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Fusion gene ID: 5742 |
FusionGeneSummary for CC2D1B_ZC3H8 |
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Fusion gene information | Fusion gene name: CC2D1B_ZC3H8 | Fusion gene ID: 5742 | Hgene | Tgene | Gene symbol | CC2D1B | ZC3H8 | Gene ID | 200014 | 84524 |
Gene name | coiled-coil and C2 domain containing 1B | zinc finger CCCH-type containing 8 | |
Synonyms | - | Fliz1|ZC3HDC8 | |
Cytomap | 1p32.3 | 2q14.1 | |
Type of gene | protein-coding | protein-coding | |
Description | coiled-coil and C2 domain-containing protein 1BFRE under dual repression-binding protein 2five prime repressor element under dual repression-binding protein 2freud-2 | zinc finger CCCH domain-containing protein 8zinc finger CCCH-type domain containing 8 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q5T0F9 | Q8N5P1 | |
Ensembl transtripts involved in fusion gene | ENST00000371586, ENST00000284376, ENST00000460261, ENST00000438831, | ENST00000409573, ENST00000272570, ENST00000476902, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 2 X 2=8 |
# samples | 3 | 2 | |
** MAII score | log2(3/4*10)=2.90689059560852 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: CC2D1B [Title/Abstract] AND ZC3H8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ZC3H8 | GO:0045892 | negative regulation of transcription, DNA-templated | 12077251 |
Tgene | ZC3H8 | GO:0046677 | response to antibiotic | 12153508 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW204034 | CC2D1B | chr1 | 52816466 | + | ZC3H8 | chr2 | 112996777 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000371586 | ENST00000409573 | CC2D1B | chr1 | 52816466 | + | ZC3H8 | chr2 | 112996777 | + |
intron-intron | ENST00000371586 | ENST00000272570 | CC2D1B | chr1 | 52816466 | + | ZC3H8 | chr2 | 112996777 | + |
intron-intron | ENST00000371586 | ENST00000476902 | CC2D1B | chr1 | 52816466 | + | ZC3H8 | chr2 | 112996777 | + |
intron-intron | ENST00000284376 | ENST00000409573 | CC2D1B | chr1 | 52816466 | + | ZC3H8 | chr2 | 112996777 | + |
intron-intron | ENST00000284376 | ENST00000272570 | CC2D1B | chr1 | 52816466 | + | ZC3H8 | chr2 | 112996777 | + |
intron-intron | ENST00000284376 | ENST00000476902 | CC2D1B | chr1 | 52816466 | + | ZC3H8 | chr2 | 112996777 | + |
intron-intron | ENST00000460261 | ENST00000409573 | CC2D1B | chr1 | 52816466 | + | ZC3H8 | chr2 | 112996777 | + |
intron-intron | ENST00000460261 | ENST00000272570 | CC2D1B | chr1 | 52816466 | + | ZC3H8 | chr2 | 112996777 | + |
intron-intron | ENST00000460261 | ENST00000476902 | CC2D1B | chr1 | 52816466 | + | ZC3H8 | chr2 | 112996777 | + |
intron-intron | ENST00000438831 | ENST00000409573 | CC2D1B | chr1 | 52816466 | + | ZC3H8 | chr2 | 112996777 | + |
intron-intron | ENST00000438831 | ENST00000272570 | CC2D1B | chr1 | 52816466 | + | ZC3H8 | chr2 | 112996777 | + |
intron-intron | ENST00000438831 | ENST00000476902 | CC2D1B | chr1 | 52816466 | + | ZC3H8 | chr2 | 112996777 | + |
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FusionProtFeatures for CC2D1B_ZC3H8 |
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Hgene | Tgene |
CC2D1B | ZC3H8 |
Transcription factor that binds specifically to the DRE(dual repressor element) and represses HTR1A gene transcription inneuronal cells. {ECO:0000269|PubMed:19423080}. | Acts as a transcriptional repressor of the GATA3promoter. Sequence-specific DNA-binding factor that binds to the5'-AGGTCTC-3' sequence within the negative cis-acting elementintronic regulatory region (IRR) of the GATA3 gene (Bysimilarity). Component of the little elongation complex (LEC), acomplex required to regulate small nuclear RNA (snRNA) genetranscription by RNA polymerase II and III (PubMed:23932780).Induces thymocyte apoptosis when overexpressed, which may indicatea role in regulation of thymocyte homeostasis. {ECO:0000250,ECO:0000269|PubMed:12077251, ECO:0000269|PubMed:12153508,ECO:0000269|PubMed:23932780}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CC2D1B_ZC3H8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CC2D1B_ZC3H8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CC2D1B_ZC3H8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CC2D1B_ZC3H8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |