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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5753

FusionGeneSummary for CCAR2_PDLIM2

check button Fusion gene summary
Fusion gene informationFusion gene name: CCAR2_PDLIM2
Fusion gene ID: 5753
HgeneTgene
Gene symbol

CCAR2

PDLIM2

Gene ID

57805

64236

Gene namecell cycle and apoptosis regulator 2PDZ and LIM domain 2
SynonymsDBC-1|DBC1|KIAA1967|NET35|p30 DBC|p30DBCMYSTIQUE|SLIM
Cytomap

8p21.3

8p21.3

Type of geneprotein-codingprotein-coding
Descriptioncell cycle and apoptosis regulator protein 2cell division cycle and apoptosis regulator protein 2deleted in breast cancer 1p30 DBC proteinPDZ and LIM domain protein 2
Modification date2018052220180519
UniProtAcc

Q8N163

Q96JY6

Ensembl transtripts involved in fusion geneENST00000308511, ENST00000521301, 
ENST00000389279, ENST00000520861, 
ENST00000308354, ENST00000397760, 
ENST00000339162, ENST00000397761, 
ENST00000409141, ENST00000265810, 
ENST00000409417, ENST00000448520, 
Fusion gene scores* DoF score3 X 3 X 4=362 X 2 X 2=8
# samples 42
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: CCAR2 [Title/Abstract] AND PDLIM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCCAR2

GO:0031647

regulation of protein stability

23398316

HgeneCCAR2

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

23398316

HgeneCCAR2

GO:0043653

mitochondrial fragmentation involved in apoptotic process

15824730

HgeneCCAR2

GO:0045892

negative regulation of transcription, DNA-templated

20160719

HgeneCCAR2

GO:0090311

regulation of protein deacetylation

21030595


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDREADTCGA-EI-6884-01ACCAR2chr8

22465578

+PDLIM2chr8

22442334

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000308511ENST00000308354CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
In-frameENST00000308511ENST00000397760CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
In-frameENST00000308511ENST00000339162CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
In-frameENST00000308511ENST00000397761CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
In-frameENST00000308511ENST00000409141CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
In-frameENST00000308511ENST00000265810CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
In-frameENST00000308511ENST00000409417CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
5CDS-intronENST00000308511ENST00000448520CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
intron-3CDSENST00000521301ENST00000308354CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
intron-3CDSENST00000521301ENST00000397760CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
intron-3CDSENST00000521301ENST00000339162CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
intron-3CDSENST00000521301ENST00000397761CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
intron-3CDSENST00000521301ENST00000409141CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
intron-3CDSENST00000521301ENST00000265810CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
intron-3CDSENST00000521301ENST00000409417CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
intron-intronENST00000521301ENST00000448520CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
In-frameENST00000389279ENST00000308354CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
In-frameENST00000389279ENST00000397760CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
In-frameENST00000389279ENST00000339162CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
In-frameENST00000389279ENST00000397761CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
In-frameENST00000389279ENST00000409141CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
In-frameENST00000389279ENST00000265810CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
In-frameENST00000389279ENST00000409417CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
5CDS-intronENST00000389279ENST00000448520CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
5UTR-3CDSENST00000520861ENST00000308354CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
5UTR-3CDSENST00000520861ENST00000397760CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
5UTR-3CDSENST00000520861ENST00000339162CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
5UTR-3CDSENST00000520861ENST00000397761CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
5UTR-3CDSENST00000520861ENST00000409141CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
5UTR-3CDSENST00000520861ENST00000265810CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
5UTR-3CDSENST00000520861ENST00000409417CCAR2chr8

22465578

+PDLIM2chr8

22442334

+
5UTR-intronENST00000520861ENST00000448520CCAR2chr8

22465578

+PDLIM2chr8

22442334

+

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FusionProtFeatures for CCAR2_PDLIM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCAR2

Q8N163

PDLIM2

Q96JY6

Probable adapter protein located at the actincytoskeleton that promotes cell attachment. Necessary for themigratory capacity of epithelial cells. Overexpression enhancescell adhesion to collagen and fibronectin and suppresses anchorageindependent growth. May contribute to tumor cell migratorycapacity. {ECO:0000269|PubMed:15659642}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDLIM2chr8:22465578chr8:22442334ENST00000265810+110114_16181367Compositional biasNote=Ser-rich
TgenePDLIM2chr8:22465578chr8:22442334ENST00000339162+29114_16181279Compositional biasNote=Ser-rich
TgenePDLIM2chr8:22465578chr8:22442334ENST00000397760+210114_16181353Compositional biasNote=Ser-rich
TgenePDLIM2chr8:22465578chr8:22442334ENST00000397761+210114_16181353Compositional biasNote=Ser-rich
TgenePDLIM2chr8:22465578chr8:22442334ENST00000409141+18114_16181279Compositional biasNote=Ser-rich
TgenePDLIM2chr8:22465578chr8:22442334ENST00000409417+19114_16181353Compositional biasNote=Ser-rich
TgenePDLIM2chr8:22465578chr8:22442334ENST00000265810+110284_34481367DomainLIM zinc-binding
TgenePDLIM2chr8:22465578chr8:22442334ENST00000339162+29284_34481279DomainLIM zinc-binding
TgenePDLIM2chr8:22465578chr8:22442334ENST00000397760+210284_34481353DomainLIM zinc-binding
TgenePDLIM2chr8:22465578chr8:22442334ENST00000397761+210284_34481353DomainLIM zinc-binding
TgenePDLIM2chr8:22465578chr8:22442334ENST00000409141+18284_34481279DomainLIM zinc-binding
TgenePDLIM2chr8:22465578chr8:22442334ENST00000409417+19284_34481353DomainLIM zinc-binding

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCAR2chr8:22465578chr8:22442334ENST00000308511+721829_909194924Coiled coilOntology_term=ECO:0000255
HgeneCCAR2chr8:22465578chr8:22442334ENST00000389279+721829_909194924Coiled coilOntology_term=ECO:0000255
TgenePDLIM2chr8:22465578chr8:22442334ENST00000308354+210114_161331603Compositional biasNote=Ser-rich
TgenePDLIM2chr8:22465578chr8:22442334ENST00000265810+1101_8481367DomainPDZ
TgenePDLIM2chr8:22465578chr8:22442334ENST00000308354+2101_84331603DomainPDZ
TgenePDLIM2chr8:22465578chr8:22442334ENST00000308354+210284_344331603DomainLIM zinc-binding
TgenePDLIM2chr8:22465578chr8:22442334ENST00000339162+291_8481279DomainPDZ
TgenePDLIM2chr8:22465578chr8:22442334ENST00000397760+2101_8481353DomainPDZ
TgenePDLIM2chr8:22465578chr8:22442334ENST00000397761+2101_8481353DomainPDZ
TgenePDLIM2chr8:22465578chr8:22442334ENST00000409141+181_8481279DomainPDZ
TgenePDLIM2chr8:22465578chr8:22442334ENST00000409417+191_8481353DomainPDZ


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FusionGeneSequence for CCAR2_PDLIM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCAR2_PDLIM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCAR2NELFCD, CCNA1, NEK6, CIAO1, WRAP73, GSTK1, MAGED1, ACTR3B, MAGEA6, MYC, RUVBL2, CDK9, MEPCE, CDK7, KBTBD7, ZNF335, ASH2L, C11orf30, RBBP5, KAT8, HDAC5, PNMA1, RAD21, SF3A2, SIRT7, CUL3, COPS5, BRCA1, EEF1A1, FN1, HTRA2, HSPA8, PRMT5, BAG2, METTL21B, METTL23, ITGA4, SOX2, HDAC9, TARDBP, AIMP1, AIMP2, CNOT1, HNRNPA1, IQGAP1, DCTN3, EEF1E1, EIF2S3, GBF1, QARS, RARS, RPL27A, SMC2, SMC4, NCAPD2, NCAPG, PLEC, RPA3, RPA2, RPA1, ZBTB1, MDM2, CEP170P1, OBSL1, CCDC8, SIRT6, HSPA1L, KCNAB2, HAO1, CEP170, TUBA1A, TUBB3, TUBB8, MCC, SIRT1, CHEK2, PSME3, HSPD1, PDIA6, PPIL4, PSMA4, PSMC1, PSMD3, SF3B3, SMEK1, COPG1, NTRK1, SCARNA22, ANKRA2, B9D2, XPO1, SEC16A, FOXB1, FOXH1, FOXP3, FOXQ1, MEX3C, NANOG, POU5F1, NLGN3, RC3H1, MTMR11, CYLD, HSD17B10, SOD1PDLIM2ACD, POT1, UBE2E2, PDLIM2, STAT4, APC, AURKA, BAG4, BCAR3, FGFR2, FGFR4, RAF1, TGFB1, MKRN2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCCAR2chr8:22465578chr8:22442334ENST00000308511+721610_670194924MCC
HgeneCCAR2chr8:22465578chr8:22442334ENST00000389279+721610_670194924MCC
HgeneCCAR2chr8:22465578chr8:22442334ENST00000308511+721704_923194924NR1D1
HgeneCCAR2chr8:22465578chr8:22442334ENST00000389279+721704_923194924NR1D1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCAR2_PDLIM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCAR2_PDLIM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCAR2C0043020Wallerian Degeneration1CTD_human