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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5806

FusionGeneSummary for CCDC149_C9orf3

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC149_C9orf3
Fusion gene ID: 5806
HgeneTgene
Gene symbol

CCDC149

C9orf3

Gene ID

91050

84909

Gene namecoiled-coil domain containing 149chromosome 9 open reading frame 3
Synonyms-AOPEP|AP-O|APO|C90RF3|ONPEP
Cytomap

4p15.2

9q22.32

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 149aminopeptidase O
Modification date2018051920180523
UniProtAcc

Q6ZUS6

Ensembl transtripts involved in fusion geneENST00000504487, ENST00000428116, 
ENST00000389609, ENST00000502801, 
ENST00000508236, 
ENST00000277198, 
ENST00000297979, ENST00000375315, 
ENST00000395357, ENST00000425634, 
ENST00000433691, ENST00000473778, 
Fusion gene scores* DoF score5 X 5 X 4=1008 X 4 X 7=224
# samples 58
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCDC149 [Title/Abstract] AND C9orf3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneC9orf3

GO:0006508

proteolysis

15687497


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-25-2401-01ACCDC149chr4

24878158

-C9orf3chr9

97822976

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000504487ENST00000277198CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000504487ENST00000297979CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000504487ENST00000375315CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000504487ENST00000395357CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000504487ENST00000425634CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000504487ENST00000433691CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000504487ENST00000473778CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000428116ENST00000277198CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000428116ENST00000297979CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000428116ENST00000375315CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000428116ENST00000395357CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000428116ENST00000425634CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000428116ENST00000433691CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000428116ENST00000473778CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000389609ENST00000277198CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000389609ENST00000297979CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000389609ENST00000375315CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000389609ENST00000395357CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000389609ENST00000425634CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000389609ENST00000433691CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000389609ENST00000473778CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000502801ENST00000277198CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000502801ENST00000297979CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000502801ENST00000375315CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000502801ENST00000395357CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000502801ENST00000425634CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000502801ENST00000433691CCDC149chr4

24878158

-C9orf3chr9

97822976

+
5CDS-intronENST00000502801ENST00000473778CCDC149chr4

24878158

-C9orf3chr9

97822976

+
intron-intronENST00000508236ENST00000277198CCDC149chr4

24878158

-C9orf3chr9

97822976

+
intron-intronENST00000508236ENST00000297979CCDC149chr4

24878158

-C9orf3chr9

97822976

+
intron-intronENST00000508236ENST00000375315CCDC149chr4

24878158

-C9orf3chr9

97822976

+
intron-intronENST00000508236ENST00000395357CCDC149chr4

24878158

-C9orf3chr9

97822976

+
intron-intronENST00000508236ENST00000425634CCDC149chr4

24878158

-C9orf3chr9

97822976

+
intron-intronENST00000508236ENST00000433691CCDC149chr4

24878158

-C9orf3chr9

97822976

+
intron-intronENST00000508236ENST00000473778CCDC149chr4

24878158

-C9orf3chr9

97822976

+

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FusionProtFeatures for CCDC149_C9orf3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC149

Q6ZUS6

C9orf3

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCDC149_C9orf3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCDC149_C9orf3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCDC149PRNP, APPC9orf3SUN2, LRRC40, ZDHHC17, TUBA4A, SUZ12, TUBB3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCDC149_C9orf3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCDC149_C9orf3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC9orf3C0004238Atrial Fibrillation1CTD_human
TgeneC9orf3C0032927Precancerous Conditions1CTD_human
TgeneC9orf3C3495559Juvenile arthritis1CTD_human