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Fusion gene ID: 5699 |
FusionGeneSummary for CBR4_ERBB4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CBR4_ERBB4 | Fusion gene ID: 5699 | Hgene | Tgene | Gene symbol | CBR4 | ERBB4 | Gene ID | 84869 | 2066 |
| Gene name | carbonyl reductase 4 | erb-b2 receptor tyrosine kinase 4 | |
| Synonyms | SDR45C1 | ALS19|HER4|p180erbB4 | |
| Cytomap | 4q32.3 | 2q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | carbonyl reductase family member 43-ketoacyl-[acyl-carrier-protein] reductase beta subunit3-oxoacyl-[acyl-carrier-protein] reductaseKAR beta subunitcarbonic reductase 4quinone reductase CBR4short chain dehydrogenase/reductase family 45C member 1 | receptor tyrosine-protein kinase erbB-4ERBB4 transcript variant I12DELERBB4 transcript variant I20DELavian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4human epidermal growth factor receptor 4proto-oncogene-like protein c-ErbB-4tyrosin | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q8N4T8 | Q15303 | |
| Ensembl transtripts involved in fusion gene | ENST00000509108, ENST00000306193, ENST00000504480, | ENST00000436443, ENST00000342788, ENST00000402597, ENST00000484474, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 7 X 6 X 6=252 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CBR4 [Title/Abstract] AND ERBB4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CBR4 | GO:0051290 | protein heterotetramerization | 25203508 |
| Hgene | CBR4 | GO:0055114 | oxidation-reduction process | 25203508 |
| Tgene | ERBB4 | GO:0007165 | signal transduction | 10572067 |
| Tgene | ERBB4 | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 10353604|18334220 |
| Tgene | ERBB4 | GO:0016477 | cell migration | 9135143 |
| Tgene | ERBB4 | GO:0018108 | peptidyl-tyrosine phosphorylation | 18334220 |
| Tgene | ERBB4 | GO:0046777 | protein autophosphorylation | 18334220 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E2-A10E-01A | CBR4 | chr4 | 169923222 | - | ERBB4 | chr2 | 212989628 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000509108 | ENST00000436443 | CBR4 | chr4 | 169923222 | - | ERBB4 | chr2 | 212989628 | - |
| 5UTR-3CDS | ENST00000509108 | ENST00000342788 | CBR4 | chr4 | 169923222 | - | ERBB4 | chr2 | 212989628 | - |
| 5UTR-3CDS | ENST00000509108 | ENST00000402597 | CBR4 | chr4 | 169923222 | - | ERBB4 | chr2 | 212989628 | - |
| 5UTR-intron | ENST00000509108 | ENST00000484474 | CBR4 | chr4 | 169923222 | - | ERBB4 | chr2 | 212989628 | - |
| In-frame | ENST00000306193 | ENST00000436443 | CBR4 | chr4 | 169923222 | - | ERBB4 | chr2 | 212989628 | - |
| In-frame | ENST00000306193 | ENST00000342788 | CBR4 | chr4 | 169923222 | - | ERBB4 | chr2 | 212989628 | - |
| In-frame | ENST00000306193 | ENST00000402597 | CBR4 | chr4 | 169923222 | - | ERBB4 | chr2 | 212989628 | - |
| 5CDS-intron | ENST00000306193 | ENST00000484474 | CBR4 | chr4 | 169923222 | - | ERBB4 | chr2 | 212989628 | - |
| intron-3CDS | ENST00000504480 | ENST00000436443 | CBR4 | chr4 | 169923222 | - | ERBB4 | chr2 | 212989628 | - |
| intron-3CDS | ENST00000504480 | ENST00000342788 | CBR4 | chr4 | 169923222 | - | ERBB4 | chr2 | 212989628 | - |
| intron-3CDS | ENST00000504480 | ENST00000402597 | CBR4 | chr4 | 169923222 | - | ERBB4 | chr2 | 212989628 | - |
| intron-intron | ENST00000504480 | ENST00000484474 | CBR4 | chr4 | 169923222 | - | ERBB4 | chr2 | 212989628 | - |
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FusionProtFeatures for CBR4_ERBB4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CBR4 | ERBB4 |
| The heterotetramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and therebyplays a role in mitochondrial fatty acid biosynthesis(PubMed:19571038, PubMed:25203508). Within the heterotetramer,HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508). Thehomotetramer has NADPH-dependent quinone reductase activity(PubMed:19000905). Both homotetramer and the heterotetramer havebroad substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinonesand p-quinones (in vitro) (PubMed:19000905, PubMed:19571038,PubMed:25203508). {ECO:0000269|PubMed:19000905,ECO:0000269|PubMed:19571038, ECO:0000269|PubMed:25203508}. | Tyrosine-protein kinase that plays an essential role ascell surface receptor for neuregulins and EGF family members andregulates development of the heart, the central nervous system andthe mammary gland, gene transcription, cell proliferation,differentiation, migration and apoptosis. Required for normalcardiac muscle differentiation during embryonic development, andfor postnatal cardiomyocyte proliferation. Required for normaldevelopment of the embryonic central nervous system, especiallyfor normal neural crest cell migration and normal axon guidance.Required for mammary gland differentiation, induction of milkproteins and lactation. Acts as cell-surface receptor for theneuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family membersBTC, EREG and HBEGF. Ligand binding triggers receptor dimerizationand autophosphorylation at specific tyrosine residues that thenserve as binding sites for scaffold proteins and effectors. Ligandspecificity and signaling is modulated by alternative splicing,proteolytic processing, and by the formation of heterodimers withother ERBB family members, thereby creating multiple combinationsof intracellular phosphotyrosines that trigger ligand- andcontext-specific cellular responses. Mediates phosphorylation ofSHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1.Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1,leading to the activation of phosphatidylinositol 3-kinase andAKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 andisoform JM-B CYT-1 mediate reorganization of the actincytoskeleton and promote cell migration in response to NRG1.Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosinethat mediates interaction with PIK3R1, and hence do notphosphorylate PIK3R1, do not protect cells against apoptosis, anddo not promote reorganization of the actin cytoskeleton and cellmigration. Proteolytic processing of isoform JM-A CYT-1 andisoform JM-A CYT-2 gives rise to the corresponding solubleintracellular domains (4ICD) that translocate to the nucleus,promote nuclear import of STAT5A, activation of STAT5A, mammaryepithelium differentiation, cell proliferation and activation ofgene expression. The ERBB4 soluble intracellular domains (4ICD)colocalize with STAT5A at the CSN2 promoter to regulatetranscription of milk proteins during lactation. The ERBB4 solubleintracellular domains can also translocate to mitochondria andpromote apoptosis. {ECO:0000269|PubMed:10348342,ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079,ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024,ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655,ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001,ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361,ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552,ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867,ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735,ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750,ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115,ECO:0000269|PubMed:9334263}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CBR4_ERBB4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CBR4_ENST00000306193_chr4_169923222_-_ERBB4_ENST00000436443_chr2_212989628_-_1444aa MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDG LLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPVC AGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAI FLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLT RTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV DSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKL NVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFS TINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTC HGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIG GLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVA IKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRL VHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREI PDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDA EEYLVPQAFNIPPPIYTSRARIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSST QRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANT LGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRN >In-frame_CBR4_ENST00000306193_chr4_169923222_-_ERBB4_ENST00000342788_chr2_212989628_-_1460aa MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDG LLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPVC AGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAI FLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLT RTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV DSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKL NVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFS TINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTC HGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIG GLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVA IKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRL VHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREI PDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDA EEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNG TLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAE DEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFS >In-frame_CBR4_ENST00000306193_chr4_169923222_-_ERBB4_ENST00000402597_chr2_212989628_-_1450aa MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDG LLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPVC AGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAI FLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLT RTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV DSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKL NVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFS TINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTC HGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCIGSSIEDCIGLMDRTPLIAAGVIGGLFILVIVGL TFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGP KANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNV LVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERL PQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFN IPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHV QEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYL NTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CBR4_ENST00000306193_chr4_169923222_-_ERBB4_ENST00000436443_chr2_212989628_-_4332nt ATGGACAAAGTGTGTGCTGTTTTTGGAGGCTCCCGAGGCATTGGCAGAGCTGTGGCCCAGTTAATGGCCCGGAAAGGCTACCGACTGGCG GTCATTGCCAGAAACCTGGAAGGGGCCAAAGCCGCCGCCGGTGACCTCGGCGGAGATCATTTGGCATTTAGCTGTGATGTTGCTAAAGAA CATGATGTTCAAAATACATTTGAAGAGCTGGAGAAACATTTAGGTCGAGTAAATTTCTTGGTAAATGCAGCTGGTATTAACAGGGATGGT CTTTTAGTAAGAACAAAAACTGAAGATATGGTATCTCAGCTTCATACTAACCTCTTGGGTTCCATGCTGACCTGTAAAGCTGCCATGAGG ACTATGATTCAACAACAGGGAGGGTCTATTGTTAATGTAGGAAGCATTGTTGGCTTAAAAGGCAACTCTGGCCAGTCCGTTTACAGTGCC AGTAAAGGAGGATTAGTTGGATTTTCACGTGCTCTTGCTAAAGAGGTAGCAAGAAAGAAAATTAGAGTGAATGTAGTTGCACCAGTGTGT GCAGGAACGGAGAATAAACTGAGCTCTCTCTCTGACCTGGAACAGCAGTACCGAGCCTTGCGCAAGTACTATGAAAACTGTGAGGTTGTC ATGGGCAACCTGGAGATAACCAGCATTGAGCACAACCGGGACCTCTCCTTCCTGCGGTCTGTTCGAGAAGTCACAGGCTACGTGTTAGTG GCTCTTAATCAGTTTCGTTACCTGCCTCTGGAGAATTTACGCATTATTCGTGGGACAAAACTTTATGAGGATCGATATGCCTTGGCAATA TTTTTAAACTACAGAAAAGATGGAAACTTTGGACTTCAAGAACTTGGATTAAAGAACTTGACAGAAATCCTAAATGGTGGAGTCTATGTA GACCAGAACAAATTCCTTTGTTATGCAGACACCATTCATTGGCAAGATATTGTTCGGAACCCATGGCCTTCCAACTTGACTCTTGTGTCA ACAAATGGTAGTTCAGGATGTGGACGTTGCCATAAGTCCTGTACTGGCCGTTGCTGGGGACCCACAGAAAATCATTGCCAGACTTTGACA AGGACGGTGTGTGCAGAACAATGTGACGGCAGATGCTACGGACCTTACGTCAGTGACTGCTGCCATCGAGAATGTGCTGGAGGCTGCTCA GGACCTAAGGACACAGACTGCTTTGCCTGCATGAATTTCAATGACAGTGGAGCATGTGTTACTCAGTGTCCCCAAACCTTTGTCTACAAT CCAACCACCTTTCAACTGGAGCACAATTTCAATGCAAAGTACACATATGGAGCATTCTGTGTCAAGAAATGTCCACATAACTTTGTGGTA GATTCCAGTTCTTGTGTGCGTGCCTGCCCTAGTTCCAAGATGGAAGTAGAAGAAAATGGGATTAAAATGTGTAAACCTTGCACTGACATT TGCCCAAAAGCTTGTGATGGCATTGGCACAGGATCATTGATGTCAGCTCAGACTGTGGATTCCAGTAACATTGACAAATTCATAAACTGT ACCAAGATCAATGGGAATTTGATCTTTCTAGTCACTGGTATTCATGGGGACCCTTACAATGCAATTGAAGCCATAGACCCAGAGAAACTG AACGTCTTTCGGACAGTCAGAGAGATAACAGGTTTCCTGAACATACAGTCATGGCCACCAAACATGACTGACTTCAGTGTTTTTTCTAAC CTGGTGACCATTGGTGGAAGAGTACTCTATAGTGGCCTGTCCTTGCTTATCCTCAAGCAACAGGGCATCACCTCTCTACAGTTCCAGTCC CTGAAGGAAATCAGCGCAGGAAACATCTATATTACTGACAACAGCAACCTGTGTTATTATCATACCATTAACTGGACAACACTCTTCAGC ACAATCAACCAGAGAATAGTAATCCGGGACAACAGAAAAGCTGAAAATTGTACTGCTGAAGGAATGGTGTGCAACCATCTGTGTTCCAGT GATGGCTGTTGGGGACCTGGGCCAGACCAATGTCTGTCGTGTCGCCGCTTCAGTAGAGGAAGGATCTGCATAGAGTCTTGTAACCTCTAT GATGGTGAATTTCGGGAGTTTGAGAATGGCTCCATCTGTGTGGAGTGTGACCCCCAGTGTGAGAAGATGGAAGATGGCCTCCTCACATGC CATGGACCGGGTCCTGACAACTGTACAAAGTGCTCTCATTTTAAAGATGGCCCAAACTGTGTGGAAAAATGTCCAGATGGCTTACAGGGG GCAAACAGTTTCATTTTCAAGTATGCTGATCCAGATCGGGAGTGCCACCCATGCCATCCAAACTGCACCCAAGGGTGTAACGGTCCCACT AGTCATGACTGCATTTACTACCCATGGACGGGCCATTCCACTTTACCACAACATGCTAGAACTCCCCTGATTGCAGCTGGAGTAATTGGT GGGCTCTTCATTCTGGTCATTGTGGGTCTGACATTTGCTGTTTATGTTAGAAGGAAGAGCATCAAAAAGAAAAGAGCCTTGAGAAGATTC TTGGAAACAGAGTTGGTGGAACCATTAACTCCCAGTGGCACAGCACCCAATCAAGCTCAACTTCGTATTTTGAAAGAAACTGAGCTGAAG AGGGTAAAAGTCCTTGGCTCAGGTGCTTTTGGAACGGTTTATAAAGGTATTTGGGTACCTGAAGGAGAAACTGTGAAGATTCCTGTGGCT ATTAAGATTCTTAATGAGACAACTGGTCCCAAGGCAAATGTGGAGTTCATGGATGAAGCTCTGATCATGGCAAGTATGGATCATCCACAC CTAGTCCGGTTGCTGGGTGTGTGTCTGAGCCCAACCATCCAGCTGGTTACTCAACTTATGCCCCATGGCTGCCTGTTGGAGTATGTCCAC GAGCACAAGGATAACATTGGATCACAACTGCTGCTTAACTGGTGTGTCCAGATAGCTAAGGGAATGATGTACCTGGAAGAAAGACGACTC GTTCATCGGGATTTGGCAGCCCGTAATGTCTTAGTGAAATCTCCAAACCATGTGAAAATCACAGATTTTGGGCTAGCCAGACTCTTGGAA GGAGATGAAAAAGAGTACAATGCTGATGGAGGAAAGATGCCAATTAAATGGATGGCTCTGGAGTGTATACATTACAGGAAATTCACCCAT CAGAGTGACGTTTGGAGCTATGGAGTTACTATATGGGAACTGATGACCTTTGGAGGAAAACCCTATGATGGAATTCCAACGCGAGAAATC CCTGATTTATTAGAGAAAGGAGAACGTTTGCCTCAGCCTCCCATCTGCACTATTGACGTTTACATGGTCATGGTCAAATGTTGGATGATT GATGCTGACAGTAGACCTAAATTTAAGGAACTGGCTGCTGAGTTTTCAAGGATGGCTCGAGACCCTCAAAGATACCTAGTTATTCAGGGT GATGATCGTATGAAGCTTCCCAGTCCAAATGACAGCAAGTTCTTTCAGAATCTCTTGGATGAAGAGGATTTGGAAGATATGATGGATGCT GAGGAGTACTTGGTCCCTCAGGCTTTCAACATCCCACCTCCCATCTATACTTCCAGAGCAAGAATTGACTCGAATAGGAACCAGTTTGTA TACCGAGATGGAGGTTTTGCTGCTGAACAAGGAGTGTCTGTGCCCTACAGAGCCCCAACTAGCACAATTCCAGAAGCTCCTGTGGCACAG GGTGCTACTGCTGAGATTTTTGATGACTCCTGCTGTAATGGCACCCTACGCAAGCCAGTGGCACCCCATGTCCAAGAGGACAGTAGCACC CAGAGGTACAGTGCTGACCCCACCGTGTTTGCCCCAGAACGGAGCCCACGAGGAGAGCTGGATGAGGAAGGTTACATGACTCCTATGCGA GACAAACCCAAACAAGAATACCTGAATCCAGTGGAGGAGAACCCTTTTGTTTCTCGGAGAAAAAATGGAGACCTTCAAGCATTGGATAAT CCCGAATATCACAATGCATCCAATGGTCCACCCAAGGCCGAGGATGAGTATGTGAATGAGCCACTGTACCTCAACACCTTTGCCAACACC TTGGGAAAAGCTGAGTACCTGAAGAACAACATACTGTCAATGCCAGAGAAGGCCAAGAAAGCGTTTGACAACCCTGACTACTGGAACCAC AGCCTGCCACCTCGGAGCACCCTTCAGCACCCAGACTACCTGCAGGAGTACAGCACAAAATATTTTTATAAACAGAATGGGCGGATCCGG CCTATTGTGGCAGAGAATCCTGAATACCTCTCTGAGTTCTCCCTGAAGCCAGGCACTGTGCTGCCGCCTCCACCTTACAGACACCGGAAT >In-frame_CBR4_ENST00000306193_chr4_169923222_-_ERBB4_ENST00000342788_chr2_212989628_-_4380nt ATGGACAAAGTGTGTGCTGTTTTTGGAGGCTCCCGAGGCATTGGCAGAGCTGTGGCCCAGTTAATGGCCCGGAAAGGCTACCGACTGGCG GTCATTGCCAGAAACCTGGAAGGGGCCAAAGCCGCCGCCGGTGACCTCGGCGGAGATCATTTGGCATTTAGCTGTGATGTTGCTAAAGAA CATGATGTTCAAAATACATTTGAAGAGCTGGAGAAACATTTAGGTCGAGTAAATTTCTTGGTAAATGCAGCTGGTATTAACAGGGATGGT CTTTTAGTAAGAACAAAAACTGAAGATATGGTATCTCAGCTTCATACTAACCTCTTGGGTTCCATGCTGACCTGTAAAGCTGCCATGAGG ACTATGATTCAACAACAGGGAGGGTCTATTGTTAATGTAGGAAGCATTGTTGGCTTAAAAGGCAACTCTGGCCAGTCCGTTTACAGTGCC AGTAAAGGAGGATTAGTTGGATTTTCACGTGCTCTTGCTAAAGAGGTAGCAAGAAAGAAAATTAGAGTGAATGTAGTTGCACCAGTGTGT GCAGGAACGGAGAATAAACTGAGCTCTCTCTCTGACCTGGAACAGCAGTACCGAGCCTTGCGCAAGTACTATGAAAACTGTGAGGTTGTC ATGGGCAACCTGGAGATAACCAGCATTGAGCACAACCGGGACCTCTCCTTCCTGCGGTCTGTTCGAGAAGTCACAGGCTACGTGTTAGTG GCTCTTAATCAGTTTCGTTACCTGCCTCTGGAGAATTTACGCATTATTCGTGGGACAAAACTTTATGAGGATCGATATGCCTTGGCAATA TTTTTAAACTACAGAAAAGATGGAAACTTTGGACTTCAAGAACTTGGATTAAAGAACTTGACAGAAATCCTAAATGGTGGAGTCTATGTA GACCAGAACAAATTCCTTTGTTATGCAGACACCATTCATTGGCAAGATATTGTTCGGAACCCATGGCCTTCCAACTTGACTCTTGTGTCA ACAAATGGTAGTTCAGGATGTGGACGTTGCCATAAGTCCTGTACTGGCCGTTGCTGGGGACCCACAGAAAATCATTGCCAGACTTTGACA AGGACGGTGTGTGCAGAACAATGTGACGGCAGATGCTACGGACCTTACGTCAGTGACTGCTGCCATCGAGAATGTGCTGGAGGCTGCTCA GGACCTAAGGACACAGACTGCTTTGCCTGCATGAATTTCAATGACAGTGGAGCATGTGTTACTCAGTGTCCCCAAACCTTTGTCTACAAT CCAACCACCTTTCAACTGGAGCACAATTTCAATGCAAAGTACACATATGGAGCATTCTGTGTCAAGAAATGTCCACATAACTTTGTGGTA GATTCCAGTTCTTGTGTGCGTGCCTGCCCTAGTTCCAAGATGGAAGTAGAAGAAAATGGGATTAAAATGTGTAAACCTTGCACTGACATT TGCCCAAAAGCTTGTGATGGCATTGGCACAGGATCATTGATGTCAGCTCAGACTGTGGATTCCAGTAACATTGACAAATTCATAAACTGT ACCAAGATCAATGGGAATTTGATCTTTCTAGTCACTGGTATTCATGGGGACCCTTACAATGCAATTGAAGCCATAGACCCAGAGAAACTG AACGTCTTTCGGACAGTCAGAGAGATAACAGGTTTCCTGAACATACAGTCATGGCCACCAAACATGACTGACTTCAGTGTTTTTTCTAAC CTGGTGACCATTGGTGGAAGAGTACTCTATAGTGGCCTGTCCTTGCTTATCCTCAAGCAACAGGGCATCACCTCTCTACAGTTCCAGTCC CTGAAGGAAATCAGCGCAGGAAACATCTATATTACTGACAACAGCAACCTGTGTTATTATCATACCATTAACTGGACAACACTCTTCAGC ACAATCAACCAGAGAATAGTAATCCGGGACAACAGAAAAGCTGAAAATTGTACTGCTGAAGGAATGGTGTGCAACCATCTGTGTTCCAGT GATGGCTGTTGGGGACCTGGGCCAGACCAATGTCTGTCGTGTCGCCGCTTCAGTAGAGGAAGGATCTGCATAGAGTCTTGTAACCTCTAT GATGGTGAATTTCGGGAGTTTGAGAATGGCTCCATCTGTGTGGAGTGTGACCCCCAGTGTGAGAAGATGGAAGATGGCCTCCTCACATGC CATGGACCGGGTCCTGACAACTGTACAAAGTGCTCTCATTTTAAAGATGGCCCAAACTGTGTGGAAAAATGTCCAGATGGCTTACAGGGG GCAAACAGTTTCATTTTCAAGTATGCTGATCCAGATCGGGAGTGCCACCCATGCCATCCAAACTGCACCCAAGGGTGTAACGGTCCCACT AGTCATGACTGCATTTACTACCCATGGACGGGCCATTCCACTTTACCACAACATGCTAGAACTCCCCTGATTGCAGCTGGAGTAATTGGT GGGCTCTTCATTCTGGTCATTGTGGGTCTGACATTTGCTGTTTATGTTAGAAGGAAGAGCATCAAAAAGAAAAGAGCCTTGAGAAGATTC TTGGAAACAGAGTTGGTGGAACCATTAACTCCCAGTGGCACAGCACCCAATCAAGCTCAACTTCGTATTTTGAAAGAAACTGAGCTGAAG AGGGTAAAAGTCCTTGGCTCAGGTGCTTTTGGAACGGTTTATAAAGGTATTTGGGTACCTGAAGGAGAAACTGTGAAGATTCCTGTGGCT ATTAAGATTCTTAATGAGACAACTGGTCCCAAGGCAAATGTGGAGTTCATGGATGAAGCTCTGATCATGGCAAGTATGGATCATCCACAC CTAGTCCGGTTGCTGGGTGTGTGTCTGAGCCCAACCATCCAGCTGGTTACTCAACTTATGCCCCATGGCTGCCTGTTGGAGTATGTCCAC GAGCACAAGGATAACATTGGATCACAACTGCTGCTTAACTGGTGTGTCCAGATAGCTAAGGGAATGATGTACCTGGAAGAAAGACGACTC GTTCATCGGGATTTGGCAGCCCGTAATGTCTTAGTGAAATCTCCAAACCATGTGAAAATCACAGATTTTGGGCTAGCCAGACTCTTGGAA GGAGATGAAAAAGAGTACAATGCTGATGGAGGAAAGATGCCAATTAAATGGATGGCTCTGGAGTGTATACATTACAGGAAATTCACCCAT CAGAGTGACGTTTGGAGCTATGGAGTTACTATATGGGAACTGATGACCTTTGGAGGAAAACCCTATGATGGAATTCCAACGCGAGAAATC CCTGATTTATTAGAGAAAGGAGAACGTTTGCCTCAGCCTCCCATCTGCACTATTGACGTTTACATGGTCATGGTCAAATGTTGGATGATT GATGCTGACAGTAGACCTAAATTTAAGGAACTGGCTGCTGAGTTTTCAAGGATGGCTCGAGACCCTCAAAGATACCTAGTTATTCAGGGT GATGATCGTATGAAGCTTCCCAGTCCAAATGACAGCAAGTTCTTTCAGAATCTCTTGGATGAAGAGGATTTGGAAGATATGATGGATGCT GAGGAGTACTTGGTCCCTCAGGCTTTCAACATCCCACCTCCCATCTATACTTCCAGAGCAAGAATTGACTCGAATAGGAGTGAAATTGGA CACAGCCCTCCTCCTGCCTACACCCCCATGTCAGGAAACCAGTTTGTATACCGAGATGGAGGTTTTGCTGCTGAACAAGGAGTGTCTGTG CCCTACAGAGCCCCAACTAGCACAATTCCAGAAGCTCCTGTGGCACAGGGTGCTACTGCTGAGATTTTTGATGACTCCTGCTGTAATGGC ACCCTACGCAAGCCAGTGGCACCCCATGTCCAAGAGGACAGTAGCACCCAGAGGTACAGTGCTGACCCCACCGTGTTTGCCCCAGAACGG AGCCCACGAGGAGAGCTGGATGAGGAAGGTTACATGACTCCTATGCGAGACAAACCCAAACAAGAATACCTGAATCCAGTGGAGGAGAAC CCTTTTGTTTCTCGGAGAAAAAATGGAGACCTTCAAGCATTGGATAATCCCGAATATCACAATGCATCCAATGGTCCACCCAAGGCCGAG GATGAGTATGTGAATGAGCCACTGTACCTCAACACCTTTGCCAACACCTTGGGAAAAGCTGAGTACCTGAAGAACAACATACTGTCAATG CCAGAGAAGGCCAAGAAAGCGTTTGACAACCCTGACTACTGGAACCACAGCCTGCCACCTCGGAGCACCCTTCAGCACCCAGACTACCTG CAGGAGTACAGCACAAAATATTTTTATAAACAGAATGGGCGGATCCGGCCTATTGTGGCAGAGAATCCTGAATACCTCTCTGAGTTCTCC >In-frame_CBR4_ENST00000306193_chr4_169923222_-_ERBB4_ENST00000402597_chr2_212989628_-_4350nt ATGGACAAAGTGTGTGCTGTTTTTGGAGGCTCCCGAGGCATTGGCAGAGCTGTGGCCCAGTTAATGGCCCGGAAAGGCTACCGACTGGCG GTCATTGCCAGAAACCTGGAAGGGGCCAAAGCCGCCGCCGGTGACCTCGGCGGAGATCATTTGGCATTTAGCTGTGATGTTGCTAAAGAA CATGATGTTCAAAATACATTTGAAGAGCTGGAGAAACATTTAGGTCGAGTAAATTTCTTGGTAAATGCAGCTGGTATTAACAGGGATGGT CTTTTAGTAAGAACAAAAACTGAAGATATGGTATCTCAGCTTCATACTAACCTCTTGGGTTCCATGCTGACCTGTAAAGCTGCCATGAGG ACTATGATTCAACAACAGGGAGGGTCTATTGTTAATGTAGGAAGCATTGTTGGCTTAAAAGGCAACTCTGGCCAGTCCGTTTACAGTGCC AGTAAAGGAGGATTAGTTGGATTTTCACGTGCTCTTGCTAAAGAGGTAGCAAGAAAGAAAATTAGAGTGAATGTAGTTGCACCAGTGTGT GCAGGAACGGAGAATAAACTGAGCTCTCTCTCTGACCTGGAACAGCAGTACCGAGCCTTGCGCAAGTACTATGAAAACTGTGAGGTTGTC ATGGGCAACCTGGAGATAACCAGCATTGAGCACAACCGGGACCTCTCCTTCCTGCGGTCTGTTCGAGAAGTCACAGGCTACGTGTTAGTG GCTCTTAATCAGTTTCGTTACCTGCCTCTGGAGAATTTACGCATTATTCGTGGGACAAAACTTTATGAGGATCGATATGCCTTGGCAATA TTTTTAAACTACAGAAAAGATGGAAACTTTGGACTTCAAGAACTTGGATTAAAGAACTTGACAGAAATCCTAAATGGTGGAGTCTATGTA GACCAGAACAAATTCCTTTGTTATGCAGACACCATTCATTGGCAAGATATTGTTCGGAACCCATGGCCTTCCAACTTGACTCTTGTGTCA ACAAATGGTAGTTCAGGATGTGGACGTTGCCATAAGTCCTGTACTGGCCGTTGCTGGGGACCCACAGAAAATCATTGCCAGACTTTGACA AGGACGGTGTGTGCAGAACAATGTGACGGCAGATGCTACGGACCTTACGTCAGTGACTGCTGCCATCGAGAATGTGCTGGAGGCTGCTCA GGACCTAAGGACACAGACTGCTTTGCCTGCATGAATTTCAATGACAGTGGAGCATGTGTTACTCAGTGTCCCCAAACCTTTGTCTACAAT CCAACCACCTTTCAACTGGAGCACAATTTCAATGCAAAGTACACATATGGAGCATTCTGTGTCAAGAAATGTCCACATAACTTTGTGGTA GATTCCAGTTCTTGTGTGCGTGCCTGCCCTAGTTCCAAGATGGAAGTAGAAGAAAATGGGATTAAAATGTGTAAACCTTGCACTGACATT TGCCCAAAAGCTTGTGATGGCATTGGCACAGGATCATTGATGTCAGCTCAGACTGTGGATTCCAGTAACATTGACAAATTCATAAACTGT ACCAAGATCAATGGGAATTTGATCTTTCTAGTCACTGGTATTCATGGGGACCCTTACAATGCAATTGAAGCCATAGACCCAGAGAAACTG AACGTCTTTCGGACAGTCAGAGAGATAACAGGTTTCCTGAACATACAGTCATGGCCACCAAACATGACTGACTTCAGTGTTTTTTCTAAC CTGGTGACCATTGGTGGAAGAGTACTCTATAGTGGCCTGTCCTTGCTTATCCTCAAGCAACAGGGCATCACCTCTCTACAGTTCCAGTCC CTGAAGGAAATCAGCGCAGGAAACATCTATATTACTGACAACAGCAACCTGTGTTATTATCATACCATTAACTGGACAACACTCTTCAGC ACAATCAACCAGAGAATAGTAATCCGGGACAACAGAAAAGCTGAAAATTGTACTGCTGAAGGAATGGTGTGCAACCATCTGTGTTCCAGT GATGGCTGTTGGGGACCTGGGCCAGACCAATGTCTGTCGTGTCGCCGCTTCAGTAGAGGAAGGATCTGCATAGAGTCTTGTAACCTCTAT GATGGTGAATTTCGGGAGTTTGAGAATGGCTCCATCTGTGTGGAGTGTGACCCCCAGTGTGAGAAGATGGAAGATGGCCTCCTCACATGC CATGGACCGGGTCCTGACAACTGTACAAAGTGCTCTCATTTTAAAGATGGCCCAAACTGTGTGGAAAAATGTCCAGATGGCTTACAGGGG GCAAACAGTTTCATTTTCAAGTATGCTGATCCAGATCGGGAGTGCCACCCATGCCATCCAAACTGCACCCAAGGGTGCATAGGCTCAAGT ATTGAAGACTGCATCGGCCTGATGGATAGAACTCCCCTGATTGCAGCTGGAGTAATTGGTGGGCTCTTCATTCTGGTCATTGTGGGTCTG ACATTTGCTGTTTATGTTAGAAGGAAGAGCATCAAAAAGAAAAGAGCCTTGAGAAGATTCTTGGAAACAGAGTTGGTGGAACCATTAACT CCCAGTGGCACAGCACCCAATCAAGCTCAACTTCGTATTTTGAAAGAAACTGAGCTGAAGAGGGTAAAAGTCCTTGGCTCAGGTGCTTTT GGAACGGTTTATAAAGGTATTTGGGTACCTGAAGGAGAAACTGTGAAGATTCCTGTGGCTATTAAGATTCTTAATGAGACAACTGGTCCC AAGGCAAATGTGGAGTTCATGGATGAAGCTCTGATCATGGCAAGTATGGATCATCCACACCTAGTCCGGTTGCTGGGTGTGTGTCTGAGC CCAACCATCCAGCTGGTTACTCAACTTATGCCCCATGGCTGCCTGTTGGAGTATGTCCACGAGCACAAGGATAACATTGGATCACAACTG CTGCTTAACTGGTGTGTCCAGATAGCTAAGGGAATGATGTACCTGGAAGAAAGACGACTCGTTCATCGGGATTTGGCAGCCCGTAATGTC TTAGTGAAATCTCCAAACCATGTGAAAATCACAGATTTTGGGCTAGCCAGACTCTTGGAAGGAGATGAAAAAGAGTACAATGCTGATGGA GGAAAGATGCCAATTAAATGGATGGCTCTGGAGTGTATACATTACAGGAAATTCACCCATCAGAGTGACGTTTGGAGCTATGGAGTTACT ATATGGGAACTGATGACCTTTGGAGGAAAACCCTATGATGGAATTCCAACGCGAGAAATCCCTGATTTATTAGAGAAAGGAGAACGTTTG CCTCAGCCTCCCATCTGCACTATTGACGTTTACATGGTCATGGTCAAATGTTGGATGATTGATGCTGACAGTAGACCTAAATTTAAGGAA CTGGCTGCTGAGTTTTCAAGGATGGCTCGAGACCCTCAAAGATACCTAGTTATTCAGGGTGATGATCGTATGAAGCTTCCCAGTCCAAAT GACAGCAAGTTCTTTCAGAATCTCTTGGATGAAGAGGATTTGGAAGATATGATGGATGCTGAGGAGTACTTGGTCCCTCAGGCTTTCAAC ATCCCACCTCCCATCTATACTTCCAGAGCAAGAATTGACTCGAATAGGAGTGAAATTGGACACAGCCCTCCTCCTGCCTACACCCCCATG TCAGGAAACCAGTTTGTATACCGAGATGGAGGTTTTGCTGCTGAACAAGGAGTGTCTGTGCCCTACAGAGCCCCAACTAGCACAATTCCA GAAGCTCCTGTGGCACAGGGTGCTACTGCTGAGATTTTTGATGACTCCTGCTGTAATGGCACCCTACGCAAGCCAGTGGCACCCCATGTC CAAGAGGACAGTAGCACCCAGAGGTACAGTGCTGACCCCACCGTGTTTGCCCCAGAACGGAGCCCACGAGGAGAGCTGGATGAGGAAGGT TACATGACTCCTATGCGAGACAAACCCAAACAAGAATACCTGAATCCAGTGGAGGAGAACCCTTTTGTTTCTCGGAGAAAAAATGGAGAC CTTCAAGCATTGGATAATCCCGAATATCACAATGCATCCAATGGTCCACCCAAGGCCGAGGATGAGTATGTGAATGAGCCACTGTACCTC AACACCTTTGCCAACACCTTGGGAAAAGCTGAGTACCTGAAGAACAACATACTGTCAATGCCAGAGAAGGCCAAGAAAGCGTTTGACAAC CCTGACTACTGGAACCACAGCCTGCCACCTCGGAGCACCCTTCAGCACCCAGACTACCTGCAGGAGTACAGCACAAAATATTTTTATAAA CAGAATGGGCGGATCCGGCCTATTGTGGCAGAGAATCCTGAATACCTCTCTGAGTTCTCCCTGAAGCCAGGCACTGTGCTGCCGCCTCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CBR4_ENST00000306193_chr4_169923222_-_ERBB4_ENST00000436443_chr2_212989628_-_12395nt ATTACTATTGTGCGGCTGCAGGAGGTGTCGAGCGGCGTTATTTTTTTTTGCGGTTTGCCTTTTTTTTTCTTTTTTTTTTTTTTGGAACCG CGGTTGTTTAAAAGCCTGAGGGAACCTGGAGAGGGGCTCCCACTCCCTACCCTCTTTCCTCCGAGTTTGTGACTCCGAGATGGACAAAGT GTGTGCTGTTTTTGGAGGCTCCCGAGGCATTGGCAGAGCTGTGGCCCAGTTAATGGCCCGGAAAGGCTACCGACTGGCGGTCATTGCCAG AAACCTGGAAGGGGCCAAAGCCGCCGCCGGTGACCTCGGCGGAGATCATTTGGCATTTAGCTGTGATGTTGCTAAAGAACATGATGTTCA AAATACATTTGAAGAGCTGGAGAAACATTTAGGTCGAGTAAATTTCTTGGTAAATGCAGCTGGTATTAACAGGGATGGTCTTTTAGTAAG AACAAAAACTGAAGATATGGTATCTCAGCTTCATACTAACCTCTTGGGTTCCATGCTGACCTGTAAAGCTGCCATGAGGACTATGATTCA ACAACAGGGAGGGTCTATTGTTAATGTAGGAAGCATTGTTGGCTTAAAAGGCAACTCTGGCCAGTCCGTTTACAGTGCCAGTAAAGGAGG ATTAGTTGGATTTTCACGTGCTCTTGCTAAAGAGGTAGCAAGAAAGAAAATTAGAGTGAATGTAGTTGCACCAGTGTGTGCAGGAACGGA GAATAAACTGAGCTCTCTCTCTGACCTGGAACAGCAGTACCGAGCCTTGCGCAAGTACTATGAAAACTGTGAGGTTGTCATGGGCAACCT GGAGATAACCAGCATTGAGCACAACCGGGACCTCTCCTTCCTGCGGTCTGTTCGAGAAGTCACAGGCTACGTGTTAGTGGCTCTTAATCA GTTTCGTTACCTGCCTCTGGAGAATTTACGCATTATTCGTGGGACAAAACTTTATGAGGATCGATATGCCTTGGCAATATTTTTAAACTA CAGAAAAGATGGAAACTTTGGACTTCAAGAACTTGGATTAAAGAACTTGACAGAAATCCTAAATGGTGGAGTCTATGTAGACCAGAACAA ATTCCTTTGTTATGCAGACACCATTCATTGGCAAGATATTGTTCGGAACCCATGGCCTTCCAACTTGACTCTTGTGTCAACAAATGGTAG TTCAGGATGTGGACGTTGCCATAAGTCCTGTACTGGCCGTTGCTGGGGACCCACAGAAAATCATTGCCAGACTTTGACAAGGACGGTGTG TGCAGAACAATGTGACGGCAGATGCTACGGACCTTACGTCAGTGACTGCTGCCATCGAGAATGTGCTGGAGGCTGCTCAGGACCTAAGGA CACAGACTGCTTTGCCTGCATGAATTTCAATGACAGTGGAGCATGTGTTACTCAGTGTCCCCAAACCTTTGTCTACAATCCAACCACCTT TCAACTGGAGCACAATTTCAATGCAAAGTACACATATGGAGCATTCTGTGTCAAGAAATGTCCACATAACTTTGTGGTAGATTCCAGTTC TTGTGTGCGTGCCTGCCCTAGTTCCAAGATGGAAGTAGAAGAAAATGGGATTAAAATGTGTAAACCTTGCACTGACATTTGCCCAAAAGC TTGTGATGGCATTGGCACAGGATCATTGATGTCAGCTCAGACTGTGGATTCCAGTAACATTGACAAATTCATAAACTGTACCAAGATCAA TGGGAATTTGATCTTTCTAGTCACTGGTATTCATGGGGACCCTTACAATGCAATTGAAGCCATAGACCCAGAGAAACTGAACGTCTTTCG GACAGTCAGAGAGATAACAGGTTTCCTGAACATACAGTCATGGCCACCAAACATGACTGACTTCAGTGTTTTTTCTAACCTGGTGACCAT TGGTGGAAGAGTACTCTATAGTGGCCTGTCCTTGCTTATCCTCAAGCAACAGGGCATCACCTCTCTACAGTTCCAGTCCCTGAAGGAAAT CAGCGCAGGAAACATCTATATTACTGACAACAGCAACCTGTGTTATTATCATACCATTAACTGGACAACACTCTTCAGCACAATCAACCA GAGAATAGTAATCCGGGACAACAGAAAAGCTGAAAATTGTACTGCTGAAGGAATGGTGTGCAACCATCTGTGTTCCAGTGATGGCTGTTG GGGACCTGGGCCAGACCAATGTCTGTCGTGTCGCCGCTTCAGTAGAGGAAGGATCTGCATAGAGTCTTGTAACCTCTATGATGGTGAATT TCGGGAGTTTGAGAATGGCTCCATCTGTGTGGAGTGTGACCCCCAGTGTGAGAAGATGGAAGATGGCCTCCTCACATGCCATGGACCGGG TCCTGACAACTGTACAAAGTGCTCTCATTTTAAAGATGGCCCAAACTGTGTGGAAAAATGTCCAGATGGCTTACAGGGGGCAAACAGTTT CATTTTCAAGTATGCTGATCCAGATCGGGAGTGCCACCCATGCCATCCAAACTGCACCCAAGGGTGTAACGGTCCCACTAGTCATGACTG CATTTACTACCCATGGACGGGCCATTCCACTTTACCACAACATGCTAGAACTCCCCTGATTGCAGCTGGAGTAATTGGTGGGCTCTTCAT TCTGGTCATTGTGGGTCTGACATTTGCTGTTTATGTTAGAAGGAAGAGCATCAAAAAGAAAAGAGCCTTGAGAAGATTCTTGGAAACAGA GTTGGTGGAACCATTAACTCCCAGTGGCACAGCACCCAATCAAGCTCAACTTCGTATTTTGAAAGAAACTGAGCTGAAGAGGGTAAAAGT CCTTGGCTCAGGTGCTTTTGGAACGGTTTATAAAGGTATTTGGGTACCTGAAGGAGAAACTGTGAAGATTCCTGTGGCTATTAAGATTCT TAATGAGACAACTGGTCCCAAGGCAAATGTGGAGTTCATGGATGAAGCTCTGATCATGGCAAGTATGGATCATCCACACCTAGTCCGGTT GCTGGGTGTGTGTCTGAGCCCAACCATCCAGCTGGTTACTCAACTTATGCCCCATGGCTGCCTGTTGGAGTATGTCCACGAGCACAAGGA TAACATTGGATCACAACTGCTGCTTAACTGGTGTGTCCAGATAGCTAAGGGAATGATGTACCTGGAAGAAAGACGACTCGTTCATCGGGA TTTGGCAGCCCGTAATGTCTTAGTGAAATCTCCAAACCATGTGAAAATCACAGATTTTGGGCTAGCCAGACTCTTGGAAGGAGATGAAAA AGAGTACAATGCTGATGGAGGAAAGATGCCAATTAAATGGATGGCTCTGGAGTGTATACATTACAGGAAATTCACCCATCAGAGTGACGT TTGGAGCTATGGAGTTACTATATGGGAACTGATGACCTTTGGAGGAAAACCCTATGATGGAATTCCAACGCGAGAAATCCCTGATTTATT AGAGAAAGGAGAACGTTTGCCTCAGCCTCCCATCTGCACTATTGACGTTTACATGGTCATGGTCAAATGTTGGATGATTGATGCTGACAG TAGACCTAAATTTAAGGAACTGGCTGCTGAGTTTTCAAGGATGGCTCGAGACCCTCAAAGATACCTAGTTATTCAGGGTGATGATCGTAT GAAGCTTCCCAGTCCAAATGACAGCAAGTTCTTTCAGAATCTCTTGGATGAAGAGGATTTGGAAGATATGATGGATGCTGAGGAGTACTT GGTCCCTCAGGCTTTCAACATCCCACCTCCCATCTATACTTCCAGAGCAAGAATTGACTCGAATAGGAACCAGTTTGTATACCGAGATGG AGGTTTTGCTGCTGAACAAGGAGTGTCTGTGCCCTACAGAGCCCCAACTAGCACAATTCCAGAAGCTCCTGTGGCACAGGGTGCTACTGC TGAGATTTTTGATGACTCCTGCTGTAATGGCACCCTACGCAAGCCAGTGGCACCCCATGTCCAAGAGGACAGTAGCACCCAGAGGTACAG TGCTGACCCCACCGTGTTTGCCCCAGAACGGAGCCCACGAGGAGAGCTGGATGAGGAAGGTTACATGACTCCTATGCGAGACAAACCCAA ACAAGAATACCTGAATCCAGTGGAGGAGAACCCTTTTGTTTCTCGGAGAAAAAATGGAGACCTTCAAGCATTGGATAATCCCGAATATCA CAATGCATCCAATGGTCCACCCAAGGCCGAGGATGAGTATGTGAATGAGCCACTGTACCTCAACACCTTTGCCAACACCTTGGGAAAAGC TGAGTACCTGAAGAACAACATACTGTCAATGCCAGAGAAGGCCAAGAAAGCGTTTGACAACCCTGACTACTGGAACCACAGCCTGCCACC TCGGAGCACCCTTCAGCACCCAGACTACCTGCAGGAGTACAGCACAAAATATTTTTATAAACAGAATGGGCGGATCCGGCCTATTGTGGC AGAGAATCCTGAATACCTCTCTGAGTTCTCCCTGAAGCCAGGCACTGTGCTGCCGCCTCCACCTTACAGACACCGGAATACTGTGGTGTA AGCTCAGTTGTGGTTTTTTAGGTGGAGAGACACACCTGCTCCAATTTCCCCACCCCCCTCTCTTTCTCTGGTGGTCTTCCTTCTACCCCA AGGCCAGTAGTTTTGACACTTCCCAGTGGAAGATACAGAGATGCAATGATAGTTATGTGCTTACCTAACTTGAACATTAGAGGGAAAGAC TGAAAGAGAAAGATAGGAGGAACCACAATGTTTCTTCATTTCTCTGCATGGGTTGGTCAGGAGAATGAAACAGCTAGAGAAGGACCAGAA AATGTAAGGCAATGCTGCCTACTATCAAACTAGCTGTCACTTTTTTTCTTTTTCTTTTTCTTTCTTTGTTTCTTTCTTCCTCTTCTTTTT TTTTTTTTTTTTTAAAGCAGATGGTTGAAACACCCATGCTATCTGTTCCTATCTGCAGGAACTGATGTGTGCATATTTAGCATCCCTGGA AATCATAATAAAGTTTCCATTAGAACAAAAGAATAACATTTTCTATAACATATGATGGTGTCTGAAATTGAGAATCCAGTTTCTTTCCCC AGCAGTTTCTGTCCTAGCAAGTAAGAATGGCCAACTCAACTTTCATAATTTAAAAATCTCCATTAAAGTTATAACTAGTAATTATGTTTT CAACACTTTTTGGTTTTTTTCATTTTGTTTTGCTCTGACCGATTCCTTTATATTTGCTCCCCTATTTTTGGCTTTAATTTCTAATTGCAA AGATGTTTACATCAAAGCTTCTTCACAGAATTTAAGCAAGAAATATTTTAATATAGTGAAATGGCCACTACTTTAAGTATACAATCTTTA AAATAAGAAAGGGAGGCTAATATTTTTCATGCTATCAAATTATCTTCACCCTCATCCTTTACATTTTTCAACATTTTTTTTTCTCCATAA ATGACACTACTTGATAGGCCGTTGGTTGTCTGAAGAGTAGAAGGGAAACTAAGAGACAGTTCTCTGTGGTTCAGGAAAACTACTGATACT TTCAGGGGTGGCCCAATGAGGGAATCCATTGAACTGGAAGAAACACACTGGATTGGGTATGTCTACCTGGCAGATACTCAGAAATGTAGT TTGCACTTAAGCTGTAATTTTATTTGTTCTTTTTCTGAACTCCATTTTGGATTTTGAATCAAGCAATATGGAAGCAACCAGCAAATTAAC TAATTTAAGTACATTTTTAAAAAAAGAGCTAAGATAAAGACTGTGGAAATGCCAAACCAAGCAAATTAGGAACCTTGCAACGGTATCCAG GGACTATGATGAGAGGCCAGCACATTATCTTCATATGTCACCTTTGCTACGCAAGGAAATTTGTTCAGTTCGTATACTTCGTAAGAAGGA ATGCGAGTAAGGATTGGCTTGAATTCCATGGAATTTCTAGTATGAGACTATTTATATGAAGTAGAAGGTAACTCTTTGCACATAAATTGG TATAATAAAAAGAAAAACACAAACATTCAAAGCTTAGGGATAGGTCCTTGGGTCAAAAGTTGTAAATAAATGTGAAACATCTTCTCATGC AATTATTTTATTATCCAACACACTAATCTTTTGATACTTTATATAATTCCCTTTCTTCATATACTGCATCCAGTACTAGAACCATCATTA TTATGTATCATTTTGAAAGAATACCTGATGAGATGAAGGATGAGAACAAATGACAGAGATGAGTCTCCAAGTAAAGGGGGCCTCACATCA ATAATTAGGAAACTTAGATATAAGTCGCCCTTTTCTGAAAATTCTACCCCAAGTCATTTAGATTTTTAAAAAATATTTCTAATGTTAAAA TATTGGGACCAAATTAGAATCAATAGTATAAGATTAATTAATTAGAGTAAAAATATCTATTAAGGCAGAGAAAGTTTAGAGAAAAAAATC CAAAGAAATTTGTGTTTCTTCCTATTCTGAACAAGTAAATCCATCCATCCATCCATCCAAACCTCCTTTATCTAACTGTGTCTACTAAAA GCACCATGTTTTGTGGGGAACACTCAGATAAATGGAATATCATCCTCAACTTCAAAATTCTATGATCTAGGAGATTTAATTAAAATGACA TTTTAATTTTTCTATGCGTTCCAACAATCAGATTGCATAGTCTCTTTTGTGAATAGCTGTCATATAATCAGTTGTACTGTAAGATATCTC CTTTAAACTCATTTGGGATATAAGTTAAACATCCTTCAAATTGTTGATGTTGACAAACAGGATAATTTCAATAATATTATTCAAACATAA ACTGGTCTAGGAGAATATTGCATCACTGACTAATTAGCCTATCTAGAGTCTAACTTCACCATTAAACCAAAAGCAGATGGTGGTCCTTGG CCAAGAATATTGGAGACATTGGAGTTGGTTTTTTTCTAAGCTATAAGAAGTGAGGCGAGCTGAAAAAGTATGGTAGAGCAGGAGAAGGGT TTGTGAGATTCCTTCTAGTGAAGTTCACCCTCAAACTTTTCAGGGGTAAAGACACAGAGTGATTCAGGGGCCACAATCTAATAGCTCAGG GCTCTCCTATCCATTCAGAGAAGTCTCTAGGAAAAGGGATCTCATATCAGTACTTATGAAAAATTGAATATAAGCCTCCCTTTCTAAATA AATCTGCATCGAGTCATCACAGCCCTCTTTTTGGATACTATACCTTGATTTTTTTTTTCTGATTTACAATATGCATATGGTTTCTACTGG GCTATAGAAAGCAGAATCACTCATTTTGGAGAAGGAAAAAATGAATAGTTAAAACAAACTTTTAACTGTTAAGGTAACAGAAATGTATTT AGTGAATGTCTCTTTCCTCCTAAGAACACAAGACTTCTACATGTTGGGTAATACCTAGAGATGCATGTAGGAATAATCCAAAATGACCCA AATGCTTTATAATAGCACCACTTTATAATTCTTTTGAATGATTTCTGTAGTATATAATTGACTTCAGTTGTTTGAGTGTTTTTTGTTTTA TTTTTGTCCCCCCTGGGAAAACATATTTCAGCATGTATAAGAGGGAGAAAAAAAGTTTCATTCCTTCCAGAGAATAACTTATTTAGTCCA GTAGGGTAGAATTTTAAAATGTCAGTTAAAGTCTTCAAAGTGCTTGGGGGGATATCAGATTCCAGAGGCCAATTGTAGCAATTGAAATTT GCAGAATCAATTATGTAAATCTGAGACAAATTAGTATTAAAATTACACGGAGTATATTTTTTAAATCACCCAACTTTGTAGATTATACCT ATTTTGGGCAGGTATGGAAAAATTTTGCAGTTAAATGATTGCCTAAAGAAAGTGGTAAACAGGTGAGGAAAGATGGCCTCTGATCTAGGA TAGATCCAGAACCACAAAGCATCTGCACCACAAAAGGTGTTAGACTACCAAGCAGCTCCTGGTTTTCTGCATAGTATTAGTAGCACAGCT TAGGATGAGAATCCTTTCTCCAGTAACATTCTTAAAATAGCATGAAAAACAACGCAAAACTCAAATTTCTATTAAAACACACAAACTAAA ATCAAGTGATTCTTTTTTGTAGATTAGGGAGAAGGACTGAATATCTAATTTAAGAGAAGGAATAGTGTTTAAGTGTTATAGTGTGTGAGC TAATACCTTCTAAAGGAAAGACATGGCATGAAGATTGTGCATACTTACAATGCTAAGGAAAAATCAAGAAAAGGACTGTGTGAGGCTCTG CTACTAGATGAAGTTGGAAGGACTATTAATGTGCTTCTTGAAGTATCAAAAATGAAAAGAAAATTAAAATTGTTTAAGCCTGACAGGGAA GGATGTAAATACAAGTTTTTCTAGAGCTCTCTAACCTTTATTTCAAAACTGGAATTATTCATCCATCTGTAATTGTTGATAATTTAACTA GTATATGTAGTTCATAAGGTAATAGAAAAGGTGATCATGAAAGCATGTATATAACTGGACAGAACCACGATAATGCTATAAGATGTAGAT TTAGTTAGGTTATCAGATGTTAAATGATTTTAATATTATTAAATAAATCAAACTAGAAAACTAACCACAAGTATAATGTAACAAAGTTAA ATGCAGGATATAAAAATGTAGGATGGATTTTGCATAGTAAAAAGATAAGTTTGCCATTTAAAATTGTTGTTTGTTGGGTTTAGCTGAAAG TAGGCATATATGGTTCCACTTGGGAAAACTTGCTTTAAAGCATTACAATGAACAATTTTTTCTCATTCTCTTATTCCTTTATCACTTTTT AAATGTAAAGAAAATTGTATTTATTTATTTTTTTAAATAAACACCACCTTGCAGAATTTAATAGGCAAACATGTTACATATGACTAAGTA AGGGTCTTCAAGATGAAGTAAAGAAAATGTAAATGTTCTATTACCTTATGCAGAGACAAAAAAAAAAAGGAGTGGTGTCATTTAGCTAGC AAACAAACAAAATACAGTTAATTGGTGATATGTCCTTTCTTTTCTCACTATGCCCTCTTGCCTCCAAAAATGACAACAAAGAATCACAAT TTTTCTGATAAATAAATGCTAAACCAAGCGTTTCAAACTATTGCATTGCCATTCTTTTGGACTTTAGTTATTAGAATGATGATTGTTATA GGGCAAATGAGAAATCCATGTGCATCAGCTTCTAGTTGTTAAAAAAACCAGATAAATTAACTTCTACTGTATACTGTGGGCAGAGGATCC TAGAGCTGATCCTACAACATCAGCTTCTAGTTGTTAAAAAAAAAAAAAGAAACAGATAAATTAACTTCTACTGTATATACTGTGGGCAGA GGATCTTACTGTGCCTCTGTTTGTGTACATGGACTTCGGTGTGTATCAGTTTGAAGGACAGCCTTGCCCCATGTAAACATATAAATGCAG ATTGGTATCGCCTGGTTGCTATTTGCTTAAGAACAAATATTATACAGATGAGATCAGGCATAATTTTAAAAGATCATTATCAGTGGAGAC CTCATTATTACTGATATTACAATGGGGCCAGTTTTTATACTTCTGGGTAGAATTAATAAAATTTTTCTGATCCCAGAGATCTGAGTTCTC TCTGCAGTTGGAAACAAGAAGCTGTTGTGGGCATTGTGTCGGGCCAGGGGCCCTTGTGTTTGTGTGGGCAAATATCTTTTAGCAGTGTGA GCTGCTTTTTTCTTTTCATTAAAAGTCTCTCTAAAATAATAGAAATTTCAGATACTCGGTTCAAGTCTCACTGATTTTGTAGAGGTCCAA AAATGTAGGATCTGTCACTTTTGCAGGCCCCTGCCTCACCTAATTCCTGGCCAGGTGACATTTTGGGCAGAAGTAAATGCTTCTATAGTC ACAAGCTAAAATGACTCTAAGCCCCAATTTCACGGGGGGTATTCACATGCTTCCTCTGGAAAATACTCTTTGACAGTCAGCTTTGCAAGT AAGTGATTACCTTGTTAGGAATCAAAGAAAAATGTATTTCTCTCTGACCTTTAGAGGAAAATAGAATCCTTCCCTTTTTTGCCCATTGAC ACAACTGGCACTGCTCTCTTCCCTTTCTACCACCCTGGTTCAAAGTAGTCCCCCGATGCTGTCCTGTTCCTTTCTTAAGCCATAGTGGAT CTCTGAGATCCTACACCCCACTTTGTGAAACACTGACTTCATCTTTGCCCTCGAATGCCTGATTTTTTCATAAGAGATTCTAGCAATTTG GACACTGTTTAAGTGAACTATCAAACTACCGCATAGAGAATATTTAAGCTATTAAAATTATGGTTTCCCATGAAGATCAATTCTCTGTGT CCTTCCCTATAGGAATTTGAGACGAGTTAGCCCTGTGATGAATCTTGAAACTCACATATGTCCACATACACTTGGTAGAACTTCGATTTA ATCTTTACATAAAAGCTGTACATATAACCAAGAAGTTATTTTTGCCAGTAAATTAACTTATTTGCTTTATTCATCTTATTTGGTTCCTAA TCGTAAATATTTTGTAGCTGCTGTAAATTTTTTTCTCCCAAATGAGGAGTCTTATTATCATAAAGGTAAAGGCTATTCAGCTTTGATAAC CACCTGCAATTCTTTTTTGGATCATTCATCCATCTAACAAATACATAATGAGGACAGTTCATGTTAATGAAAATCCATGTTGTTTAATAG AATGCCATCCTTTACCTACTTTTGCTCTTTATGGACGTTTTTCTTTTCATGCTCTAGTGAGCTTTCCCTATATCATGAGAAGTGGTTATA TTTGTGCAAATATACAAATATAGGAAAACAAAGATTCATACCTGTAGGCAATAGTCTAACTTGTCCAAACCACTTTGCCTTTACTGCTAT TTTTATCCCCAATGCGTAGATATTTCCCCCAGGCCTATAGCCTTTGTGAAGGAAAGCAAATCATACCTCCTGTATATTGACACGAATCTG GTTTTCAAATGTCATTTCCAGATTTTTTAGTTAATTGGGGGTTGTCCTTTTCCCTTAATGTGAGAGTCATTTTCCTGTATATTTCTGGAT CTCTCAGGGGCTGGGAGGGGGGAGTGAGGGGACTACAACCATAGCACTCCAAGAACCCTTTTGGGATTACTCCAGTAATCAACTACGAAA GTTATTTTCTAAATGTAGATATGTAAGGTGTTCTTTTAAAGTAAGGTACTTTGAAATATGTAGCATAAACTGGTACTGCTGTTAAATGGG TCGATTATTAAACGGAGCAGCTGTGTGAGGGCAGCTAACTTTGAATGCCTGTCTCCCTGGCTGGTGTGTCTCCTTCTCATGTTGAGAGCA CCAGGGATTGCGTGGCTGCATGCTGAAACCGCATTTTCCCATGGTGTATGACTAGTTCATCTCTTTCTTGAGCACCATTACAAGAAGATC AAATGAAAATGAGATCAATGTGGAAGACAATTCATAGCACAAAAAAAGTCATCTTAAATCTACTCTCAAACATTCATCTTATACATGCAT CAAAGTAATTTACTGACATCAGTTTGGGTGAGAGAGGGAGTCACTTTACTGAAAAGGCAGAGGCTTAAGGTGTATACATTTGTACTCACT TCCTTATTTTCTTAACTTGTAAGCAGAAAACAAGCCCTCTCTCTTGTGAAGTATCTTCAAAGGATTGGGGTGCAAAAATACCTTGCTGGT AAGCCATCAATGTTTTATTTAAATCCCTGCATTCAAAGTTAGCTGCCTTTTTGAAATAAACAAACAAAAAATACTACTGTATGTTTGAAA ATGTGAATAGTATTTTTATAGCTTGTTAAAGACATGGCTAGTTGCATTTGTAAATAAGTATAATGTTGCTTTGATTTTCTTTTGTGGACA TCTTTATTTGGAACATAATTGTCTTTAGGGTTGATTTGTATATAAGTAATTGGCCTGTGATTGTTTCTTTTTTGGTTGGAAGTTATCATT TTGACATTACTTGTGATTCTGTGTTCAGCACTATTGTGATGTGTTCAACCTCTGCACTCGCTTACACAATAGGATATGCCAATTGTGTGT GGTGTAATGTTATTTTGATTTTTTTCCATGTTATTGATGAAGGATCATGCACCTAACACATACTAACTTTTTTAATGTTAGGCATATTTT TAGTATACTTTCTCTTATTCTTTCTTCTCCTCCAACCTTTTACCCATCCTCCTTCCTTTCCCTCATTCCTGTTGTTATTTGAGAATGAGG GAGAAACAGTATTTTACATTTATGTAATTAGGCTTTTCCGTTAGTTCTCAAGGATCCTCTTTTGGCTCTTGGGAAAGAATTGTACCTGTA CAAGGCAATTATAGAATGCGAACTGCTTTGCCTCATTCCATACTGATCATCCCAGCTGAACAATTTGAAAACTGTTCTGCCTTTTTGTTA >In-frame_CBR4_ENST00000306193_chr4_169923222_-_ERBB4_ENST00000342788_chr2_212989628_-_12443nt ATTACTATTGTGCGGCTGCAGGAGGTGTCGAGCGGCGTTATTTTTTTTTGCGGTTTGCCTTTTTTTTTCTTTTTTTTTTTTTTGGAACCG CGGTTGTTTAAAAGCCTGAGGGAACCTGGAGAGGGGCTCCCACTCCCTACCCTCTTTCCTCCGAGTTTGTGACTCCGAGATGGACAAAGT GTGTGCTGTTTTTGGAGGCTCCCGAGGCATTGGCAGAGCTGTGGCCCAGTTAATGGCCCGGAAAGGCTACCGACTGGCGGTCATTGCCAG AAACCTGGAAGGGGCCAAAGCCGCCGCCGGTGACCTCGGCGGAGATCATTTGGCATTTAGCTGTGATGTTGCTAAAGAACATGATGTTCA AAATACATTTGAAGAGCTGGAGAAACATTTAGGTCGAGTAAATTTCTTGGTAAATGCAGCTGGTATTAACAGGGATGGTCTTTTAGTAAG AACAAAAACTGAAGATATGGTATCTCAGCTTCATACTAACCTCTTGGGTTCCATGCTGACCTGTAAAGCTGCCATGAGGACTATGATTCA ACAACAGGGAGGGTCTATTGTTAATGTAGGAAGCATTGTTGGCTTAAAAGGCAACTCTGGCCAGTCCGTTTACAGTGCCAGTAAAGGAGG ATTAGTTGGATTTTCACGTGCTCTTGCTAAAGAGGTAGCAAGAAAGAAAATTAGAGTGAATGTAGTTGCACCAGTGTGTGCAGGAACGGA GAATAAACTGAGCTCTCTCTCTGACCTGGAACAGCAGTACCGAGCCTTGCGCAAGTACTATGAAAACTGTGAGGTTGTCATGGGCAACCT GGAGATAACCAGCATTGAGCACAACCGGGACCTCTCCTTCCTGCGGTCTGTTCGAGAAGTCACAGGCTACGTGTTAGTGGCTCTTAATCA GTTTCGTTACCTGCCTCTGGAGAATTTACGCATTATTCGTGGGACAAAACTTTATGAGGATCGATATGCCTTGGCAATATTTTTAAACTA CAGAAAAGATGGAAACTTTGGACTTCAAGAACTTGGATTAAAGAACTTGACAGAAATCCTAAATGGTGGAGTCTATGTAGACCAGAACAA ATTCCTTTGTTATGCAGACACCATTCATTGGCAAGATATTGTTCGGAACCCATGGCCTTCCAACTTGACTCTTGTGTCAACAAATGGTAG TTCAGGATGTGGACGTTGCCATAAGTCCTGTACTGGCCGTTGCTGGGGACCCACAGAAAATCATTGCCAGACTTTGACAAGGACGGTGTG TGCAGAACAATGTGACGGCAGATGCTACGGACCTTACGTCAGTGACTGCTGCCATCGAGAATGTGCTGGAGGCTGCTCAGGACCTAAGGA CACAGACTGCTTTGCCTGCATGAATTTCAATGACAGTGGAGCATGTGTTACTCAGTGTCCCCAAACCTTTGTCTACAATCCAACCACCTT TCAACTGGAGCACAATTTCAATGCAAAGTACACATATGGAGCATTCTGTGTCAAGAAATGTCCACATAACTTTGTGGTAGATTCCAGTTC TTGTGTGCGTGCCTGCCCTAGTTCCAAGATGGAAGTAGAAGAAAATGGGATTAAAATGTGTAAACCTTGCACTGACATTTGCCCAAAAGC TTGTGATGGCATTGGCACAGGATCATTGATGTCAGCTCAGACTGTGGATTCCAGTAACATTGACAAATTCATAAACTGTACCAAGATCAA TGGGAATTTGATCTTTCTAGTCACTGGTATTCATGGGGACCCTTACAATGCAATTGAAGCCATAGACCCAGAGAAACTGAACGTCTTTCG GACAGTCAGAGAGATAACAGGTTTCCTGAACATACAGTCATGGCCACCAAACATGACTGACTTCAGTGTTTTTTCTAACCTGGTGACCAT TGGTGGAAGAGTACTCTATAGTGGCCTGTCCTTGCTTATCCTCAAGCAACAGGGCATCACCTCTCTACAGTTCCAGTCCCTGAAGGAAAT CAGCGCAGGAAACATCTATATTACTGACAACAGCAACCTGTGTTATTATCATACCATTAACTGGACAACACTCTTCAGCACAATCAACCA GAGAATAGTAATCCGGGACAACAGAAAAGCTGAAAATTGTACTGCTGAAGGAATGGTGTGCAACCATCTGTGTTCCAGTGATGGCTGTTG GGGACCTGGGCCAGACCAATGTCTGTCGTGTCGCCGCTTCAGTAGAGGAAGGATCTGCATAGAGTCTTGTAACCTCTATGATGGTGAATT TCGGGAGTTTGAGAATGGCTCCATCTGTGTGGAGTGTGACCCCCAGTGTGAGAAGATGGAAGATGGCCTCCTCACATGCCATGGACCGGG TCCTGACAACTGTACAAAGTGCTCTCATTTTAAAGATGGCCCAAACTGTGTGGAAAAATGTCCAGATGGCTTACAGGGGGCAAACAGTTT CATTTTCAAGTATGCTGATCCAGATCGGGAGTGCCACCCATGCCATCCAAACTGCACCCAAGGGTGTAACGGTCCCACTAGTCATGACTG CATTTACTACCCATGGACGGGCCATTCCACTTTACCACAACATGCTAGAACTCCCCTGATTGCAGCTGGAGTAATTGGTGGGCTCTTCAT TCTGGTCATTGTGGGTCTGACATTTGCTGTTTATGTTAGAAGGAAGAGCATCAAAAAGAAAAGAGCCTTGAGAAGATTCTTGGAAACAGA GTTGGTGGAACCATTAACTCCCAGTGGCACAGCACCCAATCAAGCTCAACTTCGTATTTTGAAAGAAACTGAGCTGAAGAGGGTAAAAGT CCTTGGCTCAGGTGCTTTTGGAACGGTTTATAAAGGTATTTGGGTACCTGAAGGAGAAACTGTGAAGATTCCTGTGGCTATTAAGATTCT TAATGAGACAACTGGTCCCAAGGCAAATGTGGAGTTCATGGATGAAGCTCTGATCATGGCAAGTATGGATCATCCACACCTAGTCCGGTT GCTGGGTGTGTGTCTGAGCCCAACCATCCAGCTGGTTACTCAACTTATGCCCCATGGCTGCCTGTTGGAGTATGTCCACGAGCACAAGGA TAACATTGGATCACAACTGCTGCTTAACTGGTGTGTCCAGATAGCTAAGGGAATGATGTACCTGGAAGAAAGACGACTCGTTCATCGGGA TTTGGCAGCCCGTAATGTCTTAGTGAAATCTCCAAACCATGTGAAAATCACAGATTTTGGGCTAGCCAGACTCTTGGAAGGAGATGAAAA AGAGTACAATGCTGATGGAGGAAAGATGCCAATTAAATGGATGGCTCTGGAGTGTATACATTACAGGAAATTCACCCATCAGAGTGACGT TTGGAGCTATGGAGTTACTATATGGGAACTGATGACCTTTGGAGGAAAACCCTATGATGGAATTCCAACGCGAGAAATCCCTGATTTATT AGAGAAAGGAGAACGTTTGCCTCAGCCTCCCATCTGCACTATTGACGTTTACATGGTCATGGTCAAATGTTGGATGATTGATGCTGACAG TAGACCTAAATTTAAGGAACTGGCTGCTGAGTTTTCAAGGATGGCTCGAGACCCTCAAAGATACCTAGTTATTCAGGGTGATGATCGTAT GAAGCTTCCCAGTCCAAATGACAGCAAGTTCTTTCAGAATCTCTTGGATGAAGAGGATTTGGAAGATATGATGGATGCTGAGGAGTACTT GGTCCCTCAGGCTTTCAACATCCCACCTCCCATCTATACTTCCAGAGCAAGAATTGACTCGAATAGGAGTGAAATTGGACACAGCCCTCC TCCTGCCTACACCCCCATGTCAGGAAACCAGTTTGTATACCGAGATGGAGGTTTTGCTGCTGAACAAGGAGTGTCTGTGCCCTACAGAGC CCCAACTAGCACAATTCCAGAAGCTCCTGTGGCACAGGGTGCTACTGCTGAGATTTTTGATGACTCCTGCTGTAATGGCACCCTACGCAA GCCAGTGGCACCCCATGTCCAAGAGGACAGTAGCACCCAGAGGTACAGTGCTGACCCCACCGTGTTTGCCCCAGAACGGAGCCCACGAGG AGAGCTGGATGAGGAAGGTTACATGACTCCTATGCGAGACAAACCCAAACAAGAATACCTGAATCCAGTGGAGGAGAACCCTTTTGTTTC TCGGAGAAAAAATGGAGACCTTCAAGCATTGGATAATCCCGAATATCACAATGCATCCAATGGTCCACCCAAGGCCGAGGATGAGTATGT GAATGAGCCACTGTACCTCAACACCTTTGCCAACACCTTGGGAAAAGCTGAGTACCTGAAGAACAACATACTGTCAATGCCAGAGAAGGC CAAGAAAGCGTTTGACAACCCTGACTACTGGAACCACAGCCTGCCACCTCGGAGCACCCTTCAGCACCCAGACTACCTGCAGGAGTACAG CACAAAATATTTTTATAAACAGAATGGGCGGATCCGGCCTATTGTGGCAGAGAATCCTGAATACCTCTCTGAGTTCTCCCTGAAGCCAGG CACTGTGCTGCCGCCTCCACCTTACAGACACCGGAATACTGTGGTGTAAGCTCAGTTGTGGTTTTTTAGGTGGAGAGACACACCTGCTCC AATTTCCCCACCCCCCTCTCTTTCTCTGGTGGTCTTCCTTCTACCCCAAGGCCAGTAGTTTTGACACTTCCCAGTGGAAGATACAGAGAT GCAATGATAGTTATGTGCTTACCTAACTTGAACATTAGAGGGAAAGACTGAAAGAGAAAGATAGGAGGAACCACAATGTTTCTTCATTTC TCTGCATGGGTTGGTCAGGAGAATGAAACAGCTAGAGAAGGACCAGAAAATGTAAGGCAATGCTGCCTACTATCAAACTAGCTGTCACTT TTTTTCTTTTTCTTTTTCTTTCTTTGTTTCTTTCTTCCTCTTCTTTTTTTTTTTTTTTTTTAAAGCAGATGGTTGAAACACCCATGCTAT CTGTTCCTATCTGCAGGAACTGATGTGTGCATATTTAGCATCCCTGGAAATCATAATAAAGTTTCCATTAGAACAAAAGAATAACATTTT CTATAACATATGATGGTGTCTGAAATTGAGAATCCAGTTTCTTTCCCCAGCAGTTTCTGTCCTAGCAAGTAAGAATGGCCAACTCAACTT TCATAATTTAAAAATCTCCATTAAAGTTATAACTAGTAATTATGTTTTCAACACTTTTTGGTTTTTTTCATTTTGTTTTGCTCTGACCGA TTCCTTTATATTTGCTCCCCTATTTTTGGCTTTAATTTCTAATTGCAAAGATGTTTACATCAAAGCTTCTTCACAGAATTTAAGCAAGAA ATATTTTAATATAGTGAAATGGCCACTACTTTAAGTATACAATCTTTAAAATAAGAAAGGGAGGCTAATATTTTTCATGCTATCAAATTA TCTTCACCCTCATCCTTTACATTTTTCAACATTTTTTTTTCTCCATAAATGACACTACTTGATAGGCCGTTGGTTGTCTGAAGAGTAGAA GGGAAACTAAGAGACAGTTCTCTGTGGTTCAGGAAAACTACTGATACTTTCAGGGGTGGCCCAATGAGGGAATCCATTGAACTGGAAGAA ACACACTGGATTGGGTATGTCTACCTGGCAGATACTCAGAAATGTAGTTTGCACTTAAGCTGTAATTTTATTTGTTCTTTTTCTGAACTC CATTTTGGATTTTGAATCAAGCAATATGGAAGCAACCAGCAAATTAACTAATTTAAGTACATTTTTAAAAAAAGAGCTAAGATAAAGACT GTGGAAATGCCAAACCAAGCAAATTAGGAACCTTGCAACGGTATCCAGGGACTATGATGAGAGGCCAGCACATTATCTTCATATGTCACC TTTGCTACGCAAGGAAATTTGTTCAGTTCGTATACTTCGTAAGAAGGAATGCGAGTAAGGATTGGCTTGAATTCCATGGAATTTCTAGTA TGAGACTATTTATATGAAGTAGAAGGTAACTCTTTGCACATAAATTGGTATAATAAAAAGAAAAACACAAACATTCAAAGCTTAGGGATA GGTCCTTGGGTCAAAAGTTGTAAATAAATGTGAAACATCTTCTCATGCAATTATTTTATTATCCAACACACTAATCTTTTGATACTTTAT ATAATTCCCTTTCTTCATATACTGCATCCAGTACTAGAACCATCATTATTATGTATCATTTTGAAAGAATACCTGATGAGATGAAGGATG AGAACAAATGACAGAGATGAGTCTCCAAGTAAAGGGGGCCTCACATCAATAATTAGGAAACTTAGATATAAGTCGCCCTTTTCTGAAAAT TCTACCCCAAGTCATTTAGATTTTTAAAAAATATTTCTAATGTTAAAATATTGGGACCAAATTAGAATCAATAGTATAAGATTAATTAAT TAGAGTAAAAATATCTATTAAGGCAGAGAAAGTTTAGAGAAAAAAATCCAAAGAAATTTGTGTTTCTTCCTATTCTGAACAAGTAAATCC ATCCATCCATCCATCCAAACCTCCTTTATCTAACTGTGTCTACTAAAAGCACCATGTTTTGTGGGGAACACTCAGATAAATGGAATATCA TCCTCAACTTCAAAATTCTATGATCTAGGAGATTTAATTAAAATGACATTTTAATTTTTCTATGCGTTCCAACAATCAGATTGCATAGTC TCTTTTGTGAATAGCTGTCATATAATCAGTTGTACTGTAAGATATCTCCTTTAAACTCATTTGGGATATAAGTTAAACATCCTTCAAATT GTTGATGTTGACAAACAGGATAATTTCAATAATATTATTCAAACATAAACTGGTCTAGGAGAATATTGCATCACTGACTAATTAGCCTAT CTAGAGTCTAACTTCACCATTAAACCAAAAGCAGATGGTGGTCCTTGGCCAAGAATATTGGAGACATTGGAGTTGGTTTTTTTCTAAGCT ATAAGAAGTGAGGCGAGCTGAAAAAGTATGGTAGAGCAGGAGAAGGGTTTGTGAGATTCCTTCTAGTGAAGTTCACCCTCAAACTTTTCA GGGGTAAAGACACAGAGTGATTCAGGGGCCACAATCTAATAGCTCAGGGCTCTCCTATCCATTCAGAGAAGTCTCTAGGAAAAGGGATCT CATATCAGTACTTATGAAAAATTGAATATAAGCCTCCCTTTCTAAATAAATCTGCATCGAGTCATCACAGCCCTCTTTTTGGATACTATA CCTTGATTTTTTTTTTCTGATTTACAATATGCATATGGTTTCTACTGGGCTATAGAAAGCAGAATCACTCATTTTGGAGAAGGAAAAAAT GAATAGTTAAAACAAACTTTTAACTGTTAAGGTAACAGAAATGTATTTAGTGAATGTCTCTTTCCTCCTAAGAACACAAGACTTCTACAT GTTGGGTAATACCTAGAGATGCATGTAGGAATAATCCAAAATGACCCAAATGCTTTATAATAGCACCACTTTATAATTCTTTTGAATGAT TTCTGTAGTATATAATTGACTTCAGTTGTTTGAGTGTTTTTTGTTTTATTTTTGTCCCCCCTGGGAAAACATATTTCAGCATGTATAAGA GGGAGAAAAAAAGTTTCATTCCTTCCAGAGAATAACTTATTTAGTCCAGTAGGGTAGAATTTTAAAATGTCAGTTAAAGTCTTCAAAGTG CTTGGGGGGATATCAGATTCCAGAGGCCAATTGTAGCAATTGAAATTTGCAGAATCAATTATGTAAATCTGAGACAAATTAGTATTAAAA TTACACGGAGTATATTTTTTAAATCACCCAACTTTGTAGATTATACCTATTTTGGGCAGGTATGGAAAAATTTTGCAGTTAAATGATTGC CTAAAGAAAGTGGTAAACAGGTGAGGAAAGATGGCCTCTGATCTAGGATAGATCCAGAACCACAAAGCATCTGCACCACAAAAGGTGTTA GACTACCAAGCAGCTCCTGGTTTTCTGCATAGTATTAGTAGCACAGCTTAGGATGAGAATCCTTTCTCCAGTAACATTCTTAAAATAGCA TGAAAAACAACGCAAAACTCAAATTTCTATTAAAACACACAAACTAAAATCAAGTGATTCTTTTTTGTAGATTAGGGAGAAGGACTGAAT ATCTAATTTAAGAGAAGGAATAGTGTTTAAGTGTTATAGTGTGTGAGCTAATACCTTCTAAAGGAAAGACATGGCATGAAGATTGTGCAT ACTTACAATGCTAAGGAAAAATCAAGAAAAGGACTGTGTGAGGCTCTGCTACTAGATGAAGTTGGAAGGACTATTAATGTGCTTCTTGAA GTATCAAAAATGAAAAGAAAATTAAAATTGTTTAAGCCTGACAGGGAAGGATGTAAATACAAGTTTTTCTAGAGCTCTCTAACCTTTATT TCAAAACTGGAATTATTCATCCATCTGTAATTGTTGATAATTTAACTAGTATATGTAGTTCATAAGGTAATAGAAAAGGTGATCATGAAA GCATGTATATAACTGGACAGAACCACGATAATGCTATAAGATGTAGATTTAGTTAGGTTATCAGATGTTAAATGATTTTAATATTATTAA ATAAATCAAACTAGAAAACTAACCACAAGTATAATGTAACAAAGTTAAATGCAGGATATAAAAATGTAGGATGGATTTTGCATAGTAAAA AGATAAGTTTGCCATTTAAAATTGTTGTTTGTTGGGTTTAGCTGAAAGTAGGCATATATGGTTCCACTTGGGAAAACTTGCTTTAAAGCA TTACAATGAACAATTTTTTCTCATTCTCTTATTCCTTTATCACTTTTTAAATGTAAAGAAAATTGTATTTATTTATTTTTTTAAATAAAC ACCACCTTGCAGAATTTAATAGGCAAACATGTTACATATGACTAAGTAAGGGTCTTCAAGATGAAGTAAAGAAAATGTAAATGTTCTATT ACCTTATGCAGAGACAAAAAAAAAAAGGAGTGGTGTCATTTAGCTAGCAAACAAACAAAATACAGTTAATTGGTGATATGTCCTTTCTTT TCTCACTATGCCCTCTTGCCTCCAAAAATGACAACAAAGAATCACAATTTTTCTGATAAATAAATGCTAAACCAAGCGTTTCAAACTATT GCATTGCCATTCTTTTGGACTTTAGTTATTAGAATGATGATTGTTATAGGGCAAATGAGAAATCCATGTGCATCAGCTTCTAGTTGTTAA AAAAACCAGATAAATTAACTTCTACTGTATACTGTGGGCAGAGGATCCTAGAGCTGATCCTACAACATCAGCTTCTAGTTGTTAAAAAAA AAAAAAGAAACAGATAAATTAACTTCTACTGTATATACTGTGGGCAGAGGATCTTACTGTGCCTCTGTTTGTGTACATGGACTTCGGTGT GTATCAGTTTGAAGGACAGCCTTGCCCCATGTAAACATATAAATGCAGATTGGTATCGCCTGGTTGCTATTTGCTTAAGAACAAATATTA TACAGATGAGATCAGGCATAATTTTAAAAGATCATTATCAGTGGAGACCTCATTATTACTGATATTACAATGGGGCCAGTTTTTATACTT CTGGGTAGAATTAATAAAATTTTTCTGATCCCAGAGATCTGAGTTCTCTCTGCAGTTGGAAACAAGAAGCTGTTGTGGGCATTGTGTCGG GCCAGGGGCCCTTGTGTTTGTGTGGGCAAATATCTTTTAGCAGTGTGAGCTGCTTTTTTCTTTTCATTAAAAGTCTCTCTAAAATAATAG AAATTTCAGATACTCGGTTCAAGTCTCACTGATTTTGTAGAGGTCCAAAAATGTAGGATCTGTCACTTTTGCAGGCCCCTGCCTCACCTA ATTCCTGGCCAGGTGACATTTTGGGCAGAAGTAAATGCTTCTATAGTCACAAGCTAAAATGACTCTAAGCCCCAATTTCACGGGGGGTAT TCACATGCTTCCTCTGGAAAATACTCTTTGACAGTCAGCTTTGCAAGTAAGTGATTACCTTGTTAGGAATCAAAGAAAAATGTATTTCTC TCTGACCTTTAGAGGAAAATAGAATCCTTCCCTTTTTTGCCCATTGACACAACTGGCACTGCTCTCTTCCCTTTCTACCACCCTGGTTCA AAGTAGTCCCCCGATGCTGTCCTGTTCCTTTCTTAAGCCATAGTGGATCTCTGAGATCCTACACCCCACTTTGTGAAACACTGACTTCAT CTTTGCCCTCGAATGCCTGATTTTTTCATAAGAGATTCTAGCAATTTGGACACTGTTTAAGTGAACTATCAAACTACCGCATAGAGAATA TTTAAGCTATTAAAATTATGGTTTCCCATGAAGATCAATTCTCTGTGTCCTTCCCTATAGGAATTTGAGACGAGTTAGCCCTGTGATGAA TCTTGAAACTCACATATGTCCACATACACTTGGTAGAACTTCGATTTAATCTTTACATAAAAGCTGTACATATAACCAAGAAGTTATTTT TGCCAGTAAATTAACTTATTTGCTTTATTCATCTTATTTGGTTCCTAATCGTAAATATTTTGTAGCTGCTGTAAATTTTTTTCTCCCAAA TGAGGAGTCTTATTATCATAAAGGTAAAGGCTATTCAGCTTTGATAACCACCTGCAATTCTTTTTTGGATCATTCATCCATCTAACAAAT ACATAATGAGGACAGTTCATGTTAATGAAAATCCATGTTGTTTAATAGAATGCCATCCTTTACCTACTTTTGCTCTTTATGGACGTTTTT CTTTTCATGCTCTAGTGAGCTTTCCCTATATCATGAGAAGTGGTTATATTTGTGCAAATATACAAATATAGGAAAACAAAGATTCATACC TGTAGGCAATAGTCTAACTTGTCCAAACCACTTTGCCTTTACTGCTATTTTTATCCCCAATGCGTAGATATTTCCCCCAGGCCTATAGCC TTTGTGAAGGAAAGCAAATCATACCTCCTGTATATTGACACGAATCTGGTTTTCAAATGTCATTTCCAGATTTTTTAGTTAATTGGGGGT TGTCCTTTTCCCTTAATGTGAGAGTCATTTTCCTGTATATTTCTGGATCTCTCAGGGGCTGGGAGGGGGGAGTGAGGGGACTACAACCAT AGCACTCCAAGAACCCTTTTGGGATTACTCCAGTAATCAACTACGAAAGTTATTTTCTAAATGTAGATATGTAAGGTGTTCTTTTAAAGT AAGGTACTTTGAAATATGTAGCATAAACTGGTACTGCTGTTAAATGGGTCGATTATTAAACGGAGCAGCTGTGTGAGGGCAGCTAACTTT GAATGCCTGTCTCCCTGGCTGGTGTGTCTCCTTCTCATGTTGAGAGCACCAGGGATTGCGTGGCTGCATGCTGAAACCGCATTTTCCCAT GGTGTATGACTAGTTCATCTCTTTCTTGAGCACCATTACAAGAAGATCAAATGAAAATGAGATCAATGTGGAAGACAATTCATAGCACAA AAAAAGTCATCTTAAATCTACTCTCAAACATTCATCTTATACATGCATCAAAGTAATTTACTGACATCAGTTTGGGTGAGAGAGGGAGTC ACTTTACTGAAAAGGCAGAGGCTTAAGGTGTATACATTTGTACTCACTTCCTTATTTTCTTAACTTGTAAGCAGAAAACAAGCCCTCTCT CTTGTGAAGTATCTTCAAAGGATTGGGGTGCAAAAATACCTTGCTGGTAAGCCATCAATGTTTTATTTAAATCCCTGCATTCAAAGTTAG CTGCCTTTTTGAAATAAACAAACAAAAAATACTACTGTATGTTTGAAAATGTGAATAGTATTTTTATAGCTTGTTAAAGACATGGCTAGT TGCATTTGTAAATAAGTATAATGTTGCTTTGATTTTCTTTTGTGGACATCTTTATTTGGAACATAATTGTCTTTAGGGTTGATTTGTATA TAAGTAATTGGCCTGTGATTGTTTCTTTTTTGGTTGGAAGTTATCATTTTGACATTACTTGTGATTCTGTGTTCAGCACTATTGTGATGT GTTCAACCTCTGCACTCGCTTACACAATAGGATATGCCAATTGTGTGTGGTGTAATGTTATTTTGATTTTTTTCCATGTTATTGATGAAG GATCATGCACCTAACACATACTAACTTTTTTAATGTTAGGCATATTTTTAGTATACTTTCTCTTATTCTTTCTTCTCCTCCAACCTTTTA CCCATCCTCCTTCCTTTCCCTCATTCCTGTTGTTATTTGAGAATGAGGGAGAAACAGTATTTTACATTTATGTAATTAGGCTTTTCCGTT AGTTCTCAAGGATCCTCTTTTGGCTCTTGGGAAAGAATTGTACCTGTACAAGGCAATTATAGAATGCGAACTGCTTTGCCTCATTCCATA CTGATCATCCCAGCTGAACAATTTGAAAACTGTTCTGCCTTTTTGTTACATGAATCTGTCAGAAATATATTTTTAATTTAATATAAATGA >In-frame_CBR4_ENST00000306193_chr4_169923222_-_ERBB4_ENST00000402597_chr2_212989628_-_4519nt ATTACTATTGTGCGGCTGCAGGAGGTGTCGAGCGGCGTTATTTTTTTTTGCGGTTTGCCTTTTTTTTTCTTTTTTTTTTTTTTGGAACCG CGGTTGTTTAAAAGCCTGAGGGAACCTGGAGAGGGGCTCCCACTCCCTACCCTCTTTCCTCCGAGTTTGTGACTCCGAGATGGACAAAGT GTGTGCTGTTTTTGGAGGCTCCCGAGGCATTGGCAGAGCTGTGGCCCAGTTAATGGCCCGGAAAGGCTACCGACTGGCGGTCATTGCCAG AAACCTGGAAGGGGCCAAAGCCGCCGCCGGTGACCTCGGCGGAGATCATTTGGCATTTAGCTGTGATGTTGCTAAAGAACATGATGTTCA AAATACATTTGAAGAGCTGGAGAAACATTTAGGTCGAGTAAATTTCTTGGTAAATGCAGCTGGTATTAACAGGGATGGTCTTTTAGTAAG AACAAAAACTGAAGATATGGTATCTCAGCTTCATACTAACCTCTTGGGTTCCATGCTGACCTGTAAAGCTGCCATGAGGACTATGATTCA ACAACAGGGAGGGTCTATTGTTAATGTAGGAAGCATTGTTGGCTTAAAAGGCAACTCTGGCCAGTCCGTTTACAGTGCCAGTAAAGGAGG ATTAGTTGGATTTTCACGTGCTCTTGCTAAAGAGGTAGCAAGAAAGAAAATTAGAGTGAATGTAGTTGCACCAGTGTGTGCAGGAACGGA GAATAAACTGAGCTCTCTCTCTGACCTGGAACAGCAGTACCGAGCCTTGCGCAAGTACTATGAAAACTGTGAGGTTGTCATGGGCAACCT GGAGATAACCAGCATTGAGCACAACCGGGACCTCTCCTTCCTGCGGTCTGTTCGAGAAGTCACAGGCTACGTGTTAGTGGCTCTTAATCA GTTTCGTTACCTGCCTCTGGAGAATTTACGCATTATTCGTGGGACAAAACTTTATGAGGATCGATATGCCTTGGCAATATTTTTAAACTA CAGAAAAGATGGAAACTTTGGACTTCAAGAACTTGGATTAAAGAACTTGACAGAAATCCTAAATGGTGGAGTCTATGTAGACCAGAACAA ATTCCTTTGTTATGCAGACACCATTCATTGGCAAGATATTGTTCGGAACCCATGGCCTTCCAACTTGACTCTTGTGTCAACAAATGGTAG TTCAGGATGTGGACGTTGCCATAAGTCCTGTACTGGCCGTTGCTGGGGACCCACAGAAAATCATTGCCAGACTTTGACAAGGACGGTGTG TGCAGAACAATGTGACGGCAGATGCTACGGACCTTACGTCAGTGACTGCTGCCATCGAGAATGTGCTGGAGGCTGCTCAGGACCTAAGGA CACAGACTGCTTTGCCTGCATGAATTTCAATGACAGTGGAGCATGTGTTACTCAGTGTCCCCAAACCTTTGTCTACAATCCAACCACCTT TCAACTGGAGCACAATTTCAATGCAAAGTACACATATGGAGCATTCTGTGTCAAGAAATGTCCACATAACTTTGTGGTAGATTCCAGTTC TTGTGTGCGTGCCTGCCCTAGTTCCAAGATGGAAGTAGAAGAAAATGGGATTAAAATGTGTAAACCTTGCACTGACATTTGCCCAAAAGC TTGTGATGGCATTGGCACAGGATCATTGATGTCAGCTCAGACTGTGGATTCCAGTAACATTGACAAATTCATAAACTGTACCAAGATCAA TGGGAATTTGATCTTTCTAGTCACTGGTATTCATGGGGACCCTTACAATGCAATTGAAGCCATAGACCCAGAGAAACTGAACGTCTTTCG GACAGTCAGAGAGATAACAGGTTTCCTGAACATACAGTCATGGCCACCAAACATGACTGACTTCAGTGTTTTTTCTAACCTGGTGACCAT TGGTGGAAGAGTACTCTATAGTGGCCTGTCCTTGCTTATCCTCAAGCAACAGGGCATCACCTCTCTACAGTTCCAGTCCCTGAAGGAAAT CAGCGCAGGAAACATCTATATTACTGACAACAGCAACCTGTGTTATTATCATACCATTAACTGGACAACACTCTTCAGCACAATCAACCA GAGAATAGTAATCCGGGACAACAGAAAAGCTGAAAATTGTACTGCTGAAGGAATGGTGTGCAACCATCTGTGTTCCAGTGATGGCTGTTG GGGACCTGGGCCAGACCAATGTCTGTCGTGTCGCCGCTTCAGTAGAGGAAGGATCTGCATAGAGTCTTGTAACCTCTATGATGGTGAATT TCGGGAGTTTGAGAATGGCTCCATCTGTGTGGAGTGTGACCCCCAGTGTGAGAAGATGGAAGATGGCCTCCTCACATGCCATGGACCGGG TCCTGACAACTGTACAAAGTGCTCTCATTTTAAAGATGGCCCAAACTGTGTGGAAAAATGTCCAGATGGCTTACAGGGGGCAAACAGTTT CATTTTCAAGTATGCTGATCCAGATCGGGAGTGCCACCCATGCCATCCAAACTGCACCCAAGGGTGCATAGGCTCAAGTATTGAAGACTG CATCGGCCTGATGGATAGAACTCCCCTGATTGCAGCTGGAGTAATTGGTGGGCTCTTCATTCTGGTCATTGTGGGTCTGACATTTGCTGT TTATGTTAGAAGGAAGAGCATCAAAAAGAAAAGAGCCTTGAGAAGATTCTTGGAAACAGAGTTGGTGGAACCATTAACTCCCAGTGGCAC AGCACCCAATCAAGCTCAACTTCGTATTTTGAAAGAAACTGAGCTGAAGAGGGTAAAAGTCCTTGGCTCAGGTGCTTTTGGAACGGTTTA TAAAGGTATTTGGGTACCTGAAGGAGAAACTGTGAAGATTCCTGTGGCTATTAAGATTCTTAATGAGACAACTGGTCCCAAGGCAAATGT GGAGTTCATGGATGAAGCTCTGATCATGGCAAGTATGGATCATCCACACCTAGTCCGGTTGCTGGGTGTGTGTCTGAGCCCAACCATCCA GCTGGTTACTCAACTTATGCCCCATGGCTGCCTGTTGGAGTATGTCCACGAGCACAAGGATAACATTGGATCACAACTGCTGCTTAACTG GTGTGTCCAGATAGCTAAGGGAATGATGTACCTGGAAGAAAGACGACTCGTTCATCGGGATTTGGCAGCCCGTAATGTCTTAGTGAAATC TCCAAACCATGTGAAAATCACAGATTTTGGGCTAGCCAGACTCTTGGAAGGAGATGAAAAAGAGTACAATGCTGATGGAGGAAAGATGCC AATTAAATGGATGGCTCTGGAGTGTATACATTACAGGAAATTCACCCATCAGAGTGACGTTTGGAGCTATGGAGTTACTATATGGGAACT GATGACCTTTGGAGGAAAACCCTATGATGGAATTCCAACGCGAGAAATCCCTGATTTATTAGAGAAAGGAGAACGTTTGCCTCAGCCTCC CATCTGCACTATTGACGTTTACATGGTCATGGTCAAATGTTGGATGATTGATGCTGACAGTAGACCTAAATTTAAGGAACTGGCTGCTGA GTTTTCAAGGATGGCTCGAGACCCTCAAAGATACCTAGTTATTCAGGGTGATGATCGTATGAAGCTTCCCAGTCCAAATGACAGCAAGTT CTTTCAGAATCTCTTGGATGAAGAGGATTTGGAAGATATGATGGATGCTGAGGAGTACTTGGTCCCTCAGGCTTTCAACATCCCACCTCC CATCTATACTTCCAGAGCAAGAATTGACTCGAATAGGAGTGAAATTGGACACAGCCCTCCTCCTGCCTACACCCCCATGTCAGGAAACCA GTTTGTATACCGAGATGGAGGTTTTGCTGCTGAACAAGGAGTGTCTGTGCCCTACAGAGCCCCAACTAGCACAATTCCAGAAGCTCCTGT GGCACAGGGTGCTACTGCTGAGATTTTTGATGACTCCTGCTGTAATGGCACCCTACGCAAGCCAGTGGCACCCCATGTCCAAGAGGACAG TAGCACCCAGAGGTACAGTGCTGACCCCACCGTGTTTGCCCCAGAACGGAGCCCACGAGGAGAGCTGGATGAGGAAGGTTACATGACTCC TATGCGAGACAAACCCAAACAAGAATACCTGAATCCAGTGGAGGAGAACCCTTTTGTTTCTCGGAGAAAAAATGGAGACCTTCAAGCATT GGATAATCCCGAATATCACAATGCATCCAATGGTCCACCCAAGGCCGAGGATGAGTATGTGAATGAGCCACTGTACCTCAACACCTTTGC CAACACCTTGGGAAAAGCTGAGTACCTGAAGAACAACATACTGTCAATGCCAGAGAAGGCCAAGAAAGCGTTTGACAACCCTGACTACTG GAACCACAGCCTGCCACCTCGGAGCACCCTTCAGCACCCAGACTACCTGCAGGAGTACAGCACAAAATATTTTTATAAACAGAATGGGCG GATCCGGCCTATTGTGGCAGAGAATCCTGAATACCTCTCTGAGTTCTCCCTGAAGCCAGGCACTGTGCTGCCGCCTCCACCTTACAGACA |
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FusionGenePPI for CBR4_ERBB4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CBR4 | ELAVL1, HSD17B8, SEPT3, NF2, TRIM25 | ERBB4 | DLG3, SNTB2, DLG4, YAP1, DLG2, STAT5A, SHC1, CRK, GRB2, PTPN11, PIK3R2, NCK1, RNF41, ERBB2, CD44, DLG1, MUC1, EREG, NRG1, NRG2, ITCH, HDAC6, LRIG1, WWP1, NEDD4, TAB2, NCOR1, PIAS3, PIAS4, WWOX, TRIM28, MDM2, TP53, BYSL, TRO, EGFR, USP8, HSP90AA1, ABL1, RASA1, ABL2, SYK, ANKS1B, ANKS1A, NUDCD1, CBL, ERBB4, TFAP2A, TFAP2C, PTPN6, PTPN7, PTPN12, PTPRR, PTPRH, PTPRT, PPM1A, PPM1B, PPM1F, ILKAP, TAB1, PTPN20B, DUSP6, DUSP10, DUSP16, DUSP14, DUSP18, DUSP19, DUSP21, STYX, PTPDC1, MTMR2, MTMR6, MTMR9, CDC25C, ESR1, VANGL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CBR4_ERBB4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | ERBB4 | Q15303 | DB08916 | Afatinib | Receptor tyrosine-protein kinase erbB-4 | small molecule | approved |
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RelatedDiseases for CBR4_ERBB4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ERBB4 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| Tgene | ERBB4 | C0036341 | Schizophrenia | 4 | PSYGENET |
| Tgene | ERBB4 | C0016978 | gallbladder neoplasm | 1 | CTD_human |
| Tgene | ERBB4 | C0025202 | melanoma | 1 | CTD_human |
| Tgene | ERBB4 | C0037286 | Skin Neoplasms | 1 | CTD_human |
| Tgene | ERBB4 | C3715155 | AMYOTROPHIC LATERAL SCLEROSIS 19 | 1 | UNIPROT |
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