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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5623

FusionGeneSummary for CAST_NEK11

check button Fusion gene summary
Fusion gene informationFusion gene name: CAST_NEK11
Fusion gene ID: 5623
HgeneTgene
Gene symbol

CAST

NEK11

Gene ID

26059

79858

Gene nameELKS/RAB6-interacting/CAST family member 2NIMA related kinase 11
SynonymsCAST|CAST1|ELKSL|SPBC110|Spc110-
Cytomap

3p14.3

3q22.1

Type of geneprotein-codingprotein-coding
DescriptionERC protein 2CAZ-associated structural proteincytomatrix protein p110serine/threonine-protein kinase Nek11NIMA (never in mitosis gene a)- related kinase 11
Modification date2018051920180523
UniProtAcc

P20810

Q8NG66

Ensembl transtripts involved in fusion geneENST00000338252, ENST00000508830, 
ENST00000359176, ENST00000395812, 
ENST00000325674, ENST00000395813, 
ENST00000510756, ENST00000508608, 
ENST00000341926, ENST00000511049, 
ENST00000309190, ENST00000509903, 
ENST00000511782, ENST00000504465, 
ENST00000348386, ENST00000508579, 
ENST00000515663, 
ENST00000356918, 
ENST00000510769, ENST00000429253, 
ENST00000510688, ENST00000511262, 
ENST00000383366, ENST00000412440, 
ENST00000507910, ENST00000508196, 
ENST00000426022, 
Fusion gene scores* DoF score5 X 7 X 3=1054 X 3 X 4=48
# samples 74
** MAII scorelog2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAST [Title/Abstract] AND NEK11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNEK11

GO:0006468

protein phosphorylation

15161910|19734889

TgeneNEK11

GO:0031573

intra-S DNA damage checkpoint

15161910

TgeneNEK11

GO:0035556

intracellular signal transduction

15161910


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW995804CASTchr5

96084253

-NEK11chr3

131069219

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000338252ENST00000356918CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000338252ENST00000510769CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000338252ENST00000429253CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000338252ENST00000510688CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000338252ENST00000511262CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000338252ENST00000383366CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000338252ENST00000412440CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000338252ENST00000507910CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000338252ENST00000508196CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000338252ENST00000426022CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508830ENST00000356918CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508830ENST00000510769CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000508830ENST00000429253CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000508830ENST00000510688CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508830ENST00000511262CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000508830ENST00000383366CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508830ENST00000412440CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508830ENST00000507910CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508830ENST00000508196CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508830ENST00000426022CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000359176ENST00000356918CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000359176ENST00000510769CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000359176ENST00000429253CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000359176ENST00000510688CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000359176ENST00000511262CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000359176ENST00000383366CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000359176ENST00000412440CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000359176ENST00000507910CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000359176ENST00000508196CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000359176ENST00000426022CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000395812ENST00000356918CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000395812ENST00000510769CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000395812ENST00000429253CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000395812ENST00000510688CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000395812ENST00000511262CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000395812ENST00000383366CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000395812ENST00000412440CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000395812ENST00000507910CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000395812ENST00000508196CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000395812ENST00000426022CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000325674ENST00000356918CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000325674ENST00000510769CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000325674ENST00000429253CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000325674ENST00000510688CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000325674ENST00000511262CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000325674ENST00000383366CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000325674ENST00000412440CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000325674ENST00000507910CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000325674ENST00000508196CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000325674ENST00000426022CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000395813ENST00000356918CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000395813ENST00000510769CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000395813ENST00000429253CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000395813ENST00000510688CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000395813ENST00000511262CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000395813ENST00000383366CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000395813ENST00000412440CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000395813ENST00000507910CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000395813ENST00000508196CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000395813ENST00000426022CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000510756ENST00000356918CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000510756ENST00000510769CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000510756ENST00000429253CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000510756ENST00000510688CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000510756ENST00000511262CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000510756ENST00000383366CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000510756ENST00000412440CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000510756ENST00000507910CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000510756ENST00000508196CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000510756ENST00000426022CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508608ENST00000356918CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508608ENST00000510769CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000508608ENST00000429253CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000508608ENST00000510688CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508608ENST00000511262CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000508608ENST00000383366CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508608ENST00000412440CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508608ENST00000507910CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508608ENST00000508196CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508608ENST00000426022CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000341926ENST00000356918CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000341926ENST00000510769CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000341926ENST00000429253CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000341926ENST00000510688CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000341926ENST00000511262CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000341926ENST00000383366CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000341926ENST00000412440CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000341926ENST00000507910CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000341926ENST00000508196CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000341926ENST00000426022CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000511049ENST00000356918CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000511049ENST00000510769CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000511049ENST00000429253CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000511049ENST00000510688CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000511049ENST00000511262CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000511049ENST00000383366CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000511049ENST00000412440CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000511049ENST00000507910CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000511049ENST00000508196CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000511049ENST00000426022CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000309190ENST00000356918CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000309190ENST00000510769CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000309190ENST00000429253CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000309190ENST00000510688CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000309190ENST00000511262CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000309190ENST00000383366CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000309190ENST00000412440CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000309190ENST00000507910CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000309190ENST00000508196CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000309190ENST00000426022CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000509903ENST00000356918CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000509903ENST00000510769CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000509903ENST00000429253CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000509903ENST00000510688CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000509903ENST00000511262CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000509903ENST00000383366CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000509903ENST00000412440CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000509903ENST00000507910CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000509903ENST00000508196CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000509903ENST00000426022CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000511782ENST00000356918CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000511782ENST00000510769CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000511782ENST00000429253CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000511782ENST00000510688CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000511782ENST00000511262CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000511782ENST00000383366CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000511782ENST00000412440CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000511782ENST00000507910CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000511782ENST00000508196CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000511782ENST00000426022CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000504465ENST00000356918CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000504465ENST00000510769CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000504465ENST00000429253CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000504465ENST00000510688CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000504465ENST00000511262CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000504465ENST00000383366CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000504465ENST00000412440CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000504465ENST00000507910CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000504465ENST00000508196CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000504465ENST00000426022CASTchr5

96084253

-NEK11chr3

131069219

-
3UTR-intronENST00000348386ENST00000356918CASTchr5

96084253

-NEK11chr3

131069219

-
3UTR-intronENST00000348386ENST00000510769CASTchr5

96084253

-NEK11chr3

131069219

-
3UTR-3UTRENST00000348386ENST00000429253CASTchr5

96084253

-NEK11chr3

131069219

-
3UTR-3UTRENST00000348386ENST00000510688CASTchr5

96084253

-NEK11chr3

131069219

-
3UTR-intronENST00000348386ENST00000511262CASTchr5

96084253

-NEK11chr3

131069219

-
3UTR-3UTRENST00000348386ENST00000383366CASTchr5

96084253

-NEK11chr3

131069219

-
3UTR-intronENST00000348386ENST00000412440CASTchr5

96084253

-NEK11chr3

131069219

-
3UTR-intronENST00000348386ENST00000507910CASTchr5

96084253

-NEK11chr3

131069219

-
3UTR-intronENST00000348386ENST00000508196CASTchr5

96084253

-NEK11chr3

131069219

-
3UTR-intronENST00000348386ENST00000426022CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508579ENST00000356918CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508579ENST00000510769CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000508579ENST00000429253CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000508579ENST00000510688CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508579ENST00000511262CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-3UTRENST00000508579ENST00000383366CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508579ENST00000412440CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508579ENST00000507910CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508579ENST00000508196CASTchr5

96084253

-NEK11chr3

131069219

-
5CDS-intronENST00000508579ENST00000426022CASTchr5

96084253

-NEK11chr3

131069219

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5CDS-intronENST00000515663ENST00000356918CASTchr5

96084253

-NEK11chr3

131069219

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5CDS-intronENST00000515663ENST00000510769CASTchr5

96084253

-NEK11chr3

131069219

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5CDS-3UTRENST00000515663ENST00000429253CASTchr5

96084253

-NEK11chr3

131069219

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5CDS-3UTRENST00000515663ENST00000510688CASTchr5

96084253

-NEK11chr3

131069219

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5CDS-intronENST00000515663ENST00000511262CASTchr5

96084253

-NEK11chr3

131069219

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5CDS-3UTRENST00000515663ENST00000383366CASTchr5

96084253

-NEK11chr3

131069219

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5CDS-intronENST00000515663ENST00000412440CASTchr5

96084253

-NEK11chr3

131069219

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5CDS-intronENST00000515663ENST00000507910CASTchr5

96084253

-NEK11chr3

131069219

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5CDS-intronENST00000515663ENST00000508196CASTchr5

96084253

-NEK11chr3

131069219

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5CDS-intronENST00000515663ENST00000426022CASTchr5

96084253

-NEK11chr3

131069219

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FusionProtFeatures for CAST_NEK11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAST

P20810

NEK11

Q8NG66

Protein kinase which plays an important role in the G2/Mcheckpoint response to DNA damage. Controls degradation of CDC25Aby directly phosphorylating it on residues whose phosphorylationis required for BTRC-mediated polyubiquitination and degradation.{ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889,ECO:0000269|PubMed:20090422}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CAST_NEK11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CAST_NEK11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CAST_NEK11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCASTP20810DB11638ArtenimolCalpastatinsmall moleculeapproved|investigational
HgeneCASTP20810DB01373CalciumCalpastatinsmall moleculeapproved|nutraceutical
TgeneNEK11Q8NG66DB08912DabrafenibSerine/threonine-protein kinase Nek11small moleculeapproved|investigational

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RelatedDiseases for CAST_NEK11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCASTC0027540Necrosis1CTD_human
HgeneCASTC0162557Liver Failure, Acute1CTD_human