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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5682

FusionGeneSummary for CBLB_LIMCH1

check button Fusion gene summary
Fusion gene informationFusion gene name: CBLB_LIMCH1
Fusion gene ID: 5682
HgeneTgene
Gene symbol

CBLB

LIMCH1

Gene ID

868

22998

Gene nameCbl proto-oncogene BLIM and calponin homology domains 1
SynonymsCbl-b|Nbla00127|RNF56LIMCH1A|LMO7B
Cytomap

3q13.11

4p13

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase CBL-BCas-Br-M (murine) ecotropic retroviral transforming sequence bCbl proto-oncogene B, E3 ubiquitin protein ligaseCbl proto-oncogene, E3 ubiquitin protein ligase BRING finger protein 56RING-type E3 ubiquitin transferase LIM and calponin homology domains-containing protein 1
Modification date2018052320180519
UniProtAcc

Q13191

Q9UPQ0

Ensembl transtripts involved in fusion geneENST00000264122, ENST00000407712, 
ENST00000394027, ENST00000403724, 
ENST00000405772, ENST00000545639, 
ENST00000513024, ENST00000509638, 
ENST00000508501, ENST00000512946, 
ENST00000313860, ENST00000512632, 
ENST00000512820, ENST00000503057, 
ENST00000511496, ENST00000514096, 
ENST00000509277, ENST00000396595, 
ENST00000381753, ENST00000509454, 
ENST00000515785, 
Fusion gene scores* DoF score5 X 6 X 2=6010 X 10 X 6=600
# samples 710
** MAII scorelog2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/600*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CBLB [Title/Abstract] AND LIMCH1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV401048CBLBchr3

105563838

-LIMCH1chr4

41617576

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000264122ENST00000513024CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000264122ENST00000509638CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000264122ENST00000508501CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000264122ENST00000512946CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000264122ENST00000313860CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000264122ENST00000512632CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000264122ENST00000512820CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000264122ENST00000503057CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000264122ENST00000511496CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000264122ENST00000514096CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000264122ENST00000509277CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000264122ENST00000396595CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000264122ENST00000381753CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000264122ENST00000509454CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000264122ENST00000515785CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000407712ENST00000513024CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000407712ENST00000509638CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000407712ENST00000508501CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000407712ENST00000512946CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000407712ENST00000313860CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000407712ENST00000512632CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000407712ENST00000512820CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000407712ENST00000503057CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000407712ENST00000511496CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000407712ENST00000514096CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000407712ENST00000509277CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000407712ENST00000396595CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000407712ENST00000381753CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000407712ENST00000509454CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000407712ENST00000515785CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000394027ENST00000513024CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000394027ENST00000509638CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000394027ENST00000508501CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000394027ENST00000512946CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000394027ENST00000313860CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000394027ENST00000512632CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000394027ENST00000512820CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000394027ENST00000503057CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000394027ENST00000511496CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000394027ENST00000514096CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000394027ENST00000509277CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000394027ENST00000396595CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000394027ENST00000381753CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000394027ENST00000509454CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000394027ENST00000515785CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000403724ENST00000513024CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000403724ENST00000509638CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000403724ENST00000508501CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000403724ENST00000512946CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000403724ENST00000313860CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000403724ENST00000512632CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000403724ENST00000512820CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000403724ENST00000503057CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000403724ENST00000511496CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000403724ENST00000514096CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000403724ENST00000509277CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000403724ENST00000396595CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000403724ENST00000381753CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000403724ENST00000509454CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000403724ENST00000515785CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000405772ENST00000513024CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000405772ENST00000509638CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000405772ENST00000508501CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000405772ENST00000512946CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000405772ENST00000313860CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000405772ENST00000512632CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000405772ENST00000512820CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000405772ENST00000503057CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000405772ENST00000511496CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000405772ENST00000514096CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000405772ENST00000509277CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000405772ENST00000396595CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000405772ENST00000381753CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000405772ENST00000509454CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000405772ENST00000515785CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000545639ENST00000513024CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000545639ENST00000509638CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000545639ENST00000508501CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000545639ENST00000512946CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000545639ENST00000313860CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000545639ENST00000512632CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000545639ENST00000512820CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000545639ENST00000503057CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000545639ENST00000511496CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000545639ENST00000514096CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000545639ENST00000509277CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000545639ENST00000396595CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000545639ENST00000381753CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000545639ENST00000509454CBLBchr3

105563838

-LIMCH1chr4

41617576

-
intron-intronENST00000545639ENST00000515785CBLBchr3

105563838

-LIMCH1chr4

41617576

-

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FusionProtFeatures for CBLB_LIMCH1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CBLB

Q13191

LIMCH1

Q9UPQ0

E3 ubiquitin-protein ligase which accepts ubiquitin fromspecific E2 ubiquitin-conjugating enzymes, and transfers it tosubstrates, generally promoting their degradation by theproteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilonreceptor) signal transduction pathways. In naive T-cells, inhibitsVAV1 activation upon TCR engagement and imposes a requirement forCD28 costimulation for proliferation and IL-2 production. Alsoacts by promoting PIK3R1/p85 ubiquitination, which impairs itsrecruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization uponrestimulation and promotes anergy. In B-cells, acts byubiquitinating SYK and promoting its proteasomal degradation.Slightly promotes SRC ubiquitination. May be involved in EGFRubiquitination and internalization. May be functionally coupledwith the E2 ubiquitin-protein ligase UB2D3.{ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340,ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404,ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CBLB_LIMCH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CBLB_LIMCH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CBLB_LIMCH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CBLB_LIMCH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCBLBC0014072Experimental Autoimmune Encephalomyelitis1CTD_human
HgeneCBLBC0026769Multiple Sclerosis1CTD_human
TgeneLIMCH1C0236969Substance-Related Disorders1CTD_human
TgeneLIMCH1C0345967Malignant mesothelioma1CTD_human