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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 589

FusionGeneSummary for ACTN4_EIF3K

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTN4_EIF3K
Fusion gene ID: 589
HgeneTgene
Gene symbol

ACTN4

EIF3K

Gene ID

81

27335

Gene nameactinin alpha 4eukaryotic translation initiation factor 3 subunit K
SynonymsACTININ-4|FSGS|FSGS1ARG134|EIF3-p28|EIF3S12|HSPC029|M9|MSTP001|PLAC-24|PLAC24|PRO1474|PTD001
Cytomap

19q13.2

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionalpha-actinin-4focal segmental glomerulosclerosis 1non-muscle alpha-actinin 4eukaryotic translation initiation factor 3 subunit KeIF-3 p28eukaryotic translation initiation factor 3, subunit 12muscle specificmuscle-specific gene M9 protein
Modification date2018052220180523
UniProtAcc

O43707

Q9UBQ5

Ensembl transtripts involved in fusion geneENST00000252699, ENST00000424234, 
ENST00000390009, ENST00000497637, 
ENST00000593149, ENST00000248342, 
ENST00000593062, ENST00000538434, 
ENST00000588934, ENST00000545173, 
ENST00000592558, 
Fusion gene scores* DoF score28 X 17 X 13=61884 X 5 X 6=120
# samples 307
** MAII scorelog2(30/6188*10)=-4.36643879095316
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACTN4 [Title/Abstract] AND EIF3K [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACTN4

GO:0035357

peroxisome proliferator activated receptor signaling pathway

22351778

HgeneACTN4

GO:0048384

retinoic acid receptor signaling pathway

22351778

HgeneACTN4

GO:0051272

positive regulation of cellular component movement

9508771

TgeneEIF3K

GO:0006413

translational initiation

17581632


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-E7-A541-01AACTN4chr19

39138547

+EIF3Kchr19

39123070

+
TCGARVLUSCTCGA-63-A5MM-01AACTN4chr19

39138547

+EIF3Kchr19

39123070

+
TCGARVSARCTCGA-HS-A5N8-01AACTN4chr19

39138547

+EIF3Kchr19

39116668

+
TCGARVSKCMTCGA-GN-A268-06AACTN4chr19

39138547

+EIF3Kchr19

39125633

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000252699ENST00000593149ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
In-frameENST00000252699ENST00000248342ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
5CDS-intronENST00000252699ENST00000593062ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
5CDS-intronENST00000252699ENST00000538434ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
5CDS-intronENST00000252699ENST00000588934ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
5CDS-intronENST00000252699ENST00000545173ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
5CDS-intronENST00000252699ENST00000592558ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
In-frameENST00000424234ENST00000593149ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
In-frameENST00000424234ENST00000248342ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
5CDS-intronENST00000424234ENST00000593062ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
5CDS-intronENST00000424234ENST00000538434ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
5CDS-intronENST00000424234ENST00000588934ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
5CDS-intronENST00000424234ENST00000545173ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
5CDS-intronENST00000424234ENST00000592558ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
In-frameENST00000390009ENST00000593149ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
In-frameENST00000390009ENST00000248342ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
5CDS-intronENST00000390009ENST00000593062ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
5CDS-intronENST00000390009ENST00000538434ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
5CDS-intronENST00000390009ENST00000588934ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
5CDS-intronENST00000390009ENST00000545173ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
5CDS-intronENST00000390009ENST00000592558ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
intron-3CDSENST00000497637ENST00000593149ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
intron-3CDSENST00000497637ENST00000248342ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
intron-intronENST00000497637ENST00000593062ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
intron-intronENST00000497637ENST00000538434ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
intron-intronENST00000497637ENST00000588934ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
intron-intronENST00000497637ENST00000545173ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
intron-intronENST00000497637ENST00000592558ACTN4chr19

39138547

+EIF3Kchr19

39123070

+
In-frameENST00000252699ENST00000593149ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
In-frameENST00000252699ENST00000248342ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
5CDS-3UTRENST00000252699ENST00000593062ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
5CDS-3UTRENST00000252699ENST00000538434ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
5CDS-3UTRENST00000252699ENST00000588934ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
5CDS-3UTRENST00000252699ENST00000545173ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
5CDS-3UTRENST00000252699ENST00000592558ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
In-frameENST00000424234ENST00000593149ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
In-frameENST00000424234ENST00000248342ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
5CDS-3UTRENST00000424234ENST00000593062ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
5CDS-3UTRENST00000424234ENST00000538434ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
5CDS-3UTRENST00000424234ENST00000588934ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
5CDS-3UTRENST00000424234ENST00000545173ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
5CDS-3UTRENST00000424234ENST00000592558ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
In-frameENST00000390009ENST00000593149ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
In-frameENST00000390009ENST00000248342ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
5CDS-3UTRENST00000390009ENST00000593062ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
5CDS-3UTRENST00000390009ENST00000538434ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
5CDS-3UTRENST00000390009ENST00000588934ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
5CDS-3UTRENST00000390009ENST00000545173ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
5CDS-3UTRENST00000390009ENST00000592558ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
intron-3CDSENST00000497637ENST00000593149ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
intron-3CDSENST00000497637ENST00000248342ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
intron-3UTRENST00000497637ENST00000593062ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
intron-3UTRENST00000497637ENST00000538434ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
intron-3UTRENST00000497637ENST00000588934ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
intron-3UTRENST00000497637ENST00000545173ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
intron-3UTRENST00000497637ENST00000592558ACTN4chr19

39138547

+EIF3Kchr19

39116668

+
Frame-shiftENST00000252699ENST00000593149ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
Frame-shiftENST00000252699ENST00000248342ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
5CDS-intronENST00000252699ENST00000593062ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
5CDS-intronENST00000252699ENST00000538434ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
5CDS-intronENST00000252699ENST00000588934ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
5CDS-intronENST00000252699ENST00000545173ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
5CDS-intronENST00000252699ENST00000592558ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
Frame-shiftENST00000424234ENST00000593149ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
Frame-shiftENST00000424234ENST00000248342ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
5CDS-intronENST00000424234ENST00000593062ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
5CDS-intronENST00000424234ENST00000538434ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
5CDS-intronENST00000424234ENST00000588934ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
5CDS-intronENST00000424234ENST00000545173ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
5CDS-intronENST00000424234ENST00000592558ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
Frame-shiftENST00000390009ENST00000593149ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
Frame-shiftENST00000390009ENST00000248342ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
5CDS-intronENST00000390009ENST00000593062ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
5CDS-intronENST00000390009ENST00000538434ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
5CDS-intronENST00000390009ENST00000588934ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
5CDS-intronENST00000390009ENST00000545173ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
5CDS-intronENST00000390009ENST00000592558ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
intron-3CDSENST00000497637ENST00000593149ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
intron-3CDSENST00000497637ENST00000248342ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
intron-intronENST00000497637ENST00000593062ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
intron-intronENST00000497637ENST00000538434ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
intron-intronENST00000497637ENST00000588934ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
intron-intronENST00000497637ENST00000545173ACTN4chr19

39138547

+EIF3Kchr19

39125633

+
intron-intronENST00000497637ENST00000592558ACTN4chr19

39138547

+EIF3Kchr19

39125633

+

Top

FusionProtFeatures for ACTN4_EIF3K


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTN4

O43707

EIF3K

Q9UBQ5

F-actin cross-linking protein which is thought to anchoractin to a variety of intracellular structures. This is a bundlingprotein (Probable). Probably involved in vesicular trafficking viaits association with the CART complex. The CART complex isnecessary for efficient transferrin receptor recycling but not forEGFR degradation (PubMed:15772161). Involved in tight junctionassembly in epithelial cells probably through interaction withMICALL2. Links MICALL2 to the actin cytoskeleton and recruits itto the tight junctions (By similarity). May also function as atranscriptional coactivator, stimulating transcription mediated bythe nuclear hormone receptors PPARG and RARA (PubMed:22351778).{ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161,ECO:0000269|PubMed:22351778, ECO:0000305|PubMed:9508771}. Component of the eukaryotic translation initiationfactor 3 (eIF-3) complex, which is required for several steps inthe initiation of protein synthesis (PubMed:17581632,PubMed:25849773, PubMed:27462815). The eIF-3 complex associateswith the 40S ribosome and facilitates the recruitment of eIF-1,eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNArecruitment to the 43S PIC and scanning of the mRNA for AUGrecognition. The eIF-3 complex is also required for disassemblyand recycling of post-termination ribosomal complexes andsubsequently prevents premature joining of the 40S and 60Sribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of asubset of mRNAs involved in cell proliferation, including cellcycling, differentiation and apoptosis, and uses different modesof RNA stem-loop binding to exert either translational activationor repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03010,ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773,ECO:0000269|PubMed:27462815}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTN4chr19:39138547chr19:39116668ENST00000252699+12119_2654912Compositional biasPoly-Gly
HgeneACTN4chr19:39138547chr19:39116668ENST00000390009+11419_2654693Compositional biasPoly-Gly
HgeneACTN4chr19:39138547chr19:39123070ENST00000252699+12119_2654912Compositional biasPoly-Gly
HgeneACTN4chr19:39138547chr19:39123070ENST00000390009+11419_2654693Compositional biasPoly-Gly

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTN4chr19:39138547chr19:39116668ENST00000252699+121778_78954912Calcium binding1
HgeneACTN4chr19:39138547chr19:39116668ENST00000252699+121819_83054912Calcium binding2
HgeneACTN4chr19:39138547chr19:39116668ENST00000390009+114778_78954693Calcium binding1
HgeneACTN4chr19:39138547chr19:39116668ENST00000390009+114819_83054693Calcium binding2
HgeneACTN4chr19:39138547chr19:39123070ENST00000252699+121778_78954912Calcium binding1
HgeneACTN4chr19:39138547chr19:39123070ENST00000252699+121819_83054912Calcium binding2
HgeneACTN4chr19:39138547chr19:39123070ENST00000390009+114778_78954693Calcium binding1
HgeneACTN4chr19:39138547chr19:39123070ENST00000390009+114819_83054693Calcium binding2
HgeneACTN4chr19:39138547chr19:39116668ENST00000252699+121163_26954912DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr19:39116668ENST00000252699+12150_15454912DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr19:39116668ENST00000252699+121765_80054912DomainEF-hand 1
HgeneACTN4chr19:39138547chr19:39116668ENST00000252699+121806_84154912DomainEF-hand 2
HgeneACTN4chr19:39138547chr19:39116668ENST00000390009+114163_26954693DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr19:39116668ENST00000390009+11450_15454693DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr19:39116668ENST00000390009+114765_80054693DomainEF-hand 1
HgeneACTN4chr19:39138547chr19:39116668ENST00000390009+114806_84154693DomainEF-hand 2
HgeneACTN4chr19:39138547chr19:39123070ENST00000252699+121163_26954912DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr19:39123070ENST00000252699+12150_15454912DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr19:39123070ENST00000252699+121765_80054912DomainEF-hand 1
HgeneACTN4chr19:39138547chr19:39123070ENST00000252699+121806_84154912DomainEF-hand 2
HgeneACTN4chr19:39138547chr19:39123070ENST00000390009+114163_26954693DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr19:39123070ENST00000390009+11450_15454693DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr19:39123070ENST00000390009+114765_80054693DomainEF-hand 1
HgeneACTN4chr19:39138547chr19:39123070ENST00000390009+114806_84154693DomainEF-hand 2
HgeneACTN4chr19:39138547chr19:39116668ENST00000252699+12184_8854912MotifLXXLL motif
HgeneACTN4chr19:39138547chr19:39116668ENST00000390009+11484_8854693MotifLXXLL motif
HgeneACTN4chr19:39138547chr19:39123070ENST00000252699+12184_8854912MotifLXXLL motif
HgeneACTN4chr19:39138547chr19:39123070ENST00000390009+11484_8854693MotifLXXLL motif
HgeneACTN4chr19:39138547chr19:39116668ENST00000252699+121177_19254912RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr19:39116668ENST00000252699+1211_26954912RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr19:39116668ENST00000390009+114177_19254693RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr19:39116668ENST00000390009+1141_26954693RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr19:39123070ENST00000252699+121177_19254912RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr19:39123070ENST00000252699+1211_26954912RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr19:39123070ENST00000390009+114177_19254693RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr19:39123070ENST00000390009+1141_26954693RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr19:39116668ENST00000252699+121293_40354912RepeatSpectrin 1
HgeneACTN4chr19:39138547chr19:39116668ENST00000252699+121413_51854912RepeatSpectrin 2
HgeneACTN4chr19:39138547chr19:39116668ENST00000252699+121528_63954912RepeatSpectrin 3
HgeneACTN4chr19:39138547chr19:39116668ENST00000252699+121649_75254912RepeatSpectrin 4
HgeneACTN4chr19:39138547chr19:39116668ENST00000390009+114293_40354693RepeatSpectrin 1
HgeneACTN4chr19:39138547chr19:39116668ENST00000390009+114413_51854693RepeatSpectrin 2
HgeneACTN4chr19:39138547chr19:39116668ENST00000390009+114528_63954693RepeatSpectrin 3
HgeneACTN4chr19:39138547chr19:39116668ENST00000390009+114649_75254693RepeatSpectrin 4
HgeneACTN4chr19:39138547chr19:39123070ENST00000252699+121293_40354912RepeatSpectrin 1
HgeneACTN4chr19:39138547chr19:39123070ENST00000252699+121413_51854912RepeatSpectrin 2
HgeneACTN4chr19:39138547chr19:39123070ENST00000252699+121528_63954912RepeatSpectrin 3
HgeneACTN4chr19:39138547chr19:39123070ENST00000252699+121649_75254912RepeatSpectrin 4
HgeneACTN4chr19:39138547chr19:39123070ENST00000390009+114293_40354693RepeatSpectrin 1
HgeneACTN4chr19:39138547chr19:39123070ENST00000390009+114413_51854693RepeatSpectrin 2
HgeneACTN4chr19:39138547chr19:39123070ENST00000390009+114528_63954693RepeatSpectrin 3
HgeneACTN4chr19:39138547chr19:39123070ENST00000390009+114649_75254693RepeatSpectrin 4
TgeneEIF3Kchr19:39138547chr19:39116668ENST00000248342+2842_20493219DomainPCI
TgeneEIF3Kchr19:39138547chr19:39123070ENST00000248342+3842_204118219DomainPCI


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FusionGeneSequence for ACTN4_EIF3K


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACTN4_EIF3K


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACTN4MYOZ2, MYOZ1, PDLIM1, USP6NL, SLC9A3R2, COL17A1, TRIM3, MAGI1, GSN, CAMK2A, CAMK2B, INO80, UBTF, STAT1, HDAC7, MEF2A, UCHL5, TJP1, ATXN7, HDAC5, VDR, ESR1, PSMA3, ELAVL1, SIRT7, SLC2A4, ISG15, COIL, SACS, HGS, UBASH3B, SHC1, NOS3, ACTN2, ACTN1, FMNL1, TRAF3IP1, FN1, VCAM1, CDH1, ITGA4, SVIL, CD81, IGSF8, ICAM1, TXN, RPS27, POT1, KPNA2, MAPK7, CDKN2A, VCP, SF3A3, GNB2, HUWE1, ACTN3, BMP7, ALK, CUL7, OBSL1, CCDC8, EGFR, LUZP4, RARA, HSPB1, AHNAK, ALDOA, ALDOC, IDH3A, MYH15, MYH2, MYH7B, NCAPG2, PSMA6, PSMB5, PUS7, TPM2, TSG101, CKB, CYC1, ECSIT, MCFD2, PSMB8, TPM1, TPM3, TPM4, NTRK1, CAPZA2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, PDLIM7, SYNPO, MAPRE1, SIN3B, MYEF2, LIMA1, ANLN, MYO5C, MYO19, MYO18A, CTNNB1, MCM2, NFYA, CDC73, DDIAS, SSH1, NCL, DLD, DNM1L, PDHA1, SOD1, TRIM25, TESEIF3KCCND3, EIF3L, EIF4A2, EIF3A, EIF1B, EIF3J, EIF3G, EIF3C, EIF3H, EIF3F, EIF3B, SPP1, EIF3E, EIF3D, EIF3I, EIF3M, DDX3X, FN1, METTL18, ITGA4, MMS19, CD81, IGSF8, ICAM1, DDX1, DIMT1, DYNC1H1, DYNC1I2, DYNC1LI2, EIF2A, EIF2B2, HNRNPD, PA2G4, PRUNE2, RPS10, RPS26, GNB2L1, LARP1, MAP2, WNK1, YBX1, EGFR, EIF3CL, EIF2B5, UTP15, IFI16, HERC2, VAPA, PTPRN, DNALI1, PFN2, GSN, ARPC4, CYLD, DLD, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneACTN4chr19:39138547chr19:39116668ENST00000252699+12112_2654912VCL
HgeneACTN4chr19:39138547chr19:39116668ENST00000390009+11412_2654693VCL
HgeneACTN4chr19:39138547chr19:39123070ENST00000252699+12112_2654912VCL
HgeneACTN4chr19:39138547chr19:39123070ENST00000390009+11412_2654693VCL


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneACTN4chr19:39138547chr19:39116668ENST00000252699+121108_12654912VCL
HgeneACTN4chr19:39138547chr19:39116668ENST00000252699+12140_6154912VCL
HgeneACTN4chr19:39138547chr19:39116668ENST00000390009+114108_12654693VCL
HgeneACTN4chr19:39138547chr19:39116668ENST00000390009+11440_6154693VCL
HgeneACTN4chr19:39138547chr19:39123070ENST00000252699+121108_12654912VCL
HgeneACTN4chr19:39138547chr19:39123070ENST00000252699+12140_6154912VCL
HgeneACTN4chr19:39138547chr19:39123070ENST00000390009+114108_12654693VCL
HgeneACTN4chr19:39138547chr19:39123070ENST00000390009+11440_6154693VCL


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACTN4_EIF3K


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACTN4_EIF3K


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACTN4C0333497Segmental glomerulosclerosis3UNIPROT
HgeneACTN4C0024667Animal Mammary Neoplasms1CTD_human
HgeneACTN4C0024668Mammary Neoplasms, Experimental1CTD_human