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Fusion gene ID: 5805 |
FusionGeneSummary for CCDC149_ARAP2 |
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Fusion gene information | Fusion gene name: CCDC149_ARAP2 | Fusion gene ID: 5805 | Hgene | Tgene | Gene symbol | CCDC149 | ARAP2 | Gene ID | 91050 | 116984 |
Gene name | coiled-coil domain containing 149 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | |
Synonyms | - | CENTD1|PARX | |
Cytomap | 4p15.2 | 4p14 | |
Type of gene | protein-coding | protein-coding | |
Description | coiled-coil domain-containing protein 149 | arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2Arf and Rho GAP adapter protein 2centaurin-delta-1 | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q6ZUS6 | Q8WZ64 | |
Ensembl transtripts involved in fusion gene | ENST00000504487, ENST00000428116, ENST00000389609, ENST00000502801, ENST00000508236, | ENST00000513032, ENST00000303965, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 2 X 2 X 2=8 |
# samples | 5 | 2 | |
** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: CCDC149 [Title/Abstract] AND ARAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-E9-A1RE-01A | CCDC149 | chr4 | 24875303 | - | ARAP2 | chr4 | 36075445 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000504487 | ENST00000513032 | CCDC149 | chr4 | 24875303 | - | ARAP2 | chr4 | 36075445 | - |
5CDS-intron | ENST00000504487 | ENST00000303965 | CCDC149 | chr4 | 24875303 | - | ARAP2 | chr4 | 36075445 | - |
5CDS-intron | ENST00000428116 | ENST00000513032 | CCDC149 | chr4 | 24875303 | - | ARAP2 | chr4 | 36075445 | - |
5CDS-intron | ENST00000428116 | ENST00000303965 | CCDC149 | chr4 | 24875303 | - | ARAP2 | chr4 | 36075445 | - |
5CDS-intron | ENST00000389609 | ENST00000513032 | CCDC149 | chr4 | 24875303 | - | ARAP2 | chr4 | 36075445 | - |
5CDS-intron | ENST00000389609 | ENST00000303965 | CCDC149 | chr4 | 24875303 | - | ARAP2 | chr4 | 36075445 | - |
5CDS-intron | ENST00000502801 | ENST00000513032 | CCDC149 | chr4 | 24875303 | - | ARAP2 | chr4 | 36075445 | - |
5CDS-intron | ENST00000502801 | ENST00000303965 | CCDC149 | chr4 | 24875303 | - | ARAP2 | chr4 | 36075445 | - |
intron-intron | ENST00000508236 | ENST00000513032 | CCDC149 | chr4 | 24875303 | - | ARAP2 | chr4 | 36075445 | - |
intron-intron | ENST00000508236 | ENST00000303965 | CCDC149 | chr4 | 24875303 | - | ARAP2 | chr4 | 36075445 | - |
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FusionProtFeatures for CCDC149_ARAP2 |
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Hgene | Tgene |
CCDC149 | ARAP2 |
Phosphatidylinositol 3,4,5-trisphosphate-dependentGTPase-activating protein that modulates actin cytoskeletonremodeling by regulating ARF and RHO family members. Is activatedby phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3)binding. Can be activated by phosphatidylinositol 3,4-bisphosphate(PtdIns(3,4,5)P2) binding, albeit with lower efficiency (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CCDC149_ARAP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CCDC149_ARAP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CCDC149 | PRNP, APP | ARAP2 | ARHGEF11 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CCDC149_ARAP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCDC149_ARAP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |