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Fusion gene ID: 5902 |
FusionGeneSummary for CCDC73_SEMA4G |
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Fusion gene information | Fusion gene name: CCDC73_SEMA4G | Fusion gene ID: 5902 | Hgene | Tgene | Gene symbol | CCDC73 | SEMA4G | Gene ID | 493860 | 57715 |
Gene name | coiled-coil domain containing 73 | semaphorin 4G | |
Synonyms | NY-SAR-79 | - | |
Cytomap | 11p13 | 10q24.31 | |
Type of gene | protein-coding | protein-coding | |
Description | coiled-coil domain-containing protein 73sarcoma antigen NY-SAR-79 | semaphorin-4Gsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q6ZRK6 | Q9NTN9 | |
Ensembl transtripts involved in fusion gene | ENST00000335185, ENST00000534415, ENST00000531481, | ENST00000370250, ENST00000517724, ENST00000210633, ENST00000519756, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 4 X 2=32 |
# samples | 3 | 4 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CCDC73 [Title/Abstract] AND SEMA4G [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ012806 | CCDC73 | chr11 | 32802235 | - | SEMA4G | chr10 | 102741133 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000335185 | ENST00000370250 | CCDC73 | chr11 | 32802235 | - | SEMA4G | chr10 | 102741133 | + |
intron-intron | ENST00000335185 | ENST00000517724 | CCDC73 | chr11 | 32802235 | - | SEMA4G | chr10 | 102741133 | + |
intron-intron | ENST00000335185 | ENST00000210633 | CCDC73 | chr11 | 32802235 | - | SEMA4G | chr10 | 102741133 | + |
intron-intron | ENST00000335185 | ENST00000519756 | CCDC73 | chr11 | 32802235 | - | SEMA4G | chr10 | 102741133 | + |
intron-intron | ENST00000534415 | ENST00000370250 | CCDC73 | chr11 | 32802235 | - | SEMA4G | chr10 | 102741133 | + |
intron-intron | ENST00000534415 | ENST00000517724 | CCDC73 | chr11 | 32802235 | - | SEMA4G | chr10 | 102741133 | + |
intron-intron | ENST00000534415 | ENST00000210633 | CCDC73 | chr11 | 32802235 | - | SEMA4G | chr10 | 102741133 | + |
intron-intron | ENST00000534415 | ENST00000519756 | CCDC73 | chr11 | 32802235 | - | SEMA4G | chr10 | 102741133 | + |
intron-intron | ENST00000531481 | ENST00000370250 | CCDC73 | chr11 | 32802235 | - | SEMA4G | chr10 | 102741133 | + |
intron-intron | ENST00000531481 | ENST00000517724 | CCDC73 | chr11 | 32802235 | - | SEMA4G | chr10 | 102741133 | + |
intron-intron | ENST00000531481 | ENST00000210633 | CCDC73 | chr11 | 32802235 | - | SEMA4G | chr10 | 102741133 | + |
intron-intron | ENST00000531481 | ENST00000519756 | CCDC73 | chr11 | 32802235 | - | SEMA4G | chr10 | 102741133 | + |
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FusionProtFeatures for CCDC73_SEMA4G |
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Hgene | Tgene |
CCDC73 | SEMA4G |
Cell surface receptor for PLXNB2. May play a role inaxon guidance (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CCDC73_SEMA4G |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CCDC73_SEMA4G |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CCDC73_SEMA4G |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCDC73_SEMA4G |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |