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Fusion gene ID: 583 |
FusionGeneSummary for ACTN4_APLP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACTN4_APLP1 | Fusion gene ID: 583 | Hgene | Tgene | Gene symbol | ACTN4 | APLP1 | Gene ID | 81 | 333 |
| Gene name | actinin alpha 4 | amyloid beta precursor like protein 1 | |
| Synonyms | ACTININ-4|FSGS|FSGS1 | APLP | |
| Cytomap | 19q13.2 | 19q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | alpha-actinin-4focal segmental glomerulosclerosis 1non-muscle alpha-actinin 4 | amyloid-like protein 1amyloid beta (A4) precursor-like protein 1amyloid precursor-like protein 1 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | O43707 | P51693 | |
| Ensembl transtripts involved in fusion gene | ENST00000252699, ENST00000424234, ENST00000390009, ENST00000497637, | ENST00000537454, ENST00000221891, ENST00000586861, ENST00000589298, | |
| Fusion gene scores | * DoF score | 28 X 17 X 13=6188 | 2 X 2 X 2=8 |
| # samples | 30 | 2 | |
| ** MAII score | log2(30/6188*10)=-4.36643879095316 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ACTN4 [Title/Abstract] AND APLP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACTN4 | GO:0035357 | peroxisome proliferator activated receptor signaling pathway | 22351778 |
| Hgene | ACTN4 | GO:0048384 | retinoic acid receptor signaling pathway | 22351778 |
| Hgene | ACTN4 | GO:0051272 | positive regulation of cellular component movement | 9508771 |
| Tgene | APLP1 | GO:0071874 | cellular response to norepinephrine stimulus | 16531006 |
| Tgene | APLP1 | GO:0106072 | negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway | 16531006 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-34-5241-01A | ACTN4 | chr19 | 39138547 | + | APLP1 | chr19 | 36360569 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000252699 | ENST00000537454 | ACTN4 | chr19 | 39138547 | + | APLP1 | chr19 | 36360569 | + |
| In-frame | ENST00000252699 | ENST00000221891 | ACTN4 | chr19 | 39138547 | + | APLP1 | chr19 | 36360569 | + |
| Frame-shift | ENST00000252699 | ENST00000586861 | ACTN4 | chr19 | 39138547 | + | APLP1 | chr19 | 36360569 | + |
| 5CDS-intron | ENST00000252699 | ENST00000589298 | ACTN4 | chr19 | 39138547 | + | APLP1 | chr19 | 36360569 | + |
| In-frame | ENST00000424234 | ENST00000537454 | ACTN4 | chr19 | 39138547 | + | APLP1 | chr19 | 36360569 | + |
| In-frame | ENST00000424234 | ENST00000221891 | ACTN4 | chr19 | 39138547 | + | APLP1 | chr19 | 36360569 | + |
| Frame-shift | ENST00000424234 | ENST00000586861 | ACTN4 | chr19 | 39138547 | + | APLP1 | chr19 | 36360569 | + |
| 5CDS-intron | ENST00000424234 | ENST00000589298 | ACTN4 | chr19 | 39138547 | + | APLP1 | chr19 | 36360569 | + |
| In-frame | ENST00000390009 | ENST00000537454 | ACTN4 | chr19 | 39138547 | + | APLP1 | chr19 | 36360569 | + |
| In-frame | ENST00000390009 | ENST00000221891 | ACTN4 | chr19 | 39138547 | + | APLP1 | chr19 | 36360569 | + |
| Frame-shift | ENST00000390009 | ENST00000586861 | ACTN4 | chr19 | 39138547 | + | APLP1 | chr19 | 36360569 | + |
| 5CDS-intron | ENST00000390009 | ENST00000589298 | ACTN4 | chr19 | 39138547 | + | APLP1 | chr19 | 36360569 | + |
| intron-3CDS | ENST00000497637 | ENST00000537454 | ACTN4 | chr19 | 39138547 | + | APLP1 | chr19 | 36360569 | + |
| intron-3CDS | ENST00000497637 | ENST00000221891 | ACTN4 | chr19 | 39138547 | + | APLP1 | chr19 | 36360569 | + |
| intron-3CDS | ENST00000497637 | ENST00000586861 | ACTN4 | chr19 | 39138547 | + | APLP1 | chr19 | 36360569 | + |
| intron-intron | ENST00000497637 | ENST00000589298 | ACTN4 | chr19 | 39138547 | + | APLP1 | chr19 | 36360569 | + |
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FusionProtFeatures for ACTN4_APLP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACTN4 | APLP1 |
| F-actin cross-linking protein which is thought to anchoractin to a variety of intracellular structures. This is a bundlingprotein (Probable). Probably involved in vesicular trafficking viaits association with the CART complex. The CART complex isnecessary for efficient transferrin receptor recycling but not forEGFR degradation (PubMed:15772161). Involved in tight junctionassembly in epithelial cells probably through interaction withMICALL2. Links MICALL2 to the actin cytoskeleton and recruits itto the tight junctions (By similarity). May also function as atranscriptional coactivator, stimulating transcription mediated bythe nuclear hormone receptors PPARG and RARA (PubMed:22351778).{ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161,ECO:0000269|PubMed:22351778, ECO:0000305|PubMed:9508771}. | May play a role in postsynaptic function. The C-terminalgamma-secretase processed fragment, ALID1, activates transcriptionactivation through APBB1 (Fe65) binding (By similarity). Couplesto JIP signal transduction through C-terminal binding. Mayinteract with cellular G-protein signaling pathways. Can regulateneurite outgrowth through binding to components of theextracellular matrix such as heparin and collagen I.{ECO:0000250}. The gamma-CTF peptide, C30, is a potent enhancer ofneuronal apoptosis. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000252699 | + | 1 | 21 | 19_26 | 54 | 912 | Compositional bias | Poly-Gly |
| Hgene | ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000390009 | + | 1 | 14 | 19_26 | 54 | 693 | Compositional bias | Poly-Gly |
| Tgene | >APLP1 | chr19:39138547 | chr19:36360569 | ENST00000221891 | + | 0 | 17 | 241_247 | 49 | 652 | Compositional bias | Note=Poly-Glu |
| Tgene | >APLP1 | chr19:39138547 | chr19:36360569 | ENST00000221891 | + | 0 | 17 | 264_268 | 49 | 652 | Compositional bias | Note=Poly-Glu |
| Tgene | >APLP1 | chr19:39138547 | chr19:36360569 | ENST00000221891 | + | 0 | 17 | 604_615 | 49 | 652 | Motif | Basolateral sorting signal |
| Tgene | >APLP1 | chr19:39138547 | chr19:36360569 | ENST00000221891 | + | 0 | 17 | 640_643 | 49 | 652 | Motif | Note=NPXY motif%3B contains endocytosis signal |
| Tgene | >APLP1 | chr19:39138547 | chr19:36360569 | ENST00000221891 | + | 0 | 17 | 158_178 | 49 | 652 | Region | Copper-binding |
| Tgene | >APLP1 | chr19:39138547 | chr19:36360569 | ENST00000221891 | + | 0 | 17 | 204_211 | 49 | 652 | Region | Note=Zinc-binding |
| Tgene | >APLP1 | chr19:39138547 | chr19:36360569 | ENST00000221891 | + | 0 | 17 | 285_305 | 49 | 652 | Region | Note=O-glycosylated at three sites |
| Tgene | >APLP1 | chr19:39138547 | chr19:36360569 | ENST00000221891 | + | 0 | 17 | 310_342 | 49 | 652 | Region | Heparin-binding |
| Tgene | >APLP1 | chr19:39138547 | chr19:36360569 | ENST00000221891 | + | 0 | 17 | 410_441 | 49 | 652 | Region | Heparin-binding |
| Tgene | >APLP1 | chr19:39138547 | chr19:36360569 | ENST00000221891 | + | 0 | 17 | 442_459 | 49 | 652 | Region | Collagen-binding |
| Tgene | >APLP1 | chr19:39138547 | chr19:36360569 | ENST00000221891 | + | 0 | 17 | 604_650 | 49 | 652 | Topological domain | Cytoplasmic |
| Tgene | >APLP1 | chr19:39138547 | chr19:36360569 | ENST00000221891 | + | 0 | 17 | 581_603 | 49 | 652 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000252699 | + | 1 | 21 | 778_789 | 54 | 912 | Calcium binding | 1 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000252699 | + | 1 | 21 | 819_830 | 54 | 912 | Calcium binding | 2 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000390009 | + | 1 | 14 | 778_789 | 54 | 693 | Calcium binding | 1 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000390009 | + | 1 | 14 | 819_830 | 54 | 693 | Calcium binding | 2 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000252699 | + | 1 | 21 | 163_269 | 54 | 912 | Domain | Calponin-homology (CH) 2 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000252699 | + | 1 | 21 | 50_154 | 54 | 912 | Domain | Calponin-homology (CH) 1 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000252699 | + | 1 | 21 | 765_800 | 54 | 912 | Domain | EF-hand 1 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000252699 | + | 1 | 21 | 806_841 | 54 | 912 | Domain | EF-hand 2 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000390009 | + | 1 | 14 | 163_269 | 54 | 693 | Domain | Calponin-homology (CH) 2 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000390009 | + | 1 | 14 | 50_154 | 54 | 693 | Domain | Calponin-homology (CH) 1 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000390009 | + | 1 | 14 | 765_800 | 54 | 693 | Domain | EF-hand 1 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000390009 | + | 1 | 14 | 806_841 | 54 | 693 | Domain | EF-hand 2 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000252699 | + | 1 | 21 | 84_88 | 54 | 912 | Motif | LXXLL motif |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000390009 | + | 1 | 14 | 84_88 | 54 | 693 | Motif | LXXLL motif |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000252699 | + | 1 | 21 | 177_192 | 54 | 912 | Region | Polyphosphoinositide (PIP2)-binding |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000252699 | + | 1 | 21 | 1_269 | 54 | 912 | Region | Note=Actin-binding |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000390009 | + | 1 | 14 | 177_192 | 54 | 693 | Region | Polyphosphoinositide (PIP2)-binding |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000390009 | + | 1 | 14 | 1_269 | 54 | 693 | Region | Note=Actin-binding |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000252699 | + | 1 | 21 | 293_403 | 54 | 912 | Repeat | Spectrin 1 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000252699 | + | 1 | 21 | 413_518 | 54 | 912 | Repeat | Spectrin 2 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000252699 | + | 1 | 21 | 528_639 | 54 | 912 | Repeat | Spectrin 3 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000252699 | + | 1 | 21 | 649_752 | 54 | 912 | Repeat | Spectrin 4 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000390009 | + | 1 | 14 | 293_403 | 54 | 693 | Repeat | Spectrin 1 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000390009 | + | 1 | 14 | 413_518 | 54 | 693 | Repeat | Spectrin 2 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000390009 | + | 1 | 14 | 528_639 | 54 | 693 | Repeat | Spectrin 3 |
| Hgene | >ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000390009 | + | 1 | 14 | 649_752 | 54 | 693 | Repeat | Spectrin 4 |
| Tgene | APLP1 | chr19:39138547 | chr19:36360569 | ENST00000221891 | + | 0 | 17 | 39_580 | 49 | 652 | Topological domain | Extracellular |
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FusionGeneSequence for ACTN4_APLP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ACTN4_ENST00000252699_chr19_39138547_+_APLP1_ENST00000537454_chr19_36360569_+_656aa MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCL RDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQ EAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEE EEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQ SILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQM RFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASP EKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLTL >In-frame_ACTN4_ENST00000252699_chr19_39138547_+_APLP1_ENST00000221891_chr19_36360569_+_657aa MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCL RDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQ EAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEE EEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQ SILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQM RFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAAS PEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLT >In-frame_ACTN4_ENST00000424234_chr19_39138547_+_APLP1_ENST00000537454_chr19_36360569_+_656aa MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCL RDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQ EAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEE EEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQ SILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQM RFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASP EKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLTL >In-frame_ACTN4_ENST00000424234_chr19_39138547_+_APLP1_ENST00000221891_chr19_36360569_+_657aa MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCL RDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQ EAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEE EEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQ SILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQM RFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAAS PEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLT >In-frame_ACTN4_ENST00000390009_chr19_39138547_+_APLP1_ENST00000537454_chr19_36360569_+_656aa MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCL RDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQ EAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEE EEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQ SILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQM RFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASP EKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLTL >In-frame_ACTN4_ENST00000390009_chr19_39138547_+_APLP1_ENST00000221891_chr19_36360569_+_657aa MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCL RDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQ EAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEE EEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQ SILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQM RFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAAS PEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ACTN4_ENST00000252699_chr19_39138547_+_APLP1_ENST00000537454_chr19_36360569_+_1968nt ATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGAC TACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGTCGGCCCAG GTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTC CGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCC ATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTT GTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAG GAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTG GAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGC AGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAG GAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGAT ATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATT AATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAG TCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAAC GACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGC TACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATG CGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAG GAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCAGCGAG GACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCCCCT GAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAGATT CAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCCCTC ATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGACCCTG >In-frame_ACTN4_ENST00000252699_chr19_39138547_+_APLP1_ENST00000221891_chr19_36360569_+_1971nt ATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGAC TACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGTCGGCCCAG GTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTC CGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCC ATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTT GTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAG GAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTG GAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGC AGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAG GAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGAT ATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATT AATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAG TCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAAC GACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGC TACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATG CGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAG GAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCAGCGAG GACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGCAGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCC CCTGAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAG ATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCC CTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGACC >In-frame_ACTN4_ENST00000424234_chr19_39138547_+_APLP1_ENST00000537454_chr19_36360569_+_1968nt ATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGAC TACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGTCGGCCCAG GTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTC CGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCC ATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTT GTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAG GAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTG GAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGC AGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAG GAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGAT ATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATT AATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAG TCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAAC GACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGC TACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATG CGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAG GAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCAGCGAG GACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCCCCT GAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAGATT CAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCCCTC ATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGACCCTG >In-frame_ACTN4_ENST00000424234_chr19_39138547_+_APLP1_ENST00000221891_chr19_36360569_+_1971nt ATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGAC TACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGTCGGCCCAG GTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTC CGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCC ATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTT GTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAG GAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTG GAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGC AGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAG GAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGAT ATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATT AATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAG TCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAAC GACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGC TACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATG CGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAG GAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCAGCGAG GACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGCAGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCC CCTGAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAG ATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCC CTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGACC >In-frame_ACTN4_ENST00000390009_chr19_39138547_+_APLP1_ENST00000537454_chr19_36360569_+_1968nt ATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGAC TACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGTCGGCCCAG GTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTC CGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCC ATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTT GTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAG GAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTG GAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGC AGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAG GAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGAT ATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATT AATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAG TCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAAC GACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGC TACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATG CGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAG GAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCAGCGAG GACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCCCCT GAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAGATT CAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCCCTC ATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGACCCTG >In-frame_ACTN4_ENST00000390009_chr19_39138547_+_APLP1_ENST00000221891_chr19_36360569_+_1971nt ATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGAC TACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGTCGGCCCAG GTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTC CGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCC ATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTT GTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAG GAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTG GAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGC AGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAG GAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGAT ATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATT AATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAG TCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAAC GACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGC TACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATG CGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAG GAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCAGCGAG GACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGCAGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCC CCTGAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAG ATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCC CTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGACC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ACTN4_ENST00000252699_chr19_39138547_+_APLP1_ENST00000537454_chr19_36360569_+_2129nt GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATG CGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCG CGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTG CGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCT GCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGC CTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTG TCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGC TGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGT CCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCAT GCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCG TGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGAC TCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGC TGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGA GCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGTGCA TACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAGGAGCTGCGGCCCCA AATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCAGCGAGGACAAGGGTGGGCT GCAGCCTCCAGATTCCAAGGATGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCCCCTGAGAAAGAGAAGAT GAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAGATTCAGAGGGATGAGCT GGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCCCTCATCGTCCTCTCCAT GCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGACCCTGGAGGAGCAGCAGCT CCGCGAACTGCAGCGGCACGGCTATGAGAACCCCACTTACCGCTTCCTGGAGGAACGACCCTGACCCGGCCCCCTTCACCCCTTCAGCCG >In-frame_ACTN4_ENST00000252699_chr19_39138547_+_APLP1_ENST00000221891_chr19_36360569_+_2394nt GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATG CGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCG CGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTG CGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCT GCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGC CTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTG TCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGC TGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGT CCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCAT GCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCG TGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGAC TCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGC TGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGA GCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGTGCA TACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAGGAGCTGCGGCCCCA AATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCAGCGAGGACAAGGGTGGGCT GCAGCCTCCAGATTCCAAGGATGCAGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCCCCTGAGAAAGAGAA GATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAGATTCAGAGGGATGA GCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCCCTCATCGTCCTCTC CATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGACCCTGGAGGAGCAGCA GCTCCGCGAACTGCAGCGGCACGGCTATGAGAACCCCACTTACCGCTTCCTGGAGGAACGACCCTGACCCGGCCCCCTTCACCCCTTCAG CCGAGCCCAGACCTCCCCTCTTCCTGGAGCCCCAGAACCCCAACTCCCAGCCTAGGGCAGCAGGGAGTCTTGAAGTGATCATTTCACACC CTTTTGTGAGACGGCTGGAAATTCTTATTTCCCCTTTCCAATTCCAAAATTCCATCCCTAAGAATTCCCAGATAGTCCCAGCAGCCTCCC CACGTGGCACCTCCTCACCTTAATTTATTTTTTAAGTTTATTTATGGCTCTTTAAGGTGACCGCCACCTTGGTCCTAGTGTCTATTCCCT >In-frame_ACTN4_ENST00000424234_chr19_39138547_+_APLP1_ENST00000537454_chr19_36360569_+_2112nt AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTC ACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCA GACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCG GCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCT GCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCC TCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCC CCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGG AGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCC ATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTG AGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAG ACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGT CTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCC TGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGC ACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGA TTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAGGAGCTGCGGCCCCAAATCCAGGAACTCCTCC ACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCAGCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCA AGGATGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCCCCTGAGAAAGAGAAGATGAACCCGCTGGAACAGT ATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAGATTCAGAGGGATGAGCTGGCACCAGCTGGGACAG GGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCCCTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGA AGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGACCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGCGGC ACGGCTATGAGAACCCCACTTACCGCTTCCTGGAGGAACGACCCTGACCCGGCCCCCTTCACCCCTTCAGCCGAGCCCAGACCTCCCCTC >In-frame_ACTN4_ENST00000424234_chr19_39138547_+_APLP1_ENST00000221891_chr19_36360569_+_2377nt AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTC ACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCA GACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCG GCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCT GCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCC TCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCC CCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGG AGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCC ATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTG AGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAG ACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGT CTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCC TGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGC ACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGA TTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAGGAGCTGCGGCCCCAAATCCAGGAACTCCTCC ACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCAGCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCA AGGATGCAGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCCCCTGAGAAAGAGAAGATGAACCCGCTGGAAC AGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAGATTCAGAGGGATGAGCTGGCACCAGCTGGGA CAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCCCTCATCGTCCTCTCCATGCTGCTCCTGCGCA GGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGACCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGC GGCACGGCTATGAGAACCCCACTTACCGCTTCCTGGAGGAACGACCCTGACCCGGCCCCCTTCACCCCTTCAGCCGAGCCCAGACCTCCC CTCTTCCTGGAGCCCCAGAACCCCAACTCCCAGCCTAGGGCAGCAGGGAGTCTTGAAGTGATCATTTCACACCCTTTTGTGAGACGGCTG GAAATTCTTATTTCCCCTTTCCAATTCCAAAATTCCATCCCTAAGAATTCCCAGATAGTCCCAGCAGCCTCCCCACGTGGCACCTCCTCA CCTTAATTTATTTTTTAAGTTTATTTATGGCTCTTTAAGGTGACCGCCACCTTGGTCCTAGTGTCTATTCCCTGGAATTCACCCTCTCAT >In-frame_ACTN4_ENST00000390009_chr19_39138547_+_APLP1_ENST00000537454_chr19_36360569_+_2061nt GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGT CGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGAC GCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGG CCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTG GTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGA GGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCC GTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCC CGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGG CTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACG GTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGC GCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGC ACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCC TTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCC TGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCAC AGCAGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACC TGGCTCAGGAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCA GCAGCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTG CATCCCCTGAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCAT CGGAGATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAG GCTCCCTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGC TGACCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGCGGCACGGCTATGAGAACCCCACTTACCGCTTCCTGGAGGAACGACCCTGACCCG >In-frame_ACTN4_ENST00000390009_chr19_39138547_+_APLP1_ENST00000221891_chr19_36360569_+_2326nt GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGT CGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGAC GCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGG CCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTG GTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGA GGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCC GTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCC CGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGG CTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACG GTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGC GCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGC ACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCC TTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCC TGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCAC AGCAGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACC TGGCTCAGGAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCA GCAGCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGCAGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATG CTGCATCCCCTGAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACT CATCGGAGATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCG GAGGCTCCCTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCA TGCTGACCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGCGGCACGGCTATGAGAACCCCACTTACCGCTTCCTGGAGGAACGACCCTGAC CCGGCCCCCTTCACCCCTTCAGCCGAGCCCAGACCTCCCCTCTTCCTGGAGCCCCAGAACCCCAACTCCCAGCCTAGGGCAGCAGGGAGT CTTGAAGTGATCATTTCACACCCTTTTGTGAGACGGCTGGAAATTCTTATTTCCCCTTTCCAATTCCAAAATTCCATCCCTAAGAATTCC CAGATAGTCCCAGCAGCCTCCCCACGTGGCACCTCCTCACCTTAATTTATTTTTTAAGTTTATTTATGGCTCTTTAAGGTGACCGCCACC |
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FusionGenePPI for ACTN4_APLP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ACTN4 | MYOZ2, MYOZ1, PDLIM1, USP6NL, SLC9A3R2, COL17A1, TRIM3, MAGI1, GSN, CAMK2A, CAMK2B, INO80, UBTF, STAT1, HDAC7, MEF2A, UCHL5, TJP1, ATXN7, HDAC5, VDR, ESR1, PSMA3, ELAVL1, SIRT7, SLC2A4, ISG15, COIL, SACS, HGS, UBASH3B, SHC1, NOS3, ACTN2, ACTN1, FMNL1, TRAF3IP1, FN1, VCAM1, CDH1, ITGA4, SVIL, CD81, IGSF8, ICAM1, TXN, RPS27, POT1, KPNA2, MAPK7, CDKN2A, VCP, SF3A3, GNB2, HUWE1, ACTN3, BMP7, ALK, CUL7, OBSL1, CCDC8, EGFR, LUZP4, RARA, HSPB1, AHNAK, ALDOA, ALDOC, IDH3A, MYH15, MYH2, MYH7B, NCAPG2, PSMA6, PSMB5, PUS7, TPM2, TSG101, CKB, CYC1, ECSIT, MCFD2, PSMB8, TPM1, TPM3, TPM4, NTRK1, CAPZA2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, PDLIM7, SYNPO, MAPRE1, SIN3B, MYEF2, LIMA1, ANLN, MYO5C, MYO19, MYO18A, CTNNB1, MCM2, NFYA, CDC73, DDIAS, SSH1, NCL, DLD, DNM1L, PDHA1, SOD1, TRIM25, TES | APLP1 | DAB1, CRCT1, PHF10, TCF21, TOE1, UTP14A, CDKN2C, GSTM4, HLA-DQA1, MPHOSPH6, NACA, STX5, TSC22D1, EIF2S2, HSPE1, PCDHA4, SAT1, TK1, ZNF24, PNP, DAB2, APBB3, APBB1, RAP1B, CSNK2B, SNCA, CDKN1A, CDK4, SMN1, RCC1, PIN1, VIM, ANXA7, KAT5, ARRB1, EEF1A1, ING5, GDF9, SETDB1, LRIF1, HAP1, RBM48, GLP1R, APBB2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000252699 | + | 1 | 21 | 12_26 | 54 | 912 | VCL |
| Hgene | ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000390009 | + | 1 | 14 | 12_26 | 54 | 693 | VCL |
| Tgene | APLP1 | chr19:39138547 | chr19:36360569 | ENST00000221891 | + | 0 | 17 | 632_649 | 49 | 652 | DAB1 |
| Tgene | APLP1 | chr19:39138547 | chr19:36360569 | ENST00000221891 | + | 0 | 17 | 636_650 | 49 | 652 | DAB2 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000252699 | + | 1 | 21 | 108_126 | 54 | 912 | VCL |
| Hgene | ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000252699 | + | 1 | 21 | 40_61 | 54 | 912 | VCL |
| Hgene | ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000390009 | + | 1 | 14 | 108_126 | 54 | 693 | VCL |
| Hgene | ACTN4 | chr19:39138547 | chr19:36360569 | ENST00000390009 | + | 1 | 14 | 40_61 | 54 | 693 | VCL |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACTN4_APLP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | APLP1 | P51693 | DB01593 | Zinc | Amyloid-like protein 1 | small molecule | approved|investigational |
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RelatedDiseases for ACTN4_APLP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ACTN4 | C0333497 | Segmental glomerulosclerosis | 3 | UNIPROT |
| Hgene | ACTN4 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | ACTN4 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
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