FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 5696

FusionGeneSummary for CBL_UBE4A

check button Fusion gene summary
Fusion gene informationFusion gene name: CBL_UBE4A
Fusion gene ID: 5696
HgeneTgene
Gene symbol

CBL

UBE4A

Gene ID

867

9354

Gene nameCbl proto-oncogeneubiquitination factor E4A
SynonymsC-CBL|CBL2|FRA11B|NSLL|RNF55E4|UBOX2|UFD2
Cytomap

11q23.3

11q23.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase CBLCas-Br-M (murine) ecotropic retroviral transforming sequenceCbl proto-oncogene, E3 ubiquitin protein ligaseRING finger protein 55RING-type E3 ubiquitin transferase CBLcasitas B-lineage lymphoma proto-oncogenefragile siubiquitin conjugation factor E4 ARING-type E3 ubiquitin transferase E4 Aubiquitination factor E4A (UFD2 homolog, yeast)
Modification date2018052320180523
UniProtAcc

P22681

Q14139

Ensembl transtripts involved in fusion geneENST00000264033, ENST00000252108, 
ENST00000431736, ENST00000545354, 
Fusion gene scores* DoF score10 X 7 X 7=4905 X 4 X 5=100
# samples 116
** MAII scorelog2(11/490*10)=-2.15527822547791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CBL [Title/Abstract] AND UBE4A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E2-A1LS-01ACBLchr11

119158656

+UBE4Achr11

118261372

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000264033ENST00000252108CBLchr11

119158656

+UBE4Achr11

118261372

+
In-frameENST00000264033ENST00000431736CBLchr11

119158656

+UBE4Achr11

118261372

+
In-frameENST00000264033ENST00000545354CBLchr11

119158656

+UBE4Achr11

118261372

+

Top

FusionProtFeatures for CBL_UBE4A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CBL

P22681

UBE4A

Q14139

Adapter protein that functions as a negative regulatorof many signaling pathways that are triggered by activation ofcell surface receptors. Acts as an E3 ubiquitin-protein ligase,which accepts ubiquitin from specific E2 ubiquitin-conjugatingenzymes, and then transfers it to substrates promoting theirdegradation by the proteasome. Recognizes activated receptortyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA,PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling.Recognizes membrane-bound HCK, SRC and other kinases of the SRCfamily and mediates their ubiquitination and degradation.Participates in signal transduction in hematopoietic cells. Playsan important role in the regulation of osteoblast differentiationand apoptosis. Essential for osteoclastic bone resorption. The'Tyr-731' phosphorylated form induces the activation andrecruitment of phosphatidylinositol 3-kinase to the cell membranein a signaling pathway that is critical for osteoclast function.May be functionally coupled with the E2 ubiquitin-protein ligaseUB2D3. {ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602,ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300,ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17509076,ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429,ECO:0000269|PubMed:21596750}. Ubiquitin-protein ligase that probably functions as anE3 ligase in conjunction with specific E1 and E2 ligases. May alsofunction as an E4 ligase mediating the assembly of polyubiquitinchains on substrates ubiquitinated by another E3 ubiquitin ligase.Mediates 'Lys-48'-linked polyubiquitination of substrates.{ECO:0000250|UniProtKB:E9Q735, ECO:0000250|UniProtKB:P54860}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCBLchr11:119158656chr11:118261372ENST00000264033+1216227_240678907Calcium binding.
HgeneCBLchr11:119158656chr11:118261372ENST00000264033+1216357_476678907Compositional biasNote=Asp/Glu-rich (acidic)
HgeneCBLchr11:119158656chr11:118261372ENST00000264033+121647_351678907DomainCbl-PTB
HgeneCBLchr11:119158656chr11:118261372ENST00000264033+1216176_248678907RegionNote=EF-hand-like
HgeneCBLchr11:119158656chr11:118261372ENST00000264033+1216249_351678907RegionNote=SH2-like
HgeneCBLchr11:119158656chr11:118261372ENST00000264033+1216352_380678907RegionNote=Linker
HgeneCBLchr11:119158656chr11:118261372ENST00000264033+121647_175678907RegionNote=4H
HgeneCBLchr11:119158656chr11:118261372ENST00000264033+1216381_420678907Zinc fingerRING-type
TgeneUBE4Achr11:119158656chr11:118261372ENST00000252108+1620987_10619221067DomainNote=U-box
TgeneUBE4Achr11:119158656chr11:118261372ENST00000431736+1620987_10619291074DomainNote=U-box

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCBLchr11:119158656chr11:118261372ENST00000264033+1216477_688678907Compositional biasNote=Pro-rich
HgeneCBLchr11:119158656chr11:118261372ENST00000264033+1216689_834678907Compositional biasNote=Asp/Glu-rich (acidic)
HgeneCBLchr11:119158656chr11:118261372ENST00000264033+1216856_895678907DomainUBA


Top

FusionGeneSequence for CBL_UBE4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CBL_ENST00000264033_chr11_119158656_+_UBE4A_ENST00000252108_chr11_118261372_+_823aa
MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPTILDLLPD
TYQHLRTILSRTEGKMETLGENETFRVFMENLMKKTKQTISLFKEGKERMTEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFR
ITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDTISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMA
FLTTDEVKARLQKFIHKPGSTIFRLSCTRLGQWAIGTVTADGNILQTIPHNKPLFQALIDGFREGFTLFPDGRNQNPDLTGLCEPTPQDH
IKVTQEQTELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGA
PSPNTDDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTASKAASGSLHKDKPLPVPPTLR
DLPPPPPPDRPTSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSLPSQMEP
RPDVPRLGSTFSLDTSMSMNSSPLVGPECDHPKIKPSSSANAITSLAARDEENFCATVPKDGRSTSPTLFAQTVRVLKKINKPGNMIMAF
SNLAERIKSLADLQQQEEETTADACDEFLDPIMSTLMCDPVVLPSSRVTVDRSTIARHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRW

>In-frame_CBL_ENST00000264033_chr11_119158656_+_UBE4A_ENST00000431736_chr11_118261372_+_823aa
MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPTILDLLPD
TYQHLRTILSRTEGKMETLGENETFRVFMENLMKKTKQTISLFKEGKERMTEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFR
ITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDTISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMA
FLTTDEVKARLQKFIHKPGSTIFRLSCTRLGQWAIGTVTADGNILQTIPHNKPLFQALIDGFREGFTLFPDGRNQNPDLTGLCEPTPQDH
IKVTQEQTELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGA
PSPNTDDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTASKAASGSLHKDKPLPVPPTLR
DLPPPPPPDRPTSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSLPSQMEP
RPDVPRLGSTFSLDTSMSMNSSPLVGPECDHPKIKPSSSANAITSLAARDEENFCATVPKDGRSTSPTLFAQTVRVLKKINKPGNMIMAF
SNLAERIKSLADLQQQEEETTADACDEFLDPIMSTLMCDPVVLPSSRVTVDRSTIARHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRW

>In-frame_CBL_ENST00000264033_chr11_119158656_+_UBE4A_ENST00000545354_chr11_118261372_+_823aa
MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPTILDLLPD
TYQHLRTILSRTEGKMETLGENETFRVFMENLMKKTKQTISLFKEGKERMTEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFR
ITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDTISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMA
FLTTDEVKARLQKFIHKPGSTIFRLSCTRLGQWAIGTVTADGNILQTIPHNKPLFQALIDGFREGFTLFPDGRNQNPDLTGLCEPTPQDH
IKVTQEQTELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGA
PSPNTDDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTASKAASGSLHKDKPLPVPPTLR
DLPPPPPPDRPTSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSLPSQMEP
RPDVPRLGSTFSLDTSMSMNSSPLVGPECDHPKIKPSSSANAITSLAARDEENFCATVPKDGRSTSPTLFAQTVRVLKKINKPGNMIMAF
SNLAERIKSLADLQQQEEETTADACDEFLDPIMSTLMCDPVVLPSSRVTVDRSTIARHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRW


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CBL_ENST00000264033_chr11_119158656_+_UBE4A_ENST00000252108_chr11_118261372_+_2469nt
ATGGCCGGCAACGTGAAGAAGAGCTCTGGGGCCGGGGGCGGCAGCGGCTCCGGGGGCTCGGGTTCGGGTGGCCTGATTGGGCTCATGAAG
GACGCCTTCCAGCCGCACCACCACCACCACCACCACCTCAGCCCCCACCCGCCGGGGACGGTGGACAAGAAGATGGTGGAGAAGTGCTGG
AAGCTCATGGACAAGGTGGTGCGGTTGTGTCAGAACCCAAAGCTGGCGCTAAAGAATAGCCCACCTTATATCTTAGACCTGCTACCAGAT
ACCTACCAGCATCTCCGTACTATCTTGTCAAGATATGAGGGGAAGATGGAGACACTTGGAGAAAATGAGTATTTTAGGGTGTTTATGGAG
AATTTGATGAAGAAAACTAAGCAAACCATAAGCCTCTTCAAGGAGGGAAAAGAAAGAATGTATGAGGAGAATTCTCAGCCTAGGCGAAAC
CTAACCAAACTGTCCCTCATCTTCAGCCACATGCTGGCAGAACTAAAAGGAATCTTTCCAAGTGGACTCTTTCAGGGAGACACATTTCGG
ATTACTAAAGCAGATGCTGCGGAATTTTGGAGAAAAGCTTTTGGGGAAAAGACAATAGTCCCTTGGAAGAGCTTTCGACAGGCTCTACAT
GAAGTGCATCCCATCAGTTCTGGGCTGGAGGCCATGGCTCTGAAATCCACTATTGATCTGACCTGCAATGATTATATTTCGGTTTTTGAA
TTTGACATCTTTACCCGACTCTTTCAGCCCTGGTCCTCTTTGCTCAGGAATTGGAACAGCCTTGCTGTAACTCATCCTGGCTACATGGCT
TTTTTGACGTATGACGAAGTGAAAGCTCGGCTCCAGAAATTCATTCACAAACCTGGCAGTTATATCTTCCGGCTGAGCTGTACTCGTCTG
GGTCAGTGGGCTATTGGGTATGTTACTGCTGATGGGAACATTCTCCAGACAATCCCTCACAATAAACCTCTCTTCCAAGCACTGATTGAT
GGCTTCAGGGAAGGCTTCTATTTGTTTCCTGATGGACGAAATCAGAATCCTGATCTGACTGGCTTATGTGAACCAACTCCCCAAGACCAT
ATCAAAGTGACCCAGGAACAATATGAATTATACTGTGAGATGGGCTCCACATTCCAACTATGTAAAATATGTGCTGAAAATGATAAGGAT
GTAAAGATTGAGCCCTGTGGACACCTCATGTGCACATCCTGTCTTACATCCTGGCAGGAATCAGAAGGTCAGGGCTGTCCTTTCTGCCGA
TGTGAAATTAAAGGTACTGAACCCATCGTGGTAGATCCGTTTGATCCTAGAGGGAGTGGCAGCCTGTTGAGGCAAGGAGCAGAGGGAGCT
CCCTCCCCAAATTATGATGATGATGATGATGAACGAGCTGATGATACTCTCTTCATGATGAAGGAATTGGCTGGTGCCAAGGTGGAACGG
CCGCCTTCTCCATTCTCCATGGCCCCACAAGCTTCCCTTCCCCCGGTGCCACCACGACTTGACCTTCTGCCGCAGCGAGTATGTGTTCCC
TCAAGTGCTTCTGCTCTTGGAACTGCTTCTAAGGCTGCTTCTGGCTCCCTTCATAAAGACAAACCATTGCCAGTACCTCCCACACTTCGA
GATCTTCCACCACCACCGCCTCCAGACCGGCCATATTCTGTTGGAGCAGAATCCCGACCTCAAAGACGCCCCTTGCCTTGTACACCAGGC
GACTGTCCCTCCAGAGACAAACTGCCCCCTGTCCCCTCTAGCCGCCTTGGAGACTCATGGCTGCCCCGGCCAATCCCCAAAGTACCAGTA
TCTGCCCCAAGTTCCAGTGATCCCTGGACAGGAAGAGAATTAACCAACCGGCACTCACTTCCATTTTCATTGCCCTCACAAATGGAGCCC
AGACCAGATGTGCCTAGGCTCGGAAGCACGTTCAGTCTGGATACCTCCATGAGTATGAATAGCAGCCCATTAGTAGGTCCAGAGTGTGAC
CACCCCAAAATCAAACCTTCCTCATCTGCCAATGCCATTTATTCTCTGGCTGCCAGGGATGAGGAGAATTTCTGTGCCACTGTGCCCAAG
GATGGACGTTCCTATTCCCCAACTCTCTTTGCACAGACAGTTCGAGTCTTGAAGAAAATAAATAAGCCTGGGAATATGATTATGGCTTTC
AGCAACTTGGCAGAGAGAATCAAGTCTCTTGCAGACCTCCAACAACAGGAAGAGGAAACCTATGCAGATGCCTGTGATGAGTTCCTGGAT
CCCATTATGAGCACACTGATGTGTGACCCTGTGGTGCTGCCATCTTCCAGAGTCACTGTGGATAGATCCACCATTGCAAGACATTTGCTC
AGTGACCAAACAGATCCCTTTAACCGTAGTCCCCTCACCATGGACCAGATCCGGCCAAACACAGAACTAAAAGAAAAAATCCAACGGTGG

>In-frame_CBL_ENST00000264033_chr11_119158656_+_UBE4A_ENST00000431736_chr11_118261372_+_2469nt
ATGGCCGGCAACGTGAAGAAGAGCTCTGGGGCCGGGGGCGGCAGCGGCTCCGGGGGCTCGGGTTCGGGTGGCCTGATTGGGCTCATGAAG
GACGCCTTCCAGCCGCACCACCACCACCACCACCACCTCAGCCCCCACCCGCCGGGGACGGTGGACAAGAAGATGGTGGAGAAGTGCTGG
AAGCTCATGGACAAGGTGGTGCGGTTGTGTCAGAACCCAAAGCTGGCGCTAAAGAATAGCCCACCTTATATCTTAGACCTGCTACCAGAT
ACCTACCAGCATCTCCGTACTATCTTGTCAAGATATGAGGGGAAGATGGAGACACTTGGAGAAAATGAGTATTTTAGGGTGTTTATGGAG
AATTTGATGAAGAAAACTAAGCAAACCATAAGCCTCTTCAAGGAGGGAAAAGAAAGAATGTATGAGGAGAATTCTCAGCCTAGGCGAAAC
CTAACCAAACTGTCCCTCATCTTCAGCCACATGCTGGCAGAACTAAAAGGAATCTTTCCAAGTGGACTCTTTCAGGGAGACACATTTCGG
ATTACTAAAGCAGATGCTGCGGAATTTTGGAGAAAAGCTTTTGGGGAAAAGACAATAGTCCCTTGGAAGAGCTTTCGACAGGCTCTACAT
GAAGTGCATCCCATCAGTTCTGGGCTGGAGGCCATGGCTCTGAAATCCACTATTGATCTGACCTGCAATGATTATATTTCGGTTTTTGAA
TTTGACATCTTTACCCGACTCTTTCAGCCCTGGTCCTCTTTGCTCAGGAATTGGAACAGCCTTGCTGTAACTCATCCTGGCTACATGGCT
TTTTTGACGTATGACGAAGTGAAAGCTCGGCTCCAGAAATTCATTCACAAACCTGGCAGTTATATCTTCCGGCTGAGCTGTACTCGTCTG
GGTCAGTGGGCTATTGGGTATGTTACTGCTGATGGGAACATTCTCCAGACAATCCCTCACAATAAACCTCTCTTCCAAGCACTGATTGAT
GGCTTCAGGGAAGGCTTCTATTTGTTTCCTGATGGACGAAATCAGAATCCTGATCTGACTGGCTTATGTGAACCAACTCCCCAAGACCAT
ATCAAAGTGACCCAGGAACAATATGAATTATACTGTGAGATGGGCTCCACATTCCAACTATGTAAAATATGTGCTGAAAATGATAAGGAT
GTAAAGATTGAGCCCTGTGGACACCTCATGTGCACATCCTGTCTTACATCCTGGCAGGAATCAGAAGGTCAGGGCTGTCCTTTCTGCCGA
TGTGAAATTAAAGGTACTGAACCCATCGTGGTAGATCCGTTTGATCCTAGAGGGAGTGGCAGCCTGTTGAGGCAAGGAGCAGAGGGAGCT
CCCTCCCCAAATTATGATGATGATGATGATGAACGAGCTGATGATACTCTCTTCATGATGAAGGAATTGGCTGGTGCCAAGGTGGAACGG
CCGCCTTCTCCATTCTCCATGGCCCCACAAGCTTCCCTTCCCCCGGTGCCACCACGACTTGACCTTCTGCCGCAGCGAGTATGTGTTCCC
TCAAGTGCTTCTGCTCTTGGAACTGCTTCTAAGGCTGCTTCTGGCTCCCTTCATAAAGACAAACCATTGCCAGTACCTCCCACACTTCGA
GATCTTCCACCACCACCGCCTCCAGACCGGCCATATTCTGTTGGAGCAGAATCCCGACCTCAAAGACGCCCCTTGCCTTGTACACCAGGC
GACTGTCCCTCCAGAGACAAACTGCCCCCTGTCCCCTCTAGCCGCCTTGGAGACTCATGGCTGCCCCGGCCAATCCCCAAAGTACCAGTA
TCTGCCCCAAGTTCCAGTGATCCCTGGACAGGAAGAGAATTAACCAACCGGCACTCACTTCCATTTTCATTGCCCTCACAAATGGAGCCC
AGACCAGATGTGCCTAGGCTCGGAAGCACGTTCAGTCTGGATACCTCCATGAGTATGAATAGCAGCCCATTAGTAGGTCCAGAGTGTGAC
CACCCCAAAATCAAACCTTCCTCATCTGCCAATGCCATTTATTCTCTGGCTGCCAGGGATGAGGAGAATTTCTGTGCCACTGTGCCCAAG
GATGGACGTTCCTATTCCCCAACTCTCTTTGCACAGACAGTTCGAGTCTTGAAGAAAATAAATAAGCCTGGGAATATGATTATGGCTTTC
AGCAACTTGGCAGAGAGAATCAAGTCTCTTGCAGACCTCCAACAACAGGAAGAGGAAACCTATGCAGATGCCTGTGATGAGTTCCTGGAT
CCCATTATGAGCACACTGATGTGTGACCCTGTGGTGCTGCCATCTTCCAGAGTCACTGTGGATAGATCCACCATTGCAAGACATTTGCTC
AGTGACCAAACAGATCCCTTTAACCGTAGTCCCCTCACCATGGACCAGATCCGGCCAAACACAGAACTAAAAGAAAAAATCCAACGGTGG

>In-frame_CBL_ENST00000264033_chr11_119158656_+_UBE4A_ENST00000545354_chr11_118261372_+_2469nt
ATGGCCGGCAACGTGAAGAAGAGCTCTGGGGCCGGGGGCGGCAGCGGCTCCGGGGGCTCGGGTTCGGGTGGCCTGATTGGGCTCATGAAG
GACGCCTTCCAGCCGCACCACCACCACCACCACCACCTCAGCCCCCACCCGCCGGGGACGGTGGACAAGAAGATGGTGGAGAAGTGCTGG
AAGCTCATGGACAAGGTGGTGCGGTTGTGTCAGAACCCAAAGCTGGCGCTAAAGAATAGCCCACCTTATATCTTAGACCTGCTACCAGAT
ACCTACCAGCATCTCCGTACTATCTTGTCAAGATATGAGGGGAAGATGGAGACACTTGGAGAAAATGAGTATTTTAGGGTGTTTATGGAG
AATTTGATGAAGAAAACTAAGCAAACCATAAGCCTCTTCAAGGAGGGAAAAGAAAGAATGTATGAGGAGAATTCTCAGCCTAGGCGAAAC
CTAACCAAACTGTCCCTCATCTTCAGCCACATGCTGGCAGAACTAAAAGGAATCTTTCCAAGTGGACTCTTTCAGGGAGACACATTTCGG
ATTACTAAAGCAGATGCTGCGGAATTTTGGAGAAAAGCTTTTGGGGAAAAGACAATAGTCCCTTGGAAGAGCTTTCGACAGGCTCTACAT
GAAGTGCATCCCATCAGTTCTGGGCTGGAGGCCATGGCTCTGAAATCCACTATTGATCTGACCTGCAATGATTATATTTCGGTTTTTGAA
TTTGACATCTTTACCCGACTCTTTCAGCCCTGGTCCTCTTTGCTCAGGAATTGGAACAGCCTTGCTGTAACTCATCCTGGCTACATGGCT
TTTTTGACGTATGACGAAGTGAAAGCTCGGCTCCAGAAATTCATTCACAAACCTGGCAGTTATATCTTCCGGCTGAGCTGTACTCGTCTG
GGTCAGTGGGCTATTGGGTATGTTACTGCTGATGGGAACATTCTCCAGACAATCCCTCACAATAAACCTCTCTTCCAAGCACTGATTGAT
GGCTTCAGGGAAGGCTTCTATTTGTTTCCTGATGGACGAAATCAGAATCCTGATCTGACTGGCTTATGTGAACCAACTCCCCAAGACCAT
ATCAAAGTGACCCAGGAACAATATGAATTATACTGTGAGATGGGCTCCACATTCCAACTATGTAAAATATGTGCTGAAAATGATAAGGAT
GTAAAGATTGAGCCCTGTGGACACCTCATGTGCACATCCTGTCTTACATCCTGGCAGGAATCAGAAGGTCAGGGCTGTCCTTTCTGCCGA
TGTGAAATTAAAGGTACTGAACCCATCGTGGTAGATCCGTTTGATCCTAGAGGGAGTGGCAGCCTGTTGAGGCAAGGAGCAGAGGGAGCT
CCCTCCCCAAATTATGATGATGATGATGATGAACGAGCTGATGATACTCTCTTCATGATGAAGGAATTGGCTGGTGCCAAGGTGGAACGG
CCGCCTTCTCCATTCTCCATGGCCCCACAAGCTTCCCTTCCCCCGGTGCCACCACGACTTGACCTTCTGCCGCAGCGAGTATGTGTTCCC
TCAAGTGCTTCTGCTCTTGGAACTGCTTCTAAGGCTGCTTCTGGCTCCCTTCATAAAGACAAACCATTGCCAGTACCTCCCACACTTCGA
GATCTTCCACCACCACCGCCTCCAGACCGGCCATATTCTGTTGGAGCAGAATCCCGACCTCAAAGACGCCCCTTGCCTTGTACACCAGGC
GACTGTCCCTCCAGAGACAAACTGCCCCCTGTCCCCTCTAGCCGCCTTGGAGACTCATGGCTGCCCCGGCCAATCCCCAAAGTACCAGTA
TCTGCCCCAAGTTCCAGTGATCCCTGGACAGGAAGAGAATTAACCAACCGGCACTCACTTCCATTTTCATTGCCCTCACAAATGGAGCCC
AGACCAGATGTGCCTAGGCTCGGAAGCACGTTCAGTCTGGATACCTCCATGAGTATGAATAGCAGCCCATTAGTAGGTCCAGAGTGTGAC
CACCCCAAAATCAAACCTTCCTCATCTGCCAATGCCATTTATTCTCTGGCTGCCAGGGATGAGGAGAATTTCTGTGCCACTGTGCCCAAG
GATGGACGTTCCTATTCCCCAACTCTCTTTGCACAGACAGTTCGAGTCTTGAAGAAAATAAATAAGCCTGGGAATATGATTATGGCTTTC
AGCAACTTGGCAGAGAGAATCAAGTCTCTTGCAGACCTCCAACAACAGGAAGAGGAAACCTATGCAGATGCCTGTGATGAGTTCCTGGAT
CCCATTATGAGCACACTGATGTGTGACCCTGTGGTGCTGCCATCTTCCAGAGTCACTGTGGATAGATCCACCATTGCAAGACATTTGCTC
AGTGACCAAACAGATCCCTTTAACCGTAGTCCCCTCACCATGGACCAGATCCGGCCAAACACAGAACTAAAAGAAAAAATCCAACGGTGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_CBL_ENST00000264033_chr11_119158656_+_UBE4A_ENST00000252108_chr11_118261372_+_5616nt
ACAGAAACCTGGCCGCGGCTTTCCGGGAGCTGTGGGCACGCGAGCTGCTCGAAGCCGGTGGCCCGGGGATCGTCGCTGCCCAGTCCGGCC
GCGGCCGGCCGCTTCCCCGAGCTTACCAGTAAGCCGGTCCGCCTCCGGGACGCGCCCCGCCCGCCCCGGGCTCGCGCGCTCTGAAGGGGC
GCGTCCCGCGCACTCCCGGCGCCGCCCACTCCCCTCCCCACGGCCGCTCCTCCCTCCGCCCGGATAGCCGGCGGCGGCGGCGGCGGCGGC
GGCGGCGGCGGCCGGGAGAGGCCCCTCCTTCACGCCCTGCTTCTCTCCCTCGCTCGCAGTCGAGCCGAGCCGGCGGACCCGCCTGGGCTC
CGACCCTGCCCAGGCCATGGCCGGCAACGTGAAGAAGAGCTCTGGGGCCGGGGGCGGCAGCGGCTCCGGGGGCTCGGGTTCGGGTGGCCT
GATTGGGCTCATGAAGGACGCCTTCCAGCCGCACCACCACCACCACCACCACCTCAGCCCCCACCCGCCGGGGACGGTGGACAAGAAGAT
GGTGGAGAAGTGCTGGAAGCTCATGGACAAGGTGGTGCGGTTGTGTCAGAACCCAAAGCTGGCGCTAAAGAATAGCCCACCTTATATCTT
AGACCTGCTACCAGATACCTACCAGCATCTCCGTACTATCTTGTCAAGATATGAGGGGAAGATGGAGACACTTGGAGAAAATGAGTATTT
TAGGGTGTTTATGGAGAATTTGATGAAGAAAACTAAGCAAACCATAAGCCTCTTCAAGGAGGGAAAAGAAAGAATGTATGAGGAGAATTC
TCAGCCTAGGCGAAACCTAACCAAACTGTCCCTCATCTTCAGCCACATGCTGGCAGAACTAAAAGGAATCTTTCCAAGTGGACTCTTTCA
GGGAGACACATTTCGGATTACTAAAGCAGATGCTGCGGAATTTTGGAGAAAAGCTTTTGGGGAAAAGACAATAGTCCCTTGGAAGAGCTT
TCGACAGGCTCTACATGAAGTGCATCCCATCAGTTCTGGGCTGGAGGCCATGGCTCTGAAATCCACTATTGATCTGACCTGCAATGATTA
TATTTCGGTTTTTGAATTTGACATCTTTACCCGACTCTTTCAGCCCTGGTCCTCTTTGCTCAGGAATTGGAACAGCCTTGCTGTAACTCA
TCCTGGCTACATGGCTTTTTTGACGTATGACGAAGTGAAAGCTCGGCTCCAGAAATTCATTCACAAACCTGGCAGTTATATCTTCCGGCT
GAGCTGTACTCGTCTGGGTCAGTGGGCTATTGGGTATGTTACTGCTGATGGGAACATTCTCCAGACAATCCCTCACAATAAACCTCTCTT
CCAAGCACTGATTGATGGCTTCAGGGAAGGCTTCTATTTGTTTCCTGATGGACGAAATCAGAATCCTGATCTGACTGGCTTATGTGAACC
AACTCCCCAAGACCATATCAAAGTGACCCAGGAACAATATGAATTATACTGTGAGATGGGCTCCACATTCCAACTATGTAAAATATGTGC
TGAAAATGATAAGGATGTAAAGATTGAGCCCTGTGGACACCTCATGTGCACATCCTGTCTTACATCCTGGCAGGAATCAGAAGGTCAGGG
CTGTCCTTTCTGCCGATGTGAAATTAAAGGTACTGAACCCATCGTGGTAGATCCGTTTGATCCTAGAGGGAGTGGCAGCCTGTTGAGGCA
AGGAGCAGAGGGAGCTCCCTCCCCAAATTATGATGATGATGATGATGAACGAGCTGATGATACTCTCTTCATGATGAAGGAATTGGCTGG
TGCCAAGGTGGAACGGCCGCCTTCTCCATTCTCCATGGCCCCACAAGCTTCCCTTCCCCCGGTGCCACCACGACTTGACCTTCTGCCGCA
GCGAGTATGTGTTCCCTCAAGTGCTTCTGCTCTTGGAACTGCTTCTAAGGCTGCTTCTGGCTCCCTTCATAAAGACAAACCATTGCCAGT
ACCTCCCACACTTCGAGATCTTCCACCACCACCGCCTCCAGACCGGCCATATTCTGTTGGAGCAGAATCCCGACCTCAAAGACGCCCCTT
GCCTTGTACACCAGGCGACTGTCCCTCCAGAGACAAACTGCCCCCTGTCCCCTCTAGCCGCCTTGGAGACTCATGGCTGCCCCGGCCAAT
CCCCAAAGTACCAGTATCTGCCCCAAGTTCCAGTGATCCCTGGACAGGAAGAGAATTAACCAACCGGCACTCACTTCCATTTTCATTGCC
CTCACAAATGGAGCCCAGACCAGATGTGCCTAGGCTCGGAAGCACGTTCAGTCTGGATACCTCCATGAGTATGAATAGCAGCCCATTAGT
AGGTCCAGAGTGTGACCACCCCAAAATCAAACCTTCCTCATCTGCCAATGCCATTTATTCTCTGGCTGCCAGGGATGAGGAGAATTTCTG
TGCCACTGTGCCCAAGGATGGACGTTCCTATTCCCCAACTCTCTTTGCACAGACAGTTCGAGTCTTGAAGAAAATAAATAAGCCTGGGAA
TATGATTATGGCTTTCAGCAACTTGGCAGAGAGAATCAAGTCTCTTGCAGACCTCCAACAACAGGAAGAGGAAACCTATGCAGATGCCTG
TGATGAGTTCCTGGATCCCATTATGAGCACACTGATGTGTGACCCTGTGGTGCTGCCATCTTCCAGAGTCACTGTGGATAGATCCACCAT
TGCAAGACATTTGCTCAGTGACCAAACAGATCCCTTTAACCGTAGTCCCCTCACCATGGACCAGATCCGGCCAAACACAGAACTAAAAGA
AAAAATCCAACGGTGGCTTGCAGAGAGGAAACAACAAAAGGAGCAACTTGAATAGATACTGTGAACTAACCAAACCAAAACCAACCCCAG
AGTGCAGATAAACAATTGTTTGTGGTTTCTCTCTTTCTGGTTCTGTTCCTTTTCTTTCTTCTTTTCTTTTTCTTTTTTTTTTTTTTTTTT
ACTAAATTAGAGAACTGCTCTTGCTGAAATTATGATAGTTAAGATTCCTAAGAACTTGACAATGCTCCCCTGGCTTGCAGGAAATTATAC
TTATTATAGCATCACCAAGTTTAGAAATCATCACTAATTTTCACCCTCTGTTGTCTCTTCATATTCTTCTTCCTTTTCCTAAATGAAATT
ATATTATTTCAACTACTAAAACTTCCCGCCACCCTGCTATTTCTCTTCCAATTACTGTTCAAACATTTTTGGTGAGTGCTGCTTTTATAA
ATATGTGATGTCACATATTTCAGTGACAGCTGATGTTATCAGAAAAATCCTGTTATCCTGTGTATTTACTAGTCCTCATGATCTAGACTT
AACCCCTTTTCTGTGTTACAGAGTAACTTCACATAAAAGCAGATACCTTTAAGTTTGTGTAGACTTCTGAATAAGATGATAGACGAGAAT
TTTTTTTAAAAAAGGAATTTAAAGGAATCTTGTGCAACTTCTGTTGATAGCTCTTAATTTTGTTATACAGTCTTTTTAATGAGGATTGGT
AGGGCAATCCTACCAATTGATGGGGGTGAGGAGACTGTTGGGCCCTTATTCTCTTATGAAAATCTGTTTCTACAAGGACTAGGCCTAAGT
AGATTTAGGCAACGGGTATCATATCCATGAAAAATGTCATTTTAAGACACTAATATCAACAGTATATCTCAGTGTGTGAGATATATAAAT
ACACATACACCCCATGTGCTTTTTTGTTGGTTTAGTGTAAACTGAGTACCACTTTATATTTTCTCTTCCATAGTGAGATGTATGCAGTAT
GTGGCCATGTTTACTAACATACTCATTCTTCACAAAATTCTGAGATTATAAAATGTATATAGTTAATATTTGTTTGAGCTTGTGACCTGA
CTTCTAAGAGCTACTTCTAACACAGCCTTAGGTCTTCAATTAACAAAGTAGGAAGTTGAGCACAACCTTGTCCACAGCCATTTTAAATAT
CCACTTAGCCCTGTGTAGTTGGTAGGTGGACACCACTTTCATAAGTGAACTTGAGCTCACTACTCAATTGTGCAGCTTAATATGCTGACT
AGGGACATTCCCCTATGGATTATCTTTATATCACTGTCTTTCTAAGCCCAGAGATGTCATAAGTGACAAGAAAAGTGATAGGATCAAGAA
ATGGGTGTCACTGCTTCATTTGGAACATGTTATTAACTATGGTCTCTTTCAAATAAATAGTAGTTTTATATTTCAACACAAGTTGCTATA
AGCAGTCCTTGATGGGTTTTTGATTGCATCAGCTGGAAAGCCTCAAATCTAAGAGGGCTTCCCATCCTAGATATAAAATAGGTGTTGCCT
ATTGCTGTGCTTATAAAATGAAAAAGGAAATTGAGGACACTTTTGCAAATGCCAGAATGTAAGATTCATTCAGTGTGCTCCCTGGGCCTT
TATGGCATGGGTTGACAGGATTTGTTTATTTTCTAAAATTAGCTTCATTCAATATTTATCATCCTCCTTTCCCTCTCTGAGAATGAACTA
TGTATAAAATAAGCTTCTGCCTATTTGCATTTATCTTCCAAACCCAATCTAGTAGGATGTTCTCATTTTAAAAACGAGGGGAAAAGACCA
GAGTTTTTCAGGAGAAAACTGGAGGAAAATGGGCACAAAAACTCAGAAGGCAGCTATTCCCAGCAGCTTCCTAGTTAACAACCCCCATGC
TGCCTCCAGTCTTTGTCTGTATTCTTCTGTATTTAACCTTCAGATTGTAAGCCTTTTCTGGCAAGCTTTTCTTCTTTTTTTAAACTCTTT
TCCTGAAACTTTTTATGAATGGCTATGGCACCATTAATGCTGCTGAATATCTTTAAACTCTGCACAAGCAAGTGTGTAGCTTAAGGCCAC
TACTGGTAAGGAAACCAAGTGTCCTCTGTGCCTTTTTTCTTTCTGTGAAGTAATTTAAGAATATCCAAAAAAATTAGACTTTAAAAAGTT
ATCTTGGTACAACACCGTGTGTATATACACTTGGAAGCTTAAAAAGGTGTTTTGTCTGGAACTTAGAAGCAGCTCTAAATCTAGTAGAGC
AGACTTTCTAACATACCTAGTTTTGTGTATTGGCTTTGCTGGAGTATGATAGCAAAATGAAGACTCTTTTACTCAGCTCTGGTATTGCTC
ATAACTTACCAAGAGGCTAATACTAAACTTGGAAAATTGTTTAAGTATGTTTTATCAAGCAGTCTGGGTTTTGTTTTTTAATATACTTTT
TAATGGATATGTGAAAACTGAAGGAAATGTTAAAGGTTTTTTAATGGTGCAAGTGAAGGTGCCAGTTGCTATTTGATATCACACTCTACA
AAAGCTTCATTACTTTATTTGATGGTGGTTGCTAAGCAGCCATTGCACAGAGCATAAGTCTACTGGGTGCCTTTACATGCCAGAGGCTGA
TGCTGCACTGTTGATGTCATGTGAGGAAATAATGCACATGCTCTAACTGCTCAACAGGAAATGAACCTAGAAACAGAAAATGAAAAGGTT
GATTGAAATAAAACTTGATCAACGCGACTGTATTTTGAAACATTCCAGGAAGGTTACTTCTTGTCAAACTTGCCTGGCAGTGTTTGTTCA

>In-frame_CBL_ENST00000264033_chr11_119158656_+_UBE4A_ENST00000431736_chr11_118261372_+_5612nt
ACAGAAACCTGGCCGCGGCTTTCCGGGAGCTGTGGGCACGCGAGCTGCTCGAAGCCGGTGGCCCGGGGATCGTCGCTGCCCAGTCCGGCC
GCGGCCGGCCGCTTCCCCGAGCTTACCAGTAAGCCGGTCCGCCTCCGGGACGCGCCCCGCCCGCCCCGGGCTCGCGCGCTCTGAAGGGGC
GCGTCCCGCGCACTCCCGGCGCCGCCCACTCCCCTCCCCACGGCCGCTCCTCCCTCCGCCCGGATAGCCGGCGGCGGCGGCGGCGGCGGC
GGCGGCGGCGGCCGGGAGAGGCCCCTCCTTCACGCCCTGCTTCTCTCCCTCGCTCGCAGTCGAGCCGAGCCGGCGGACCCGCCTGGGCTC
CGACCCTGCCCAGGCCATGGCCGGCAACGTGAAGAAGAGCTCTGGGGCCGGGGGCGGCAGCGGCTCCGGGGGCTCGGGTTCGGGTGGCCT
GATTGGGCTCATGAAGGACGCCTTCCAGCCGCACCACCACCACCACCACCACCTCAGCCCCCACCCGCCGGGGACGGTGGACAAGAAGAT
GGTGGAGAAGTGCTGGAAGCTCATGGACAAGGTGGTGCGGTTGTGTCAGAACCCAAAGCTGGCGCTAAAGAATAGCCCACCTTATATCTT
AGACCTGCTACCAGATACCTACCAGCATCTCCGTACTATCTTGTCAAGATATGAGGGGAAGATGGAGACACTTGGAGAAAATGAGTATTT
TAGGGTGTTTATGGAGAATTTGATGAAGAAAACTAAGCAAACCATAAGCCTCTTCAAGGAGGGAAAAGAAAGAATGTATGAGGAGAATTC
TCAGCCTAGGCGAAACCTAACCAAACTGTCCCTCATCTTCAGCCACATGCTGGCAGAACTAAAAGGAATCTTTCCAAGTGGACTCTTTCA
GGGAGACACATTTCGGATTACTAAAGCAGATGCTGCGGAATTTTGGAGAAAAGCTTTTGGGGAAAAGACAATAGTCCCTTGGAAGAGCTT
TCGACAGGCTCTACATGAAGTGCATCCCATCAGTTCTGGGCTGGAGGCCATGGCTCTGAAATCCACTATTGATCTGACCTGCAATGATTA
TATTTCGGTTTTTGAATTTGACATCTTTACCCGACTCTTTCAGCCCTGGTCCTCTTTGCTCAGGAATTGGAACAGCCTTGCTGTAACTCA
TCCTGGCTACATGGCTTTTTTGACGTATGACGAAGTGAAAGCTCGGCTCCAGAAATTCATTCACAAACCTGGCAGTTATATCTTCCGGCT
GAGCTGTACTCGTCTGGGTCAGTGGGCTATTGGGTATGTTACTGCTGATGGGAACATTCTCCAGACAATCCCTCACAATAAACCTCTCTT
CCAAGCACTGATTGATGGCTTCAGGGAAGGCTTCTATTTGTTTCCTGATGGACGAAATCAGAATCCTGATCTGACTGGCTTATGTGAACC
AACTCCCCAAGACCATATCAAAGTGACCCAGGAACAATATGAATTATACTGTGAGATGGGCTCCACATTCCAACTATGTAAAATATGTGC
TGAAAATGATAAGGATGTAAAGATTGAGCCCTGTGGACACCTCATGTGCACATCCTGTCTTACATCCTGGCAGGAATCAGAAGGTCAGGG
CTGTCCTTTCTGCCGATGTGAAATTAAAGGTACTGAACCCATCGTGGTAGATCCGTTTGATCCTAGAGGGAGTGGCAGCCTGTTGAGGCA
AGGAGCAGAGGGAGCTCCCTCCCCAAATTATGATGATGATGATGATGAACGAGCTGATGATACTCTCTTCATGATGAAGGAATTGGCTGG
TGCCAAGGTGGAACGGCCGCCTTCTCCATTCTCCATGGCCCCACAAGCTTCCCTTCCCCCGGTGCCACCACGACTTGACCTTCTGCCGCA
GCGAGTATGTGTTCCCTCAAGTGCTTCTGCTCTTGGAACTGCTTCTAAGGCTGCTTCTGGCTCCCTTCATAAAGACAAACCATTGCCAGT
ACCTCCCACACTTCGAGATCTTCCACCACCACCGCCTCCAGACCGGCCATATTCTGTTGGAGCAGAATCCCGACCTCAAAGACGCCCCTT
GCCTTGTACACCAGGCGACTGTCCCTCCAGAGACAAACTGCCCCCTGTCCCCTCTAGCCGCCTTGGAGACTCATGGCTGCCCCGGCCAAT
CCCCAAAGTACCAGTATCTGCCCCAAGTTCCAGTGATCCCTGGACAGGAAGAGAATTAACCAACCGGCACTCACTTCCATTTTCATTGCC
CTCACAAATGGAGCCCAGACCAGATGTGCCTAGGCTCGGAAGCACGTTCAGTCTGGATACCTCCATGAGTATGAATAGCAGCCCATTAGT
AGGTCCAGAGTGTGACCACCCCAAAATCAAACCTTCCTCATCTGCCAATGCCATTTATTCTCTGGCTGCCAGGGATGAGGAGAATTTCTG
TGCCACTGTGCCCAAGGATGGACGTTCCTATTCCCCAACTCTCTTTGCACAGACAGTTCGAGTCTTGAAGAAAATAAATAAGCCTGGGAA
TATGATTATGGCTTTCAGCAACTTGGCAGAGAGAATCAAGTCTCTTGCAGACCTCCAACAACAGGAAGAGGAAACCTATGCAGATGCCTG
TGATGAGTTCCTGGATCCCATTATGAGCACACTGATGTGTGACCCTGTGGTGCTGCCATCTTCCAGAGTCACTGTGGATAGATCCACCAT
TGCAAGACATTTGCTCAGTGACCAAACAGATCCCTTTAACCGTAGTCCCCTCACCATGGACCAGATCCGGCCAAACACAGAACTAAAAGA
AAAAATCCAACGGTGGCTTGCAGAGAGGAAACAACAAAAGGAGCAACTTGAATAGATACTGTGAACTAACCAAACCAAAACCAACCCCAG
AGTGCAGATAAACAATTGTTTGTGGTTTCTCTCTTTCTGGTTCTGTTCCTTTTCTTTCTTCTTTTCTTTTTCTTTTTTTTTTTTTTTTTT
ACTAAATTAGAGAACTGCTCTTGCTGAAATTATGATAGTTAAGATTCCTAAGAACTTGACAATGCTCCCCTGGCTTGCAGGAAATTATAC
TTATTATAGCATCACCAAGTTTAGAAATCATCACTAATTTTCACCCTCTGTTGTCTCTTCATATTCTTCTTCCTTTTCCTAAATGAAATT
ATATTATTTCAACTACTAAAACTTCCCGCCACCCTGCTATTTCTCTTCCAATTACTGTTCAAACATTTTTGGTGAGTGCTGCTTTTATAA
ATATGTGATGTCACATATTTCAGTGACAGCTGATGTTATCAGAAAAATCCTGTTATCCTGTGTATTTACTAGTCCTCATGATCTAGACTT
AACCCCTTTTCTGTGTTACAGAGTAACTTCACATAAAAGCAGATACCTTTAAGTTTGTGTAGACTTCTGAATAAGATGATAGACGAGAAT
TTTTTTTAAAAAAGGAATTTAAAGGAATCTTGTGCAACTTCTGTTGATAGCTCTTAATTTTGTTATACAGTCTTTTTAATGAGGATTGGT
AGGGCAATCCTACCAATTGATGGGGGTGAGGAGACTGTTGGGCCCTTATTCTCTTATGAAAATCTGTTTCTACAAGGACTAGGCCTAAGT
AGATTTAGGCAACGGGTATCATATCCATGAAAAATGTCATTTTAAGACACTAATATCAACAGTATATCTCAGTGTGTGAGATATATAAAT
ACACATACACCCCATGTGCTTTTTTGTTGGTTTAGTGTAAACTGAGTACCACTTTATATTTTCTCTTCCATAGTGAGATGTATGCAGTAT
GTGGCCATGTTTACTAACATACTCATTCTTCACAAAATTCTGAGATTATAAAATGTATATAGTTAATATTTGTTTGAGCTTGTGACCTGA
CTTCTAAGAGCTACTTCTAACACAGCCTTAGGTCTTCAATTAACAAAGTAGGAAGTTGAGCACAACCTTGTCCACAGCCATTTTAAATAT
CCACTTAGCCCTGTGTAGTTGGTAGGTGGACACCACTTTCATAAGTGAACTTGAGCTCACTACTCAATTGTGCAGCTTAATATGCTGACT
AGGGACATTCCCCTATGGATTATCTTTATATCACTGTCTTTCTAAGCCCAGAGATGTCATAAGTGACAAGAAAAGTGATAGGATCAAGAA
ATGGGTGTCACTGCTTCATTTGGAACATGTTATTAACTATGGTCTCTTTCAAATAAATAGTAGTTTTATATTTCAACACAAGTTGCTATA
AGCAGTCCTTGATGGGTTTTTGATTGCATCAGCTGGAAAGCCTCAAATCTAAGAGGGCTTCCCATCCTAGATATAAAATAGGTGTTGCCT
ATTGCTGTGCTTATAAAATGAAAAAGGAAATTGAGGACACTTTTGCAAATGCCAGAATGTAAGATTCATTCAGTGTGCTCCCTGGGCCTT
TATGGCATGGGTTGACAGGATTTGTTTATTTTCTAAAATTAGCTTCATTCAATATTTATCATCCTCCTTTCCCTCTCTGAGAATGAACTA
TGTATAAAATAAGCTTCTGCCTATTTGCATTTATCTTCCAAACCCAATCTAGTAGGATGTTCTCATTTTAAAAACGAGGGGAAAAGACCA
GAGTTTTTCAGGAGAAAACTGGAGGAAAATGGGCACAAAAACTCAGAAGGCAGCTATTCCCAGCAGCTTCCTAGTTAACAACCCCCATGC
TGCCTCCAGTCTTTGTCTGTATTCTTCTGTATTTAACCTTCAGATTGTAAGCCTTTTCTGGCAAGCTTTTCTTCTTTTTTTAAACTCTTT
TCCTGAAACTTTTTATGAATGGCTATGGCACCATTAATGCTGCTGAATATCTTTAAACTCTGCACAAGCAAGTGTGTAGCTTAAGGCCAC
TACTGGTAAGGAAACCAAGTGTCCTCTGTGCCTTTTTTCTTTCTGTGAAGTAATTTAAGAATATCCAAAAAAATTAGACTTTAAAAAGTT
ATCTTGGTACAACACCGTGTGTATATACACTTGGAAGCTTAAAAAGGTGTTTTGTCTGGAACTTAGAAGCAGCTCTAAATCTAGTAGAGC
AGACTTTCTAACATACCTAGTTTTGTGTATTGGCTTTGCTGGAGTATGATAGCAAAATGAAGACTCTTTTACTCAGCTCTGGTATTGCTC
ATAACTTACCAAGAGGCTAATACTAAACTTGGAAAATTGTTTAAGTATGTTTTATCAAGCAGTCTGGGTTTTGTTTTTTAATATACTTTT
TAATGGATATGTGAAAACTGAAGGAAATGTTAAAGGTTTTTTAATGGTGCAAGTGAAGGTGCCAGTTGCTATTTGATATCACACTCTACA
AAAGCTTCATTACTTTATTTGATGGTGGTTGCTAAGCAGCCATTGCACAGAGCATAAGTCTACTGGGTGCCTTTACATGCCAGAGGCTGA
TGCTGCACTGTTGATGTCATGTGAGGAAATAATGCACATGCTCTAACTGCTCAACAGGAAATGAACCTAGAAACAGAAAATGAAAAGGTT
GATTGAAATAAAACTTGATCAACGCGACTGTATTTTGAAACATTCCAGGAAGGTTACTTCTTGTCAAACTTGCCTGGCAGTGTTTGTTCA

>In-frame_CBL_ENST00000264033_chr11_119158656_+_UBE4A_ENST00000545354_chr11_118261372_+_2912nt
ACAGAAACCTGGCCGCGGCTTTCCGGGAGCTGTGGGCACGCGAGCTGCTCGAAGCCGGTGGCCCGGGGATCGTCGCTGCCCAGTCCGGCC
GCGGCCGGCCGCTTCCCCGAGCTTACCAGTAAGCCGGTCCGCCTCCGGGACGCGCCCCGCCCGCCCCGGGCTCGCGCGCTCTGAAGGGGC
GCGTCCCGCGCACTCCCGGCGCCGCCCACTCCCCTCCCCACGGCCGCTCCTCCCTCCGCCCGGATAGCCGGCGGCGGCGGCGGCGGCGGC
GGCGGCGGCGGCCGGGAGAGGCCCCTCCTTCACGCCCTGCTTCTCTCCCTCGCTCGCAGTCGAGCCGAGCCGGCGGACCCGCCTGGGCTC
CGACCCTGCCCAGGCCATGGCCGGCAACGTGAAGAAGAGCTCTGGGGCCGGGGGCGGCAGCGGCTCCGGGGGCTCGGGTTCGGGTGGCCT
GATTGGGCTCATGAAGGACGCCTTCCAGCCGCACCACCACCACCACCACCACCTCAGCCCCCACCCGCCGGGGACGGTGGACAAGAAGAT
GGTGGAGAAGTGCTGGAAGCTCATGGACAAGGTGGTGCGGTTGTGTCAGAACCCAAAGCTGGCGCTAAAGAATAGCCCACCTTATATCTT
AGACCTGCTACCAGATACCTACCAGCATCTCCGTACTATCTTGTCAAGATATGAGGGGAAGATGGAGACACTTGGAGAAAATGAGTATTT
TAGGGTGTTTATGGAGAATTTGATGAAGAAAACTAAGCAAACCATAAGCCTCTTCAAGGAGGGAAAAGAAAGAATGTATGAGGAGAATTC
TCAGCCTAGGCGAAACCTAACCAAACTGTCCCTCATCTTCAGCCACATGCTGGCAGAACTAAAAGGAATCTTTCCAAGTGGACTCTTTCA
GGGAGACACATTTCGGATTACTAAAGCAGATGCTGCGGAATTTTGGAGAAAAGCTTTTGGGGAAAAGACAATAGTCCCTTGGAAGAGCTT
TCGACAGGCTCTACATGAAGTGCATCCCATCAGTTCTGGGCTGGAGGCCATGGCTCTGAAATCCACTATTGATCTGACCTGCAATGATTA
TATTTCGGTTTTTGAATTTGACATCTTTACCCGACTCTTTCAGCCCTGGTCCTCTTTGCTCAGGAATTGGAACAGCCTTGCTGTAACTCA
TCCTGGCTACATGGCTTTTTTGACGTATGACGAAGTGAAAGCTCGGCTCCAGAAATTCATTCACAAACCTGGCAGTTATATCTTCCGGCT
GAGCTGTACTCGTCTGGGTCAGTGGGCTATTGGGTATGTTACTGCTGATGGGAACATTCTCCAGACAATCCCTCACAATAAACCTCTCTT
CCAAGCACTGATTGATGGCTTCAGGGAAGGCTTCTATTTGTTTCCTGATGGACGAAATCAGAATCCTGATCTGACTGGCTTATGTGAACC
AACTCCCCAAGACCATATCAAAGTGACCCAGGAACAATATGAATTATACTGTGAGATGGGCTCCACATTCCAACTATGTAAAATATGTGC
TGAAAATGATAAGGATGTAAAGATTGAGCCCTGTGGACACCTCATGTGCACATCCTGTCTTACATCCTGGCAGGAATCAGAAGGTCAGGG
CTGTCCTTTCTGCCGATGTGAAATTAAAGGTACTGAACCCATCGTGGTAGATCCGTTTGATCCTAGAGGGAGTGGCAGCCTGTTGAGGCA
AGGAGCAGAGGGAGCTCCCTCCCCAAATTATGATGATGATGATGATGAACGAGCTGATGATACTCTCTTCATGATGAAGGAATTGGCTGG
TGCCAAGGTGGAACGGCCGCCTTCTCCATTCTCCATGGCCCCACAAGCTTCCCTTCCCCCGGTGCCACCACGACTTGACCTTCTGCCGCA
GCGAGTATGTGTTCCCTCAAGTGCTTCTGCTCTTGGAACTGCTTCTAAGGCTGCTTCTGGCTCCCTTCATAAAGACAAACCATTGCCAGT
ACCTCCCACACTTCGAGATCTTCCACCACCACCGCCTCCAGACCGGCCATATTCTGTTGGAGCAGAATCCCGACCTCAAAGACGCCCCTT
GCCTTGTACACCAGGCGACTGTCCCTCCAGAGACAAACTGCCCCCTGTCCCCTCTAGCCGCCTTGGAGACTCATGGCTGCCCCGGCCAAT
CCCCAAAGTACCAGTATCTGCCCCAAGTTCCAGTGATCCCTGGACAGGAAGAGAATTAACCAACCGGCACTCACTTCCATTTTCATTGCC
CTCACAAATGGAGCCCAGACCAGATGTGCCTAGGCTCGGAAGCACGTTCAGTCTGGATACCTCCATGAGTATGAATAGCAGCCCATTAGT
AGGTCCAGAGTGTGACCACCCCAAAATCAAACCTTCCTCATCTGCCAATGCCATTTATTCTCTGGCTGCCAGGGATGAGGAGAATTTCTG
TGCCACTGTGCCCAAGGATGGACGTTCCTATTCCCCAACTCTCTTTGCACAGACAGTTCGAGTCTTGAAGAAAATAAATAAGCCTGGGAA
TATGATTATGGCTTTCAGCAACTTGGCAGAGAGAATCAAGTCTCTTGCAGACCTCCAACAACAGGAAGAGGAAACCTATGCAGATGCCTG
TGATGAGTTCCTGGATCCCATTATGAGCACACTGATGTGTGACCCTGTGGTGCTGCCATCTTCCAGAGTCACTGTGGATAGATCCACCAT
TGCAAGACATTTGCTCAGTGACCAAACAGATCCCTTTAACCGTAGTCCCCTCACCATGGACCAGATCCGGCCAAACACAGAACTAAAAGA
AAAAATCCAACGGTGGCTTGCAGAGAGGAAACAACAAAAGGAGCAACTTGAATAGATACTGTGAACTAACCAAACCAAAACCAACCCCAG


Top

FusionGenePPI for CBL_UBE4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CBLKRT18, MYO1C, ZAP70, PDGFRA, CRKL, GRB2, ARHGEF7, HCK, PTK2B, SORBS2, SORBS1, CD2AP, SH2B2, SH3KBP1, PIK3R2, YWHAQ, SLA, SH3BP2, EGFR, PTPN6, LCK, SPRY2, CSF1R, SH3GL3, MET, SYK, FRS2, UBE2L3, BTK, LYN, FYN, TYK2, YWHAB, YWHAZ, VAV1, LCP2, UBE2D2, FGR, ABL1, SLA2, INPPL1, SHC1, NCK1, PLCG1, SH3GL2, FLOT1, PIK3R1, CRK, CSK, ITK, CD5, LTK, IGF1R, PTPN11, UBE2D1, SPRY4, UBC, CBL, CSF1, GAPVD1, KDR, ITSN1, MST1R, UBE2M, AXL, ITGA5, KIT, LRIG1, UBASH3A, UBASH3B, GAPDH, EEF1A1, CDC42, SRC, NOTCH1, CD247, STAP2, TNFRSF10A, TNFRSF10B, FCGR2A, MYH9, ACTA1, ACTB, ACTG2, VIM, HSPA4, HSPA5, EPHA8, UBE4B, EPHB1, IL7R, CD33, NTRK1, CFTR, PSMC5, ITCH, TEK, BAG1, PTK2, PXN, VAV2, IRF8, RET, IRS1, ITSN2, HRAS, DBNL, ASAP1, TNFRSF1A, MAPK14, MAPK8, BLNK, INPP5D, TUBB, TUBA1A, SOS1, NOTCH3, SMAD3, CALM1, YES1, SFN, YWHAH, YWHAE, EPHA2, RAPGEF1, ABI1, GIF, TCN1, TCN2, MYH2, HTR2A, FYB, FGFR2, GBA, SORBS3, ITGAV, BCAR1, CD38, BCR, OSTF1, GRAP2, PIK3CA, CD40, BLK, SYNM, CUBN, SPRY1, LAT, SNX18, KRT10, KRT1, KRT2, HSPA8, PIK3CB, SPTBN1, KRT6C, KRT6B, KRT9, KRT14, KRT5, ACACA, KRT16, TUBB4B, KRT6A, TUBA1C, HSPA9, HSPA1L, MYH10, IQGAP1, KRT17, HSPA1B, SPTA1, SPTAN1, HSPA6, CCT8, KRT79, RPS19, CBLB, KRT84, CORO1C, TRIM21, KRT3, TUBA4B, CAD, ACTN1, POP1, PRKCA, PRKCQ, MAP3K11, EPOR, UBE2D3, TRPV1, USP21, PTPN22, ITGA4, STAT5A, PTEN, TNS4, CTNNB1, WAS, TRAF4, TRIM8, IRF1, FLT3, LOX, NCK2, ERBB2, CAPZA1, PRPSAP2, ERBB4, SIRT2, FRS3, FLT1, TGFBR2, SSFA2, SMAD7, PIK3R3, APPL1, EPS8, STAT3, MZF1, SERPINA5, CEP170, CEP128, FBF1, NPHP1, XPO1, PSMC1, XRCC5, ERBB2IP, SP7, ARHGEF6, TGM2, TSG101, IRF3, CDH1, RAB39B, TRIM25, TRAF2UBE4APTP4A3, UBE2D1, UBE2D2, UBE2D3, UBE2D4, CASP6, GZMB, PTTG1, MAVS, ELAVL1, CBX7, SLA, EPHA2, VIMP, UBXN4, PARP16, IL9R, B4GALT3, VAPB, NTRK1, FOXB1, FOXI2, FOXL1, FOXL2, FOXQ1, FAM3C, VSIG1, FGFR2, GYPB, SIGLECL1, CD70, SV2C, LRRTM1, PRDM1, MTA1, PCBP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCBLchr11:119158656chr11:118261372ENST00000264033+1216648_906678907CD2AP


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CBL_UBE4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CBL_UBE4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCBLC0349639Juvenile Myelomonocytic Leukemia3CTD_human;HPO;ORPHANET
HgeneCBLC0008073Developmental Disabilities1CTD_human
HgeneCBLC0010417Cryptorchidism1CTD_human;HPO
HgeneCBLC0018273Growth Disorders1CTD_human
HgeneCBLC0042384Vasculitis1CTD_human
HgeneCBLC3150803NOONAN SYNDROME-LIKE DISORDER WITH OR WITHOUT JUVENILE MYELOMONOCYTIC LEUKEMIA1CTD_human;ORPHANET;UNIPROT