	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 59

FusionGeneSummary for AASDH_AASDH

Fusion gene summary

Fusion gene information	Fusion gene name: AASDH_AASDH
	Fusion gene ID: 59
		Hgene	Tgene
	Gene symbol	AASDH	AASDH
	Gene ID	132949	132949
	Gene name	aminoadipate-semialdehyde dehydrogenase	aminoadipate-semialdehyde dehydrogenase
	Synonyms	ACSF4\|LYS2\|NRPS1098\|NRPS998	ACSF4\|LYS2\|NRPS1098\|NRPS998
	Cytomap	4q12	4q12
	Type of gene	protein-coding	protein-coding
	Description	beta-alanine-activating enzyme2-aminoadipic 6-semialdehyde dehydrogenaseacyl-CoA synthetase family member 4non-ribosomal peptide synthetase 1098non-ribosomal peptide synthetase 998	beta-alanine-activating enzyme2-aminoadipic 6-semialdehyde dehydrogenaseacyl-CoA synthetase family member 4non-ribosomal peptide synthetase 1098non-ribosomal peptide synthetase 998
	Modification date	20180519	20180519
	UniProtAcc	Q4L235	Q4L235
	Ensembl transtripts involved in fusion gene	ENST00000513376, ENST00000205214, ENST00000434343, ENST00000451613, ENST00000602986, ENST00000502617, ENST00000510762,	ENST00000513376, ENST00000205214, ENST00000434343, ENST00000451613, ENST00000602986, ENST00000502617, ENST00000510762,
Fusion gene scores	* DoF score	5 X 5 X 3=75	1 X 1 X 1=1
	# samples	5	1
	** MAII score	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: AASDH [Title/Abstract] AND AASDH [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AA731353	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000513376	ENST00000513376	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000513376	ENST00000205214	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000513376	ENST00000434343	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000513376	ENST00000451613	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000513376	ENST00000602986	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000513376	ENST00000502617	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000513376	ENST00000510762	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000205214	ENST00000513376	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000205214	ENST00000205214	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000205214	ENST00000434343	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000205214	ENST00000451613	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000205214	ENST00000602986	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000205214	ENST00000502617	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000205214	ENST00000510762	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000434343	ENST00000513376	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000434343	ENST00000205214	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000434343	ENST00000434343	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000434343	ENST00000451613	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000434343	ENST00000602986	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000434343	ENST00000502617	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000434343	ENST00000510762	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000451613	ENST00000513376	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000451613	ENST00000205214	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000451613	ENST00000434343	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000451613	ENST00000451613	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000451613	ENST00000602986	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000451613	ENST00000502617	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000451613	ENST00000510762	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000602986	ENST00000513376	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000602986	ENST00000205214	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000602986	ENST00000434343	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000602986	ENST00000451613	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000602986	ENST00000602986	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000602986	ENST00000502617	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000602986	ENST00000510762	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000502617	ENST00000513376	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000502617	ENST00000205214	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000502617	ENST00000434343	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000502617	ENST00000451613	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000502617	ENST00000602986	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000502617	ENST00000502617	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000502617	ENST00000510762	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000510762	ENST00000513376	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000510762	ENST00000205214	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000510762	ENST00000434343	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000510762	ENST00000451613	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000510762	ENST00000602986	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000510762	ENST00000502617	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+
intron-intron	ENST00000510762	ENST00000510762	AASDH	chr4	57252172	+	AASDH	chr4	57249807	+

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FusionProtFeatures for AASDH_AASDH

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AASDH Q4L235	AASDH Q4L235

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for AASDH_AASDH

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AASDH_AASDH

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for AASDH_AASDH

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for AASDH_AASDH

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 59

FusionGeneSummary for AASDH_AASDH

FusionProtFeatures for AASDH_AASDH

FusionGeneSequence for AASDH_AASDH

FusionGenePPI for AASDH_AASDH

RelatedDrugs for AASDH_AASDH

RelatedDiseases for AASDH_AASDH