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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 5692

FusionGeneSummary for CBL_PHLDB1

check button Fusion gene summary
Fusion gene informationFusion gene name: CBL_PHLDB1
Fusion gene ID: 5692
HgeneTgene
Gene symbol

CBL

PHLDB1

Gene ID

867

23187

Gene nameCbl proto-oncogenepleckstrin homology like domain family B member 1
SynonymsC-CBL|CBL2|FRA11B|NSLL|RNF55LL5A
Cytomap

11q23.3

11q23.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase CBLCas-Br-M (murine) ecotropic retroviral transforming sequenceCbl proto-oncogene, E3 ubiquitin protein ligaseRING finger protein 55RING-type E3 ubiquitin transferase CBLcasitas B-lineage lymphoma proto-oncogenefragile sipleckstrin homology-like domain family B member 1LL5alphapleckstrin homology-like domain family B member 1 variant 3pleckstrin homology-like domain family B member 1 variant 4protein LL5-alpha
Modification date2018052320180520
UniProtAcc

P22681

Q86UU1

Ensembl transtripts involved in fusion geneENST00000264033, ENST00000361417, 
ENST00000356063, ENST00000534672, 
ENST00000527898, ENST00000524713, 
Fusion gene scores* DoF score10 X 7 X 7=4904 X 5 X 3=60
# samples 116
** MAII scorelog2(11/490*10)=-2.15527822547791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/60*10)=0
Context

PubMed: CBL [Title/Abstract] AND PHLDB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-GM-A2DD-01ACBLchr11

119156276

+PHLDB1chr11

118514518

+
TCGARVESCATCGA-L5-A4OQ-01ACBLchr11

119077322

+PHLDB1chr11

118484531

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000264033ENST00000361417CBLchr11

119156276

+PHLDB1chr11

118514518

+
In-frameENST00000264033ENST00000356063CBLchr11

119156276

+PHLDB1chr11

118514518

+
5CDS-3UTRENST00000264033ENST00000534672CBLchr11

119156276

+PHLDB1chr11

118514518

+
5CDS-5UTRENST00000264033ENST00000527898CBLchr11

119156276

+PHLDB1chr11

118514518

+
5CDS-5UTRENST00000264033ENST00000524713CBLchr11

119156276

+PHLDB1chr11

118514518

+
5CDS-5UTRENST00000264033ENST00000361417CBLchr11

119077322

+PHLDB1chr11

118484531

+
5CDS-5UTRENST00000264033ENST00000356063CBLchr11

119077322

+PHLDB1chr11

118484531

+
5CDS-intronENST00000264033ENST00000534672CBLchr11

119077322

+PHLDB1chr11

118484531

+
5CDS-intronENST00000264033ENST00000527898CBLchr11

119077322

+PHLDB1chr11

118484531

+
5CDS-intronENST00000264033ENST00000524713CBLchr11

119077322

+PHLDB1chr11

118484531

+

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FusionProtFeatures for CBL_PHLDB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CBL

P22681

PHLDB1

Q86UU1

Adapter protein that functions as a negative regulatorof many signaling pathways that are triggered by activation ofcell surface receptors. Acts as an E3 ubiquitin-protein ligase,which accepts ubiquitin from specific E2 ubiquitin-conjugatingenzymes, and then transfers it to substrates promoting theirdegradation by the proteasome. Recognizes activated receptortyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA,PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling.Recognizes membrane-bound HCK, SRC and other kinases of the SRCfamily and mediates their ubiquitination and degradation.Participates in signal transduction in hematopoietic cells. Playsan important role in the regulation of osteoblast differentiationand apoptosis. Essential for osteoclastic bone resorption. The'Tyr-731' phosphorylated form induces the activation andrecruitment of phosphatidylinositol 3-kinase to the cell membranein a signaling pathway that is critical for osteoclast function.May be functionally coupled with the E2 ubiquitin-protein ligaseUB2D3. {ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602,ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300,ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17509076,ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429,ECO:0000269|PubMed:21596750}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCBLchr11:119156276chr11:118514518ENST00000264033+1116227_240647907Calcium binding.
HgeneCBLchr11:119156276chr11:118514518ENST00000264033+1116357_476647907Compositional biasNote=Asp/Glu-rich (acidic)
HgeneCBLchr11:119156276chr11:118514518ENST00000264033+111647_351647907DomainCbl-PTB
HgeneCBLchr11:119156276chr11:118514518ENST00000264033+1116176_248647907RegionNote=EF-hand-like
HgeneCBLchr11:119156276chr11:118514518ENST00000264033+1116249_351647907RegionNote=SH2-like
HgeneCBLchr11:119156276chr11:118514518ENST00000264033+1116352_380647907RegionNote=Linker
HgeneCBLchr11:119156276chr11:118514518ENST00000264033+111647_175647907RegionNote=4H
HgeneCBLchr11:119156276chr11:118514518ENST00000264033+1116381_420647907Zinc fingerRING-type
TgenePHLDB1chr11:119156276chr11:118514518ENST00000356063+11211144_12089121320Coiled coilOntology_term=ECO:0000255
TgenePHLDB1chr11:119156276chr11:118514518ENST00000361417+13241144_12089591378Coiled coilOntology_term=ECO:0000255
TgenePHLDB1chr11:119156276chr11:118514518ENST00000356063+11211256_13709121320DomainPH
TgenePHLDB1chr11:119156276chr11:118514518ENST00000361417+13241256_13709591378DomainPH

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCBLchr11:119156276chr11:118514518ENST00000264033+1116477_688647907Compositional biasNote=Pro-rich
HgeneCBLchr11:119156276chr11:118514518ENST00000264033+1116689_834647907Compositional biasNote=Asp/Glu-rich (acidic)
HgeneCBLchr11:119156276chr11:118514518ENST00000264033+1116856_895647907DomainUBA
TgenePHLDB1chr11:119156276chr11:118514518ENST00000356063+1121683_8099121320Coiled coilOntology_term=ECO:0000255
TgenePHLDB1chr11:119156276chr11:118514518ENST00000361417+1324683_8099591378Coiled coilOntology_term=ECO:0000255
TgenePHLDB1chr11:119156276chr11:118514518ENST00000356063+112164_1259121320DomainNote=FHA
TgenePHLDB1chr11:119156276chr11:118514518ENST00000361417+132464_1259591378DomainNote=FHA


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FusionGeneSequence for CBL_PHLDB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CBL_ENST00000264033_chr11_119156276_+_PHLDB1_ENST00000361417_chr11_118514518_+_1066aa
MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPD
TYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFR
ITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMA
FLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDH
IKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGA
PSPNYDDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTASKAASGSLHKDKPLPVPPTLR
DLPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSLPSQMEP
RPDVPRLGSTFSLDTSMVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETK
RQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMET
SISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMR
EKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVI

>In-frame_CBL_ENST00000264033_chr11_119156276_+_PHLDB1_ENST00000356063_chr11_118514518_+_1055aa
MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPD
TYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFR
ITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMA
FLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDH
IKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGA
PSPNYDDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTASKAASGSLHKDKPLPVPPTLR
DLPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSLPSQMEP
RPDVPRLGSTFSLDTSMVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETK
RQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMET
SISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMR
EKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CBL_ENST00000264033_chr11_119156276_+_PHLDB1_ENST00000361417_chr11_118514518_+_3198nt
ATGGCCGGCAACGTGAAGAAGAGCTCTGGGGCCGGGGGCGGCAGCGGCTCCGGGGGCTCGGGTTCGGGTGGCCTGATTGGGCTCATGAAG
GACGCCTTCCAGCCGCACCACCACCACCACCACCACCTCAGCCCCCACCCGCCGGGGACGGTGGACAAGAAGATGGTGGAGAAGTGCTGG
AAGCTCATGGACAAGGTGGTGCGGTTGTGTCAGAACCCAAAGCTGGCGCTAAAGAATAGCCCACCTTATATCTTAGACCTGCTACCAGAT
ACCTACCAGCATCTCCGTACTATCTTGTCAAGATATGAGGGGAAGATGGAGACACTTGGAGAAAATGAGTATTTTAGGGTGTTTATGGAG
AATTTGATGAAGAAAACTAAGCAAACCATAAGCCTCTTCAAGGAGGGAAAAGAAAGAATGTATGAGGAGAATTCTCAGCCTAGGCGAAAC
CTAACCAAACTGTCCCTCATCTTCAGCCACATGCTGGCAGAACTAAAAGGAATCTTTCCAAGTGGACTCTTTCAGGGAGACACATTTCGG
ATTACTAAAGCAGATGCTGCGGAATTTTGGAGAAAAGCTTTTGGGGAAAAGACAATAGTCCCTTGGAAGAGCTTTCGACAGGCTCTACAT
GAAGTGCATCCCATCAGTTCTGGGCTGGAGGCCATGGCTCTGAAATCCACTATTGATCTGACCTGCAATGATTATATTTCGGTTTTTGAA
TTTGACATCTTTACCCGACTCTTTCAGCCCTGGTCCTCTTTGCTCAGGAATTGGAACAGCCTTGCTGTAACTCATCCTGGCTACATGGCT
TTTTTGACGTATGACGAAGTGAAAGCTCGGCTCCAGAAATTCATTCACAAACCTGGCAGTTATATCTTCCGGCTGAGCTGTACTCGTCTG
GGTCAGTGGGCTATTGGGTATGTTACTGCTGATGGGAACATTCTCCAGACAATCCCTCACAATAAACCTCTCTTCCAAGCACTGATTGAT
GGCTTCAGGGAAGGCTTCTATTTGTTTCCTGATGGACGAAATCAGAATCCTGATCTGACTGGCTTATGTGAACCAACTCCCCAAGACCAT
ATCAAAGTGACCCAGGAACAATATGAATTATACTGTGAGATGGGCTCCACATTCCAACTATGTAAAATATGTGCTGAAAATGATAAGGAT
GTAAAGATTGAGCCCTGTGGACACCTCATGTGCACATCCTGTCTTACATCCTGGCAGGAATCAGAAGGTCAGGGCTGTCCTTTCTGCCGA
TGTGAAATTAAAGGTACTGAACCCATCGTGGTAGATCCGTTTGATCCTAGAGGGAGTGGCAGCCTGTTGAGGCAAGGAGCAGAGGGAGCT
CCCTCCCCAAATTATGATGATGATGATGATGAACGAGCTGATGATACTCTCTTCATGATGAAGGAATTGGCTGGTGCCAAGGTGGAACGG
CCGCCTTCTCCATTCTCCATGGCCCCACAAGCTTCCCTTCCCCCGGTGCCACCACGACTTGACCTTCTGCCGCAGCGAGTATGTGTTCCC
TCAAGTGCTTCTGCTCTTGGAACTGCTTCTAAGGCTGCTTCTGGCTCCCTTCATAAAGACAAACCATTGCCAGTACCTCCCACACTTCGA
GATCTTCCACCACCACCGCCTCCAGACCGGCCATATTCTGTTGGAGCAGAATCCCGACCTCAAAGACGCCCCTTGCCTTGTACACCAGGC
GACTGTCCCTCCAGAGACAAACTGCCCCCTGTCCCCTCTAGCCGCCTTGGAGACTCATGGCTGCCCCGGCCAATCCCCAAAGTACCAGTA
TCTGCCCCAAGTTCCAGTGATCCCTGGACAGGAAGAGAATTAACCAACCGGCACTCACTTCCATTTTCATTGCCCTCACAAATGGAGCCC
AGACCAGATGTGCCTAGGCTCGGAAGCACGTTCAGTCTGGATACCTCCATGGTTTACCGCTCCAAGATGGATGGCGAGGCCACCAGCCCC
CTTCCCCGGACCCGCAGCGGCCCCCTCCCCTCCTCCTCTGGCTCTTCCTCCTCCTCCTCCCAGCTCAGCGTGGCTACCCTGGGGCGTAGC
CCCTCCCCAAAGAGCGCTCTACTCACCCAGAATGGCACGGGCAGCCTTCCTCGCAACCTGGCAGCCACACTGCAGGACATCGAGACCAAG
CGCCAACTAGCTCTGCAGCAGAAGGGACAACAAGTGATTGAAGAGCAGCGGCGGCGACTGGCTGAGCTGAAGCAGAAAGCGGCAGCTGAG
GCACAGTGCCAGTGGGATGCCCTTCACGGGGCAGCACCCTTCCCAGCGGGCCCCTCGGGCTTCCCCCCTCTCATGCACCACTCTATCCTA
CACCACCTGCCTGCGGGGCGGGAGCGTGGGGAGGAGGGTGAGCACGCCTATGATACGCTGAGTCTGGAGAGCTCTGACAGCATGGAGACC
AGCATCTCCACCGGGGGCAACTCGGCCTGCTCCCCTGACAACATGTCCAGCGCGAGTGGTCTGGACATGGGGAAGATCGAGGAGATGGAG
AAGATGCTGAAAGAGGCTCATGCAGAGAAGAACCGGCTCATGGAGTCGAGGGAGCGGGAGATGGAGCTGCGGCGGCAGGCCCTGGAGGAG
GAGCGGCGGAGGCGTGAGCAGGTAGAACGGAGGCTGCAGAGTGAGAGTGCCCGGAGGCAGCAGCTGGTCGAGAAGGAGGTCAAGATGCGG
GAGAAACAATTTTCCCAGGCACGACCCCTGACCCGCTACCTGCCAATCCGGAAGGAGGACTTTGACCTGAAGACACATATTGAGTCATCG
GGCCATGGTGTTGATACCTGCCTGCACGTGGTGCTCAGCAGCAAGGTCTGCCGTGGCTACTTGGTCAAGATGGGCGGCAAGATTAAATCA
TGGAAGAAGCGCTGGTTTGTCTTCGACCGGCTCAAGCGCACCCTTTCCTATTATGTGGACAAGCATGAGACGAAGCTGAAGGGAGTCATC
TATTTCCAGGCCATTGAGGAAGTGTACTACGACCACCTGCGCAGTGCAGCCAAGAAGAGGTTTTTCCGCTTCACTATGGTGACTGAGAGC
CCGAACCCAGCCCTCACCTTCTGCGTAAAGACCCATGACCGGCTGTACTACATGGTGGCCCCATCTGCAGAGGCCATGCGTATCTGGATG

>In-frame_CBL_ENST00000264033_chr11_119156276_+_PHLDB1_ENST00000356063_chr11_118514518_+_3165nt
ATGGCCGGCAACGTGAAGAAGAGCTCTGGGGCCGGGGGCGGCAGCGGCTCCGGGGGCTCGGGTTCGGGTGGCCTGATTGGGCTCATGAAG
GACGCCTTCCAGCCGCACCACCACCACCACCACCACCTCAGCCCCCACCCGCCGGGGACGGTGGACAAGAAGATGGTGGAGAAGTGCTGG
AAGCTCATGGACAAGGTGGTGCGGTTGTGTCAGAACCCAAAGCTGGCGCTAAAGAATAGCCCACCTTATATCTTAGACCTGCTACCAGAT
ACCTACCAGCATCTCCGTACTATCTTGTCAAGATATGAGGGGAAGATGGAGACACTTGGAGAAAATGAGTATTTTAGGGTGTTTATGGAG
AATTTGATGAAGAAAACTAAGCAAACCATAAGCCTCTTCAAGGAGGGAAAAGAAAGAATGTATGAGGAGAATTCTCAGCCTAGGCGAAAC
CTAACCAAACTGTCCCTCATCTTCAGCCACATGCTGGCAGAACTAAAAGGAATCTTTCCAAGTGGACTCTTTCAGGGAGACACATTTCGG
ATTACTAAAGCAGATGCTGCGGAATTTTGGAGAAAAGCTTTTGGGGAAAAGACAATAGTCCCTTGGAAGAGCTTTCGACAGGCTCTACAT
GAAGTGCATCCCATCAGTTCTGGGCTGGAGGCCATGGCTCTGAAATCCACTATTGATCTGACCTGCAATGATTATATTTCGGTTTTTGAA
TTTGACATCTTTACCCGACTCTTTCAGCCCTGGTCCTCTTTGCTCAGGAATTGGAACAGCCTTGCTGTAACTCATCCTGGCTACATGGCT
TTTTTGACGTATGACGAAGTGAAAGCTCGGCTCCAGAAATTCATTCACAAACCTGGCAGTTATATCTTCCGGCTGAGCTGTACTCGTCTG
GGTCAGTGGGCTATTGGGTATGTTACTGCTGATGGGAACATTCTCCAGACAATCCCTCACAATAAACCTCTCTTCCAAGCACTGATTGAT
GGCTTCAGGGAAGGCTTCTATTTGTTTCCTGATGGACGAAATCAGAATCCTGATCTGACTGGCTTATGTGAACCAACTCCCCAAGACCAT
ATCAAAGTGACCCAGGAACAATATGAATTATACTGTGAGATGGGCTCCACATTCCAACTATGTAAAATATGTGCTGAAAATGATAAGGAT
GTAAAGATTGAGCCCTGTGGACACCTCATGTGCACATCCTGTCTTACATCCTGGCAGGAATCAGAAGGTCAGGGCTGTCCTTTCTGCCGA
TGTGAAATTAAAGGTACTGAACCCATCGTGGTAGATCCGTTTGATCCTAGAGGGAGTGGCAGCCTGTTGAGGCAAGGAGCAGAGGGAGCT
CCCTCCCCAAATTATGATGATGATGATGATGAACGAGCTGATGATACTCTCTTCATGATGAAGGAATTGGCTGGTGCCAAGGTGGAACGG
CCGCCTTCTCCATTCTCCATGGCCCCACAAGCTTCCCTTCCCCCGGTGCCACCACGACTTGACCTTCTGCCGCAGCGAGTATGTGTTCCC
TCAAGTGCTTCTGCTCTTGGAACTGCTTCTAAGGCTGCTTCTGGCTCCCTTCATAAAGACAAACCATTGCCAGTACCTCCCACACTTCGA
GATCTTCCACCACCACCGCCTCCAGACCGGCCATATTCTGTTGGAGCAGAATCCCGACCTCAAAGACGCCCCTTGCCTTGTACACCAGGC
GACTGTCCCTCCAGAGACAAACTGCCCCCTGTCCCCTCTAGCCGCCTTGGAGACTCATGGCTGCCCCGGCCAATCCCCAAAGTACCAGTA
TCTGCCCCAAGTTCCAGTGATCCCTGGACAGGAAGAGAATTAACCAACCGGCACTCACTTCCATTTTCATTGCCCTCACAAATGGAGCCC
AGACCAGATGTGCCTAGGCTCGGAAGCACGTTCAGTCTGGATACCTCCATGGTTTACCGCTCCAAGATGGATGGCGAGGCCACCAGCCCC
CTTCCCCGGACCCGCAGCGGCCCCCTCCCCTCCTCCTCTGGCTCTTCCTCCTCCTCCTCCCAGCTCAGCGTGGCTACCCTGGGGCGTAGC
CCCTCCCCAAAGAGCGCTCTACTCACCCAGAATGGCACGGGCAGCCTTCCTCGCAACCTGGCAGCCACACTGCAGGACATCGAGACCAAG
CGCCAACTAGCTCTGCAGCAGAAGGGACAACAAGTGATTGAAGAGCAGCGGCGGCGACTGGCTGAGCTGAAGCAGAAAGCGGCAGCTGAG
GCACAGTGCCAGTGGGATGCCCTTCACGGGGCAGCACCCTTCCCAGCGGGCCCCTCGGGCTTCCCCCCTCTCATGCACCACTCTATCCTA
CACCACCTGCCTGCGGGGCGGGAGCGTGGGGAGGAGGGTGAGCACGCCTATGATACGCTGAGTCTGGAGAGCTCTGACAGCATGGAGACC
AGCATCTCCACCGGGGGCAACTCGGCCTGCTCCCCTGACAACATGTCCAGCGCGAGTGGTCTGGACATGGGGAAGATCGAGGAGATGGAG
AAGATGCTGAAAGAGGCTCATGCAGAGAAGAACCGGCTCATGGAGTCGAGGGAGCGGGAGATGGAGCTGCGGCGGCAGGCCCTGGAGGAG
GAGCGGCGGAGGCGTGAGCAGGTAGAACGGAGGCTGCAGAGTGAGAGTGCCCGGAGGCAGCAGCTGGTCGAGAAGGAGGTCAAGATGCGG
GAGAAACAATTTTCCCAGGCACGACCCCTGACCCGCTACCTGCCAATCCGGAAGGAGGACTTTGACCTGAAGACACATATTGAGTCATCG
GGCCATGGTGTTGATACCTGCCTGCACGTGGTGCTCAGCAGCAAGGTCTGCCGTGGCTACTTGGTCAAGATGGGCGGCAAGATTAAATCA
TGGAAGAAGCGCTGGTTTGTCTTCGACCGGCTCAAGCGCACCCTTTCCTATTATGTGGACAAGCATGAGACGAAGCTGAAGGGAGTCATC
TATTTCCAGGCCATTGAGGAAGTGTACTACGACCACCTGCGCAGTGCAGCCAAGAGCCCGAACCCAGCCCTCACCTTCTGCGTAAAGACC
CATGACCGGCTGTACTACATGGTGGCCCCATCTGCAGAGGCCATGCGTATCTGGATGGATGTCATTGTCACAGGGGCTGAGGGCTACACT


* Fusion transcript sequences (Full-length transcript).
>In-frame_CBL_ENST00000264033_chr11_119156276_+_PHLDB1_ENST00000361417_chr11_118514518_+_4782nt
ACAGAAACCTGGCCGCGGCTTTCCGGGAGCTGTGGGCACGCGAGCTGCTCGAAGCCGGTGGCCCGGGGATCGTCGCTGCCCAGTCCGGCC
GCGGCCGGCCGCTTCCCCGAGCTTACCAGTAAGCCGGTCCGCCTCCGGGACGCGCCCCGCCCGCCCCGGGCTCGCGCGCTCTGAAGGGGC
GCGTCCCGCGCACTCCCGGCGCCGCCCACTCCCCTCCCCACGGCCGCTCCTCCCTCCGCCCGGATAGCCGGCGGCGGCGGCGGCGGCGGC
GGCGGCGGCGGCCGGGAGAGGCCCCTCCTTCACGCCCTGCTTCTCTCCCTCGCTCGCAGTCGAGCCGAGCCGGCGGACCCGCCTGGGCTC
CGACCCTGCCCAGGCCATGGCCGGCAACGTGAAGAAGAGCTCTGGGGCCGGGGGCGGCAGCGGCTCCGGGGGCTCGGGTTCGGGTGGCCT
GATTGGGCTCATGAAGGACGCCTTCCAGCCGCACCACCACCACCACCACCACCTCAGCCCCCACCCGCCGGGGACGGTGGACAAGAAGAT
GGTGGAGAAGTGCTGGAAGCTCATGGACAAGGTGGTGCGGTTGTGTCAGAACCCAAAGCTGGCGCTAAAGAATAGCCCACCTTATATCTT
AGACCTGCTACCAGATACCTACCAGCATCTCCGTACTATCTTGTCAAGATATGAGGGGAAGATGGAGACACTTGGAGAAAATGAGTATTT
TAGGGTGTTTATGGAGAATTTGATGAAGAAAACTAAGCAAACCATAAGCCTCTTCAAGGAGGGAAAAGAAAGAATGTATGAGGAGAATTC
TCAGCCTAGGCGAAACCTAACCAAACTGTCCCTCATCTTCAGCCACATGCTGGCAGAACTAAAAGGAATCTTTCCAAGTGGACTCTTTCA
GGGAGACACATTTCGGATTACTAAAGCAGATGCTGCGGAATTTTGGAGAAAAGCTTTTGGGGAAAAGACAATAGTCCCTTGGAAGAGCTT
TCGACAGGCTCTACATGAAGTGCATCCCATCAGTTCTGGGCTGGAGGCCATGGCTCTGAAATCCACTATTGATCTGACCTGCAATGATTA
TATTTCGGTTTTTGAATTTGACATCTTTACCCGACTCTTTCAGCCCTGGTCCTCTTTGCTCAGGAATTGGAACAGCCTTGCTGTAACTCA
TCCTGGCTACATGGCTTTTTTGACGTATGACGAAGTGAAAGCTCGGCTCCAGAAATTCATTCACAAACCTGGCAGTTATATCTTCCGGCT
GAGCTGTACTCGTCTGGGTCAGTGGGCTATTGGGTATGTTACTGCTGATGGGAACATTCTCCAGACAATCCCTCACAATAAACCTCTCTT
CCAAGCACTGATTGATGGCTTCAGGGAAGGCTTCTATTTGTTTCCTGATGGACGAAATCAGAATCCTGATCTGACTGGCTTATGTGAACC
AACTCCCCAAGACCATATCAAAGTGACCCAGGAACAATATGAATTATACTGTGAGATGGGCTCCACATTCCAACTATGTAAAATATGTGC
TGAAAATGATAAGGATGTAAAGATTGAGCCCTGTGGACACCTCATGTGCACATCCTGTCTTACATCCTGGCAGGAATCAGAAGGTCAGGG
CTGTCCTTTCTGCCGATGTGAAATTAAAGGTACTGAACCCATCGTGGTAGATCCGTTTGATCCTAGAGGGAGTGGCAGCCTGTTGAGGCA
AGGAGCAGAGGGAGCTCCCTCCCCAAATTATGATGATGATGATGATGAACGAGCTGATGATACTCTCTTCATGATGAAGGAATTGGCTGG
TGCCAAGGTGGAACGGCCGCCTTCTCCATTCTCCATGGCCCCACAAGCTTCCCTTCCCCCGGTGCCACCACGACTTGACCTTCTGCCGCA
GCGAGTATGTGTTCCCTCAAGTGCTTCTGCTCTTGGAACTGCTTCTAAGGCTGCTTCTGGCTCCCTTCATAAAGACAAACCATTGCCAGT
ACCTCCCACACTTCGAGATCTTCCACCACCACCGCCTCCAGACCGGCCATATTCTGTTGGAGCAGAATCCCGACCTCAAAGACGCCCCTT
GCCTTGTACACCAGGCGACTGTCCCTCCAGAGACAAACTGCCCCCTGTCCCCTCTAGCCGCCTTGGAGACTCATGGCTGCCCCGGCCAAT
CCCCAAAGTACCAGTATCTGCCCCAAGTTCCAGTGATCCCTGGACAGGAAGAGAATTAACCAACCGGCACTCACTTCCATTTTCATTGCC
CTCACAAATGGAGCCCAGACCAGATGTGCCTAGGCTCGGAAGCACGTTCAGTCTGGATACCTCCATGGTTTACCGCTCCAAGATGGATGG
CGAGGCCACCAGCCCCCTTCCCCGGACCCGCAGCGGCCCCCTCCCCTCCTCCTCTGGCTCTTCCTCCTCCTCCTCCCAGCTCAGCGTGGC
TACCCTGGGGCGTAGCCCCTCCCCAAAGAGCGCTCTACTCACCCAGAATGGCACGGGCAGCCTTCCTCGCAACCTGGCAGCCACACTGCA
GGACATCGAGACCAAGCGCCAACTAGCTCTGCAGCAGAAGGGACAACAAGTGATTGAAGAGCAGCGGCGGCGACTGGCTGAGCTGAAGCA
GAAAGCGGCAGCTGAGGCACAGTGCCAGTGGGATGCCCTTCACGGGGCAGCACCCTTCCCAGCGGGCCCCTCGGGCTTCCCCCCTCTCAT
GCACCACTCTATCCTACACCACCTGCCTGCGGGGCGGGAGCGTGGGGAGGAGGGTGAGCACGCCTATGATACGCTGAGTCTGGAGAGCTC
TGACAGCATGGAGACCAGCATCTCCACCGGGGGCAACTCGGCCTGCTCCCCTGACAACATGTCCAGCGCGAGTGGTCTGGACATGGGGAA
GATCGAGGAGATGGAGAAGATGCTGAAAGAGGCTCATGCAGAGAAGAACCGGCTCATGGAGTCGAGGGAGCGGGAGATGGAGCTGCGGCG
GCAGGCCCTGGAGGAGGAGCGGCGGAGGCGTGAGCAGGTAGAACGGAGGCTGCAGAGTGAGAGTGCCCGGAGGCAGCAGCTGGTCGAGAA
GGAGGTCAAGATGCGGGAGAAACAATTTTCCCAGGCACGACCCCTGACCCGCTACCTGCCAATCCGGAAGGAGGACTTTGACCTGAAGAC
ACATATTGAGTCATCGGGCCATGGTGTTGATACCTGCCTGCACGTGGTGCTCAGCAGCAAGGTCTGCCGTGGCTACTTGGTCAAGATGGG
CGGCAAGATTAAATCATGGAAGAAGCGCTGGTTTGTCTTCGACCGGCTCAAGCGCACCCTTTCCTATTATGTGGACAAGCATGAGACGAA
GCTGAAGGGAGTCATCTATTTCCAGGCCATTGAGGAAGTGTACTACGACCACCTGCGCAGTGCAGCCAAGAAGAGGTTTTTCCGCTTCAC
TATGGTGACTGAGAGCCCGAACCCAGCCCTCACCTTCTGCGTAAAGACCCATGACCGGCTGTACTACATGGTGGCCCCATCTGCAGAGGC
CATGCGTATCTGGATGGATGTCATTGTCACAGGGGCTGAGGGCTACACTCAGTTCATGAACTAACTGCCGTGGGCCTCCTGGCAGAGCAC
AACTGGGGCTTTTGTATAAGAAGACTTTAATATTCTGTAAGGAGCTTGGTCCTGTGAGTTTCTGGGCTCTGGCCTCCTGAAGAACCAGCC
AGAAGAAGAAAAGTAGAGGTGGCTTTGCTGCCTCCTGGGAGCCCAGAACTTGCAGTAACCCTTTAGGGTCCTGCCCCAGGCCCAGCCAGG
GCTGAGGAGCTGTCACAGAGAGGGCCTCAGCTCTGACCTGACACCTGCTCTCCCCAGCCTGTTTTCTCTTTTCTAAAAGACAAATTATGG
TACCATAAGCTGCCAAAGATCCCCTCCTGCCTCAGACCCCTTTGCCAGGGGCTTTGGGGGCTGAGCAGAGCCACATCCAGAGTGGGGTAA
TAGCTCAGGCGGCCCGCTTCCCATTTCTCAAACCCCGCTCTGCCCCATTGTTCTCCTTTCCCTTATACTTTTTATTACCTTGCTCAAGGG
CCAGAGATCTCAAGTGTCAACCTTGAGGTCCCAGCTCCATCCCCTAGTTGCAGACTCATCACCATGGTTACCATAGTGACTGCTTCATTG
CCATGGTTACATACTAATTGCTGCAGCTCTGTGGCCCAGCCCACTGCTTCAGCTGTGGGCCATCTGAGGGTACGTGCCATCATCTCTCCA
GCCCAGGCCCCTGGGCATCTCATGCTGGGGGGAAGGGACTGAATACCTTTTTCCTTCCCCCTGCCTGTGTCTTCAGCCCTGATGCACAGG
CTGCCAGCCCCCCAGTCCAGCCCTCTCCCTTCCACTGGTGCCTTGCTTAGAGCCAGAAGGGATGAAGCCGGGGGATCTATGGAACAGAGG
AGGAGCGATGCAGTTGGGAGAGGAAGCTAGAAGGGTTATGGTTGGAGTTCTGTACAGTGTTGAGTTTCCGACAGGGAAAGAGGATTCCTC
CAATGCTCCTAGAGAGAAAGCCTGAGCAGGAGATGATGCAGCAGAGGGGAAGGGCCCTGTGGTGCCGCCGCCCTTCCTTCAGCCTCCGAA
GGGTGATGGAAATGGAGAGTGGAGGACCAGGCCTCCAGCTGTCTGGCCTCGCCCTTCACGCCTTAACACTAAGCCCACCTCCCCTGCTCT
CCTTCCCAGCATTGAGCCCTTGGTTGCCTGGGCCCAGGCTGGGGGTTTTCAGTATTTGTAAGCATTTCAGCAGAACAATAAAGCCTTTGG

>In-frame_CBL_ENST00000264033_chr11_119156276_+_PHLDB1_ENST00000356063_chr11_118514518_+_4743nt
ACAGAAACCTGGCCGCGGCTTTCCGGGAGCTGTGGGCACGCGAGCTGCTCGAAGCCGGTGGCCCGGGGATCGTCGCTGCCCAGTCCGGCC
GCGGCCGGCCGCTTCCCCGAGCTTACCAGTAAGCCGGTCCGCCTCCGGGACGCGCCCCGCCCGCCCCGGGCTCGCGCGCTCTGAAGGGGC
GCGTCCCGCGCACTCCCGGCGCCGCCCACTCCCCTCCCCACGGCCGCTCCTCCCTCCGCCCGGATAGCCGGCGGCGGCGGCGGCGGCGGC
GGCGGCGGCGGCCGGGAGAGGCCCCTCCTTCACGCCCTGCTTCTCTCCCTCGCTCGCAGTCGAGCCGAGCCGGCGGACCCGCCTGGGCTC
CGACCCTGCCCAGGCCATGGCCGGCAACGTGAAGAAGAGCTCTGGGGCCGGGGGCGGCAGCGGCTCCGGGGGCTCGGGTTCGGGTGGCCT
GATTGGGCTCATGAAGGACGCCTTCCAGCCGCACCACCACCACCACCACCACCTCAGCCCCCACCCGCCGGGGACGGTGGACAAGAAGAT
GGTGGAGAAGTGCTGGAAGCTCATGGACAAGGTGGTGCGGTTGTGTCAGAACCCAAAGCTGGCGCTAAAGAATAGCCCACCTTATATCTT
AGACCTGCTACCAGATACCTACCAGCATCTCCGTACTATCTTGTCAAGATATGAGGGGAAGATGGAGACACTTGGAGAAAATGAGTATTT
TAGGGTGTTTATGGAGAATTTGATGAAGAAAACTAAGCAAACCATAAGCCTCTTCAAGGAGGGAAAAGAAAGAATGTATGAGGAGAATTC
TCAGCCTAGGCGAAACCTAACCAAACTGTCCCTCATCTTCAGCCACATGCTGGCAGAACTAAAAGGAATCTTTCCAAGTGGACTCTTTCA
GGGAGACACATTTCGGATTACTAAAGCAGATGCTGCGGAATTTTGGAGAAAAGCTTTTGGGGAAAAGACAATAGTCCCTTGGAAGAGCTT
TCGACAGGCTCTACATGAAGTGCATCCCATCAGTTCTGGGCTGGAGGCCATGGCTCTGAAATCCACTATTGATCTGACCTGCAATGATTA
TATTTCGGTTTTTGAATTTGACATCTTTACCCGACTCTTTCAGCCCTGGTCCTCTTTGCTCAGGAATTGGAACAGCCTTGCTGTAACTCA
TCCTGGCTACATGGCTTTTTTGACGTATGACGAAGTGAAAGCTCGGCTCCAGAAATTCATTCACAAACCTGGCAGTTATATCTTCCGGCT
GAGCTGTACTCGTCTGGGTCAGTGGGCTATTGGGTATGTTACTGCTGATGGGAACATTCTCCAGACAATCCCTCACAATAAACCTCTCTT
CCAAGCACTGATTGATGGCTTCAGGGAAGGCTTCTATTTGTTTCCTGATGGACGAAATCAGAATCCTGATCTGACTGGCTTATGTGAACC
AACTCCCCAAGACCATATCAAAGTGACCCAGGAACAATATGAATTATACTGTGAGATGGGCTCCACATTCCAACTATGTAAAATATGTGC
TGAAAATGATAAGGATGTAAAGATTGAGCCCTGTGGACACCTCATGTGCACATCCTGTCTTACATCCTGGCAGGAATCAGAAGGTCAGGG
CTGTCCTTTCTGCCGATGTGAAATTAAAGGTACTGAACCCATCGTGGTAGATCCGTTTGATCCTAGAGGGAGTGGCAGCCTGTTGAGGCA
AGGAGCAGAGGGAGCTCCCTCCCCAAATTATGATGATGATGATGATGAACGAGCTGATGATACTCTCTTCATGATGAAGGAATTGGCTGG
TGCCAAGGTGGAACGGCCGCCTTCTCCATTCTCCATGGCCCCACAAGCTTCCCTTCCCCCGGTGCCACCACGACTTGACCTTCTGCCGCA
GCGAGTATGTGTTCCCTCAAGTGCTTCTGCTCTTGGAACTGCTTCTAAGGCTGCTTCTGGCTCCCTTCATAAAGACAAACCATTGCCAGT
ACCTCCCACACTTCGAGATCTTCCACCACCACCGCCTCCAGACCGGCCATATTCTGTTGGAGCAGAATCCCGACCTCAAAGACGCCCCTT
GCCTTGTACACCAGGCGACTGTCCCTCCAGAGACAAACTGCCCCCTGTCCCCTCTAGCCGCCTTGGAGACTCATGGCTGCCCCGGCCAAT
CCCCAAAGTACCAGTATCTGCCCCAAGTTCCAGTGATCCCTGGACAGGAAGAGAATTAACCAACCGGCACTCACTTCCATTTTCATTGCC
CTCACAAATGGAGCCCAGACCAGATGTGCCTAGGCTCGGAAGCACGTTCAGTCTGGATACCTCCATGGTTTACCGCTCCAAGATGGATGG
CGAGGCCACCAGCCCCCTTCCCCGGACCCGCAGCGGCCCCCTCCCCTCCTCCTCTGGCTCTTCCTCCTCCTCCTCCCAGCTCAGCGTGGC
TACCCTGGGGCGTAGCCCCTCCCCAAAGAGCGCTCTACTCACCCAGAATGGCACGGGCAGCCTTCCTCGCAACCTGGCAGCCACACTGCA
GGACATCGAGACCAAGCGCCAACTAGCTCTGCAGCAGAAGGGACAACAAGTGATTGAAGAGCAGCGGCGGCGACTGGCTGAGCTGAAGCA
GAAAGCGGCAGCTGAGGCACAGTGCCAGTGGGATGCCCTTCACGGGGCAGCACCCTTCCCAGCGGGCCCCTCGGGCTTCCCCCCTCTCAT
GCACCACTCTATCCTACACCACCTGCCTGCGGGGCGGGAGCGTGGGGAGGAGGGTGAGCACGCCTATGATACGCTGAGTCTGGAGAGCTC
TGACAGCATGGAGACCAGCATCTCCACCGGGGGCAACTCGGCCTGCTCCCCTGACAACATGTCCAGCGCGAGTGGTCTGGACATGGGGAA
GATCGAGGAGATGGAGAAGATGCTGAAAGAGGCTCATGCAGAGAAGAACCGGCTCATGGAGTCGAGGGAGCGGGAGATGGAGCTGCGGCG
GCAGGCCCTGGAGGAGGAGCGGCGGAGGCGTGAGCAGGTAGAACGGAGGCTGCAGAGTGAGAGTGCCCGGAGGCAGCAGCTGGTCGAGAA
GGAGGTCAAGATGCGGGAGAAACAATTTTCCCAGGCACGACCCCTGACCCGCTACCTGCCAATCCGGAAGGAGGACTTTGACCTGAAGAC
ACATATTGAGTCATCGGGCCATGGTGTTGATACCTGCCTGCACGTGGTGCTCAGCAGCAAGGTCTGCCGTGGCTACTTGGTCAAGATGGG
CGGCAAGATTAAATCATGGAAGAAGCGCTGGTTTGTCTTCGACCGGCTCAAGCGCACCCTTTCCTATTATGTGGACAAGCATGAGACGAA
GCTGAAGGGAGTCATCTATTTCCAGGCCATTGAGGAAGTGTACTACGACCACCTGCGCAGTGCAGCCAAGAGCCCGAACCCAGCCCTCAC
CTTCTGCGTAAAGACCCATGACCGGCTGTACTACATGGTGGCCCCATCTGCAGAGGCCATGCGTATCTGGATGGATGTCATTGTCACAGG
GGCTGAGGGCTACACTCAGTTCATGAACTAACTGCCGTGGGCCTCCTGGCAGAGCACAACTGGGGCTTTTGTATAAGAAGACTTTAATAT
TCTGTAAGGAGCTTGGTCCTGTGAGTTTCTGGGCTCTGGCCTCCTGAAGAACCAGCCAGAAGAAGAAAAGTAGAGGTGGCTTTGCTGCCT
CCTGGGAGCCCAGAACTTGCAGTAACCCTTTAGGGTCCTGCCCCAGGCCCAGCCAGGGCTGAGGAGCTGTCACAGAGAGGGCCTCAGCTC
TGACCTGACACCTGCTCTCCCCAGCCTGTTTTCTCTTTTCTAAAAGACAAATTATGGTACCATAAGCTGCCAAAGATCCCCTCCTGCCTC
AGACCCCTTTGCCAGGGGCTTTGGGGGCTGAGCAGAGCCACATCCAGAGTGGGGTAATAGCTCAGGCGGCCCGCTTCCCATTTCTCAAAC
CCCGCTCTGCCCCATTGTTCTCCTTTCCCTTATACTTTTTATTACCTTGCTCAAGGGCCAGAGATCTCAAGTGTCAACCTTGAGGTCCCA
GCTCCATCCCCTAGTTGCAGACTCATCACCATGGTTACCATAGTGACTGCTTCATTGCCATGGTTACATACTAATTGCTGCAGCTCTGTG
GCCCAGCCCACTGCTTCAGCTGTGGGCCATCTGAGGGTACGTGCCATCATCTCTCCAGCCCAGGCCCCTGGGCATCTCATGCTGGGGGGA
AGGGACTGAATACCTTTTTCCTTCCCCCTGCCTGTGTCTTCAGCCCTGATGCACAGGCTGCCAGCCCCCCAGTCCAGCCCTCTCCCTTCC
ACTGGTGCCTTGCTTAGAGCCAGAAGGGATGAAGCCGGGGGATCTATGGAACAGAGGAGGAGCGATGCAGTTGGGAGAGGAAGCTAGAAG
GGTTATGGTTGGAGTTCTGTACAGTGTTGAGTTTCCGACAGGGAAAGAGGATTCCTCCAATGCTCCTAGAGAGAAAGCCTGAGCAGGAGA
TGATGCAGCAGAGGGGAAGGGCCCTGTGGTGCCGCCGCCCTTCCTTCAGCCTCCGAAGGGTGATGGAAATGGAGAGTGGAGGACCAGGCC
TCCAGCTGTCTGGCCTCGCCCTTCACGCCTTAACACTAAGCCCACCTCCCCTGCTCTCCTTCCCAGCATTGAGCCCTTGGTTGCCTGGGC


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FusionGenePPI for CBL_PHLDB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CBLKRT18, MYO1C, ZAP70, PDGFRA, CRKL, GRB2, ARHGEF7, HCK, PTK2B, SORBS2, SORBS1, CD2AP, SH2B2, SH3KBP1, PIK3R2, YWHAQ, SLA, SH3BP2, EGFR, PTPN6, LCK, SPRY2, CSF1R, SH3GL3, MET, SYK, FRS2, UBE2L3, BTK, LYN, FYN, TYK2, YWHAB, YWHAZ, VAV1, LCP2, UBE2D2, FGR, ABL1, SLA2, INPPL1, SHC1, NCK1, PLCG1, SH3GL2, FLOT1, PIK3R1, CRK, CSK, ITK, CD5, LTK, IGF1R, PTPN11, UBE2D1, SPRY4, UBC, CBL, CSF1, GAPVD1, KDR, ITSN1, MST1R, UBE2M, AXL, ITGA5, KIT, LRIG1, UBASH3A, UBASH3B, GAPDH, EEF1A1, CDC42, SRC, NOTCH1, CD247, STAP2, TNFRSF10A, TNFRSF10B, FCGR2A, MYH9, ACTA1, ACTB, ACTG2, VIM, HSPA4, HSPA5, EPHA8, UBE4B, EPHB1, IL7R, CD33, NTRK1, CFTR, PSMC5, ITCH, TEK, BAG1, PTK2, PXN, VAV2, IRF8, RET, IRS1, ITSN2, HRAS, DBNL, ASAP1, TNFRSF1A, MAPK14, MAPK8, BLNK, INPP5D, TUBB, TUBA1A, SOS1, NOTCH3, SMAD3, CALM1, YES1, SFN, YWHAH, YWHAE, EPHA2, RAPGEF1, ABI1, GIF, TCN1, TCN2, MYH2, HTR2A, FYB, FGFR2, GBA, SORBS3, ITGAV, BCAR1, CD38, BCR, OSTF1, GRAP2, PIK3CA, CD40, BLK, SYNM, CUBN, SPRY1, LAT, SNX18, KRT10, KRT1, KRT2, HSPA8, PIK3CB, SPTBN1, KRT6C, KRT6B, KRT9, KRT14, KRT5, ACACA, KRT16, TUBB4B, KRT6A, TUBA1C, HSPA9, HSPA1L, MYH10, IQGAP1, KRT17, HSPA1B, SPTA1, SPTAN1, HSPA6, CCT8, KRT79, RPS19, CBLB, KRT84, CORO1C, TRIM21, KRT3, TUBA4B, CAD, ACTN1, POP1, PRKCA, PRKCQ, MAP3K11, EPOR, UBE2D3, TRPV1, USP21, PTPN22, ITGA4, STAT5A, PTEN, TNS4, CTNNB1, WAS, TRAF4, TRIM8, IRF1, FLT3, LOX, NCK2, ERBB2, CAPZA1, PRPSAP2, ERBB4, SIRT2, FRS3, FLT1, TGFBR2, SSFA2, SMAD7, PIK3R3, APPL1, EPS8, STAT3, MZF1, SERPINA5, CEP170, CEP128, FBF1, NPHP1, XPO1, PSMC1, XRCC5, ERBB2IP, SP7, ARHGEF6, TGM2, TSG101, IRF3, CDH1, RAB39B, TRIM25, TRAF2PHLDB1SH3KBP1, BAG3, CCDC8, NTRK1, SRPK2, XPO1, GAN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCBLchr11:119156276chr11:118514518ENST00000264033+1116648_906647907CD2AP


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CBL_PHLDB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CBL_PHLDB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCBLC0349639Juvenile Myelomonocytic Leukemia3CTD_human;HPO;ORPHANET
HgeneCBLC0008073Developmental Disabilities1CTD_human
HgeneCBLC0010417Cryptorchidism1CTD_human;HPO
HgeneCBLC0018273Growth Disorders1CTD_human
HgeneCBLC0042384Vasculitis1CTD_human
HgeneCBLC3150803NOONAN SYNDROME-LIKE DISORDER WITH OR WITHOUT JUVENILE MYELOMONOCYTIC LEUKEMIA1CTD_human;ORPHANET;UNIPROT
TgenePHLDB1C0017638Glioma1CTD_human