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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 5652

FusionGeneSummary for CBFA2T2_ACOX1

check button Fusion gene summary
Fusion gene informationFusion gene name: CBFA2T2_ACOX1
Fusion gene ID: 5652
HgeneTgene
Gene symbol

CBFA2T2

ACOX1

Gene ID

9139

51

Gene nameCBFA2/RUNX1 translocation partner 2acyl-CoA oxidase 1
SynonymsEHT|MTGR1|ZMYND3|p85ACOX|PALMCOX|SCOX
Cytomap

20q11.21-q11.22

17q25.1

Type of geneprotein-codingprotein-coding
Descriptionprotein CBFA2T2ETO homolog on chromosome 20ETO homologous on chromosome 20MTG8-like proteinMTG8-related protein 1core-binding factor, runt domain, alpha subunit 2; translocated to, 2myeloid translocation gene-related protein 1myeloid translocation-peroxisomal acyl-coenzyme A oxidase 1AOXacyl-CoA oxidase 1, palmitoylacyl-CoA oxidase, straight-chainacyl-Coenzyme A oxidase 1, palmitoylpalmitoyl-CoA oxidaseperoxisomal fatty acyl-CoA oxidasestraight-chain acyl-CoA oxidase
Modification date2018052320180523
UniProtAcc

O43439

Q15067

Ensembl transtripts involved in fusion geneENST00000342704, ENST00000375279, 
ENST00000344201, ENST00000397798, 
ENST00000346541, ENST00000397800, 
ENST00000492345, ENST00000359606, 
ENST00000491618, ENST00000543126, 
ENST00000293217, ENST00000537812, 
ENST00000301608, ENST00000591857, 
Fusion gene scores* DoF score11 X 4 X 6=2649 X 8 X 7=504
# samples 1210
** MAII scorelog2(12/264*10)=-1.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/504*10)=-2.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CBFA2T2 [Title/Abstract] AND ACOX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCBFA2T2

GO:0010976

positive regulation of neuron projection development

19026687

HgeneCBFA2T2

GO:0045892

negative regulation of transcription, DNA-templated

23251453

TgeneACOX1

GO:0006629

lipid metabolic process

8117268


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-8289-01ACBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000342704ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
In-frameENST00000342704ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
In-frameENST00000342704ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
5CDS-5UTRENST00000342704ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
5UTR-3CDSENST00000375279ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
5UTR-3CDSENST00000375279ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
5UTR-3CDSENST00000375279ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
5UTR-5UTRENST00000375279ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000344201ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000344201ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000344201ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-5UTRENST00000344201ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000397798ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000397798ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000397798ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-5UTRENST00000397798ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000346541ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000346541ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000346541ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-5UTRENST00000346541ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000397800ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000397800ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000397800ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-5UTRENST00000397800ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000492345ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000492345ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000492345ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-5UTRENST00000492345ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000359606ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000359606ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000359606ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-5UTRENST00000359606ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000491618ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000491618ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000491618ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-5UTRENST00000491618ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000543126ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000543126ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000543126ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-5UTRENST00000543126ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-

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FusionProtFeatures for CBFA2T2_ACOX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CBFA2T2

O43439

ACOX1

Q15067


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneACOX1chr20:32078107chr17:73953647ENST00000293217-214658_660143661MotifNote=Microbody targeting signal
TgeneACOX1chr20:32078107chr17:73953647ENST00000301608-214658_660143661MotifNote=Microbody targeting signal
TgeneACOX1chr20:32078107chr17:73953647ENST00000537812-214658_660105623MotifNote=Microbody targeting signal

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000342704+111451_49111596Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000344201+16451_491-123264Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000346541+112451_491-179605Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000359606+111451_491-13615Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000375279+112451_491-76605Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397798+17451_491-208264Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397800+111451_491-112576Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000492345+113451_491-229576Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000342704+11133_9711596Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000344201+1633_97-123264Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000346541+11233_97-179605Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000359606+11133_97-13615Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000375279+11233_97-76605Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397798+1733_97-208264Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397800+11133_97-112576Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000492345+11333_97-229576Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000342704+111113_20811596DomainTAFH
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000344201+16113_208-123264DomainTAFH
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000346541+112113_208-179605DomainTAFH
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000359606+111113_208-13615DomainTAFH
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000375279+112113_208-76605DomainTAFH
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397798+17113_208-208264DomainTAFH
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397800+111113_208-112576DomainTAFH
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000492345+113113_208-229576DomainTAFH
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000342704+111331_37711596RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000342704+111435_48411596RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000344201+16331_377-123264RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000344201+16435_484-123264RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000346541+112331_377-179605RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000346541+112435_484-179605RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000359606+111331_377-13615RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000359606+111435_484-13615RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000375279+112331_377-76605RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000375279+112435_484-76605RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397798+17331_377-208264RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397798+17435_484-208264RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397800+111331_377-112576RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397800+111435_484-112576RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000492345+113331_377-229576RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000492345+113435_484-229576RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000342704+111517_55311596Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000344201+16517_553-123264Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000346541+112517_553-179605Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000359606+111517_553-13615Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000375279+112517_553-76605Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397798+17517_553-208264Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397800+111517_553-112576Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000492345+113517_553-229576Zinc fingerMYND-type


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FusionGeneSequence for CBFA2T2_ACOX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CBFA2T2_ENST00000342704_chr20_32078107_+_ACOX1_ENST00000293217_chr17_73953647_-_529aa
MVGVPGAAAFQRTHLRGLETTATYDPETQEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITKGKCYGLHAFIVPIREIGTHKPLPGIT
VGDIGPKFGYDEIDNGYLKMDNHRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGEAARALSKACTIAIRYSAVRHQSEI
KPGEPEPQILDFQTQQYKLFPLLATAYAFQFVGAYMKETYHRINEGIGQGDLSELPELHALTAGLKAFTSWTANTGIEACRMACGGHGYS
HCSGLPNIYVNFTPSCTFEGENTVMMLQTARFLMKSYDQVHSGKLVCGMVSYLNDLPSQRIQPQQVAVWPTMVDINSPESLTEAYKLRAA
RLVEIAAKNLQKEVIHRKSKEVAWNLTSVDLVRASEAHCHYVVVKLFSEKLLKIQDKAIQAVLRSLCLLYSLYGISQNAGDFLQGSIMTE

>In-frame_CBFA2T2_ENST00000342704_chr20_32078107_+_ACOX1_ENST00000537812_chr17_73953647_-_529aa
MVGVPGAAAFQRTHLRGLETTATYDPETQEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITKGKCYGLHAFIVPIREIGTHKPLPGIT
VGDIGPKFGYDEIDNGYLKMDNHRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGEAARALSKACTIAIRYSAVRHQSEI
KPGEPEPQILDFQTQQYKLFPLLATAYAFQFVGAYMKETYHRINEGIGQGDLSELPELHALTAGLKAFTSWTANTGIEACRMACGGHGYS
HCSGLPNIYVNFTPSCTFEGENTVMMLQTARFLMKSYDQVHSGKLVCGMVSYLNDLPSQRIQPQQVAVWPTMVDINSPESLTEAYKLRAA
RLVEIAAKNLQKEVIHRKSKEVAWNLTSVDLVRASEAHCHYVVVKLFSEKLLKIQDKAIQAVLRSLCLLYSLYGISQNAGDFLQGSIMTE

>In-frame_CBFA2T2_ENST00000342704_chr20_32078107_+_ACOX1_ENST00000301608_chr17_73953647_-_529aa
MVGVPGAAAFQRTHLRGLETTATYDPETQEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITKGKCYGLHAFIVPIREIGTHKPLPGIT
VGDIGPKFGYDEIDNGYLKMDNHRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGEAARALSKACTIAIRYSAVRHQSEI
KPGEPEPQILDFQTQQYKLFPLLATAYAFQFVGAYMKETYHRINEGIGQGDLSELPELHALTAGLKAFTSWTANTGIEACRMACGGHGYS
HCSGLPNIYVNFTPSCTFEGENTVMMLQTARFLMKSYDQVHSGKLVCGMVSYLNDLPSQRIQPQQVAVWPTMVDINSPESLTEAYKLRAA
RLVEIAAKNLQKEVIHRKSKEVAWNLTSVDLVRASEAHCHYVVVKLFSEKLLKIQDKAIQAVLRSLCLLYSLYGISQNAGDFLQGSIMTE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CBFA2T2_ENST00000342704_chr20_32078107_+_ACOX1_ENST00000293217_chr17_73953647_-_1587nt
ATGGTAGGCGTCCCTGGAGCGGCCGCCTTCCAGCGAACTCACCTTCGAGGCTTGGAAACCACAGCCACGTATGACCCTGAAACCCAGGAG
TTCATTCTCAACAGTCCTACTGTGACCTCCATTAAATGGTGGCCTGGTGGGCTTGGAAAGACTTCAAATCATGCAATAGTTCTTGCCCAG
CTCATCACTAAGGGGAAATGCTATGGATTACATGCCTTTATCGTACCTATTCGTGAAATCGGGACCCATAAGCCTTTGCCAGGAATTACC
GTTGGTGACATCGGCCCCAAATTTGGTTATGATGAGATAGACAATGGCTACCTCAAAATGGACAACCATCGTATTCCCAGAGAAAACATG
CTGATGAAGTATGCCCAGGTGAAGCCTGATGGCACATACGTGAAACCGCTGAGTAACAAGCTGACTTACGGGACCATGGTGTTTGTCAGG
TCCTTCCTTGTGGGAGAAGCTGCTCGGGCTCTGTCTAAGGCGTGCACCATTGCCATCCGATACAGCGCTGTGAGGCACCAGTCTGAAATC
AAGCCAGGTGAACCAGAACCACAGATTTTGGATTTTCAAACCCAGCAGTATAAACTCTTTCCACTCCTGGCCACTGCCTATGCCTTCCAG
TTTGTGGGCGCATACATGAAGGAGACCTATCACCGGATTAACGAAGGCATTGGTCAAGGGGACCTGAGTGAACTGCCTGAGCTTCATGCC
CTCACCGCTGGACTGAAGGCTTTCACCTCCTGGACTGCAAACACTGGCATTGAAGCATGTCGGATGGCTTGTGGTGGGCATGGCTATTCT
CATTGCAGTGGTCTTCCAAATATTTATGTCAATTTCACCCCAAGCTGTACCTTTGAGGGAGAAAACACTGTCATGATGCTCCAGACGGCT
AGGTTCCTGATGAAAAGTTATGATCAGGTGCACTCAGGAAAGTTGGTGTGTGGCATGGTGTCCTATTTGAACGACCTGCCCAGTCAGCGC
ATCCAGCCACAGCAGGTAGCAGTCTGGCCAACCATGGTGGATATCAACAGCCCCGAAAGCCTAACCGAAGCATATAAACTCCGTGCAGCC
AGATTAGTAGAAATTGCTGCAAAAAACCTTCAAAAAGAAGTGATTCACAGAAAAAGCAAGGAGGTAGCTTGGAACCTAACTTCTGTTGAC
CTTGTTCGAGCAAGTGAGGCACATTGCCACTATGTGGTAGTTAAGCTCTTTTCAGAAAAACTCCTCAAAATTCAAGATAAAGCCATTCAA
GCTGTCTTAAGGAGTTTATGTCTGCTGTATTCTCTGTATGGAATCAGTCAGAACGCGGGGGATTTCCTTCAGGGGAGCATCATGACAGAG
CCTCAGATTACACAAGTAAACCAGCGTGTAAAGGAGTTACTCACTCTGATTCGCTCAGATGCTGTTGCTTTGGTTGATGCATTTGATTTT
CAGGATGTGACACTTGGCTCTGTGCTTGGCCGCTATGATGGGAATGTGTATGAAAACTTGTTTGAGTGGGCTAAGAACTCCCCACTGAAC

>In-frame_CBFA2T2_ENST00000342704_chr20_32078107_+_ACOX1_ENST00000537812_chr17_73953647_-_1587nt
ATGGTAGGCGTCCCTGGAGCGGCCGCCTTCCAGCGAACTCACCTTCGAGGCTTGGAAACCACAGCCACGTATGACCCTGAAACCCAGGAG
TTCATTCTCAACAGTCCTACTGTGACCTCCATTAAATGGTGGCCTGGTGGGCTTGGAAAGACTTCAAATCATGCAATAGTTCTTGCCCAG
CTCATCACTAAGGGGAAATGCTATGGATTACATGCCTTTATCGTACCTATTCGTGAAATCGGGACCCATAAGCCTTTGCCAGGAATTACC
GTTGGTGACATCGGCCCCAAATTTGGTTATGATGAGATAGACAATGGCTACCTCAAAATGGACAACCATCGTATTCCCAGAGAAAACATG
CTGATGAAGTATGCCCAGGTGAAGCCTGATGGCACATACGTGAAACCGCTGAGTAACAAGCTGACTTACGGGACCATGGTGTTTGTCAGG
TCCTTCCTTGTGGGAGAAGCTGCTCGGGCTCTGTCTAAGGCGTGCACCATTGCCATCCGATACAGCGCTGTGAGGCACCAGTCTGAAATC
AAGCCAGGTGAACCAGAACCACAGATTTTGGATTTTCAAACCCAGCAGTATAAACTCTTTCCACTCCTGGCCACTGCCTATGCCTTCCAG
TTTGTGGGCGCATACATGAAGGAGACCTATCACCGGATTAACGAAGGCATTGGTCAAGGGGACCTGAGTGAACTGCCTGAGCTTCATGCC
CTCACCGCTGGACTGAAGGCTTTCACCTCCTGGACTGCAAACACTGGCATTGAAGCATGTCGGATGGCTTGTGGTGGGCATGGCTATTCT
CATTGCAGTGGTCTTCCAAATATTTATGTCAATTTCACCCCAAGCTGTACCTTTGAGGGAGAAAACACTGTCATGATGCTCCAGACGGCT
AGGTTCCTGATGAAAAGTTATGATCAGGTGCACTCAGGAAAGTTGGTGTGTGGCATGGTGTCCTATTTGAACGACCTGCCCAGTCAGCGC
ATCCAGCCACAGCAGGTAGCAGTCTGGCCAACCATGGTGGATATCAACAGCCCCGAAAGCCTAACCGAAGCATATAAACTCCGTGCAGCC
AGATTAGTAGAAATTGCTGCAAAAAACCTTCAAAAAGAAGTGATTCACAGAAAAAGCAAGGAGGTAGCTTGGAACCTAACTTCTGTTGAC
CTTGTTCGAGCAAGTGAGGCACATTGCCACTATGTGGTAGTTAAGCTCTTTTCAGAAAAACTCCTCAAAATTCAAGATAAAGCCATTCAA
GCTGTCTTAAGGAGTTTATGTCTGCTGTATTCTCTGTATGGAATCAGTCAGAACGCGGGGGATTTCCTTCAGGGGAGCATCATGACAGAG
CCTCAGATTACACAAGTAAACCAGCGTGTAAAGGAGTTACTCACTCTGATTCGCTCAGATGCTGTTGCTTTGGTTGATGCATTTGATTTT
CAGGATGTGACACTTGGCTCTGTGCTTGGCCGCTATGATGGGAATGTGTATGAAAACTTGTTTGAGTGGGCTAAGAACTCCCCACTGAAC

>In-frame_CBFA2T2_ENST00000342704_chr20_32078107_+_ACOX1_ENST00000301608_chr17_73953647_-_1587nt
ATGGTAGGCGTCCCTGGAGCGGCCGCCTTCCAGCGAACTCACCTTCGAGGCTTGGAAACCACAGCCACGTATGACCCTGAAACCCAGGAG
TTCATTCTCAACAGTCCTACTGTGACCTCCATTAAATGGTGGCCTGGTGGGCTTGGAAAGACTTCAAATCATGCAATAGTTCTTGCCCAG
CTCATCACTAAGGGGAAATGCTATGGATTACATGCCTTTATCGTACCTATTCGTGAAATCGGGACCCATAAGCCTTTGCCAGGAATTACC
GTTGGTGACATCGGCCCCAAATTTGGTTATGATGAGATAGACAATGGCTACCTCAAAATGGACAACCATCGTATTCCCAGAGAAAACATG
CTGATGAAGTATGCCCAGGTGAAGCCTGATGGCACATACGTGAAACCGCTGAGTAACAAGCTGACTTACGGGACCATGGTGTTTGTCAGG
TCCTTCCTTGTGGGAGAAGCTGCTCGGGCTCTGTCTAAGGCGTGCACCATTGCCATCCGATACAGCGCTGTGAGGCACCAGTCTGAAATC
AAGCCAGGTGAACCAGAACCACAGATTTTGGATTTTCAAACCCAGCAGTATAAACTCTTTCCACTCCTGGCCACTGCCTATGCCTTCCAG
TTTGTGGGCGCATACATGAAGGAGACCTATCACCGGATTAACGAAGGCATTGGTCAAGGGGACCTGAGTGAACTGCCTGAGCTTCATGCC
CTCACCGCTGGACTGAAGGCTTTCACCTCCTGGACTGCAAACACTGGCATTGAAGCATGTCGGATGGCTTGTGGTGGGCATGGCTATTCT
CATTGCAGTGGTCTTCCAAATATTTATGTCAATTTCACCCCAAGCTGTACCTTTGAGGGAGAAAACACTGTCATGATGCTCCAGACGGCT
AGGTTCCTGATGAAAAGTTATGATCAGGTGCACTCAGGAAAGTTGGTGTGTGGCATGGTGTCCTATTTGAACGACCTGCCCAGTCAGCGC
ATCCAGCCACAGCAGGTAGCAGTCTGGCCAACCATGGTGGATATCAACAGCCCCGAAAGCCTAACCGAAGCATATAAACTCCGTGCAGCC
AGATTAGTAGAAATTGCTGCAAAAAACCTTCAAAAAGAAGTGATTCACAGAAAAAGCAAGGAGGTAGCTTGGAACCTAACTTCTGTTGAC
CTTGTTCGAGCAAGTGAGGCACATTGCCACTATGTGGTAGTTAAGCTCTTTTCAGAAAAACTCCTCAAAATTCAAGATAAAGCCATTCAA
GCTGTCTTAAGGAGTTTATGTCTGCTGTATTCTCTGTATGGAATCAGTCAGAACGCGGGGGATTTCCTTCAGGGGAGCATCATGACAGAG
CCTCAGATTACACAAGTAAACCAGCGTGTAAAGGAGTTACTCACTCTGATTCGCTCAGATGCTGTTGCTTTGGTTGATGCATTTGATTTT
CAGGATGTGACACTTGGCTCTGTGCTTGGCCGCTATGATGGGAATGTGTATGAAAACTTGTTTGAGTGGGCTAAGAACTCCCCACTGAAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_CBFA2T2_ENST00000342704_chr20_32078107_+_ACOX1_ENST00000293217_chr17_73953647_-_7009nt
AACGGCGGCGGCGGCGGCGGCGACGGCGACAGCAGCGGTGGTGGTGTCTGGTTAGCTCGGCGGCTGCAGATCTCGCGGCGACGCCTGCGA
GGGACCCGGGCCGCGGGTCGAGGCGGGCGGCGCCTGCGAGGGACCCGTGTCGCGGGTAGAGGCGGGCGGCGCGCGGCGGCGGCGCTCGGC
GATGGTAGGCGTCCCTGGAGCGGCCGCCTTCCAGCGAACTCACCTTCGAGGCTTGGAAACCACAGCCACGTATGACCCTGAAACCCAGGA
GTTCATTCTCAACAGTCCTACTGTGACCTCCATTAAATGGTGGCCTGGTGGGCTTGGAAAGACTTCAAATCATGCAATAGTTCTTGCCCA
GCTCATCACTAAGGGGAAATGCTATGGATTACATGCCTTTATCGTACCTATTCGTGAAATCGGGACCCATAAGCCTTTGCCAGGAATTAC
CGTTGGTGACATCGGCCCCAAATTTGGTTATGATGAGATAGACAATGGCTACCTCAAAATGGACAACCATCGTATTCCCAGAGAAAACAT
GCTGATGAAGTATGCCCAGGTGAAGCCTGATGGCACATACGTGAAACCGCTGAGTAACAAGCTGACTTACGGGACCATGGTGTTTGTCAG
GTCCTTCCTTGTGGGAGAAGCTGCTCGGGCTCTGTCTAAGGCGTGCACCATTGCCATCCGATACAGCGCTGTGAGGCACCAGTCTGAAAT
CAAGCCAGGTGAACCAGAACCACAGATTTTGGATTTTCAAACCCAGCAGTATAAACTCTTTCCACTCCTGGCCACTGCCTATGCCTTCCA
GTTTGTGGGCGCATACATGAAGGAGACCTATCACCGGATTAACGAAGGCATTGGTCAAGGGGACCTGAGTGAACTGCCTGAGCTTCATGC
CCTCACCGCTGGACTGAAGGCTTTCACCTCCTGGACTGCAAACACTGGCATTGAAGCATGTCGGATGGCTTGTGGTGGGCATGGCTATTC
TCATTGCAGTGGTCTTCCAAATATTTATGTCAATTTCACCCCAAGCTGTACCTTTGAGGGAGAAAACACTGTCATGATGCTCCAGACGGC
TAGGTTCCTGATGAAAAGTTATGATCAGGTGCACTCAGGAAAGTTGGTGTGTGGCATGGTGTCCTATTTGAACGACCTGCCCAGTCAGCG
CATCCAGCCACAGCAGGTAGCAGTCTGGCCAACCATGGTGGATATCAACAGCCCCGAAAGCCTAACCGAAGCATATAAACTCCGTGCAGC
CAGATTAGTAGAAATTGCTGCAAAAAACCTTCAAAAAGAAGTGATTCACAGAAAAAGCAAGGAGGTAGCTTGGAACCTAACTTCTGTTGA
CCTTGTTCGAGCAAGTGAGGCACATTGCCACTATGTGGTAGTTAAGCTCTTTTCAGAAAAACTCCTCAAAATTCAAGATAAAGCCATTCA
AGCTGTCTTAAGGAGTTTATGTCTGCTGTATTCTCTGTATGGAATCAGTCAGAACGCGGGGGATTTCCTTCAGGGGAGCATCATGACAGA
GCCTCAGATTACACAAGTAAACCAGCGTGTAAAGGAGTTACTCACTCTGATTCGCTCAGATGCTGTTGCTTTGGTTGATGCATTTGATTT
TCAGGATGTGACACTTGGCTCTGTGCTTGGCCGCTATGATGGGAATGTGTATGAAAACTTGTTTGAGTGGGCTAAGAACTCCCCACTGAA
CAAAGCAGAGGTCCACGAATCTTACAAGCACCTGAAGTCACTGCAGTCCAAGCTCTGAAGTGTCACAAGGACAAGTTTAATCTGCTTCAG
AAAGCGCCTGTGTGCAACTCAAATTTTGTGGAATCTTTTTCGAATTCAAATAGCTATAGAGCAAATGATAAATTGACCCCTTTTTATAAA
TGGAGGGAAAAAATGAACAGATTTCAGAGATTAAATGAAAAAAAGCAGATGTTTTAAGTGCAATTAACACTGAAAGAGACCTGTTAAACC
ATTCAGAAAAAGCTTAAGAAATGCGATATGACTTCCTTTTGTAATGCTGCTGATCCCAGTAGACTATGACTTTTGATAATTAGCAGAATT
TAACTACTGAGTAGTTGATTATTTTCACATTTTAATTGCTAATCACTGGCTATATAAGTGTTTTTAAGCAAAGGTATTTTTGAAGTGGTG
TAGAACCCTTCCAAGCTTTCCTGCTCAGTGTTCTACCAGACTTACCCTGGGGCCTGGCTTAAAAGCAGGATTGAAGAAAAGGGACTGGGG
GAAGGAAACTTATTGGAAAACTTGATGCGAATGAGTTTCTGCTTGGCACAGTCTCTGCCTGCTTGCTCTCCTTTGCTGATGGATTGCATT
TATCAAACTATTCATGCTAGCATTTTTCCAACGAGGGAACTTATTCCGCACGGGCCTACTGTAGGACCATTGTCTCGTGTAATTAGGAAT
TTTCCATTTGAAGGATTGCTAAATTGTCACAGTAGTAGGAAGTATAGGGAAACCTCTCAGCTGTGGCACTGTTGTAGCTTTGGAGTGCAG
AGTGTAACTCTGGGACAATCAGATTTCACATATTCTGTCATCTTGGCATAAGCCATTAAAAGCTTGGAGATTACTGTATTTGGCATTAAA
AAAAAATGTCACTTAGGTCAGCACTCCCAGACGTAGCACAGAAAAACCCTTTGACACAAACCATGTGTTCTGATTTTTGGTTCAGAAAAT
ATTGAAACTGTGAGTTGTTTTTTTTTTAACAACTGGGAAAAAACAAAAACAAAAAACTATAGTTAGAAAAATGGAAGTTCCATAGGTTCT
ATTTCTTACTCTATGTATGGCTTTGTTTTCAGTCTATTTCTAGGAGCTTTCTCTGAATCGCTAATTGTCCTTTCAGTTGAAATCTAATTT
ATACAATCATTCTATACTTAAAGGTTAAATACATCTTAATTAATTTTTTCTTAAAGTCAATGTAAGTCACTTTGTTTTGTTTTTTTTTAA
TCTACGCCATATGCCTCATGAAACCAGCTGTTCTAGAATCAGTCCTGAGAATATGGCTTAATTCCATGGAAACATAACTCCTATCTTGGG
ACCTGACATAATATCTATCTATCCTGGGGAACTGGTAATATGAGACTTATAGGTTACAGCAGAAATGCTACATGTTGACAAAAGCCTTAA
TCGTTCCACTGGGAGAACTAATTGATAATTGTGTTAAGATTGAAGATTAACCCTGTGTTAATCTCACTTGAGTCTATCCTGACAGTAGTT
CAGATTCTGGAAAATGATAAACTGACCTGCTAGATGTAGAATTGTTTCAAAATTAGTGTTGAAATACCTTGTTCACAGATGAATATCTGG
GCAGGATCTGAGGGTGTTTGGAATGACACCCCCCAATCCAGTTGCATAGATGGGATGTCTTTGCAGGTTTGAGGAGATCATCGACCTGCA
GAGCCCCCTTTGACCCAGTACCTCACGTTTTATTTAAAATCTAAATCTGGGGCCAGGCGTGGTGGCTCACGCCTGTAATCCAAGCACTTT
GGGAGGCCGAAGCGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCATCCTGGCCAACATGGTGAAACCCCGTCTCTACTGAAAAAAATA
CAAAAATTAGCTGGGCATGGTGGTAGCACGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGATAATCGCTTGAACTTGGCGGGT
AGAGGTTGCAGTGAGCCAAGATGGTGCCACTACACTGCAGCCTGGGTGGCTGAGCGAGACTCCGTCTCAAAAAAAAAATCTAAATCTGAC
ATTTGATGCTATTTTTATTAATATTGGAATGTTCTGTCTTGAACTTTATTCAATATAATCAAGAATAAAGATAGAGTAAACGTCACTGAT
TTGTACTATTAAGAGAGAAAAAATATGCCACACAACTAAACATAGGTTTAAATTATGAAGAAATTTAGAATAGAGGTTTATTAGATTTAG
GGAACACTAAGAACAAAAAAGGAAGGAGTGATACCTGCCTGAGTGGACAGCTGTAAATCAGCTGTAATTACTGCAGTTGTACCAATAGTT
GTGAGTGGCTCCAGTCACTTTAGGAGTCCTTGGAAGTACTTGGTACACATTTGTTGGCTGTACCTTAAAGGAAGTGGCAAGTCCAGTTTG
TTCTCTCTACCACACTAGACTGCCACTGACAAGTTTGGGTCTGTTGGATTCAAAATTTTGTAAGCCATTTTCACAAGTACAAAGATACAT
TTTAACCTTGTCTTCTCCAAAATTACTGAGTAGGAATTTTATTTTTATCTTTTTGAGACAGGGTATCACTGTCACCCAGACTGGAGTGCA
GTGGTGGGATCTTGGCTTACTGTGACCTCTGCCTCCCGGGTTCAAATGGTCCTCCCTCCTCAGTCTCCTGAGTAGCTGGGACGACAGGCA
CGTGCCACCATGCCCAGCTAATTTGTTCTATTTTTTCTGTAGAGACGGGGTTTTGCCATGTTGCCCAGGCTGGTCTCAGACTCCTGGGCT
CAAGCGATCATTTCGCCTCAGCCTCCCAAAGTGCTGAGATTATAGGTGTGAGCCACAGCATCTGGCCCAGAGTGAGGAGAATTAATGAGA
TTTTTTGTGTGTGTTAGATAATATTGATTTAAGCCTTTTTTTAAAAAGTACTCTCAACCAAATACAAAATTGAAAATGTGAGGTTTAATA
GAAATGTGTTGGCTATTTGCAATGGATTTTCTTCTTGCCCAAGTGTTTGGAGTTCTACTTTATGCTCTGTATTTAAAAATTAGTGACCTC
AAAGCAGAGTTGATGACACAGGCTTTGGGGCCCTCATGTTCTTGTCTTTAGAACATATCACTACTAAGTATCAGCTTATCTTCAGAACAT
TACAACATTCACCGTGTTCATATGCTTTCTGAGAAGTCACCACTTGTAATTTCAGATCACATACACCTGAAGGCATTTTATAGTTCCTAA
AGTTAACATGTTAGATCTTTTTTTTCCACCCCATGAGGGTCTCACTCTCACCCAGGCTGGAATGCAGTGGTGTGATTGTAGCACACTTTG
GCCACCAACTCCTGGGCTCAAGTGATCCTCCTGCTTTGGCCTCCTCTGAGAAGCTGGGATTACTGGTGCACACCACCACACCTGGCTAAT
TTTTTATTTTTTTTTATTTTTGGAAATAGGGTATGGCTATGTTGCCTTGGGCCCGTCATGAACTCCTAGCCTCAGGTGACCCTCCCACCT
CAGGCCTCCCAAAGGGTTGGGATTACAGGAGTGAGCTACTGCACTGGGCCAACATGTTAATTTTTTTTTTTTTTTTTTTGAGATGGAGTC
TCCCAGGCGGGAATGCAATGGTGCGATCTCGACTTCACTGCAATCTTCACCTCCCGGGTTCGAGCGATTCTCCCACCTCAGCCTCCTGAG
TAGCTGGGATTACAGGCACCTGCCATCACGCTCGGCTAATTTTTGTATTTTGAGCAGAGATGGAGTTTCACCATGTTGGCCAGGTGATCT
GCACTCCCACTCCCCCCACACTTCCCAAAGTGCTGGGATTACAGGCATAAGCCACAAGCCACCTCACCCAGCCAACATGTTACATCTTAA
TTCTTGGATTTTCTTCACTGCAGGGCTTTGGGTGGAGAAATAAAACTCTTCAAATGCATGATCTTGGAGATCCCTGTGAATCAATAATTC
TTTAGACAACTGCGGCTCAAAATCCCTCCTTTCCCTTTTCCGAGTTATTCCATCCATCTTATTAGAAAGGAAGTGAATTAGGTGTAGGTG
GTCTGTAACACCTGCACATCTTTTTATACGTGTAGAGGGTATGCCTGGGATATATAGGTTGTCTTCAAGCAGTAGCTGCTACTACAGCTA
GAGAGAGGAGGAGTGCCAGGAAACTGATGACCTGAGACCAAGAGTCTTGTTGATGTTCTGACTTAGATAAAGGTTTTGATCATTTTCATG
AAATAATGCAGGGAAGTCATTTCTGCTGTTTCTTTACTACTCCATTCTTGGAGGATTAGAACAAGTCACACTGTAATTGACTAAAACGAC
TTTTTATTTTAAAATATTGATGGTGGGGTTTTGCTTTTTTTTTTTTTTTTTTTTTTGAGACGTTGTCTTGCTCTTTCACCCAGGGTAGAG
TGCAGTGGCGAAATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCTGCCTCAGCCTCCTGAGAAGCTGGGATTACAG
CGCCTGCCACCATGCCTGTCTAGTTTTTTTGTATTTTTAGTAGAGACAGGGGTTTCACCAAGTTGGCCAGGCTGGTCTTGAACTCCTGAC
CTCGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCGGGCCAGTGTTTTTAACTGTCCACACTT
ACTAAATTTTCCAGTACTTCTTCCTATGGTTCATGATAGTAAACACAGAAACATATAAGGAACATTATTAGAGTTACCAGATGTTAGCTG
TTGCATATGTGCACATTCCTAGATTCAAGGGTGTTTTTGCCTTAAATTTAAGTGGGTCATTGGTTGTCTTGGGAAGATCATGGAAAATTC
GGGATTTTTTAGAATTCTGAACCAAAATATGTTTTGAGTGTTTCTTAGTAAATGTGTGATCTTCCACCTTCCACATTCAGACTGCGGACT
ACACTTCATAAATGCCTTTTTATTTCCAGTTATGGATTCAACTAAATGACTGCCTTGGGAGCACATAATTACTTTGCTACCTTTTTCCCC
CTTTGCTGTTGTGGCTCGAGTTTGGTTCTCACCTGAGAAGATGCATTGAGCATATGTTGTTACCCAGCCCTGGCTTAATGGTGTCCTGTG
GGGTAGGGGTGGGAGGACGAGGGGCACGGGGCCAGAGCATGTGAATGGATCATGGTTGGACAGCTGTGACCTGCCAGCACTGCGGGTAAG

>In-frame_CBFA2T2_ENST00000342704_chr20_32078107_+_ACOX1_ENST00000537812_chr17_73953647_-_7001nt
AACGGCGGCGGCGGCGGCGGCGACGGCGACAGCAGCGGTGGTGGTGTCTGGTTAGCTCGGCGGCTGCAGATCTCGCGGCGACGCCTGCGA
GGGACCCGGGCCGCGGGTCGAGGCGGGCGGCGCCTGCGAGGGACCCGTGTCGCGGGTAGAGGCGGGCGGCGCGCGGCGGCGGCGCTCGGC
GATGGTAGGCGTCCCTGGAGCGGCCGCCTTCCAGCGAACTCACCTTCGAGGCTTGGAAACCACAGCCACGTATGACCCTGAAACCCAGGA
GTTCATTCTCAACAGTCCTACTGTGACCTCCATTAAATGGTGGCCTGGTGGGCTTGGAAAGACTTCAAATCATGCAATAGTTCTTGCCCA
GCTCATCACTAAGGGGAAATGCTATGGATTACATGCCTTTATCGTACCTATTCGTGAAATCGGGACCCATAAGCCTTTGCCAGGAATTAC
CGTTGGTGACATCGGCCCCAAATTTGGTTATGATGAGATAGACAATGGCTACCTCAAAATGGACAACCATCGTATTCCCAGAGAAAACAT
GCTGATGAAGTATGCCCAGGTGAAGCCTGATGGCACATACGTGAAACCGCTGAGTAACAAGCTGACTTACGGGACCATGGTGTTTGTCAG
GTCCTTCCTTGTGGGAGAAGCTGCTCGGGCTCTGTCTAAGGCGTGCACCATTGCCATCCGATACAGCGCTGTGAGGCACCAGTCTGAAAT
CAAGCCAGGTGAACCAGAACCACAGATTTTGGATTTTCAAACCCAGCAGTATAAACTCTTTCCACTCCTGGCCACTGCCTATGCCTTCCA
GTTTGTGGGCGCATACATGAAGGAGACCTATCACCGGATTAACGAAGGCATTGGTCAAGGGGACCTGAGTGAACTGCCTGAGCTTCATGC
CCTCACCGCTGGACTGAAGGCTTTCACCTCCTGGACTGCAAACACTGGCATTGAAGCATGTCGGATGGCTTGTGGTGGGCATGGCTATTC
TCATTGCAGTGGTCTTCCAAATATTTATGTCAATTTCACCCCAAGCTGTACCTTTGAGGGAGAAAACACTGTCATGATGCTCCAGACGGC
TAGGTTCCTGATGAAAAGTTATGATCAGGTGCACTCAGGAAAGTTGGTGTGTGGCATGGTGTCCTATTTGAACGACCTGCCCAGTCAGCG
CATCCAGCCACAGCAGGTAGCAGTCTGGCCAACCATGGTGGATATCAACAGCCCCGAAAGCCTAACCGAAGCATATAAACTCCGTGCAGC
CAGATTAGTAGAAATTGCTGCAAAAAACCTTCAAAAAGAAGTGATTCACAGAAAAAGCAAGGAGGTAGCTTGGAACCTAACTTCTGTTGA
CCTTGTTCGAGCAAGTGAGGCACATTGCCACTATGTGGTAGTTAAGCTCTTTTCAGAAAAACTCCTCAAAATTCAAGATAAAGCCATTCA
AGCTGTCTTAAGGAGTTTATGTCTGCTGTATTCTCTGTATGGAATCAGTCAGAACGCGGGGGATTTCCTTCAGGGGAGCATCATGACAGA
GCCTCAGATTACACAAGTAAACCAGCGTGTAAAGGAGTTACTCACTCTGATTCGCTCAGATGCTGTTGCTTTGGTTGATGCATTTGATTT
TCAGGATGTGACACTTGGCTCTGTGCTTGGCCGCTATGATGGGAATGTGTATGAAAACTTGTTTGAGTGGGCTAAGAACTCCCCACTGAA
CAAAGCAGAGGTCCACGAATCTTACAAGCACCTGAAGTCACTGCAGTCCAAGCTCTGAAGTGTCACAAGGACAAGTTTAATCTGCTTCAG
AAAGCGCCTGTGTGCAACTCAAATTTTGTGGAATCTTTTTCGAATTCAAATAGCTATAGAGCAAATGATAAATTGACCCCTTTTTATAAA
TGGAGGGAAAAAATGAACAGATTTCAGAGATTAAATGAAAAAAAGCAGATGTTTTAAGTGCAATTAACACTGAAAGAGACCTGTTAAACC
ATTCAGAAAAAGCTTAAGAAATGCGATATGACTTCCTTTTGTAATGCTGCTGATCCCAGTAGACTATGACTTTTGATAATTAGCAGAATT
TAACTACTGAGTAGTTGATTATTTTCACATTTTAATTGCTAATCACTGGCTATATAAGTGTTTTTAAGCAAAGGTATTTTTGAAGTGGTG
TAGAACCCTTCCAAGCTTTCCTGCTCAGTGTTCTACCAGACTTACCCTGGGGCCTGGCTTAAAAGCAGGATTGAAGAAAAGGGACTGGGG
GAAGGAAACTTATTGGAAAACTTGATGCGAATGAGTTTCTGCTTGGCACAGTCTCTGCCTGCTTGCTCTCCTTTGCTGATGGATTGCATT
TATCAAACTATTCATGCTAGCATTTTTCCAACGAGGGAACTTATTCCGCACGGGCCTACTGTAGGACCATTGTCTCGTGTAATTAGGAAT
TTTCCATTTGAAGGATTGCTAAATTGTCACAGTAGTAGGAAGTATAGGGAAACCTCTCAGCTGTGGCACTGTTGTAGCTTTGGAGTGCAG
AGTGTAACTCTGGGACAATCAGATTTCACATATTCTGTCATCTTGGCATAAGCCATTAAAAGCTTGGAGATTACTGTATTTGGCATTAAA
AAAAAATGTCACTTAGGTCAGCACTCCCAGACGTAGCACAGAAAAACCCTTTGACACAAACCATGTGTTCTGATTTTTGGTTCAGAAAAT
ATTGAAACTGTGAGTTGTTTTTTTTTTAACAACTGGGAAAAAACAAAAACAAAAAACTATAGTTAGAAAAATGGAAGTTCCATAGGTTCT
ATTTCTTACTCTATGTATGGCTTTGTTTTCAGTCTATTTCTAGGAGCTTTCTCTGAATCGCTAATTGTCCTTTCAGTTGAAATCTAATTT
ATACAATCATTCTATACTTAAAGGTTAAATACATCTTAATTAATTTTTTCTTAAAGTCAATGTAAGTCACTTTGTTTTGTTTTTTTTTAA
TCTACGCCATATGCCTCATGAAACCAGCTGTTCTAGAATCAGTCCTGAGAATATGGCTTAATTCCATGGAAACATAACTCCTATCTTGGG
ACCTGACATAATATCTATCTATCCTGGGGAACTGGTAATATGAGACTTATAGGTTACAGCAGAAATGCTACATGTTGACAAAAGCCTTAA
TCGTTCCACTGGGAGAACTAATTGATAATTGTGTTAAGATTGAAGATTAACCCTGTGTTAATCTCACTTGAGTCTATCCTGACAGTAGTT
CAGATTCTGGAAAATGATAAACTGACCTGCTAGATGTAGAATTGTTTCAAAATTAGTGTTGAAATACCTTGTTCACAGATGAATATCTGG
GCAGGATCTGAGGGTGTTTGGAATGACACCCCCCAATCCAGTTGCATAGATGGGATGTCTTTGCAGGTTTGAGGAGATCATCGACCTGCA
GAGCCCCCTTTGACCCAGTACCTCACGTTTTATTTAAAATCTAAATCTGGGGCCAGGCGTGGTGGCTCACGCCTGTAATCCAAGCACTTT
GGGAGGCCGAAGCGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCATCCTGGCCAACATGGTGAAACCCCGTCTCTACTGAAAAAAATA
CAAAAATTAGCTGGGCATGGTGGTAGCACGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGATAATCGCTTGAACTTGGCGGGT
AGAGGTTGCAGTGAGCCAAGATGGTGCCACTACACTGCAGCCTGGGTGGCTGAGCGAGACTCCGTCTCAAAAAAAAAATCTAAATCTGAC
ATTTGATGCTATTTTTATTAATATTGGAATGTTCTGTCTTGAACTTTATTCAATATAATCAAGAATAAAGATAGAGTAAACGTCACTGAT
TTGTACTATTAAGAGAGAAAAAATATGCCACACAACTAAACATAGGTTTAAATTATGAAGAAATTTAGAATAGAGGTTTATTAGATTTAG
GGAACACTAAGAACAAAAAAGGAAGGAGTGATACCTGCCTGAGTGGACAGCTGTAAATCAGCTGTAATTACTGCAGTTGTACCAATAGTT
GTGAGTGGCTCCAGTCACTTTAGGAGTCCTTGGAAGTACTTGGTACACATTTGTTGGCTGTACCTTAAAGGAAGTGGCAAGTCCAGTTTG
TTCTCTCTACCACACTAGACTGCCACTGACAAGTTTGGGTCTGTTGGATTCAAAATTTTGTAAGCCATTTTCACAAGTACAAAGATACAT
TTTAACCTTGTCTTCTCCAAAATTACTGAGTAGGAATTTTATTTTTATCTTTTTGAGACAGGGTATCACTGTCACCCAGACTGGAGTGCA
GTGGTGGGATCTTGGCTTACTGTGACCTCTGCCTCCCGGGTTCAAATGGTCCTCCCTCCTCAGTCTCCTGAGTAGCTGGGACGACAGGCA
CGTGCCACCATGCCCAGCTAATTTGTTCTATTTTTTCTGTAGAGACGGGGTTTTGCCATGTTGCCCAGGCTGGTCTCAGACTCCTGGGCT
CAAGCGATCATTTCGCCTCAGCCTCCCAAAGTGCTGAGATTATAGGTGTGAGCCACAGCATCTGGCCCAGAGTGAGGAGAATTAATGAGA
TTTTTTGTGTGTGTTAGATAATATTGATTTAAGCCTTTTTTTAAAAAGTACTCTCAACCAAATACAAAATTGAAAATGTGAGGTTTAATA
GAAATGTGTTGGCTATTTGCAATGGATTTTCTTCTTGCCCAAGTGTTTGGAGTTCTACTTTATGCTCTGTATTTAAAAATTAGTGACCTC
AAAGCAGAGTTGATGACACAGGCTTTGGGGCCCTCATGTTCTTGTCTTTAGAACATATCACTACTAAGTATCAGCTTATCTTCAGAACAT
TACAACATTCACCGTGTTCATATGCTTTCTGAGAAGTCACCACTTGTAATTTCAGATCACATACACCTGAAGGCATTTTATAGTTCCTAA
AGTTAACATGTTAGATCTTTTTTTTCCACCCCATGAGGGTCTCACTCTCACCCAGGCTGGAATGCAGTGGTGTGATTGTAGCACACTTTG
GCCACCAACTCCTGGGCTCAAGTGATCCTCCTGCTTTGGCCTCCTCTGAGAAGCTGGGATTACTGGTGCACACCACCACACCTGGCTAAT
TTTTTATTTTTTTTTATTTTTGGAAATAGGGTATGGCTATGTTGCCTTGGGCCCGTCATGAACTCCTAGCCTCAGGTGACCCTCCCACCT
CAGGCCTCCCAAAGGGTTGGGATTACAGGAGTGAGCTACTGCACTGGGCCAACATGTTAATTTTTTTTTTTTTTTTTTTGAGATGGAGTC
TCCCAGGCGGGAATGCAATGGTGCGATCTCGACTTCACTGCAATCTTCACCTCCCGGGTTCGAGCGATTCTCCCACCTCAGCCTCCTGAG
TAGCTGGGATTACAGGCACCTGCCATCACGCTCGGCTAATTTTTGTATTTTGAGCAGAGATGGAGTTTCACCATGTTGGCCAGGTGATCT
GCACTCCCACTCCCCCCACACTTCCCAAAGTGCTGGGATTACAGGCATAAGCCACAAGCCACCTCACCCAGCCAACATGTTACATCTTAA
TTCTTGGATTTTCTTCACTGCAGGGCTTTGGGTGGAGAAATAAAACTCTTCAAATGCATGATCTTGGAGATCCCTGTGAATCAATAATTC
TTTAGACAACTGCGGCTCAAAATCCCTCCTTTCCCTTTTCCGAGTTATTCCATCCATCTTATTAGAAAGGAAGTGAATTAGGTGTAGGTG
GTCTGTAACACCTGCACATCTTTTTATACGTGTAGAGGGTATGCCTGGGATATATAGGTTGTCTTCAAGCAGTAGCTGCTACTACAGCTA
GAGAGAGGAGGAGTGCCAGGAAACTGATGACCTGAGACCAAGAGTCTTGTTGATGTTCTGACTTAGATAAAGGTTTTGATCATTTTCATG
AAATAATGCAGGGAAGTCATTTCTGCTGTTTCTTTACTACTCCATTCTTGGAGGATTAGAACAAGTCACACTGTAATTGACTAAAACGAC
TTTTTATTTTAAAATATTGATGGTGGGGTTTTGCTTTTTTTTTTTTTTTTTTTTTTGAGACGTTGTCTTGCTCTTTCACCCAGGGTAGAG
TGCAGTGGCGAAATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCTGCCTCAGCCTCCTGAGAAGCTGGGATTACAG
CGCCTGCCACCATGCCTGTCTAGTTTTTTTGTATTTTTAGTAGAGACAGGGGTTTCACCAAGTTGGCCAGGCTGGTCTTGAACTCCTGAC
CTCGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCGGGCCAGTGTTTTTAACTGTCCACACTT
ACTAAATTTTCCAGTACTTCTTCCTATGGTTCATGATAGTAAACACAGAAACATATAAGGAACATTATTAGAGTTACCAGATGTTAGCTG
TTGCATATGTGCACATTCCTAGATTCAAGGGTGTTTTTGCCTTAAATTTAAGTGGGTCATTGGTTGTCTTGGGAAGATCATGGAAAATTC
GGGATTTTTTAGAATTCTGAACCAAAATATGTTTTGAGTGTTTCTTAGTAAATGTGTGATCTTCCACCTTCCACATTCAGACTGCGGACT
ACACTTCATAAATGCCTTTTTATTTCCAGTTATGGATTCAACTAAATGACTGCCTTGGGAGCACATAATTACTTTGCTACCTTTTTCCCC
CTTTGCTGTTGTGGCTCGAGTTTGGTTCTCACCTGAGAAGATGCATTGAGCATATGTTGTTACCCAGCCCTGGCTTAATGGTGTCCTGTG
GGGTAGGGGTGGGAGGACGAGGGGCACGGGGCCAGAGCATGTGAATGGATCATGGTTGGACAGCTGTGACCTGCCAGCACTGCGGGTAAG

>In-frame_CBFA2T2_ENST00000342704_chr20_32078107_+_ACOX1_ENST00000301608_chr17_73953647_-_1939nt
AACGGCGGCGGCGGCGGCGGCGACGGCGACAGCAGCGGTGGTGGTGTCTGGTTAGCTCGGCGGCTGCAGATCTCGCGGCGACGCCTGCGA
GGGACCCGGGCCGCGGGTCGAGGCGGGCGGCGCCTGCGAGGGACCCGTGTCGCGGGTAGAGGCGGGCGGCGCGCGGCGGCGGCGCTCGGC
GATGGTAGGCGTCCCTGGAGCGGCCGCCTTCCAGCGAACTCACCTTCGAGGCTTGGAAACCACAGCCACGTATGACCCTGAAACCCAGGA
GTTCATTCTCAACAGTCCTACTGTGACCTCCATTAAATGGTGGCCTGGTGGGCTTGGAAAGACTTCAAATCATGCAATAGTTCTTGCCCA
GCTCATCACTAAGGGGAAATGCTATGGATTACATGCCTTTATCGTACCTATTCGTGAAATCGGGACCCATAAGCCTTTGCCAGGAATTAC
CGTTGGTGACATCGGCCCCAAATTTGGTTATGATGAGATAGACAATGGCTACCTCAAAATGGACAACCATCGTATTCCCAGAGAAAACAT
GCTGATGAAGTATGCCCAGGTGAAGCCTGATGGCACATACGTGAAACCGCTGAGTAACAAGCTGACTTACGGGACCATGGTGTTTGTCAG
GTCCTTCCTTGTGGGAGAAGCTGCTCGGGCTCTGTCTAAGGCGTGCACCATTGCCATCCGATACAGCGCTGTGAGGCACCAGTCTGAAAT
CAAGCCAGGTGAACCAGAACCACAGATTTTGGATTTTCAAACCCAGCAGTATAAACTCTTTCCACTCCTGGCCACTGCCTATGCCTTCCA
GTTTGTGGGCGCATACATGAAGGAGACCTATCACCGGATTAACGAAGGCATTGGTCAAGGGGACCTGAGTGAACTGCCTGAGCTTCATGC
CCTCACCGCTGGACTGAAGGCTTTCACCTCCTGGACTGCAAACACTGGCATTGAAGCATGTCGGATGGCTTGTGGTGGGCATGGCTATTC
TCATTGCAGTGGTCTTCCAAATATTTATGTCAATTTCACCCCAAGCTGTACCTTTGAGGGAGAAAACACTGTCATGATGCTCCAGACGGC
TAGGTTCCTGATGAAAAGTTATGATCAGGTGCACTCAGGAAAGTTGGTGTGTGGCATGGTGTCCTATTTGAACGACCTGCCCAGTCAGCG
CATCCAGCCACAGCAGGTAGCAGTCTGGCCAACCATGGTGGATATCAACAGCCCCGAAAGCCTAACCGAAGCATATAAACTCCGTGCAGC
CAGATTAGTAGAAATTGCTGCAAAAAACCTTCAAAAAGAAGTGATTCACAGAAAAAGCAAGGAGGTAGCTTGGAACCTAACTTCTGTTGA
CCTTGTTCGAGCAAGTGAGGCACATTGCCACTATGTGGTAGTTAAGCTCTTTTCAGAAAAACTCCTCAAAATTCAAGATAAAGCCATTCA
AGCTGTCTTAAGGAGTTTATGTCTGCTGTATTCTCTGTATGGAATCAGTCAGAACGCGGGGGATTTCCTTCAGGGGAGCATCATGACAGA
GCCTCAGATTACACAAGTAAACCAGCGTGTAAAGGAGTTACTCACTCTGATTCGCTCAGATGCTGTTGCTTTGGTTGATGCATTTGATTT
TCAGGATGTGACACTTGGCTCTGTGCTTGGCCGCTATGATGGGAATGTGTATGAAAACTTGTTTGAGTGGGCTAAGAACTCCCCACTGAA
CAAAGCAGAGGTCCACGAATCTTACAAGCACCTGAAGTCACTGCAGTCCAAGCTCTGAAGTGTCACAAGGACAAGTTTAATCTGCTTCAG
AAAGCGCCTGTGTGCAACTCAAATTTTGTGGAATCTTTTTCGAATTCAAATAGCTATAGAGCAAATGATAAATTGACCCCTTTTTATAAA


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FusionGenePPI for CBFA2T2_ACOX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CBFA2T2WDYHV1, MDFI, RUNX1T1, CBFA2T3, TAL1, RUNX1, GTF2E1, ID3, NEUROG1, TAL2, FBXL19, PRDM14, SIN3A, NCOR1, HDAC3, ATN1, ATXN1L, RERE, APP, LBP, TCP1, CBFA2T2, PDP1, NOTCH3, PRDM6, TCF4ACOX1SLC2A4, M6PR, PALLD, TMED9, MRPL12, ECI1, COX6B1, GRHPR, PEX5, TYSND1, GSTA1, RPLP0, FOXS1, DDX19B, MBNL2, PNMA1, UBE2D2, CAT, NUP62, PPWD1, RAF1, MCM2, ATOH1, UBA5, HRSP12, ACBD7, DUSP14, KHDRBS2, RAB30, RAB6B, BOC, RECK, ADAMTSL1, LACRT, FAM60A, HNRNPF, LITAF


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000342704+111107_21511596PRDM14
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000344201+16107_215-123264PRDM14
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000346541+112107_215-179605PRDM14
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000359606+111107_215-13615PRDM14
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000375279+112107_215-76605PRDM14
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397798+17107_215-208264PRDM14
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397800+111107_215-112576PRDM14
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000492345+113107_215-229576PRDM14


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CBFA2T2_ACOX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CBFA2T2_ACOX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneACOX1C2239176Liver carcinoma2CTD_human
TgeneACOX1C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneACOX1C1849678Peroxisomal ACYL-COA oxidase deficiency1CTD_human;ORPHANET;UNIPROT