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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5900

FusionGeneSummary for CCDC71_TTC3

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC71_TTC3
Fusion gene ID: 5900
HgeneTgene
Gene symbol

CCDC71

TTC3

Gene ID

64925

7267

Gene namecoiled-coil domain containing 71tetratricopeptide repeat domain 3
Synonyms-DCRR1|RNF105|TPRDIII
Cytomap

3p21.31

21q22.13

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 712600016J21RikE3 ubiquitin-protein ligase TTC3RING finger protein 105RING-type E3 ubiquitin transferase TTC3TPR repeat protein 3TPR repeat protein Dtetratricopeptide repeat protein 3
Modification date2018051920180522
UniProtAcc

Q8IV32

P53804

Ensembl transtripts involved in fusion geneENST00000321895, ENST00000355666, 
ENST00000399017, ENST00000354749, 
ENST00000479930, ENST00000540756, 
ENST00000399010, 
Fusion gene scores* DoF score1 X 1 X 1=19 X 12 X 7=756
# samples 114
** MAII scorelog2(1/1*10)=3.32192809488736log2(14/756*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCDC71 [Title/Abstract] AND TTC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTTC3

GO:0006511

ubiquitin-dependent protein catabolic process

20059950

TgeneTTC3

GO:0070936

protein K48-linked ubiquitination

20059950


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU688294CCDC71chr3

49200054

+TTC3chr21

38538111

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000321895ENST00000355666CCDC71chr3

49200054

+TTC3chr21

38538111

-
intron-3CDSENST00000321895ENST00000399017CCDC71chr3

49200054

+TTC3chr21

38538111

-
intron-3CDSENST00000321895ENST00000354749CCDC71chr3

49200054

+TTC3chr21

38538111

-
intron-3UTRENST00000321895ENST00000479930CCDC71chr3

49200054

+TTC3chr21

38538111

-
intron-intronENST00000321895ENST00000540756CCDC71chr3

49200054

+TTC3chr21

38538111

-
intron-intronENST00000321895ENST00000399010CCDC71chr3

49200054

+TTC3chr21

38538111

-

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FusionProtFeatures for CCDC71_TTC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC71

Q8IV32

TTC3

P53804


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCDC71_TTC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCDC71_TTC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCDC71H3F3A, EED, RBBP7, HDAC1TTC3AKT1, AKT2, AKT3, UBE3A, UBC, UBE2D2, HSPB1, CSNK2A2, RAB5C, FGFR1OP, WAPAL, PARD6A, SMC6, KIF18A, DSN1, KRBOX4, DYNC2LI1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCDC71_TTC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCDC71_TTC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource