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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5781

FusionGeneSummary for CCDC126_OSBPL3

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC126_OSBPL3
Fusion gene ID: 5781
HgeneTgene
Gene symbol

CCDC126

OSBPL3

Gene ID

90693

26031

Gene namecoiled-coil domain containing 126oxysterol binding protein like 3
Synonyms-ORP-3|ORP3|OSBP3
Cytomap

7p15.3

7p15.3

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 126oxysterol-binding protein-related protein 3OSBP-related protein 3
Modification date2018051920180523
UniProtAcc

Q96EE4

Q9H4L5

Ensembl transtripts involved in fusion geneENST00000307471, ENST00000409765, 
ENST00000410069, ENST00000486109, 
ENST00000313367, ENST00000431825, 
ENST00000352860, ENST00000353930, 
ENST00000396431, ENST00000409069, 
ENST00000396429, ENST00000487020, 
Fusion gene scores* DoF score2 X 1 X 2=45 X 5 X 4=100
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCDC126 [Title/Abstract] AND OSBPL3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-69-7979-01ACCDC126chr7

23651172

+OSBPL3chr7

24932240

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000307471ENST00000313367CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-5UTRENST00000307471ENST00000431825CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-5UTRENST00000307471ENST00000352860CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-5UTRENST00000307471ENST00000353930CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-intronENST00000307471ENST00000396431CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-intronENST00000307471ENST00000409069CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-intronENST00000307471ENST00000396429CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-intronENST00000307471ENST00000487020CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-5UTRENST00000409765ENST00000313367CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-5UTRENST00000409765ENST00000431825CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-5UTRENST00000409765ENST00000352860CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-5UTRENST00000409765ENST00000353930CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-intronENST00000409765ENST00000396431CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-intronENST00000409765ENST00000409069CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-intronENST00000409765ENST00000396429CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-intronENST00000409765ENST00000487020CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-5UTRENST00000410069ENST00000313367CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-5UTRENST00000410069ENST00000431825CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-5UTRENST00000410069ENST00000352860CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-5UTRENST00000410069ENST00000353930CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-intronENST00000410069ENST00000396431CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-intronENST00000410069ENST00000409069CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-intronENST00000410069ENST00000396429CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-intronENST00000410069ENST00000487020CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-5UTRENST00000486109ENST00000313367CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-5UTRENST00000486109ENST00000431825CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-5UTRENST00000486109ENST00000352860CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-5UTRENST00000486109ENST00000353930CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-intronENST00000486109ENST00000396431CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-intronENST00000486109ENST00000409069CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-intronENST00000486109ENST00000396429CCDC126chr7

23651172

+OSBPL3chr7

24932240

-
5CDS-intronENST00000486109ENST00000487020CCDC126chr7

23651172

+OSBPL3chr7

24932240

-

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FusionProtFeatures for CCDC126_OSBPL3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC126

Q96EE4

OSBPL3

Q9H4L5


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCDC126_OSBPL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCDC126_OSBPL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCDC126HTT, GPM6A, MFFOSBPL3YWHAG, YWHAB, SFN, ELAVL1, YWHAE, VAPB, ENO1, NXF1, ARRDC1, TTI2, ADCYAP1, AURKA, SMC1A, VAPA, MMGT1, GLTSCR2, ZFPL1, CPNE2, TSPYL1, ACTR3B, HDAC11, ILVBL, JPH4, PRICKLE3, TRAF1, HIF1AN, KCTD3, CBY1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCDC126_OSBPL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCDC126_OSBPL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCDC126C0023893Liver Cirrhosis, Experimental1CTD_human