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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 584

FusionGeneSummary for ACTN4_CATSPERG

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTN4_CATSPERG
Fusion gene ID: 584
HgeneTgene
Gene symbol

ACTN4

CATSPERG

Gene ID

81

57828

Gene nameactinin alpha 4cation channel sperm associated auxiliary subunit gamma
SynonymsACTININ-4|FSGS|FSGS1C19orf15
Cytomap

19q13.2

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionalpha-actinin-4focal segmental glomerulosclerosis 1non-muscle alpha-actinin 4cation channel sperm-associated protein subunit gammacatsper channel auxiliary subunit gamma
Modification date2018052220180522
UniProtAcc

O43707

Q6ZRH7

Ensembl transtripts involved in fusion geneENST00000252699, ENST00000424234, 
ENST00000390009, ENST00000497637, 
ENST00000409235, ENST00000410018, 
ENST00000215069, ENST00000467739, 
Fusion gene scores* DoF score28 X 17 X 13=61885 X 4 X 4=80
# samples 304
** MAII scorelog2(30/6188*10)=-4.36643879095316
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACTN4 [Title/Abstract] AND CATSPERG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACTN4

GO:0035357

peroxisome proliferator activated receptor signaling pathway

22351778

HgeneACTN4

GO:0048384

retinoic acid receptor signaling pathway

22351778

HgeneACTN4

GO:0051272

positive regulation of cellular component movement

9508771


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-22-1005-01AACTN4chr19

39200116

+CATSPERGchr19

38834220

+
TCGALDLUSCTCGA-22-1005-01AACTN4chr19

39200116

+CATSPERGchr19

38848918

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000252699ENST00000409235ACTN4chr19

39200116

+CATSPERGchr19

38834220

+
Frame-shitENST00000252699ENST00000410018ACTN4chr19

39200116

+CATSPERGchr19

38834220

+
Frame-shitENST00000252699ENST00000215069ACTN4chr19

39200116

+CATSPERGchr19

38834220

+
5CDS-intronENST00000252699ENST00000467739ACTN4chr19

39200116

+CATSPERGchr19

38834220

+
intron-3CDSENST00000424234ENST00000409235ACTN4chr19

39200116

+CATSPERGchr19

38834220

+
intron-3CDSENST00000424234ENST00000410018ACTN4chr19

39200116

+CATSPERGchr19

38834220

+
intron-3CDSENST00000424234ENST00000215069ACTN4chr19

39200116

+CATSPERGchr19

38834220

+
intron-intronENST00000424234ENST00000467739ACTN4chr19

39200116

+CATSPERGchr19

38834220

+
intron-3CDSENST00000390009ENST00000409235ACTN4chr19

39200116

+CATSPERGchr19

38834220

+
intron-3CDSENST00000390009ENST00000410018ACTN4chr19

39200116

+CATSPERGchr19

38834220

+
intron-3CDSENST00000390009ENST00000215069ACTN4chr19

39200116

+CATSPERGchr19

38834220

+
intron-intronENST00000390009ENST00000467739ACTN4chr19

39200116

+CATSPERGchr19

38834220

+
intron-3CDSENST00000497637ENST00000409235ACTN4chr19

39200116

+CATSPERGchr19

38834220

+
intron-3CDSENST00000497637ENST00000410018ACTN4chr19

39200116

+CATSPERGchr19

38834220

+
intron-3CDSENST00000497637ENST00000215069ACTN4chr19

39200116

+CATSPERGchr19

38834220

+
intron-intronENST00000497637ENST00000467739ACTN4chr19

39200116

+CATSPERGchr19

38834220

+
In-frameENST00000252699ENST00000409235ACTN4chr19

39200116

+CATSPERGchr19

38848918

+
In-frameENST00000252699ENST00000410018ACTN4chr19

39200116

+CATSPERGchr19

38848918

+
In-frameENST00000252699ENST00000215069ACTN4chr19

39200116

+CATSPERGchr19

38848918

+
5CDS-intronENST00000252699ENST00000467739ACTN4chr19

39200116

+CATSPERGchr19

38848918

+
intron-3CDSENST00000424234ENST00000409235ACTN4chr19

39200116

+CATSPERGchr19

38848918

+
intron-3CDSENST00000424234ENST00000410018ACTN4chr19

39200116

+CATSPERGchr19

38848918

+
intron-3CDSENST00000424234ENST00000215069ACTN4chr19

39200116

+CATSPERGchr19

38848918

+
intron-intronENST00000424234ENST00000467739ACTN4chr19

39200116

+CATSPERGchr19

38848918

+
intron-3CDSENST00000390009ENST00000409235ACTN4chr19

39200116

+CATSPERGchr19

38848918

+
intron-3CDSENST00000390009ENST00000410018ACTN4chr19

39200116

+CATSPERGchr19

38848918

+
intron-3CDSENST00000390009ENST00000215069ACTN4chr19

39200116

+CATSPERGchr19

38848918

+
intron-intronENST00000390009ENST00000467739ACTN4chr19

39200116

+CATSPERGchr19

38848918

+
intron-3CDSENST00000497637ENST00000409235ACTN4chr19

39200116

+CATSPERGchr19

38848918

+
intron-3CDSENST00000497637ENST00000410018ACTN4chr19

39200116

+CATSPERGchr19

38848918

+
intron-3CDSENST00000497637ENST00000215069ACTN4chr19

39200116

+CATSPERGchr19

38848918

+
intron-intronENST00000497637ENST00000467739ACTN4chr19

39200116

+CATSPERGchr19

38848918

+

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FusionProtFeatures for ACTN4_CATSPERG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTN4

O43707

CATSPERG

Q6ZRH7

F-actin cross-linking protein which is thought to anchoractin to a variety of intracellular structures. This is a bundlingprotein (Probable). Probably involved in vesicular trafficking viaits association with the CART complex. The CART complex isnecessary for efficient transferrin receptor recycling but not forEGFR degradation (PubMed:15772161). Involved in tight junctionassembly in epithelial cells probably through interaction withMICALL2. Links MICALL2 to the actin cytoskeleton and recruits itto the tight junctions (By similarity). May also function as atranscriptional coactivator, stimulating transcription mediated bythe nuclear hormone receptors PPARG and RARA (PubMed:22351778).{ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161,ECO:0000269|PubMed:22351778, ECO:0000305|PubMed:9508771}. Probably involved in sperm cell hyperactivation via itsassociation with CATSPER1. Sperm cell hyperactivation is neededfor sperm motility which is essential late in the preparation ofsperm for fertilization. {ECO:0000250|UniProtKB:C6KI89}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTN4chr19:39200116chr19:38848918ENST00000252699+72119_26244912Compositional biasPoly-Gly
HgeneACTN4chr19:39200116chr19:38848918ENST00000252699+72150_154244912DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39200116chr19:38848918ENST00000252699+72184_88244912MotifLXXLL motif
HgeneACTN4chr19:39200116chr19:38848918ENST00000252699+721177_192244912RegionPolyphosphoinositide (PIP2)-binding
TgeneCATSPERGchr19:39200116chr19:38848918ENST00000409235+10291088_11594381160Topological domainCytoplasmic
TgeneCATSPERGchr19:39200116chr19:38848918ENST00000409235+10291067_10874381160TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTN4chr19:39200116chr19:38848918ENST00000252699+721778_789244912Calcium binding1
HgeneACTN4chr19:39200116chr19:38848918ENST00000252699+721819_830244912Calcium binding2
HgeneACTN4chr19:39200116chr19:38848918ENST00000390009+114778_789-3693Calcium binding1
HgeneACTN4chr19:39200116chr19:38848918ENST00000390009+114819_830-3693Calcium binding2
HgeneACTN4chr19:39200116chr19:38848918ENST00000390009+11419_26-3693Compositional biasPoly-Gly
HgeneACTN4chr19:39200116chr19:38848918ENST00000252699+721163_269244912DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39200116chr19:38848918ENST00000252699+721765_800244912DomainEF-hand 1
HgeneACTN4chr19:39200116chr19:38848918ENST00000252699+721806_841244912DomainEF-hand 2
HgeneACTN4chr19:39200116chr19:38848918ENST00000390009+114163_269-3693DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39200116chr19:38848918ENST00000390009+11450_154-3693DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39200116chr19:38848918ENST00000390009+114765_800-3693DomainEF-hand 1
HgeneACTN4chr19:39200116chr19:38848918ENST00000390009+114806_841-3693DomainEF-hand 2
HgeneACTN4chr19:39200116chr19:38848918ENST00000390009+11484_88-3693MotifLXXLL motif
HgeneACTN4chr19:39200116chr19:38848918ENST00000252699+7211_269244912RegionNote=Actin-binding
HgeneACTN4chr19:39200116chr19:38848918ENST00000390009+114177_192-3693RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39200116chr19:38848918ENST00000390009+1141_269-3693RegionNote=Actin-binding
HgeneACTN4chr19:39200116chr19:38848918ENST00000252699+721293_403244912RepeatSpectrin 1
HgeneACTN4chr19:39200116chr19:38848918ENST00000252699+721413_518244912RepeatSpectrin 2
HgeneACTN4chr19:39200116chr19:38848918ENST00000252699+721528_639244912RepeatSpectrin 3
HgeneACTN4chr19:39200116chr19:38848918ENST00000252699+721649_752244912RepeatSpectrin 4
HgeneACTN4chr19:39200116chr19:38848918ENST00000390009+114293_403-3693RepeatSpectrin 1
HgeneACTN4chr19:39200116chr19:38848918ENST00000390009+114413_518-3693RepeatSpectrin 2
HgeneACTN4chr19:39200116chr19:38848918ENST00000390009+114528_639-3693RepeatSpectrin 3
HgeneACTN4chr19:39200116chr19:38848918ENST00000390009+114649_752-3693RepeatSpectrin 4
TgeneCATSPERGchr19:39200116chr19:38848918ENST00000409235+102936_10664381160Topological domainExtracellular


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FusionGeneSequence for ACTN4_CATSPERG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ACTN4_ENST00000252699_chr19_39200116_+_CATSPERG_ENST00000409235_chr19_38848918_+_966aa
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPT
KNVNVQNFHISWKDGLAFNALIHRHRPELIETDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEASDDLELLYHIPEFIPEARGLEFLMI
LGTESYTSTAMAPKGIFCNPYNNLIFIWGNFLLQSSNKENFIYLADFPKELSIKYMARSFRGAVAIVTETEEIWYLLEGSYRVYQLFPSK
GWQVHISLKLMQQSSLYASNETMLTLFYEDSKLYQLVYLMNNQKGQLVKRLVPVEQLLMTQQHTSHTDLERKGGYLMLSFIDFCPFSVMR
LRSLPSPQRYTRQERYRARPPRVLERSGFHNENSLAIYQGLVYYLLWLHSVYDKPYADPVHDPTWRWWANNKQDQDYYFFLASNWRSAGG
VSIEMDSYEKIYNLESAYELPERIFLDKGTEYSFAIFLSAQGHSFRTQSELGTAFQLHSQVDVGVVLADPGCIEASVKQEVLINRNSVLF
SITLKDKKLCTDQGISGHHLMETSMTVNVVGSSGLCFQETHLGPHMQGNLMVPVFIGCPPGKRLAFDITYTLEYSRLKNKHYFDCVNVNP
EMPCFLFRDIFYPFFLIQDLVTGDSGSFQGSTVLLVVGGGPTLDSLKDYSEDEIYRFNSPLDKTNSLIWTTRTTRTTKDSAFHIMSHESP
GIEWLCLENAPCTDNVPQGIFAPEFFFKVLVSNRGVDTSTYCNYQLTFLLHIHGLPLSPKRALFIIMVSASVFVGLVIFYIAFCLLWPLV

>In-frame_ACTN4_ENST00000252699_chr19_39200116_+_CATSPERG_ENST00000410018_chr19_38848918_+_966aa
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPT
KNVNVQNFHISWKDGLAFNALIHRHRPELIETDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEASDDLELLYHIPEFIPEARGLEFLMI
LGTESYTSTAMAPKGIFCNPYNNLIFIWGNFLLQSSNKENFIYLADFPKELSIKYMARSFRGAVAIVTETEEIWYLLEGSYRVYQLFPSK
GWQVHISLKLMQQSSLYASNETMLTLFYEDSKLYQLVYLMNNQKGQLVKRLVPVEQLLMTQQHTSHTDLERKGGYLMLSFIDFCPFSVMR
LRSLPSPQRYTRQERYRARPPRVLERSGFHNENSLAIYQGLVYYLLWLHSVYDKPYADPVHDPTWRWWANNKQDQDYYFFLASNWRSAGG
VSIEMDSYEKIYNLESAYELPERIFLDKGTEYSFAIFLSAQGHSFRTQSELGTAFQLHSQVDVGVVLADPGCIEASVKQEVLINRNSVLF
SITLKDKKLCTDQGISGHHLMETSMTVNVVGSSGLCFQETHLGPHMQGNLMVPVFIGCPPGKRLAFDITYTLEYSRLKNKHYFDCVNVNP
EMPCFLFRDIFYPFFLIQDLVTGDSGSFQGSTVLLVVGGGPTLDSLKDYSEDEIYRFNSPLDKTNSLIWTTRTTRTTKDSAFHIMSHESP
GIEWLCLENAPCTDNVPQGIFAPEFFFKVLVSNRGVDTSTYCNYQLTFLLHIHGLPLSPKRALFIIMVSASVFVGLVIFYIAFCLLWPLV

>In-frame_ACTN4_ENST00000252699_chr19_39200116_+_CATSPERG_ENST00000215069_chr19_38848918_+_331aa
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPT
KNVNVQNFHISWKDGLAFNALIHRHRPELIETDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEASDDLELLYHIPEFIPEARGLEFLMI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ACTN4_ENST00000252699_chr19_39200116_+_CATSPERG_ENST00000409235_chr19_38848918_+_2898nt
ATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGAC
TACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGACCTTCACGGCATGGTGC
AACTCCCACCTGCGGAAGGCAGGCACACAGATCGAGAACATTGATGAGGACTTCCGAGACGGGCTCAAGCTCATGCTGCTCCTGGAGGTC
ATATCAGGGGAGCGGTTACCTAAGCCGGAGCGGGGGAAGATGAGAGTGCACAAAATCAACAATGTGAACAAAGCGCTGGACTTTATTGCC
AGCAAAGGCGTCAAGCTGGTCTCCATCGGGGCAGAAGAGATTGTGGACGGCAACGCAAAGATGACCCTGGGAATGATCTGGACCATCATC
CTTAGGTTCGCCATCCAGGACATCTCCGTGGAAGAGACCTCGGCCAAGGAAGGGCTCCTTCTCTGGTGCCAGAGAAAGACAGCCCCGTAT
AAGAACGTCAATGTGCAGAACTTCCACATCAGCTGGAAGGATGGTCTTGCCTTCAATGCCCTGATCCACCGGCACAGACCAGAGCTGATT
GAGTATGACAAGCTGAGGAAGGACGACCCTGTCACCAACCTGAACAATGCCTTCGAAGTGGCTGAGAAATACCTCGACATCCCCAAGATG
CTGGATGCAGAGGCTAGTGATGACCTGGAACTTCTCTACCACATCCCAGAATTCATCCCTGAAGCTCGAGGATTGGAGTTCCTGATGATC
CTAGGGACAGAGTCCTACACCAGCACTGCAATGGCCCCCAAGGGCATCTTCTGTAACCCGTACAACAATCTGATCTTCATCTGGGGCAAC
TTCCTCCTGCAGAGCTCTAACAAGGAAAACTTCATCTACCTGGCAGACTTCCCCAAGGAACTGTCCATCAAATACATGGCCAGATCGTTC
CGTGGGGCTGTGGCTATTGTCACAGAGACGGAGGAGATCTGGTACCTCCTGGAGGGCAGCTACCGGGTCTACCAGCTGTTCCCTTCCAAG
GGCTGGCAGGTGCACATCAGCTTAAAGCTGATGCAACAGTCCTCTCTCTACGCATCCAATGAGACCATGCTGACCCTCTTCTACGAAGAC
AGCAAACTGTACCAGCTGGTGTACCTTATGAACAACCAGAAGGGCCAGCTGGTCAAGAGGCTCGTGCCCGTGGAGCAGCTTCTGATGTAT
CAACAGCACACCAGCCACTATGACTTGGAGCGGAAAGGGGGCTACTTGATGCTCTCCTTCATCGACTTCTGCCCCTTCTCGGTGATGCGC
CTGCGGAGCCTGCCCAGTCCGCAGAGATACACGCGCCAGGAGCGCTACCGGGCGCGGCCGCCGCGCGTCCTGGAGCGCTCGGGCTTCCAC
AACGAGAACTCGCTCGCCATCTACCAGGGCCTGGTCTACTACCTGCTGTGGCTGCACTCCGTGTACGACAAGCCGTACGCGGACCCGGTG
CACGACCCCACCTGGCGCTGGTGGGCGAACAACAAACAAGACCAGGATTACTACTTCTTCTTGGCGAGCAATTGGCGAAGCGCGGGCGGC
GTGTCCATAGAAATGGACAGCTACGAAAAGATCTACAACCTCGAGTCCGCGTACGAGCTGCCGGAGCGCATTTTCCTGGACAAGGGCACT
GAGTACAGCTTCGCCATCTTCCTGTCGGCGCAGGGCCACTCGTTCCGGACGCAGTCAGAACTCGGCACCGCCTTCCAGCTGCATAGCCAG
GTGGACGTGGGCGTGGTGCTGGCCGACCCCGGCTGCATCGAGGCCTCGGTGAAGCAGGAGGTCCTGATTAATCGCAACTCGGTGCTATTT
TCGATTACGCTCAAGGATAAAAAGCTTTGCTATGACCAAGGCATTAGTGGACATCACCTTATGGAGACTTCCATGACGGTCAATGTGGTG
GGTTCATCCGGGCTCTGCTTCCAGGAAACACACCTGGGGCCCCATATGCAAGGCAACCTGATGGTGCCAGTGTTCATTGGCTGCCCCCCA
GGCAAGCGCCTGGCCTTCGACATCACCTACACGCTGGAATACAGCCGCCTGAAGAACAAACACTACTTTGACTGCGTTAACGTGAACCCG
GAGATGCCCTGCTTTCTCTTCCGGGACATTTTCTACCCCTTCTTCTTGATTCAAGATTTGGTGACAGGAGACTCCGGCAGTTTCCAGGGC
AGCTATGTTCTGCTGGTGGTGGGTGGCGGGCCCACACTGGACAGCCTCAAGGACTACAGTGAGGACGAAATCTACCGCTTCAACAGCCCC
CTGGACAAGACCAACAGCCTTATCTGGACCACGAGGACCACAAGGACCACCAAAGACTCAGCCTTTCACATCATGTCCCACGAGAGCCCA
GGCATCGAGTGGCTCTGTCTGGAGAATGCCCCATGCTATGACAATGTTCCCCAAGGCATCTTTGCCCCTGAATTCTTCTTCAAGGTGTTG
GTGAGCAATAGAGGAGTGGACACGAGCACCTACTGCAACTACCAGCTCACCTTCCTGCTGCACATCCACGGGCTGCCACTCAGTCCCAAG
CGGGCCCTTTTCATCATCATGGTGTCAGCTAGCGTGTTTGTGGGCCTGGTGATCTTCTACATCGCCTTCTGCCTCCTGTGGCCCCTCGTG
GTGAAGGGCTGCACGATGATCCGGTGGAAGATAAACAACCTCATTGCCTCAGAATCCTACTACACCTACGCCTCCATTTCCGGAATCTCG
AGCATGCCGTCTCTGAGACATTCCAGGATGGGCTCCATGTTCAGCTCCAGGATGACAGAGGACAGGGCTGAACCCAAGGAAGCCGTGGAG

>In-frame_ACTN4_ENST00000252699_chr19_39200116_+_CATSPERG_ENST00000410018_chr19_38848918_+_2898nt
ATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGAC
TACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGACCTTCACGGCATGGTGC
AACTCCCACCTGCGGAAGGCAGGCACACAGATCGAGAACATTGATGAGGACTTCCGAGACGGGCTCAAGCTCATGCTGCTCCTGGAGGTC
ATATCAGGGGAGCGGTTACCTAAGCCGGAGCGGGGGAAGATGAGAGTGCACAAAATCAACAATGTGAACAAAGCGCTGGACTTTATTGCC
AGCAAAGGCGTCAAGCTGGTCTCCATCGGGGCAGAAGAGATTGTGGACGGCAACGCAAAGATGACCCTGGGAATGATCTGGACCATCATC
CTTAGGTTCGCCATCCAGGACATCTCCGTGGAAGAGACCTCGGCCAAGGAAGGGCTCCTTCTCTGGTGCCAGAGAAAGACAGCCCCGTAT
AAGAACGTCAATGTGCAGAACTTCCACATCAGCTGGAAGGATGGTCTTGCCTTCAATGCCCTGATCCACCGGCACAGACCAGAGCTGATT
GAGTATGACAAGCTGAGGAAGGACGACCCTGTCACCAACCTGAACAATGCCTTCGAAGTGGCTGAGAAATACCTCGACATCCCCAAGATG
CTGGATGCAGAGGCTAGTGATGACCTGGAACTTCTCTACCACATCCCAGAATTCATCCCTGAAGCTCGAGGATTGGAGTTCCTGATGATC
CTAGGGACAGAGTCCTACACCAGCACTGCAATGGCCCCCAAGGGCATCTTCTGTAACCCGTACAACAATCTGATCTTCATCTGGGGCAAC
TTCCTCCTGCAGAGCTCTAACAAGGAAAACTTCATCTACCTGGCAGACTTCCCCAAGGAACTGTCCATCAAATACATGGCCAGATCGTTC
CGTGGGGCTGTGGCTATTGTCACAGAGACGGAGGAGATCTGGTACCTCCTGGAGGGCAGCTACCGGGTCTACCAGCTGTTCCCTTCCAAG
GGCTGGCAGGTGCACATCAGCTTAAAGCTGATGCAACAGTCCTCTCTCTACGCATCCAATGAGACCATGCTGACCCTCTTCTACGAAGAC
AGCAAACTGTACCAGCTGGTGTACCTTATGAACAACCAGAAGGGCCAGCTGGTCAAGAGGCTCGTGCCCGTGGAGCAGCTTCTGATGTAT
CAACAGCACACCAGCCACTATGACTTGGAGCGGAAAGGGGGCTACTTGATGCTCTCCTTCATCGACTTCTGCCCCTTCTCGGTGATGCGC
CTGCGGAGCCTGCCCAGTCCGCAGAGATACACGCGCCAGGAGCGCTACCGGGCGCGGCCGCCGCGCGTCCTGGAGCGCTCGGGCTTCCAC
AACGAGAACTCGCTCGCCATCTACCAGGGCCTGGTCTACTACCTGCTGTGGCTGCACTCCGTGTACGACAAGCCGTACGCGGACCCGGTG
CACGACCCCACCTGGCGCTGGTGGGCGAACAACAAACAAGACCAGGATTACTACTTCTTCTTGGCGAGCAATTGGCGAAGCGCGGGCGGC
GTGTCCATAGAAATGGACAGCTACGAAAAGATCTACAACCTCGAGTCCGCGTACGAGCTGCCGGAGCGCATTTTCCTGGACAAGGGCACT
GAGTACAGCTTCGCCATCTTCCTGTCGGCGCAGGGCCACTCGTTCCGGACGCAGTCAGAACTCGGCACCGCCTTCCAGCTGCATAGCCAG
GTGGACGTGGGCGTGGTGCTGGCCGACCCCGGCTGCATCGAGGCCTCGGTGAAGCAGGAGGTCCTGATTAATCGCAACTCGGTGCTATTT
TCGATTACGCTCAAGGATAAAAAGCTTTGCTATGACCAAGGCATTAGTGGACATCACCTTATGGAGACTTCCATGACGGTCAATGTGGTG
GGTTCATCCGGGCTCTGCTTCCAGGAAACACACCTGGGGCCCCATATGCAAGGCAACCTGATGGTGCCAGTGTTCATTGGCTGCCCCCCA
GGCAAGCGCCTGGCCTTCGACATCACCTACACGCTGGAATACAGCCGCCTGAAGAACAAACACTACTTTGACTGCGTTAACGTGAACCCG
GAGATGCCCTGCTTTCTCTTCCGGGACATTTTCTACCCCTTCTTCTTGATTCAAGATTTGGTGACAGGAGACTCCGGCAGTTTCCAGGGC
AGCTATGTTCTGCTGGTGGTGGGTGGCGGGCCCACACTGGACAGCCTCAAGGACTACAGTGAGGACGAAATCTACCGCTTCAACAGCCCC
CTGGACAAGACCAACAGCCTTATCTGGACCACGAGGACCACAAGGACCACCAAAGACTCAGCCTTTCACATCATGTCCCACGAGAGCCCA
GGCATCGAGTGGCTCTGTCTGGAGAATGCCCCATGCTATGACAATGTTCCCCAAGGCATCTTTGCCCCTGAATTCTTCTTCAAGGTGTTG
GTGAGCAATAGAGGAGTGGACACGAGCACCTACTGCAACTACCAGCTCACCTTCCTGCTGCACATCCACGGGCTGCCACTCAGTCCCAAG
CGGGCCCTTTTCATCATCATGGTGTCAGCTAGCGTGTTTGTGGGCCTGGTGATCTTCTACATCGCCTTCTGCCTCCTGTGGCCCCTCGTG
GTGAAGGGCTGCACGATGATCCGGTGGAAGATAAACAACCTCATTGCCTCAGAATCCTACTACACCTACGCCTCCATTTCCGGAATCTCG
AGCATGCCGTCTCTGAGACATTCCAGGATGGGCTCCATGTTCAGCTCCAGGATGACAGAGGACAGGGCTGAACCCAAGGAAGCCGTGGAG

>In-frame_ACTN4_ENST00000252699_chr19_39200116_+_CATSPERG_ENST00000215069_chr19_38848918_+_993nt
ATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGAC
TACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGACCTTCACGGCATGGTGC
AACTCCCACCTGCGGAAGGCAGGCACACAGATCGAGAACATTGATGAGGACTTCCGAGACGGGCTCAAGCTCATGCTGCTCCTGGAGGTC
ATATCAGGGGAGCGGTTACCTAAGCCGGAGCGGGGGAAGATGAGAGTGCACAAAATCAACAATGTGAACAAAGCGCTGGACTTTATTGCC
AGCAAAGGCGTCAAGCTGGTCTCCATCGGGGCAGAAGAGATTGTGGACGGCAACGCAAAGATGACCCTGGGAATGATCTGGACCATCATC
CTTAGGTTCGCCATCCAGGACATCTCCGTGGAAGAGACCTCGGCCAAGGAAGGGCTCCTTCTCTGGTGCCAGAGAAAGACAGCCCCGTAT
AAGAACGTCAATGTGCAGAACTTCCACATCAGCTGGAAGGATGGTCTTGCCTTCAATGCCCTGATCCACCGGCACAGACCAGAGCTGATT
GAGTATGACAAGCTGAGGAAGGACGACCCTGTCACCAACCTGAACAATGCCTTCGAAGTGGCTGAGAAATACCTCGACATCCCCAAGATG
CTGGATGCAGAGGCTAGTGATGACCTGGAACTTCTCTACCACATCCCAGAATTCATCCCTGAAGCTCGAGGATTGGAGTTCCTGATGATC
CTAGGGACAGAGTCCTACACCAGCACTGCAATGGCCCCCAAGGGCATCTTCTGTAACCCGTACAACAATCTGATCTTCATCTGGGGCAAC
TTCCTCCTGCAGAGATCTGGTACCTCCTGGAGGGCAGCTACCGGGTCTACCAGCTGTTCCCTTCCAAGGGCTGGCAGGTGCACATCAGCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ACTN4_ENST00000252699_chr19_39200116_+_CATSPERG_ENST00000409235_chr19_38848918_+_3125nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGACCTTCACGGCATGGTGCAACTCCCACCTGCG
GAAGGCAGGCACACAGATCGAGAACATTGATGAGGACTTCCGAGACGGGCTCAAGCTCATGCTGCTCCTGGAGGTCATATCAGGGGAGCG
GTTACCTAAGCCGGAGCGGGGGAAGATGAGAGTGCACAAAATCAACAATGTGAACAAAGCGCTGGACTTTATTGCCAGCAAAGGCGTCAA
GCTGGTCTCCATCGGGGCAGAAGAGATTGTGGACGGCAACGCAAAGATGACCCTGGGAATGATCTGGACCATCATCCTTAGGTTCGCCAT
CCAGGACATCTCCGTGGAAGAGACCTCGGCCAAGGAAGGGCTCCTTCTCTGGTGCCAGAGAAAGACAGCCCCGTATAAGAACGTCAATGT
GCAGAACTTCCACATCAGCTGGAAGGATGGTCTTGCCTTCAATGCCCTGATCCACCGGCACAGACCAGAGCTGATTGAGTATGACAAGCT
GAGGAAGGACGACCCTGTCACCAACCTGAACAATGCCTTCGAAGTGGCTGAGAAATACCTCGACATCCCCAAGATGCTGGATGCAGAGGC
TAGTGATGACCTGGAACTTCTCTACCACATCCCAGAATTCATCCCTGAAGCTCGAGGATTGGAGTTCCTGATGATCCTAGGGACAGAGTC
CTACACCAGCACTGCAATGGCCCCCAAGGGCATCTTCTGTAACCCGTACAACAATCTGATCTTCATCTGGGGCAACTTCCTCCTGCAGAG
CTCTAACAAGGAAAACTTCATCTACCTGGCAGACTTCCCCAAGGAACTGTCCATCAAATACATGGCCAGATCGTTCCGTGGGGCTGTGGC
TATTGTCACAGAGACGGAGGAGATCTGGTACCTCCTGGAGGGCAGCTACCGGGTCTACCAGCTGTTCCCTTCCAAGGGCTGGCAGGTGCA
CATCAGCTTAAAGCTGATGCAACAGTCCTCTCTCTACGCATCCAATGAGACCATGCTGACCCTCTTCTACGAAGACAGCAAACTGTACCA
GCTGGTGTACCTTATGAACAACCAGAAGGGCCAGCTGGTCAAGAGGCTCGTGCCCGTGGAGCAGCTTCTGATGTATCAACAGCACACCAG
CCACTATGACTTGGAGCGGAAAGGGGGCTACTTGATGCTCTCCTTCATCGACTTCTGCCCCTTCTCGGTGATGCGCCTGCGGAGCCTGCC
CAGTCCGCAGAGATACACGCGCCAGGAGCGCTACCGGGCGCGGCCGCCGCGCGTCCTGGAGCGCTCGGGCTTCCACAACGAGAACTCGCT
CGCCATCTACCAGGGCCTGGTCTACTACCTGCTGTGGCTGCACTCCGTGTACGACAAGCCGTACGCGGACCCGGTGCACGACCCCACCTG
GCGCTGGTGGGCGAACAACAAACAAGACCAGGATTACTACTTCTTCTTGGCGAGCAATTGGCGAAGCGCGGGCGGCGTGTCCATAGAAAT
GGACAGCTACGAAAAGATCTACAACCTCGAGTCCGCGTACGAGCTGCCGGAGCGCATTTTCCTGGACAAGGGCACTGAGTACAGCTTCGC
CATCTTCCTGTCGGCGCAGGGCCACTCGTTCCGGACGCAGTCAGAACTCGGCACCGCCTTCCAGCTGCATAGCCAGGTGGACGTGGGCGT
GGTGCTGGCCGACCCCGGCTGCATCGAGGCCTCGGTGAAGCAGGAGGTCCTGATTAATCGCAACTCGGTGCTATTTTCGATTACGCTCAA
GGATAAAAAGCTTTGCTATGACCAAGGCATTAGTGGACATCACCTTATGGAGACTTCCATGACGGTCAATGTGGTGGGTTCATCCGGGCT
CTGCTTCCAGGAAACACACCTGGGGCCCCATATGCAAGGCAACCTGATGGTGCCAGTGTTCATTGGCTGCCCCCCAGGCAAGCGCCTGGC
CTTCGACATCACCTACACGCTGGAATACAGCCGCCTGAAGAACAAACACTACTTTGACTGCGTTAACGTGAACCCGGAGATGCCCTGCTT
TCTCTTCCGGGACATTTTCTACCCCTTCTTCTTGATTCAAGATTTGGTGACAGGAGACTCCGGCAGTTTCCAGGGCAGCTATGTTCTGCT
GGTGGTGGGTGGCGGGCCCACACTGGACAGCCTCAAGGACTACAGTGAGGACGAAATCTACCGCTTCAACAGCCCCCTGGACAAGACCAA
CAGCCTTATCTGGACCACGAGGACCACAAGGACCACCAAAGACTCAGCCTTTCACATCATGTCCCACGAGAGCCCAGGCATCGAGTGGCT
CTGTCTGGAGAATGCCCCATGCTATGACAATGTTCCCCAAGGCATCTTTGCCCCTGAATTCTTCTTCAAGGTGTTGGTGAGCAATAGAGG
AGTGGACACGAGCACCTACTGCAACTACCAGCTCACCTTCCTGCTGCACATCCACGGGCTGCCACTCAGTCCCAAGCGGGCCCTTTTCAT
CATCATGGTGTCAGCTAGCGTGTTTGTGGGCCTGGTGATCTTCTACATCGCCTTCTGCCTCCTGTGGCCCCTCGTGGTGAAGGGCTGCAC
GATGATCCGGTGGAAGATAAACAACCTCATTGCCTCAGAATCCTACTACACCTACGCCTCCATTTCCGGAATCTCGAGCATGCCGTCTCT
GAGACATTCCAGGATGGGCTCCATGTTCAGCTCCAGGATGACAGAGGACAGGGCTGAACCCAAGGAAGCCGTGGAGAGACAGTTGATGAC
CTGAGTGTCCCACCTGCCCCAGCCCCCAGTTACTGTCACGCCTCTCTTATGAGGCCCATCTTGAAGATGCAACCTGTCACCCAGCCCAGG

>In-frame_ACTN4_ENST00000252699_chr19_39200116_+_CATSPERG_ENST00000410018_chr19_38848918_+_3125nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGACCTTCACGGCATGGTGCAACTCCCACCTGCG
GAAGGCAGGCACACAGATCGAGAACATTGATGAGGACTTCCGAGACGGGCTCAAGCTCATGCTGCTCCTGGAGGTCATATCAGGGGAGCG
GTTACCTAAGCCGGAGCGGGGGAAGATGAGAGTGCACAAAATCAACAATGTGAACAAAGCGCTGGACTTTATTGCCAGCAAAGGCGTCAA
GCTGGTCTCCATCGGGGCAGAAGAGATTGTGGACGGCAACGCAAAGATGACCCTGGGAATGATCTGGACCATCATCCTTAGGTTCGCCAT
CCAGGACATCTCCGTGGAAGAGACCTCGGCCAAGGAAGGGCTCCTTCTCTGGTGCCAGAGAAAGACAGCCCCGTATAAGAACGTCAATGT
GCAGAACTTCCACATCAGCTGGAAGGATGGTCTTGCCTTCAATGCCCTGATCCACCGGCACAGACCAGAGCTGATTGAGTATGACAAGCT
GAGGAAGGACGACCCTGTCACCAACCTGAACAATGCCTTCGAAGTGGCTGAGAAATACCTCGACATCCCCAAGATGCTGGATGCAGAGGC
TAGTGATGACCTGGAACTTCTCTACCACATCCCAGAATTCATCCCTGAAGCTCGAGGATTGGAGTTCCTGATGATCCTAGGGACAGAGTC
CTACACCAGCACTGCAATGGCCCCCAAGGGCATCTTCTGTAACCCGTACAACAATCTGATCTTCATCTGGGGCAACTTCCTCCTGCAGAG
CTCTAACAAGGAAAACTTCATCTACCTGGCAGACTTCCCCAAGGAACTGTCCATCAAATACATGGCCAGATCGTTCCGTGGGGCTGTGGC
TATTGTCACAGAGACGGAGGAGATCTGGTACCTCCTGGAGGGCAGCTACCGGGTCTACCAGCTGTTCCCTTCCAAGGGCTGGCAGGTGCA
CATCAGCTTAAAGCTGATGCAACAGTCCTCTCTCTACGCATCCAATGAGACCATGCTGACCCTCTTCTACGAAGACAGCAAACTGTACCA
GCTGGTGTACCTTATGAACAACCAGAAGGGCCAGCTGGTCAAGAGGCTCGTGCCCGTGGAGCAGCTTCTGATGTATCAACAGCACACCAG
CCACTATGACTTGGAGCGGAAAGGGGGCTACTTGATGCTCTCCTTCATCGACTTCTGCCCCTTCTCGGTGATGCGCCTGCGGAGCCTGCC
CAGTCCGCAGAGATACACGCGCCAGGAGCGCTACCGGGCGCGGCCGCCGCGCGTCCTGGAGCGCTCGGGCTTCCACAACGAGAACTCGCT
CGCCATCTACCAGGGCCTGGTCTACTACCTGCTGTGGCTGCACTCCGTGTACGACAAGCCGTACGCGGACCCGGTGCACGACCCCACCTG
GCGCTGGTGGGCGAACAACAAACAAGACCAGGATTACTACTTCTTCTTGGCGAGCAATTGGCGAAGCGCGGGCGGCGTGTCCATAGAAAT
GGACAGCTACGAAAAGATCTACAACCTCGAGTCCGCGTACGAGCTGCCGGAGCGCATTTTCCTGGACAAGGGCACTGAGTACAGCTTCGC
CATCTTCCTGTCGGCGCAGGGCCACTCGTTCCGGACGCAGTCAGAACTCGGCACCGCCTTCCAGCTGCATAGCCAGGTGGACGTGGGCGT
GGTGCTGGCCGACCCCGGCTGCATCGAGGCCTCGGTGAAGCAGGAGGTCCTGATTAATCGCAACTCGGTGCTATTTTCGATTACGCTCAA
GGATAAAAAGCTTTGCTATGACCAAGGCATTAGTGGACATCACCTTATGGAGACTTCCATGACGGTCAATGTGGTGGGTTCATCCGGGCT
CTGCTTCCAGGAAACACACCTGGGGCCCCATATGCAAGGCAACCTGATGGTGCCAGTGTTCATTGGCTGCCCCCCAGGCAAGCGCCTGGC
CTTCGACATCACCTACACGCTGGAATACAGCCGCCTGAAGAACAAACACTACTTTGACTGCGTTAACGTGAACCCGGAGATGCCCTGCTT
TCTCTTCCGGGACATTTTCTACCCCTTCTTCTTGATTCAAGATTTGGTGACAGGAGACTCCGGCAGTTTCCAGGGCAGCTATGTTCTGCT
GGTGGTGGGTGGCGGGCCCACACTGGACAGCCTCAAGGACTACAGTGAGGACGAAATCTACCGCTTCAACAGCCCCCTGGACAAGACCAA
CAGCCTTATCTGGACCACGAGGACCACAAGGACCACCAAAGACTCAGCCTTTCACATCATGTCCCACGAGAGCCCAGGCATCGAGTGGCT
CTGTCTGGAGAATGCCCCATGCTATGACAATGTTCCCCAAGGCATCTTTGCCCCTGAATTCTTCTTCAAGGTGTTGGTGAGCAATAGAGG
AGTGGACACGAGCACCTACTGCAACTACCAGCTCACCTTCCTGCTGCACATCCACGGGCTGCCACTCAGTCCCAAGCGGGCCCTTTTCAT
CATCATGGTGTCAGCTAGCGTGTTTGTGGGCCTGGTGATCTTCTACATCGCCTTCTGCCTCCTGTGGCCCCTCGTGGTGAAGGGCTGCAC
GATGATCCGGTGGAAGATAAACAACCTCATTGCCTCAGAATCCTACTACACCTACGCCTCCATTTCCGGAATCTCGAGCATGCCGTCTCT
GAGACATTCCAGGATGGGCTCCATGTTCAGCTCCAGGATGACAGAGGACAGGGCTGAACCCAAGGAAGCCGTGGAGAGACAGTTGATGAC
CTGAGTGTCCCACCTGCCCCAGCCCCCAGTTACTGTCACGCCTCTCTTATGAGGCCCATCTTGAAGATGCAACCTGTCACCCAGCCCAGG

>In-frame_ACTN4_ENST00000252699_chr19_39200116_+_CATSPERG_ENST00000215069_chr19_38848918_+_3019nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGACCTTCACGGCATGGTGCAACTCCCACCTGCG
GAAGGCAGGCACACAGATCGAGAACATTGATGAGGACTTCCGAGACGGGCTCAAGCTCATGCTGCTCCTGGAGGTCATATCAGGGGAGCG
GTTACCTAAGCCGGAGCGGGGGAAGATGAGAGTGCACAAAATCAACAATGTGAACAAAGCGCTGGACTTTATTGCCAGCAAAGGCGTCAA
GCTGGTCTCCATCGGGGCAGAAGAGATTGTGGACGGCAACGCAAAGATGACCCTGGGAATGATCTGGACCATCATCCTTAGGTTCGCCAT
CCAGGACATCTCCGTGGAAGAGACCTCGGCCAAGGAAGGGCTCCTTCTCTGGTGCCAGAGAAAGACAGCCCCGTATAAGAACGTCAATGT
GCAGAACTTCCACATCAGCTGGAAGGATGGTCTTGCCTTCAATGCCCTGATCCACCGGCACAGACCAGAGCTGATTGAGTATGACAAGCT
GAGGAAGGACGACCCTGTCACCAACCTGAACAATGCCTTCGAAGTGGCTGAGAAATACCTCGACATCCCCAAGATGCTGGATGCAGAGGC
TAGTGATGACCTGGAACTTCTCTACCACATCCCAGAATTCATCCCTGAAGCTCGAGGATTGGAGTTCCTGATGATCCTAGGGACAGAGTC
CTACACCAGCACTGCAATGGCCCCCAAGGGCATCTTCTGTAACCCGTACAACAATCTGATCTTCATCTGGGGCAACTTCCTCCTGCAGAG
ATCTGGTACCTCCTGGAGGGCAGCTACCGGGTCTACCAGCTGTTCCCTTCCAAGGGCTGGCAGGTGCACATCAGCTTAAAGCTGATGCAA
CAGTCCTCTCTCTACGCATCCAATGAGACCATGCTGACCCTCTTCTACGAAGACAGCAAACTGTACCAGCTGGTGTACCTTATGAACAAC
CAGAAGGGCCAGCTGGTCAAGAGGCTCGTGCCCGTGGAGCAGCTTCTGATGTATCAACAGCACACCAGCCACTATGACTTGGAGCGGAAA
GGGGGCTACTTGATGCTCTCCTTCATCGACTTCTGCCCCTTCTCGGTGATGCGCCTGCGGAGCCTGCCCAGTCCGCAGAGATACACGCGC
CAGGAGCGCTACCGGGCGCGGCCGCCGCGCGTCCTGGAGCGCTCGGGCTTCCACAACGAGAACTCGCTCGCCATCTACCAGGGCCTGGTC
TACTACCTGCTGTGGCTGCACTCCGTGTACGACAAGCCGTACGCGGACCCGGTGCACGACCCCACCTGGCGCTGGTGGGCGAACAACAAA
CAAGACCAGGATTACTACTTCTTCTTGGCGAGCAATTGGCGAAGCGCGGGCGGCGTGTCCATAGAAATGGACAGCTACGAAAAGATCTAC
AACCTCGAGTCCGCGTACGAGCTGCCGGAGCGCATTTTCCTGGACAAGGGCACTGAGTACAGCTTCGCCATCTTCCTGTCGGCGCAGGGC
CACTCGTTCCGGACGCAGTCAGAACTCGGCACCGCCTTCCAGCTGCATAGCCAGGTGGACGTGGGCGTGGTGCTGGCCGACCCCGGCTGC
ATCGAGGCCTCGGTGAAGCAGGAGGTCCTGATTAATCGCAACTCGGTGCTATTTTCGATTACGCTCAAGGATAAAAAGCTTTGCTATGAC
CAAGGCATTAGTGGACATCACCTTATGGAGACTTCCATGACGGTCAATGTGGTGGGTTCATCCGGGCTCTGCTTCCAGGAAACACACCTG
GGGCCCCATATGCAAGGCAACCTGATGGTGCCAGTGTTCATTGGCTGCCCCCCAGGCAAGCGCCTGGCCTTCGACATCACCTACACGCTG
GAATACAGCCGCCTGAAGAACAAACACTACTTTGACTGCGTTAACGTGAACCCGGAGATGCCCTGCTTTCTCTTCCGGGACATTTTCTAC
CCCTTCTTCTTGATTCAAGATTTGGTGACAGGAGACTCCGGCAGTTTCCAGGGCAGCTATGTTCTGCTGGTGGTGGGTGGCGGGCCCACA
CTGGACAGCCTCAAGGACTACAGTGAGGACGAAATCTACCGCTTCAACAGCCCCCTGGACAAGACCAACAGCCTTATCTGGACCACGAGG
ACCACAAGGACCACCAAAGACTCAGCCTTTCACATCATGTCCCACGAGAGCCCAGGCATCGAGTGGCTCTGTCTGGAGAATGCCCCATGC
TATGACAATGTTCCCCAAGGCATCTTTGCCCCTGAATTCTTCTTCAAGGTGTTGGTGAGCAATAGAGGAGTGGACACGAGCACCTACTGC
AACTACCAGCTCACCTTCCTGCTGCACATCCACGGGCTGCCACTCAGTCCCAAGCGGGCCCTTTTCATCATCATGGTGTCAGCTAGCGTG
TTTGTGGGCCTGGTGATCTTCTACATCGCCTTCTGCCTCCTGTGGCCCCTCGTGGTGAAGGGCTGCACGATGATCCGGTGGAAGATAAAC
AACCTCATTGCCTCAGAATCCTACTACACCTACGCCTCCATTTCCGGAATCTCGAGCATGCCGTCTCTGAGACATTCCAGGATGGGCTCC
ATGTTCAGCTCCAGGATGACAGAGGACAGGGCTGAACCCAAGGAAGCCGTGGAGAGACAGTTGATGACCTGAGTGTCCCACCTGCCCCAG
CCCCCAGTTACTGTCACGCCTCTCTTATGAGGCCCATCTTGAAGATGCAACCTGTCACCCAGCCCAGGCCTCTCTTTCTGTTTTGCTTGA


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FusionGenePPI for ACTN4_CATSPERG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACTN4MYOZ2, MYOZ1, PDLIM1, USP6NL, SLC9A3R2, COL17A1, TRIM3, MAGI1, GSN, CAMK2A, CAMK2B, INO80, UBTF, STAT1, HDAC7, MEF2A, UCHL5, TJP1, ATXN7, HDAC5, VDR, ESR1, PSMA3, ELAVL1, SIRT7, SLC2A4, ISG15, COIL, SACS, HGS, UBASH3B, SHC1, NOS3, ACTN2, ACTN1, FMNL1, TRAF3IP1, FN1, VCAM1, CDH1, ITGA4, SVIL, CD81, IGSF8, ICAM1, TXN, RPS27, POT1, KPNA2, MAPK7, CDKN2A, VCP, SF3A3, GNB2, HUWE1, ACTN3, BMP7, ALK, CUL7, OBSL1, CCDC8, EGFR, LUZP4, RARA, HSPB1, AHNAK, ALDOA, ALDOC, IDH3A, MYH15, MYH2, MYH7B, NCAPG2, PSMA6, PSMB5, PUS7, TPM2, TSG101, CKB, CYC1, ECSIT, MCFD2, PSMB8, TPM1, TPM3, TPM4, NTRK1, CAPZA2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, PDLIM7, SYNPO, MAPRE1, SIN3B, MYEF2, LIMA1, ANLN, MYO5C, MYO19, MYO18A, CTNNB1, MCM2, NFYA, CDC73, DDIAS, SSH1, NCL, DLD, DNM1L, PDHA1, SOD1, TRIM25, TESCATSPERGPAXIP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneACTN4chr19:39200116chr19:38848918ENST00000252699+721108_126244912VCL
HgeneACTN4chr19:39200116chr19:38848918ENST00000252699+72112_26244912VCL
HgeneACTN4chr19:39200116chr19:38848918ENST00000252699+72140_61244912VCL


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneACTN4chr19:39200116chr19:38848918ENST00000390009+114108_126-3693VCL
HgeneACTN4chr19:39200116chr19:38848918ENST00000390009+11412_26-3693VCL
HgeneACTN4chr19:39200116chr19:38848918ENST00000390009+11440_61-3693VCL


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACTN4_CATSPERG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACTN4_CATSPERG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACTN4C0333497Segmental glomerulosclerosis3UNIPROT
HgeneACTN4C0024667Animal Mammary Neoplasms1CTD_human
HgeneACTN4C0024668Mammary Neoplasms, Experimental1CTD_human