCCTTCGGGTCGCGGAACAGTGCGAAGATTATTCCAATGCCTCATTCGGAGAGGTGATAATCTGGTCTGTGGTTTCTTT
TTCGGTGGGGCATGGGGTGGGGGTGAGTGTCATGCTTTCTAAGGCACAGGGCTGACTAAAGGGTGTCCTATTTATAAGTCAGTAAAACAC
AGCGGCTTCATACTCTGTGCTTATTACCCAGAAGCCCCGGCTCTTAGAGTTTCTATTAAGATGTACCTCATAAATATATACGCCTCCTAT

>In-frame_ACTN4_ENST00000424234_chr19_39138547_+_FTO_ENST00000471389_chr16_53844052_+_11720nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGAAACTGAGGCTTCTTGAAGAGCTTGAAGACACTTGGCTCCCTTATCTGA
CCCCCAAAGATGATGAATTCTATCAGCAGTGGCAGCTGAAATATCCTAAACTAATTCTCCGAGAAGCCAGCAGTGTATCTGAGGAGCTCC
ATAAAGAGGTTCAAGAAGCCTTTCTCACACTGCACAAGCATGGCTGCTTATTTCGGGACCTGGTTAGGATCCAAGGCAAAGATCTGCTCA
CTCCGGTATCTCGCATCCTCATTGGTAATCCAGGCTGCACCTACAAGTACCTGAACACCAGGCTCTTTACGGTCCCCTGGCCAGTGAAAG
GGTCTAATATAAAACACACCGAGGCTGAAATAGCCGCTGCTTGTGAGACCTTCCTCAAGCTCAATGACTACCTGCAGATAGAAACCATCC
AGGCTTTGGAAGAACTTGCTGCCAAAGAGAAGGCTAATGAGGATGCTGTGCCATTGTGTATGTCTGCAGATTTCCCCAGGGTTGGGATGG
GTTCATCCTACAACGGACAAGATGAAGTGGACATTAAGAGCAGAGCAGCATACAACGTAACTTTGCTGAATTTCATGGATCCTCAGAAAA
TGCCATACCTGAAAGAGGAACCTTATTTTGGCATGGGGAAAATGGCAGTGAGCTGGCATCATGATGAAAATCTGGTGGACAGGTCAGCGG
TGGCAGTGTACAGTTATAGCTGTGAAGGCCCTGAAGAGGAAAGTGAGGATGACTCTCATCTCGAAGGCAGGGATCCTGATATTTGGCATG
TTGGTTTTAAGATCTCATGGGACATAGAGACACCTGGTTTGGCGATACCCCTTCACCAAGGAGACTGCTATTTCATGCTTGATGATCTCA
ATGCCACCCACCAACACTGTGTTTTGGCCGGTTCACAACCTCGGTTTAGTTCCACCCACCGAGTGGCAGAGTGCTCAACAGGAACCTTGG
ATTATATTTTACAACGCTGTCAGTTGGCTCTGCAGAATGTCTGTGACGATGTGGACAATGATGATGTCTCTTTGAAATCCTTTGAGCCTG
CAGTTTTGAAACAAGGAGAAGAAATTCATAATGAGGTCGAGTTTGAGTGGCTGAGGCAGTTTTGGTTTCAAGGCAATCGATACAGAAAGT
GCACTGACTGGTGGTGTCAACCCATGGCTCAACTGGAAGCACTGTGGAAGAAGATGGAGGGTGTGACAAATGCTGTGCTTCATGAAGTTA
AAAGAGAGGGGCTCCCCGTGGAACAAAGGAATGAAATCTTGACTGCCATCCTTGCCTCGCTCACTGCACGCCAGAACCTGAGGAGAGAAT
GGCATGCCAGGTGCCAGTCACGAATTGCCCGAACATTACCTGCTGATCAGAAGCCAGAATGTCGGCCATACTGGGAAAAGGATGATGCTT
CGATGCCTCTGCCGTTTGACCTCACAGACATCGTTTCAGAACTCAGAGGTCAGCTTCTGGAAGCAAAACCCTAGAAGGAGCACAAGTCTC
AGGCGGAGGAGAAAAAGAGATCGGCTTTTCTCCTCCAACGTTGTCATGGGCTTAAGCAAGAGCAGTGGAGACTTCTCTTGGCCCCTAGAT
TGTAGCACCCGGGTCCCAATCCAAAACAGCTAGGAAATGGTGCCCATGAAGTTTTAAATGTTTTAAAATGACCCTGTGTTATAGTCTGAT
TTGGTGTTAAACAGGACCTTCTTCCCCCAAAATTGTTCAGATTATAAAATGTGAGCCATTCAGCCCCCAAGGTCCAGGGCAGGCGACAGG
AACGAGCCCAGCGTGTGACAAAGCCTAACCTACTTTCCTCTTTCCCAAGCTTTTTCAGAGACTCTGGAGTGGACCCAGCCCTCTGGGGAA
AGACAGAACTTAGAGACATCCCAGTTACTCACCACACCCATAGTGCTGTCCAATATGGTAGCCACTAGCTAGCTGTGGCTACTTCAATTT
AAATTCAGTTTTAATTTTAATTAAAAATGCAGCTCTTCAGTCGCCCTGGCCACATTTCAAGTGCTTAACAGCCTCATGTGGCTAGTGACT
GCTGTATTGGACGGTACAGATATGGAACATTTTCATCATCGAAGAAAGTCCTATTGGACAACACTTCTATAAAAAGTTTGAGAGCAGGAA
TTCTCATTTCCATTCGTCTGTAGCTTCTATCCCCAAAGGCAAAGAAACTAAAAGAGAAATGACTCATTGAAGATTGGCCTCTTTCCTTTC
TCTAAGACAAACCTAAGTAAAAGCCTGAGCTTTGAGTCCTATGCTCAGCACACGGGAAGGAGATGTTAATAATTAAAATAAAGTTGATAT
CCTGTCTTTAGGGAGTTCCCTTGATCTCTTGAAAGAGACACAGCCCCATTTACATTATTTCGTGGATTTCACCAGCATAGTATAGTTTTT
TTCTGTAAGTCCCTCATTCTTATGTAATAACAGGTGGAACTGAGGTTTGAAGAACCTCAGTGGCCCATCCTGATGACATTGGAGACTCAA
AGAGACAAGAGAGAGTAGGGTTTAAAACCTGAGCTTTAAGACTCCCACTAGCTTCGTGTCCTTTGGCATGTTAACGTGCCTCAGTTTCCT
CATCTGTATAATGGGGATATATGAAAGGCACCAGTCCTAAGGTGAACATTAAGTGAGATGATTCTAGTTACAGACTTAGAACAATTTCCA
GCACATAGTTAAATATCCAGGAAATTCTGGTACTGTTATGTGTGGGTGAGCTGACCTGGATGTAGATGTTTTCCTCTCTCTTGCTGACCC
CTCCGCCAGTTTTGTCTTGTGATGCCATTAACACATCTCTCCCTTTCTGACCTGGCTCCTGCCCATTGGTGTCCCAAGAAATCGTGAGAA
TAGTTAGCCCCCCGTCTCCCCAGCCTGTTGCTTTCTCGTGTAGTTGTTCACAGTAGTTGAGAAGTTGAAGAGCTTTTGCCTATTGAAGGT
GCACTGAGAATAAACTCTTTCCTGCCACCAGAATTGCAGTGGTTCACGGCCTGCACTCATTCCCATGAATGCAGTTAATAGCCACAGAAA
TGTCACATTAAGCAAAGCAGCCAGGGTCTCATCGTGTTGAGACTCGAGTCTCTCAGACCTTGGATTCATTCCCTGGTGTCTTTGAGCCTC
AGTTTCCTCATTGGTAAAAGAGAAGTGAAGCAGTGTCTCACAGGGTCATTACAGAGATTAAATGAAATAAATGAAATAACATAGACCAGG
AGGGCGTGGTGTTTAAAAGTCACAGATGGGGCACCCTCGGGCCATCCAGCCCAGTGTTTTCTTTAGCCCCTATGATGTTCATTTTTTGTT
ATATCCCATTAGGTGCCCATATTTAAAAATTGGGAGATTTCACATAAAATTAAAAGGTCTGCATTTTCTTTTTTCTTTTCTTTTTTTTTT
TTTTTGAGACACAGTCTCACTCTGTCACCAGGCTAGAGTGCAGTGGCACGATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTA
ATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACGTGCCACCACGCCCAGCTAATTTTTGTATTTTTAGCAGAGATGGGGT
TTCACCACATTGGCCAGGATGGTCTCGATCTCAACCTCGTGATCCACCCACCTCGGTCTCCCAAAGCGCTGGGATTACAGGCGTGAGCCA
CCGCGCCAAGCCAAGGTCTGCATTTTTCTTTAGAACTCAGAACACCCAATAGTCCTAGGCCCCCATCCTCGCATGGCAGCAAGCTAAATA
AGCATCTTCCCACTGCGAGTTGGGGCATGACCCAGCCTATGGTTTGCCATACTCCCTCTTTTTCTCCGTTTTTTCATTAATTGTGAACCT
GACCTGCATCACCCTTTCATGTCAGTGCTCTCCAAACCTGCTTGCTTGCACCCCTCTAGTCGAAATATTTTGTGCTTACCCCAATATATG
TGTGTGACTATTGAACTCTATTCGTAGACTGCTTGTACTAATGTCATTTGCATCATAAAATATTCATATCCAATAAACATATTAAAAGGA
TGAGATAAGAAACCGAGAGATTTTGCTGTTTTTTTCCTTTTGCATGGATGAGCCAGCTTCACTGTCCTGGGTGGGGCCCAGGTGGAATTA
GTTCTCAAAGTCCTCCAGGTGGAGTCAGGGAATGTGCAACAGGGTTGGAGAAATCACTACTTTAAGTGAATCCGAAAGGTGAGATCACAT
TTGCTCTAAAGAAATGGTGATCCCAGCACTTTGGGAGGCTGAGGCAGCAGATCACTGGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACA
CGGTGAAACCCCGTCTCTACTGAAAACACAAAAATTAGCTGGGTGTGGTGGTGTGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCA
GGCAAATCGCTTGGCCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACTCCAGCCTGGGCCACGGAGCGAGAGAAGAAA
GAAATGGTGACTTTCATTGATCATGTGTTTGAGGATTTCATGTGCTCTCCAGGGAGGTTTCAGGTGGGTAGAAGGAGGTGGGCAAGACCC
AATAAAAAAGCAGCTGGTGCGGGCAATGACAATGAACTCGTATCCTGCAGGGTCAAAGGAAGGCTTGCTTCTGCTGTGAATTGGAGAAGG
ACTTTCCTGGAAGCACAGGCCCAGAAATCGCACCCTTCTCCCCATGTGTGCGGATAAGGGACCACTTCCATCAGCAGCAGCCCCCTCCTG
CTTTCCTGCCAGTCCTCCCTGTGGTCCCAGGTCTCTTGAGAAAAGTGATCTAAGAGATCCCTTTGCAATGAGGTGCTACTGACTGCCCTA
CCTCCCTCCCTTCCTCCCATGAATGTTTCTTGGTGCTGACCACAGCCTCAGCAATGAGGCAAGCCTGGGGACCCAAGACAGATCTCTGCC
TCCCAGGCTAGTGGATGCCCTGGGATATGTAGTCACCAAAATAGGAACTTACCCCATAGTGGGGAAATAGACAGTAAGCAGCAAATCAAT
AACAAGAGTGTTCCAGATGGTTGTAAGTGCCAGGAAGGGAACCAACTGGGAGAGGGACAAGAGGAGATGGTGACTGACCAAGGGGACCTT
GATCAGGCTGTGGGGAAGGGAGGTGGTTGGGAAGAGCTTCCCAGGAAAGGGGACGGCGGGCCCAGGCAGGAGAGCCTTGGGAGGGGGTGC
CCAAGGAAGGAAAAGGGCCCTGAGCCTGAAGCCGAGAAGACCAGGAGGGGAGAAGGGGAGATGTAGGGCAGAGCAGACGGGAGCCGCTCG
GGTTTTATTCCACACACCCCAGGAAGCATGAGAGGGTTTCAAGCAGCAAGGGCATGGAAGTAACTTGGTGAGATATTTTTATGCATTAGA
TCATCGCTCTATCTGGATTCCAGAGGGTCTCTGAGAGAGCAAACAGCTTAATCCAAAGGAGCGGCTTTCCAACTGGGAATGTCCCCCTGG
CTGGGTGAGATCTCAAGATGGCCTGCGGCCCCTCTAGATTGCCTGCCTACAGAGTTCACTCTAAACAGCCCCTCCCCTCCACACCCCAGC
AGATCCATTCCTGACGCCCTCACTGGCAGGCTCCAGCCCCACAGAGCTTTCTAGACATAAAAGAGCAGGGTCATGGCATCATTGGTGACA
CAATTTTAGTAATAAGCTTCAAAACCCATCACTCCACTGAATCCAGGGATGCCAGAATTGAGAGTCCATAGGACCCGTTTAACGGATCCC
ACATTCAGTAGACGGTTTTTTGTATGCTTCGAGGGAAGGAAGGTATTTTCAAATGCAACTTCTTTTTTTTTTTTCTTGCTCTAGTTAGGG
CTGATTTTACCACTGGGCAAATTGCATACATTTGGATCCATGCCACGCTAAAAACTGTTTATTTTGGAGATCTGTCAGAGGCAAGCACAT
GGAAGACAAGGGGATTCTGGTTTGAAAAGGCAATTCTCATCCAGACAGATTCAGATGGAGAGGAGCGGTGTGGATTAAAATGCGCCGAAG
TGGTAATGCCGTTTATCCCGTTTGCCTTTGTTACTCTGTGATTAAATGGTATTTTTAATTAAGTTTCATTGGGAGCCATAGGTATCGCGG
TGGTGAAATCAATTTGACAACCATAAAGGGGAGAGACGGCACAGGCGTGTTGTGATGATTGCGGCTGTAGGGAAAGCCGGGCAGCTTGCA
GAGGATGGGTGGGAGGAGGGGAAGCCGGCTAAGAATGACTTCCTGCAAGACAGCAAGGGCACCCCTGGGCCACTGCTGTGTTTGGGAGGC
AGGTTTTGGGGGTTGTCAGAAGGCATTCACCTGGTTCTCTCGCTCACCTGAGACACCCGATAGATTCCTGGAAACTCCAGGAAAGTATCT
GAAGATCTGGTTCTCCATTCTCTCTTATTAACAAGGAGAACCACAAGTGCCCCCCAGATCCCGGCTAGAAGGACCAGACAGCTTTCCACC
CCGGTTCCCAGGCAGCCCTGCTCCCATAGTCCTGTGTCCCATCGGCCCCATGCTCCCAGGACAGTCCTAATTCCCACCTCTCAGAACCTT
GTCAGCCAAGTTCTTCCTGCTCTCTGGCCCAAATCCTCCTCCTACATTGGAAACTGAGCCTCTCTGCATCCTCTGCTCTTTCTATCCCGC
TGTCATTCATCAGATTTTCCAAATCTTTGGATTCCTGAGTGGCAGAAGAGGTTTTCTGAGTTTAAGTTCTGATTCTGTGTGTGATTCTCA
CTCTACCACCTCTTCAAACCTTTGTTGTCTTATCTACAAAATAGAATAGTAGTAATCCATCACCTAAGGTTGTTGTGAAGGTTCAATAAG
TTAATGCGTATTTAAAATGCCTCCCACAGTACCTGACATATACTGGGCTTCAGTGAGGTACTAGCTATTATTATTAACCAAGTTTCCTGT
GGTAACAGTTGTAGCTTTGTGACTGGGCCAAATCACTTAACCCCTCTGCGCTCCAGTCTTTGTTTCTATAATGGGGATGATGATAATGCC
TAGCTCATTGGATTGTTCTGTCCCCTACGATCAGCCATGTTAAGTGATTCATATCATGTCTGGTACTTAAAAATCACGCCACGCATGTAC
ATTATTATGATGAAAAATATGATCCGTGATATCCTGACCAAAATATTAAAGGGACTAAAGATAGCTGTGGCTTGTTCAAGAAGAATATTG
TGTCACTATCCCATATATTATCCCATTTGCTCTTCACAGCTTCCATTTTTCGCTAGGCGGATGGCATGGAACTTTTTATAAATGAGATAT
TATGAAAAATGATGTTTTAGGACTCTCATTTCTACAGTGGGAGTAGGTCACCCATTGCAATTTTGGATTTGCTTAAAAAAATTCTTGCCA
TCACCTTCTAATGGATGATCTGTGTACAACAATTGTTTATTGACTCTGAATGTCTAAGTACCAGGGTCAGTCTATTTCAAGGGGAGGGAA
GCATTAATTAACCTCCAGCATTAGATTCAGTGATTCTTTTCCAATGATGCAGTTCATGACTTTGCTCGCATTTACTTTTCATCAATCCTG
AAAGAATTGAGGTAAAATAGTTCCTCTGCACATGTGTGTCAAGCTAAATGGATAACAGCAGATACAGATCTGTTTGCCTGTCTGCACTTG
CCTTTAGACAAAATTCATCAATTTTACAAAAGCCACTGACTAAACATGGCACCAATACAAATGAAGCACTTCTAGCAGGCGGAGATTCCC
TTTGTTTCTGATCTGGTAAATGCGGTAGTTTCCTGCTGAGAGATGGGAAGTGCTGGCCTAGGACAGCAAGGTGCCCTACAGGTGGGGCCA
AAAGGGTCAAGACCGTTCTACAGGAAGTTTAGGAGAAGTTCAATGGTTCCAGATCCTGTGTGCTTCGGGTAATTCTGACCCTCTTCATTA
GTGATAATGGCATGAAGCTCTTTCACACAGTCTTTTTTTTTTTTCTTTTTTTTTTTCAGACAGGGTCTCACCCTGTCACGTAGGCTGGAG
TGCAGTGGTGAGATCACGGCTCACTGCAGCCTCGACTTCATGGGCTCAAGCGATTCTCCTGCCTCAGCCTCCTAAGTAGTCGGGATCATA
GGCACTTGCCACCACATCCGGCTAATTTTTTTGTAGAGACAGGATTTCACCACATTACACAGGCTGGTTTCAAACTCCGAGGCTCAAGTG
ATCTGCCTGCATCGGCCTCCCAAAGCGCTGAGATTACAAGCGTGAGCCACTACGCCTTGCCCTCCACACAGCCTTGCTTGGTGTTAAAGA
TTAAACAAAGACCACAGGTGATCACTGTCTTCGTGGTGCCAGTTTCAAGGGCACCCTTCTTCCCTTCCCAGCCTCCGAGAGAAGGAGAGA
GGGTCCACAAGCCAGATCCATCCCCATCCACACAGGTAAAACCACGACTGTGCAGCTAGCAGGTGGAGATAACATTTGGAAAAAGGCTTT
GTAAATGCTAAAGTCCTACTCAAGTCCAAGGGAGAGAAATTATTATTATTCGTTTTGTGAAACCAATTTAGTTTGGCTGGGTAATGGAAG
AATTTCTACATACATTCATTACTTCTGATCAGGCAAGACCAGTCTGACACAGGAACAGTCTATGGCTCACTCTTAAAGCCACAGCAGGCT
GCCAGGGCTTGGAGAAATAGAAACCTCTCTTGCACAAGAATAGTCTCAATGAATCATGTTAAGGCCTCTTTAGGTTTTTCAGACTCCATG
CACCCTGTGGAAACTGCCTTTCTTGAGTAGAGGTACGTTCAGCACTTCATAAAATAATCTTGGAGCCTCCAGACACACGGATGGAGGAGC
ATGATTTCATTTGTTTCTTTGCAAAACTGCTGTCCCCAACTGAAAAACCTGATTATCCTTTCAAATAGGGAATTCGGCTTTCCACGTTGG
AACCAGAACAGTTAACCTTCAAACCCCCAAGGCTTGCAAGAGATGAATCAGTTTCTCAGACAGCCAAAGCCGTGGCTTATAACTCATCCA
ACCCAGAAAACTGGACCGCTGGTCACCTTCCTTCCCCCTGCCCCCAACTCTGCAGACAGAGGTTTCCCGTTGATTATGCCTTGATTAGAG
TCAGGAGAGAAGCAAACCAGGTATATAGGATTCCATTATCCTTCCCTCCTCTGCTCCCAACCAGGGTCACGCTGAGAGGGATCTCGGTGA
ACATGTGAACAATCAAGCCATGTTTACCATGGACGTTTAGTTTTCTTTTCTCAAAATCAAAACAGAGTTTAGTAGGCAGCGTATTTCATA
CATGCCCCTTGATCAATGGAATGATCTGTCAGAAGCCATTAAAGCCCCCATTAGCTTGAATGCATTCAAAGCTAAACTATTGGATCATTT
AAGGGCTGCAGTGATTGTTTTTAATATACCGTACATTGATTTCTCCCTGTGAGCAGCAACATAAGTTTGAAACTAACTGTGTATGACTAA
GGCTCCATTTGCTGTCTCCAACCCTCTGTGAGAAGCATGGTTTCACTTCGACCAGAAATGTCTGTGTATAGTTTTCAAAGAGATGCAGAC
CCTGTTCGATTTCCCAAGATTTAGACTGGGTCGGGTTGTTATTTCTTTTTTCCCTGAGCTTTCTCCCATTTCTTTGTGCCCATTAAGTGA
GCTGTGCGTGCAGAATGGGAGAGGCATCCCTGCCAAGGACTTCAAGTGAAAGGCGGTGGGAGAAATTGTTCTGAAAGCATGAAGCCCAGC
TGAGGCCAAAATCAAAGTGAATTTGACAGCCTTGGGCCAGCAAAACTCTGTACCCAGCAGAAAACAATAGATGTGTGGCTGTGTCAGGGG
CATCCTCACTGGGACATAGCTTGGGGAGCTGAAGGTACCTTGGAAGGGCCAGATGAGGAAGCTAGCCAAGGCCACAGGCCTTCCTTTGAC
TGCCATATTGCCAGCTCTTCATAGTATTGACTCTTCAGTCTTAGCCAACACACACTTGTTGATTCCTTCCGGAATGTCAGACTCTGCTAG
CAACACAAGGTCCCTGTCCTCAAAATCCTATTCTTAATCAGCATTTCTAATTTCTGCCCTTTGCTCATTTTAATACAGAGCCTGAGGATA
GGAGAGCAGCGTGGTGAAAGAAGCAATAGTTACCACATTTGCAAAGGCACATACCCCAAAGAGAAGTTTTTAATATGTCACACCCATATT
TTATAGATGGGGCAATGGAAGTCCAGATGGGAGAAGTTATTTCAGGTGAATTATAGAAACTGGATTTCAAGTTTCTGATAAGTATTGAAT
TTGGGAAGGCTGTGAACATTCTTGAGCCCCCCTCCCAAGTTCACCTTCAACATCCTAAAGCAGGTTGAAGAGGAAGATGGTTCCAGGTCA
CTTACAAGAACAGGAACAGCCCCTCCCTCCAAATTTGAGCCCAGAAAGGAGAACCTTTGTTACTCTAGAAAACAGTGTGTGTGCTATTGT
TTTCTCCATAGGTCACAAACATCCACAAGATATTGGTGATTTTACATATTATTAGAGCCACTGAAATTTATGATGCAGGATATTAACGTC
AAAGAGGCCAAGATGCATCATTCAGAACACTGGCAGGTCAAGCAGAAACCACCGTAGTAAAATTGAAAGCTGGAGTCAGCAAAGTATAGC
CCACAGCCAAATCTGGCCCATCCCCTGTTCTTATAAAGTTTTATTGGAACGCAGCCATGCTCATCGGTTTATGTATTATCTATGGCTGTT
TCCAACTACAGTGGCAGAGCTGAATAGTTGCAAAGGACCATAGGGCTATCAAAGCCCCAAATAGTCATTGTCTGACCCTTCATAGAAAAA
TTTTGCTGAACTGTAGTCTAGCTCCAAGGATTGTTGTATCACCTGTGATCGTGCCTATTAAGCAATTAACGTCATGTCTAGTACTTAGTA
ATGACTCAGCATGTATCAATTACGATGATAAATATTATCATGGCATCCAAACCAAAATACTCATGCCAACATCTCTCTGTACAGAAACAT
GGAAAAAGAGCGATGCTATTAAGGAGGAAAATGGAGCCAGGAGCAAAACCTAAGGCTATTTCTGAACTAAAGAGGCCTGAATAAGGTAGT
GAAAGGACCAGGGAAAGCCTTCCCACGGGGATGGAGAGCCACCTCCTCCCCGGCTTTCTGGTTCAGATGTCTTGTCTCAACAGACGGCAG
ATTCGCAGGGAAGCAGGCCGAGCCTGATCTTTTCTCCGCTAGAACTGCTCAACAGGTGAAGAATCTTTTTCCAGCACTCCTGAGCCCTTC
GGGTCGCGGAACAGTGCGAAGATTATTCCAATGCCTCATTCGGAGAGGTGATAATCTGGTCTGTGGTTTCTTTTTCGGTGGGGCATGGGG
TGGGGGTGAGTGTCATGCTTTCTAAGGCACAGGGCTGACTAAAGGGTGTCCTATTTATAAGTCAGTAAAACACAGCGGCTTCATACTCTG
TGCTTATTACCCAGAAGCCCCGGCTCTTAGAGTTTCTATTAAGATGTACCTCATAAATATATACGCCTCCTATGTACCCACAAAAATTAA

>In-frame_ACTN4_ENST00000390009_chr19_39138547_+_FTO_ENST00000471389_chr16_53844052_+_11669nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGAAACTGAGGC
TTCTTGAAGAGCTTGAAGACACTTGGCTCCCTTATCTGACCCCCAAAGATGATGAATTCTATCAGCAGTGGCAGCTGAAATATCCTAAAC
TAATTCTCCGAGAAGCCAGCAGTGTATCTGAGGAGCTCCATAAAGAGGTTCAAGAAGCCTTTCTCACACTGCACAAGCATGGCTGCTTAT
TTCGGGACCTGGTTAGGATCCAAGGCAAAGATCTGCTCACTCCGGTATCTCGCATCCTCATTGGTAATCCAGGCTGCACCTACAAGTACC
TGAACACCAGGCTCTTTACGGTCCCCTGGCCAGTGAAAGGGTCTAATATAAAACACACCGAGGCTGAAATAGCCGCTGCTTGTGAGACCT
TCCTCAAGCTCAATGACTACCTGCAGATAGAAACCATCCAGGCTTTGGAAGAACTTGCTGCCAAAGAGAAGGCTAATGAGGATGCTGTGC
CATTGTGTATGTCTGCAGATTTCCCCAGGGTTGGGATGGGTTCATCCTACAACGGACAAGATGAAGTGGACATTAAGAGCAGAGCAGCAT
ACAACGTAACTTTGCTGAATTTCATGGATCCTCAGAAAATGCCATACCTGAAAGAGGAACCTTATTTTGGCATGGGGAAAATGGCAGTGA
GCTGGCATCATGATGAAAATCTGGTGGACAGGTCAGCGGTGGCAGTGTACAGTTATAGCTGTGAAGGCCCTGAAGAGGAAAGTGAGGATG
ACTCTCATCTCGAAGGCAGGGATCCTGATATTTGGCATGTTGGTTTTAAGATCTCATGGGACATAGAGACACCTGGTTTGGCGATACCCC
TTCACCAAGGAGACTGCTATTTCATGCTTGATGATCTCAATGCCACCCACCAACACTGTGTTTTGGCCGGTTCACAACCTCGGTTTAGTT
CCACCCACCGAGTGGCAGAGTGCTCAACAGGAACCTTGGATTATATTTTACAACGCTGTCAGTTGGCTCTGCAGAATGTCTGTGACGATG
TGGACAATGATGATGTCTCTTTGAAATCCTTTGAGCCTGCAGTTTTGAAACAAGGAGAAGAAATTCATAATGAGGTCGAGTTTGAGTGGC
TGAGGCAGTTTTGGTTTCAAGGCAATCGATACAGAAAGTGCACTGACTGGTGGTGTCAACCCATGGCTCAACTGGAAGCACTGTGGAAGA
AGATGGAGGGTGTGACAAATGCTGTGCTTCATGAAGTTAAAAGAGAGGGGCTCCCCGTGGAACAAAGGAATGAAATCTTGACTGCCATCC
TTGCCTCGCTCACTGCACGCCAGAACCTGAGGAGAGAATGGCATGCCAGGTGCCAGTCACGAATTGCCCGAACATTACCTGCTGATCAGA
AGCCAGAATGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCACAGACATCGTTTCAGAACTCAGAGGTC
AGCTTCTGGAAGCAAAACCCTAGAAGGAGCACAAGTCTCAGGCGGAGGAGAAAAAGAGATCGGCTTTTCTCCTCCAACGTTGTCATGGGC
TTAAGCAAGAGCAGTGGAGACTTCTCTTGGCCCCTAGATTGTAGCACCCGGGTCCCAATCCAAAACAGCTAGGAAATGGTGCCCATGAAG
TTTTAAATGTTTTAAAATGACCCTGTGTTATAGTCTGATTTGGTGTTAAACAGGACCTTCTTCCCCCAAAATTGTTCAGATTATAAAATG
TGAGCCATTCAGCCCCCAAGGTCCAGGGCAGGCGACAGGAACGAGCCCAGCGTGTGACAAAGCCTAACCTACTTTCCTCTTTCCCAAGCT
TTTTCAGAGACTCTGGAGTGGACCCAGCCCTCTGGGGAAAGACAGAACTTAGAGACATCCCAGTTACTCACCACACCCATAGTGCTGTCC
AATATGGTAGCCACTAGCTAGCTGTGGCTACTTCAATTTAAATTCAGTTTTAATTTTAATTAAAAATGCAGCTCTTCAGTCGCCCTGGCC
ACATTTCAAGTGCTTAACAGCCTCATGTGGCTAGTGACTGCTGTATTGGACGGTACAGATATGGAACATTTTCATCATCGAAGAAAGTCC
TATTGGACAACACTTCTATAAAAAGTTTGAGAGCAGGAATTCTCATTTCCATTCGTCTGTAGCTTCTATCCCCAAAGGCAAAGAAACTAA
AAGAGAAATGACTCATTGAAGATTGGCCTCTTTCCTTTCTCTAAGACAAACCTAAGTAAAAGCCTGAGCTTTGAGTCCTATGCTCAGCAC
ACGGGAAGGAGATGTTAATAATTAAAATAAAGTTGATATCCTGTCTTTAGGGAGTTCCCTTGATCTCTTGAAAGAGACACAGCCCCATTT
ACATTATTTCGTGGATTTCACCAGCATAGTATAGTTTTTTTCTGTAAGTCCCTCATTCTTATGTAATAACAGGTGGAACTGAGGTTTGAA
GAACCTCAGTGGCCCATCCTGATGACATTGGAGACTCAAAGAGACAAGAGAGAGTAGGGTTTAAAACCTGAGCTTTAAGACTCCCACTAG
CTTCGTGTCCTTTGGCATGTTAACGTGCCTCAGTTTCCTCATCTGTATAATGGGGATATATGAAAGGCACCAGTCCTAAGGTGAACATTA
AGTGAGATGATTCTAGTTACAGACTTAGAACAATTTCCAGCACATAGTTAAATATCCAGGAAATTCTGGTACTGTTATGTGTGGGTGAGC
TGACCTGGATGTAGATGTTTTCCTCTCTCTTGCTGACCCCTCCGCCAGTTTTGTCTTGTGATGCCATTAACACATCTCTCCCTTTCTGAC
CTGGCTCCTGCCCATTGGTGTCCCAAGAAATCGTGAGAATAGTTAGCCCCCCGTCTCCCCAGCCTGTTGCTTTCTCGTGTAGTTGTTCAC
AGTAGTTGAGAAGTTGAAGAGCTTTTGCCTATTGAAGGTGCACTGAGAATAAACTCTTTCCTGCCACCAGAATTGCAGTGGTTCACGGCC
TGCACTCATTCCCATGAATGCAGTTAATAGCCACAGAAATGTCACATTAAGCAAAGCAGCCAGGGTCTCATCGTGTTGAGACTCGAGTCT
CTCAGACCTTGGATTCATTCCCTGGTGTCTTTGAGCCTCAGTTTCCTCATTGGTAAAAGAGAAGTGAAGCAGTGTCTCACAGGGTCATTA
CAGAGATTAAATGAAATAAATGAAATAACATAGACCAGGAGGGCGTGGTGTTTAAAAGTCACAGATGGGGCACCCTCGGGCCATCCAGCC
CAGTGTTTTCTTTAGCCCCTATGATGTTCATTTTTTGTTATATCCCATTAGGTGCCCATATTTAAAAATTGGGAGATTTCACATAAAATT
AAAAGGTCTGCATTTTCTTTTTTCTTTTCTTTTTTTTTTTTTTTGAGACACAGTCTCACTCTGTCACCAGGCTAGAGTGCAGTGGCACGA
TCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACGTGCCACC
ACGCCCAGCTAATTTTTGTATTTTTAGCAGAGATGGGGTTTCACCACATTGGCCAGGATGGTCTCGATCTCAACCTCGTGATCCACCCAC
CTCGGTCTCCCAAAGCGCTGGGATTACAGGCGTGAGCCACCGCGCCAAGCCAAGGTCTGCATTTTTCTTTAGAACTCAGAACACCCAATA
GTCCTAGGCCCCCATCCTCGCATGGCAGCAAGCTAAATAAGCATCTTCCCACTGCGAGTTGGGGCATGACCCAGCCTATGGTTTGCCATA
CTCCCTCTTTTTCTCCGTTTTTTCATTAATTGTGAACCTGACCTGCATCACCCTTTCATGTCAGTGCTCTCCAAACCTGCTTGCTTGCAC
CCCTCTAGTCGAAATATTTTGTGCTTACCCCAATATATGTGTGTGACTATTGAACTCTATTCGTAGACTGCTTGTACTAATGTCATTTGC
ATCATAAAATATTCATATCCAATAAACATATTAAAAGGATGAGATAAGAAACCGAGAGATTTTGCTGTTTTTTTCCTTTTGCATGGATGA
GCCAGCTTCACTGTCCTGGGTGGGGCCCAGGTGGAATTAGTTCTCAAAGTCCTCCAGGTGGAGTCAGGGAATGTGCAACAGGGTTGGAGA
AATCACTACTTTAAGTGAATCCGAAAGGTGAGATCACATTTGCTCTAAAGAAATGGTGATCCCAGCACTTTGGGAGGCTGAGGCAGCAGA
TCACTGGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACACGGTGAAACCCCGTCTCTACTGAAAACACAAAAATTAGCTGGGTGTGGTGG
TGTGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGCAAATCGCTTGGCCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCATGC
CACTGCACTCCAGCCTGGGCCACGGAGCGAGAGAAGAAAGAAATGGTGACTTTCATTGATCATGTGTTTGAGGATTTCATGTGCTCTCCA
GGGAGGTTTCAGGTGGGTAGAAGGAGGTGGGCAAGACCCAATAAAAAAGCAGCTGGTGCGGGCAATGACAATGAACTCGTATCCTGCAGG
GTCAAAGGAAGGCTTGCTTCTGCTGTGAATTGGAGAAGGACTTTCCTGGAAGCACAGGCCCAGAAATCGCACCCTTCTCCCCATGTGTGC
GGATAAGGGACCACTTCCATCAGCAGCAGCCCCCTCCTGCTTTCCTGCCAGTCCTCCCTGTGGTCCCAGGTCTCTTGAGAAAAGTGATCT
AAGAGATCCCTTTGCAATGAGGTGCTACTGACTGCCCTACCTCCCTCCCTTCCTCCCATGAATGTTTCTTGGTGCTGACCACAGCCTCAG
CAATGAGGCAAGCCTGGGGACCCAAGACAGATCTCTGCCTCCCAGGCTAGTGGATGCCCTGGGATATGTAGTCACCAAAATAGGAACTTA
CCCCATAGTGGGGAAATAGACAGTAAGCAGCAAATCAATAACAAGAGTGTTCCAGATGGTTGTAAGTGCCAGGAAGGGAACCAACTGGGA
GAGGGACAAGAGGAGATGGTGACTGACCAAGGGGACCTTGATCAGGCTGTGGGGAAGGGAGGTGGTTGGGAAGAGCTTCCCAGGAAAGGG
GACGGCGGGCCCAGGCAGGAGAGCCTTGGGAGGGGGTGCCCAAGGAAGGAAAAGGGCCCTGAGCCTGAAGCCGAGAAGACCAGGAGGGGA
GAAGGGGAGATGTAGGGCAGAGCAGACGGGAGCCGCTCGGGTTTTATTCCACACACCCCAGGAAGCATGAGAGGGTTTCAAGCAGCAAGG
GCATGGAAGTAACTTGGTGAGATATTTTTATGCATTAGATCATCGCTCTATCTGGATTCCAGAGGGTCTCTGAGAGAGCAAACAGCTTAA
TCCAAAGGAGCGGCTTTCCAACTGGGAATGTCCCCCTGGCTGGGTGAGATCTCAAGATGGCCTGCGGCCCCTCTAGATTGCCTGCCTACA
GAGTTCACTCTAAACAGCCCCTCCCCTCCACACCCCAGCAGATCCATTCCTGACGCCCTCACTGGCAGGCTCCAGCCCCACAGAGCTTTC
TAGACATAAAAGAGCAGGGTCATGGCATCATTGGTGACACAATTTTAGTAATAAGCTTCAAAACCCATCACTCCACTGAATCCAGGGATG
CCAGAATTGAGAGTCCATAGGACCCGTTTAACGGATCCCACATTCAGTAGACGGTTTTTTGTATGCTTCGAGGGAAGGAAGGTATTTTCA
AATGCAACTTCTTTTTTTTTTTTCTTGCTCTAGTTAGGGCTGATTTTACCACTGGGCAAATTGCATACATTTGGATCCATGCCACGCTAA
AAACTGTTTATTTTGGAGATCTGTCAGAGGCAAGCACATGGAAGACAAGGGGATTCTGGTTTGAAAAGGCAATTCTCATCCAGACAGATT
CAGATGGAGAGGAGCGGTGTGGATTAAAATGCGCCGAAGTGGTAATGCCGTTTATCCCGTTTGCCTTTGTTACTCTGTGATTAAATGGTA
TTTTTAATTAAGTTTCATTGGGAGCCATAGGTATCGCGGTGGTGAAATCAATTTGACAACCATAAAGGGGAGAGACGGCACAGGCGTGTT
GTGATGATTGCGGCTGTAGGGAAAGCCGGGCAGCTTGCAGAGGATGGGTGGGAGGAGGGGAAGCCGGCTAAGAATGACTTCCTGCAAGAC
AGCAAGGGCACCCCTGGGCCACTGCTGTGTTTGGGAGGCAGGTTTTGGGGGTTGTCAGAAGGCATTCACCTGGTTCTCTCGCTCACCTGA
GACACCCGATAGATTCCTGGAAACTCCAGGAAAGTATCTGAAGATCTGGTTCTCCATTCTCTCTTATTAACAAGGAGAACCACAAGTGCC
CCCCAGATCCCGGCTAGAAGGACCAGACAGCTTTCCACCCCGGTTCCCAGGCAGCCCTGCTCCCATAGTCCTGTGTCCCATCGGCCCCAT
GCTCCCAGGACAGTCCTAATTCCCACCTCTCAGAACCTTGTCAGCCAAGTTCTTCCTGCTCTCTGGCCCAAATCCTCCTCCTACATTGGA
AACTGAGCCTCTCTGCATCCTCTGCTCTTTCTATCCCGCTGTCATTCATCAGATTTTCCAAATCTTTGGATTCCTGAGTGGCAGAAGAGG
TTTTCTGAGTTTAAGTTCTGATTCTGTGTGTGATTCTCACTCTACCACCTCTTCAAACCTTTGTTGTCTTATCTACAAAATAGAATAGTA
GTAATCCATCACCTAAGGTTGTTGTGAAGGTTCAATAAGTTAATGCGTATTTAAAATGCCTCCCACAGTACCTGACATATACTGGGCTTC
AGTGAGGTACTAGCTATTATTATTAACCAAGTTTCCTGTGGTAACAGTTGTAGCTTTGTGACTGGGCCAAATCACTTAACCCCTCTGCGC
TCCAGTCTTTGTTTCTATAATGGGGATGATGATAATGCCTAGCTCATTGGATTGTTCTGTCCCCTACGATCAGCCATGTTAAGTGATTCA
TATCATGTCTGGTACTTAAAAATCACGCCACGCATGTACATTATTATGATGAAAAATATGATCCGTGATATCCTGACCAAAATATTAAAG
GGACTAAAGATAGCTGTGGCTTGTTCAAGAAGAATATTGTGTCACTATCCCATATATTATCCCATTTGCTCTTCACAGCTTCCATTTTTC
GCTAGGCGGATGGCATGGAACTTTTTATAAATGAGATATTATGAAAAATGATGTTTTAGGACTCTCATTTCTACAGTGGGAGTAGGTCAC
CCATTGCAATTTTGGATTTGCTTAAAAAAATTCTTGCCATCACCTTCTAATGGATGATCTGTGTACAACAATTGTTTATTGACTCTGAAT
GTCTAAGTACCAGGGTCAGTCTATTTCAAGGGGAGGGAAGCATTAATTAACCTCCAGCATTAGATTCAGTGATTCTTTTCCAATGATGCA
GTTCATGACTTTGCTCGCATTTACTTTTCATCAATCCTGAAAGAATTGAGGTAAAATAGTTCCTCTGCACATGTGTGTCAAGCTAAATGG
ATAACAGCAGATACAGATCTGTTTGCCTGTCTGCACTTGCCTTTAGACAAAATTCATCAATTTTACAAAAGCCACTGACTAAACATGGCA
CCAATACAAATGAAGCACTTCTAGCAGGCGGAGATTCCCTTTGTTTCTGATCTGGTAAATGCGGTAGTTTCCTGCTGAGAGATGGGAAGT
GCTGGCCTAGGACAGCAAGGTGCCCTACAGGTGGGGCCAAAAGGGTCAAGACCGTTCTACAGGAAGTTTAGGAGAAGTTCAATGGTTCCA
GATCCTGTGTGCTTCGGGTAATTCTGACCCTCTTCATTAGTGATAATGGCATGAAGCTCTTTCACACAGTCTTTTTTTTTTTTCTTTTTT
TTTTTCAGACAGGGTCTCACCCTGTCACGTAGGCTGGAGTGCAGTGGTGAGATCACGGCTCACTGCAGCCTCGACTTCATGGGCTCAAGC
GATTCTCCTGCCTCAGCCTCCTAAGTAGTCGGGATCATAGGCACTTGCCACCACATCCGGCTAATTTTTTTGTAGAGACAGGATTTCACC
ACATTACACAGGCTGGTTTCAAACTCCGAGGCTCAAGTGATCTGCCTGCATCGGCCTCCCAAAGCGCTGAGATTACAAGCGTGAGCCACT
ACGCCTTGCCCTCCACACAGCCTTGCTTGGTGTTAAAGATTAAACAAAGACCACAGGTGATCACTGTCTTCGTGGTGCCAGTTTCAAGGG
CACCCTTCTTCCCTTCCCAGCCTCCGAGAGAAGGAGAGAGGGTCCACAAGCCAGATCCATCCCCATCCACACAGGTAAAACCACGACTGT
GCAGCTAGCAGGTGGAGATAACATTTGGAAAAAGGCTTTGTAAATGCTAAAGTCCTACTCAAGTCCAAGGGAGAGAAATTATTATTATTC
GTTTTGTGAAACCAATTTAGTTTGGCTGGGTAATGGAAGAATTTCTACATACATTCATTACTTCTGATCAGGCAAGACCAGTCTGACACA
GGAACAGTCTATGGCTCACTCTTAAAGCCACAGCAGGCTGCCAGGGCTTGGAGAAATAGAAACCTCTCTTGCACAAGAATAGTCTCAATG
AATCATGTTAAGGCCTCTTTAGGTTTTTCAGACTCCATGCACCCTGTGGAAACTGCCTTTCTTGAGTAGAGGTACGTTCAGCACTTCATA
AAATAATCTTGGAGCCTCCAGACACACGGATGGAGGAGCATGATTTCATTTGTTTCTTTGCAAAACTGCTGTCCCCAACTGAAAAACCTG
ATTATCCTTTCAAATAGGGAATTCGGCTTTCCACGTTGGAACCAGAACAGTTAACCTTCAAACCCCCAAGGCTTGCAAGAGATGAATCAG
TTTCTCAGACAGCCAAAGCCGTGGCTTATAACTCATCCAACCCAGAAAACTGGACCGCTGGTCACCTTCCTTCCCCCTGCCCCCAACTCT
GCAGACAGAGGTTTCCCGTTGATTATGCCTTGATTAGAGTCAGGAGAGAAGCAAACCAGGTATATAGGATTCCATTATCCTTCCCTCCTC
TGCTCCCAACCAGGGTCACGCTGAGAGGGATCTCGGTGAACATGTGAACAATCAAGCCATGTTTACCATGGACGTTTAGTTTTCTTTTCT
CAAAATCAAAACAGAGTTTAGTAGGCAGCGTATTTCATACATGCCCCTTGATCAATGGAATGATCTGTCAGAAGCCATTAAAGCCCCCAT
TAGCTTGAATGCATTCAAAGCTAAACTATTGGATCATTTAAGGGCTGCAGTGATTGTTTTTAATATACCGTACATTGATTTCTCCCTGTG
AGCAGCAACATAAGTTTGAAACTAACTGTGTATGACTAAGGCTCCATTTGCTGTCTCCAACCCTCTGTGAGAAGCATGGTTTCACTTCGA
CCAGAAATGTCTGTGTATAGTTTTCAAAGAGATGCAGACCCTGTTCGATTTCCCAAGATTTAGACTGGGTCGGGTTGTTATTTCTTTTTT
CCCTGAGCTTTCTCCCATTTCTTTGTGCCCATTAAGTGAGCTGTGCGTGCAGAATGGGAGAGGCATCCCTGCCAAGGACTTCAAGTGAAA
GGCGGTGGGAGAAATTGTTCTGAAAGCATGAAGCCCAGCTGAGGCCAAAATCAAAGTGAATTTGACAGCCTTGGGCCAGCAAAACTCTGT
ACCCAGCAGAAAACAATAGATGTGTGGCTGTGTCAGGGGCATCCTCACTGGGACATAGCTTGGGGAGCTGAAGGTACCTTGGAAGGGCCA
GATGAGGAAGCTAGCCAAGGCCACAGGCCTTCCTTTGACTGCCATATTGCCAGCTCTTCATAGTATTGACTCTTCAGTCTTAGCCAACAC
ACACTTGTTGATTCCTTCCGGAATGTCAGACTCTGCTAGCAACACAAGGTCCCTGTCCTCAAAATCCTATTCTTAATCAGCATTTCTAAT
TTCTGCCCTTTGCTCATTTTAATACAGAGCCTGAGGATAGGAGAGCAGCGTGGTGAAAGAAGCAATAGTTACCACATTTGCAAAGGCACA
TACCCCAAAGAGAAGTTTTTAATATGTCACACCCATATTTTATAGATGGGGCAATGGAAGTCCAGATGGGAGAAGTTATTTCAGGTGAAT
TATAGAAACTGGATTTCAAGTTTCTGATAAGTATTGAATTTGGGAAGGCTGTGAACATTCTTGAGCCCCCCTCCCAAGTTCACCTTCAAC
ATCCTAAAGCAGGTTGAAGAGGAAGATGGTTCCAGGTCACTTACAAGAACAGGAACAGCCCCTCCCTCCAAATTTGAGCCCAGAAAGGAG
AACCTTTGTTACTCTAGAAAACAGTGTGTGTGCTATTGTTTTCTCCATAGGTCACAAACATCCACAAGATATTGGTGATTTTACATATTA
TTAGAGCCACTGAAATTTATGATGCAGGATATTAACGTCAAAGAGGCCAAGATGCATCATTCAGAACACTGGCAGGTCAAGCAGAAACCA
CCGTAGTAAAATTGAAAGCTGGAGTCAGCAAAGTATAGCCCACAGCCAAATCTGGCCCATCCCCTGTTCTTATAAAGTTTTATTGGAACG
CAGCCATGCTCATCGGTTTATGTATTATCTATGGCTGTTTCCAACTACAGTGGCAGAGCTGAATAGTTGCAAAGGACCATAGGGCTATCA
AAGCCCCAAATAGTCATTGTCTGACCCTTCATAGAAAAATTTTGCTGAACTGTAGTCTAGCTCCAAGGATTGTTGTATCACCTGTGATCG
TGCCTATTAAGCAATTAACGTCATGTCTAGTACTTAGTAATGACTCAGCATGTATCAATTACGATGATAAATATTATCATGGCATCCAAA
CCAAAATACTCATGCCAACATCTCTCTGTACAGAAACATGGAAAAAGAGCGATGCTATTAAGGAGGAAAATGGAGCCAGGAGCAAAACCT
AAGGCTATTTCTGAACTAAAGAGGCCTGAATAAGGTAGTGAAAGGACCAGGGAAAGCCTTCCCACGGGGATGGAGAGCCACCTCCTCCCC
GGCTTTCTGGTTCAGATGTCTTGTCTCAACAGACGGCAGATTCGCAGGGAAGCAGGCCGAGCCTGATCTTTTCTCCGCTAGAACTGCTCA
ACAGGTGAAGAATCTTTTTCCAGCACTCCTGAGCCCTTCGGGTCGCGGAACAGTGCGAAGATTATTCCAATGCCTCATTCGGAGAGGTGA
TAATCTGGTCTGTGGTTTCTTTTTCGGTGGGGCATGGGGTGGGGGTGAGTGTCATGCTTTCTAAGGCACAGGGCTGACTAAAGGGTGTCC
TATTTATAAGTCAGTAAAACACAGCGGCTTCATACTCTGTGCTTATTACCCAGAAGCCCCGGCTCTTAGAGTTTCTATTAAGATGTACCT


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FusionGenePPI for ACTN4_FTO


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACTN4MYOZ2, MYOZ1, PDLIM1, USP6NL, SLC9A3R2, COL17A1, TRIM3, MAGI1, GSN, CAMK2A, CAMK2B, INO80, UBTF, STAT1, HDAC7, MEF2A, UCHL5, TJP1, ATXN7, HDAC5, VDR, ESR1, PSMA3, ELAVL1, SIRT7, SLC2A4, ISG15, COIL, SACS, HGS, UBASH3B, SHC1, NOS3, ACTN2, ACTN1, FMNL1, TRAF3IP1, FN1, VCAM1, CDH1, ITGA4, SVIL, CD81, IGSF8, ICAM1, TXN, RPS27, POT1, KPNA2, MAPK7, CDKN2A, VCP, SF3A3, GNB2, HUWE1, ACTN3, BMP7, ALK, CUL7, OBSL1, CCDC8, EGFR, LUZP4, RARA, HSPB1, AHNAK, ALDOA, ALDOC, IDH3A, MYH15, MYH2, MYH7B, NCAPG2, PSMA6, PSMB5, PUS7, TPM2, TSG101, CKB, CYC1, ECSIT, MCFD2, PSMB8, TPM1, TPM3, TPM4, NTRK1, CAPZA2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, PDLIM7, SYNPO, MAPRE1, SIN3B, MYEF2, LIMA1, ANLN, MYO5C, MYO19, MYO18A, CTNNB1, MCM2, NFYA, CDC73, DDIAS, SSH1, NCL, DLD, DNM1L, PDHA1, SOD1, TRIM25, TESFTOBCCIP, CKB, CNDP2, DAK, EEF2, PEPD, CTSA, LDHA, LDHB, MVD, NDRG1, NPEPPS, SLC9A3R1, ZMAT3, SBF2, GPX7, MPZL1, ZNF232, FSD1, FGB, NFYA, OR5F1, ALX3, DIRAS2, TYW3, SDC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneACTN4chr19:39138547chr16:53844052ENST00000252699+12112_2654912VCL
HgeneACTN4chr19:39138547chr16:53844052ENST00000390009+11412_2654693VCL


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneACTN4chr19:39138547chr16:53844052ENST00000252699+121108_12654912VCL
HgeneACTN4chr19:39138547chr16:53844052ENST00000252699+12140_6154912VCL
HgeneACTN4chr19:39138547chr16:53844052ENST00000390009+114108_12654693VCL
HgeneACTN4chr19:39138547chr16:53844052ENST00000390009+11440_6154693VCL


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACTN4_FTO


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFTOQ9C0B1DB11638ArtenimolAlpha-ketoglutarate-dependent dioxygenase FTOsmall moleculeapproved|investigational

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RelatedDiseases for ACTN4_FTO


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACTN4C0333497Segmental glomerulosclerosis3UNIPROT
HgeneACTN4C0024667Animal Mammary Neoplasms1CTD_human
HgeneACTN4C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneFTOC0028754Obesity6CTD_human
TgeneFTOC0001973Alcoholic Intoxication, Chronic3PSYGENET
TgeneFTOC0011581Depressive disorder3PSYGENET
TgeneFTOC2752001Growth Retardation, Developmental Delay, Coarse Facies, And Early Death3CTD_human;ORPHANET;UNIPROT
TgeneFTOC0005910Body Weight2CTD_human
TgeneFTOC0011570Mental Depression2PSYGENET
TgeneFTOC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneFTOC0025202melanoma1CTD_human
TgeneFTOC0043094Weight Gain1CTD_human
TgeneFTOC0525045Mood Disorders1PSYGENET
TgeneFTOC1458155Mammary Neoplasms1CTD_human
TgeneFTOC2362324Pediatric Obesity1CTD_human