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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5829

FusionGeneSummary for CCDC18_MBP

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC18_MBP
Fusion gene ID: 5829
HgeneTgene
Gene symbol

CCDC18

MBP

Gene ID

343099

5553

Gene namecoiled-coil domain containing 18proteoglycan 2, pro eosinophil major basic protein
SynonymsNY-SAR-41BMPG|MBP|MBP1|proMBP
Cytomap

1p22.1

11q12.1

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 18sarcoma antigen NY-SAR-24sarcoma antigen NY-SAR-41bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Modification date2018051920180519
UniProtAcc

Q5T9S5

P02686

Ensembl transtripts involved in fusion geneENST00000343253, ENST00000401026, 
ENST00000338949, ENST00000334652, 
ENST00000557479, ENST00000421014, 
ENST00000382582, ENST00000355994, 
ENST00000397875, ENST00000397866, 
ENST00000397865, ENST00000527041, 
ENST00000359645, ENST00000528160, 
ENST00000397869, ENST00000354542, 
ENST00000526111, ENST00000580402, 
ENST00000579129, ENST00000578193, 
ENST00000397863, ENST00000397860, 
ENST00000487778, 
Fusion gene scores* DoF score2 X 2 X 1=426 X 20 X 3=1560
# samples 227
** MAII scorelog2(2/4*10)=2.32192809488736log2(27/1560*10)=-2.53051471669878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCDC18 [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA132471CCDC18chr1

93658054

+MBPchr18

74692208

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000343253ENST00000382582CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000343253ENST00000355994CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000343253ENST00000397875CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000343253ENST00000397866CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000343253ENST00000397865CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000343253ENST00000527041CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000343253ENST00000359645CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000343253ENST00000528160CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000343253ENST00000397869CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000343253ENST00000354542CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000343253ENST00000526111CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000343253ENST00000580402CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000343253ENST00000579129CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000343253ENST00000578193CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000343253ENST00000397863CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000343253ENST00000397860CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000343253ENST00000487778CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000401026ENST00000382582CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000401026ENST00000355994CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000401026ENST00000397875CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000401026ENST00000397866CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000401026ENST00000397865CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000401026ENST00000527041CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000401026ENST00000359645CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000401026ENST00000528160CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000401026ENST00000397869CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000401026ENST00000354542CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000401026ENST00000526111CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000401026ENST00000580402CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000401026ENST00000579129CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000401026ENST00000578193CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000401026ENST00000397863CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000401026ENST00000397860CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000401026ENST00000487778CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000338949ENST00000382582CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000338949ENST00000355994CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000338949ENST00000397875CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000338949ENST00000397866CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000338949ENST00000397865CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000338949ENST00000527041CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000338949ENST00000359645CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000338949ENST00000528160CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000338949ENST00000397869CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000338949ENST00000354542CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000338949ENST00000526111CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000338949ENST00000580402CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000338949ENST00000579129CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000338949ENST00000578193CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000338949ENST00000397863CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000338949ENST00000397860CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000338949ENST00000487778CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000334652ENST00000382582CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000334652ENST00000355994CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000334652ENST00000397875CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000334652ENST00000397866CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000334652ENST00000397865CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000334652ENST00000527041CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000334652ENST00000359645CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000334652ENST00000528160CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000334652ENST00000397869CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000334652ENST00000354542CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000334652ENST00000526111CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000334652ENST00000580402CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000334652ENST00000579129CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000334652ENST00000578193CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000334652ENST00000397863CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000334652ENST00000397860CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000334652ENST00000487778CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000557479ENST00000382582CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000557479ENST00000355994CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000557479ENST00000397875CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000557479ENST00000397866CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000557479ENST00000397865CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000557479ENST00000527041CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000557479ENST00000359645CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000557479ENST00000528160CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000557479ENST00000397869CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000557479ENST00000354542CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000557479ENST00000526111CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000557479ENST00000580402CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000557479ENST00000579129CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000557479ENST00000578193CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000557479ENST00000397863CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000557479ENST00000397860CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000557479ENST00000487778CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000421014ENST00000382582CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000421014ENST00000355994CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000421014ENST00000397875CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000421014ENST00000397866CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000421014ENST00000397865CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000421014ENST00000527041CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000421014ENST00000359645CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-3UTRENST00000421014ENST00000528160CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000421014ENST00000397869CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000421014ENST00000354542CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000421014ENST00000526111CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000421014ENST00000580402CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000421014ENST00000579129CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000421014ENST00000578193CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000421014ENST00000397863CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000421014ENST00000397860CCDC18chr1

93658054

+MBPchr18

74692208

-
intron-intronENST00000421014ENST00000487778CCDC18chr1

93658054

+MBPchr18

74692208

-

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FusionProtFeatures for CCDC18_MBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC18

Q5T9S5

MBP

P02686


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCDC18_MBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCDC18_MBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CCDC18_MBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CCDC18_MBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMBPC0036341Schizophrenia4PSYGENET
TgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
TgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneMBPC0011303Demyelinating Diseases1CTD_human
TgeneMBPC0027873Neuromyelitis Optica1CTD_human