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Fusion gene ID: 565 |
FusionGeneSummary for ACTG1_ZNF827 |
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Fusion gene information | Fusion gene name: ACTG1_ZNF827 | Fusion gene ID: 565 | Hgene | Tgene | Gene symbol | ACTG1 | ZNF827 | Gene ID | 71 | 152485 |
Gene name | actin gamma 1 | zinc finger protein 827 | |
Synonyms | ACT|ACTG|DFNA20|DFNA26|HEL-176 | - | |
Cytomap | 17q25.3 | 4q31.21-q31.22 | |
Type of gene | protein-coding | protein-coding | |
Description | actin, cytoplasmic 2cytoskeletal gamma-actinepididymis luminal protein 176 | zinc finger protein 827 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P63261 | Q17R98 | |
Ensembl transtripts involved in fusion gene | ENST00000331925, ENST00000573283, ENST00000575842, ENST00000575087, | ENST00000508784, ENST00000513320, ENST00000379448, ENST00000511534, | |
Fusion gene scores | * DoF score | 25 X 19 X 11=5225 | 10 X 4 X 7=280 |
# samples | 34 | 10 | |
** MAII score | log2(34/5225*10)=-3.94182438571791 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACTG1 [Title/Abstract] AND ZNF827 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-HC-7736-01A | ACTG1 | chr17 | 79476999 | - | ZNF827 | chr4 | 146859787 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000331925 | ENST00000508784 | ACTG1 | chr17 | 79476999 | - | ZNF827 | chr4 | 146859787 | - |
5CDS-intron | ENST00000331925 | ENST00000513320 | ACTG1 | chr17 | 79476999 | - | ZNF827 | chr4 | 146859787 | - |
5CDS-intron | ENST00000331925 | ENST00000379448 | ACTG1 | chr17 | 79476999 | - | ZNF827 | chr4 | 146859787 | - |
5CDS-intron | ENST00000331925 | ENST00000511534 | ACTG1 | chr17 | 79476999 | - | ZNF827 | chr4 | 146859787 | - |
intron-3CDS | ENST00000573283 | ENST00000508784 | ACTG1 | chr17 | 79476999 | - | ZNF827 | chr4 | 146859787 | - |
intron-intron | ENST00000573283 | ENST00000513320 | ACTG1 | chr17 | 79476999 | - | ZNF827 | chr4 | 146859787 | - |
intron-intron | ENST00000573283 | ENST00000379448 | ACTG1 | chr17 | 79476999 | - | ZNF827 | chr4 | 146859787 | - |
intron-intron | ENST00000573283 | ENST00000511534 | ACTG1 | chr17 | 79476999 | - | ZNF827 | chr4 | 146859787 | - |
intron-3CDS | ENST00000575842 | ENST00000508784 | ACTG1 | chr17 | 79476999 | - | ZNF827 | chr4 | 146859787 | - |
intron-intron | ENST00000575842 | ENST00000513320 | ACTG1 | chr17 | 79476999 | - | ZNF827 | chr4 | 146859787 | - |
intron-intron | ENST00000575842 | ENST00000379448 | ACTG1 | chr17 | 79476999 | - | ZNF827 | chr4 | 146859787 | - |
intron-intron | ENST00000575842 | ENST00000511534 | ACTG1 | chr17 | 79476999 | - | ZNF827 | chr4 | 146859787 | - |
intron-3CDS | ENST00000575087 | ENST00000508784 | ACTG1 | chr17 | 79476999 | - | ZNF827 | chr4 | 146859787 | - |
intron-intron | ENST00000575087 | ENST00000513320 | ACTG1 | chr17 | 79476999 | - | ZNF827 | chr4 | 146859787 | - |
intron-intron | ENST00000575087 | ENST00000379448 | ACTG1 | chr17 | 79476999 | - | ZNF827 | chr4 | 146859787 | - |
intron-intron | ENST00000575087 | ENST00000511534 | ACTG1 | chr17 | 79476999 | - | ZNF827 | chr4 | 146859787 | - |
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FusionProtFeatures for ACTG1_ZNF827 |
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Hgene | Tgene |
ACTG1 | ZNF827 |
Actins are highly conserved proteins that are involvedin various types of cell motility and are ubiquitously expressedin all eukaryotic cells. | May be involved in transcriptional regulation.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACTG1_ZNF827 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACTG1_ZNF827 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ACTG1 | CFL2, CFL1, ACTG1, ACTB, DSTN, CDH1, TMSB4X, FHOD1, EPS8L1, EPS8L2, FEZ1, CTNND1, ST3GAL3, SH3GL2, EIF6, PFN2, PRSS23, BCAP31, RBX1, MDK, CAP1, CAP2, RUVBL2, MEPCE, RUVBL1, MORF4L1, MORF4L2, MRGBP, DMAP1, KAT5, POU5F1, UCHL5, YWHAQ, DISC1, TNIK, RPS6KA5, MAPK6, NDRG1, SP1, UBE2Q2, FBXO25, MYOC, LRRK2, APOE, PSEN2, BRCA1, LIG4, TSGA10, TRAF3IP1, GZMK, GZMA, HSP90AA1, HSP90AB1, PPP1CC, MYC, MLH1, UBL4A, ITGA4, ILF3, AICDA, WIPF1, FN1, CTTN, ADRB2, PLD1, CTBP2, GIT2, GRB2, COTL1, WASL, FBXO6, TOPBP1, CDKN2A, ACTA1, ACTBL2, BRK1, HSPA5, UBASH3B, ERRFI1, LGR4, EHHADH, CCDC22, WDYHV1, CCDC101, CCDC8, EZH2, SUZ12, EED, RNF2, BMI1, FAF2, RPS6KB2, CORO1B, CORO1C, CAD, EEF1A1, EEF1A2, NCKAP1, RAN, YARS, SFN, HSPB2, SRPK2, HIST1H3E, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, VCL, IQGAP1, PDLIM7, LIMA1, ANLN, MYO5C, MYO19, MYO18A, TRAF2, VASP, GAN, MCM2, SHC1, ERBB3, RC3H1, DUSP19, C17orf89, MCPH1, HDAC6 | ZNF827 | PPP1CA, UBE2E1, ATP6V1E1, CHERP, VPS45, UNC80, HDAC1, GATAD2A, GATAD2B, RBBP7, RBBP4, CHD3, CHD4, MTA1, MTA2, MTA3, HDAC2, MCPH1, BRCA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACTG1_ZNF827 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ACTG1 | P63261 | DB11638 | Artenimol | Actin, cytoplasmic 2 | small molecule | approved|investigational |
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RelatedDiseases for ACTG1_ZNF827 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACTG1 | C1858172 | Deafness, Autosomal Dominant 20 | 5 | CTD_human;UNIPROT |
Hgene | ACTG1 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | ACTG1 | C0009363 | Congenital ocular coloboma (disorder) | 1 | CTD_human |
Hgene | ACTG1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | ACTG1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | ACTG1 | C0029456 | Osteoporosis | 1 | CTD_human |
Hgene | ACTG1 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Hgene | ACTG1 | C0497552 | Congenital neurologic anomalies | 1 | CTD_human |
Hgene | ACTG1 | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
Hgene | ACTG1 | C3281235 | BARAITSER-WINTER SYNDROME 2 | 1 | UNIPROT |