![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 5610 |
FusionGeneSummary for CASP8_ALS2CR12 |
![]() |
Fusion gene information | Fusion gene name: CASP8_ALS2CR12 | Fusion gene ID: 5610 | Hgene | Tgene | Gene symbol | CASP8 | ALS2CR12 | Gene ID | 841 | 130540 |
Gene name | caspase 8 | amyotrophic lateral sclerosis 2 chromosome region 12 | |
Synonyms | ALPS2B|CAP4|Casp-8|FLICE|MACH|MCH5 | - | |
Cytomap | 2q33.1 | 2q33.1 | |
Type of gene | protein-coding | protein-coding | |
Description | caspase-8FADD-homologous ICE/CED-3-like proteaseFADD-like ICEICE-like apoptotic protease 5MACH-alpha-1/2/3 proteinMACH-beta-1/2/3/4 proteinMORT1-associated ced-3 homologapoptotic cysteine proteaseapoptotic protease Mch-5caspase 8, apoptosis-relat | amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 proteinamyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12amyotrophic lateral sclerosis 2 chromosome region candidate 12 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q14790 | Q96Q35 | |
Ensembl transtripts involved in fusion gene | ENST00000392259, ENST00000392266, ENST00000264274, ENST00000432109, ENST00000264275, ENST00000392258, ENST00000490682, ENST00000358485, ENST00000323492, | ENST00000286190, ENST00000405148, ENST00000392257, ENST00000439709, ENST00000448967, | |
Fusion gene scores | * DoF score | 8 X 4 X 10=320 | 6 X 4 X 4=96 |
# samples | 10 | 6 | |
** MAII score | log2(10/320*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CASP8 [Title/Abstract] AND ALS2CR12 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CASP8 | GO:0006508 | proteolysis | 12888622 |
Hgene | CASP8 | GO:0036462 | TRAIL-activated apoptotic signaling pathway | 21785459 |
Hgene | CASP8 | GO:0045862 | positive regulation of proteolysis | 18387192 |
Hgene | CASP8 | GO:0097191 | extrinsic apoptotic signaling pathway | 21785459 |
Hgene | CASP8 | GO:0097202 | activation of cysteine-type endopeptidase activity | 18387192 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-BH-A18T-01A | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000392259 | ENST00000286190 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000392259 | ENST00000405148 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000392259 | ENST00000392257 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000392259 | ENST00000439709 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
5CDS-intron | ENST00000392259 | ENST00000448967 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000392266 | ENST00000286190 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000392266 | ENST00000405148 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000392266 | ENST00000392257 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000392266 | ENST00000439709 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
5CDS-intron | ENST00000392266 | ENST00000448967 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000264274 | ENST00000286190 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000264274 | ENST00000405148 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000264274 | ENST00000392257 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000264274 | ENST00000439709 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
5CDS-intron | ENST00000264274 | ENST00000448967 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000432109 | ENST00000286190 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000432109 | ENST00000405148 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000432109 | ENST00000392257 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000432109 | ENST00000439709 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
5CDS-intron | ENST00000432109 | ENST00000448967 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000264275 | ENST00000286190 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000264275 | ENST00000405148 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000264275 | ENST00000392257 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000264275 | ENST00000439709 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
5CDS-intron | ENST00000264275 | ENST00000448967 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000392258 | ENST00000286190 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000392258 | ENST00000405148 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000392258 | ENST00000392257 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000392258 | ENST00000439709 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
5CDS-intron | ENST00000392258 | ENST00000448967 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
intron-3CDS | ENST00000490682 | ENST00000286190 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
intron-3CDS | ENST00000490682 | ENST00000405148 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
intron-3CDS | ENST00000490682 | ENST00000392257 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
intron-3CDS | ENST00000490682 | ENST00000439709 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
intron-intron | ENST00000490682 | ENST00000448967 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000358485 | ENST00000286190 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000358485 | ENST00000405148 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000358485 | ENST00000392257 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000358485 | ENST00000439709 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
5CDS-intron | ENST00000358485 | ENST00000448967 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000323492 | ENST00000286190 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000323492 | ENST00000405148 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000323492 | ENST00000392257 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
In-frame | ENST00000323492 | ENST00000439709 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
5CDS-intron | ENST00000323492 | ENST00000448967 | CASP8 | chr2 | 202131514 | + | ALS2CR12 | chr2 | 202195556 | - |
Top |
FusionProtFeatures for CASP8_ALS2CR12 |
![]() |
Hgene | Tgene |
CASP8 | ALS2CR12 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CASP8 | chr2:202131514 | chr2:202195556 | ENST00000264274 | + | 3 | 7 | 2_80 | 101 | 396 | Domain | DED 1 |
Hgene | CASP8 | chr2:202131514 | chr2:202195556 | ENST00000264275 | + | 3 | 10 | 2_80 | 101 | 497 | Domain | DED 1 |
Hgene | CASP8 | chr2:202131514 | chr2:202195556 | ENST00000323492 | + | 2 | 8 | 2_80 | 101 | 465 | Domain | DED 1 |
Hgene | CASP8 | chr2:202131514 | chr2:202195556 | ENST00000358485 | + | 2 | 9 | 2_80 | 160 | 539 | Domain | DED 1 |
Hgene | CASP8 | chr2:202131514 | chr2:202195556 | ENST00000392258 | + | 3 | 8 | 2_80 | 101 | 224 | Domain | DED 1 |
Hgene | CASP8 | chr2:202131514 | chr2:202195556 | ENST00000392259 | + | 3 | 9 | 2_80 | 101 | 751 | Domain | DED 1 |
Hgene | CASP8 | chr2:202131514 | chr2:202195556 | ENST00000392266 | + | 3 | 8 | 2_80 | 101 | 736 | Domain | DED 1 |
Hgene | CASP8 | chr2:202131514 | chr2:202195556 | ENST00000432109 | + | 3 | 10 | 2_80 | 101 | 480 | Domain | DED 1 |
Tgene | >ALS2CR12 | chr2:202131514 | chr2:202195556 | ENST00000286190 | - | 5 | 14 | 283_315 | 174 | 446 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >ALS2CR12 | chr2:202131514 | chr2:202195556 | ENST00000286190 | - | 5 | 14 | 387_414 | 174 | 446 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >ALS2CR12 | chr2:202131514 | chr2:202195556 | ENST00000392257 | - | 6 | 15 | 283_315 | 174 | 423 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >ALS2CR12 | chr2:202131514 | chr2:202195556 | ENST00000392257 | - | 6 | 15 | 387_414 | 174 | 423 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >ALS2CR12 | chr2:202131514 | chr2:202195556 | ENST00000405148 | - | 6 | 15 | 283_315 | 174 | 446 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >ALS2CR12 | chr2:202131514 | chr2:202195556 | ENST00000405148 | - | 6 | 15 | 387_414 | 174 | 446 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >ALS2CR12 | chr2:202131514 | chr2:202195556 | ENST00000439709 | - | 6 | 15 | 283_315 | 174 | 423 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >ALS2CR12 | chr2:202131514 | chr2:202195556 | ENST00000439709 | - | 6 | 15 | 387_414 | 174 | 423 | Coiled coil | Ontology_term=ECO:0000255 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >CASP8 | chr2:202131514 | chr2:202195556 | ENST00000264274 | + | 3 | 7 | 100_177 | 101 | 396 | Domain | DED 2 |
Hgene | >CASP8 | chr2:202131514 | chr2:202195556 | ENST00000264275 | + | 3 | 10 | 100_177 | 101 | 497 | Domain | DED 2 |
Hgene | >CASP8 | chr2:202131514 | chr2:202195556 | ENST00000323492 | + | 2 | 8 | 100_177 | 101 | 465 | Domain | DED 2 |
Hgene | >CASP8 | chr2:202131514 | chr2:202195556 | ENST00000358485 | + | 2 | 9 | 100_177 | 160 | 539 | Domain | DED 2 |
Hgene | >CASP8 | chr2:202131514 | chr2:202195556 | ENST00000392258 | + | 3 | 8 | 100_177 | 101 | 224 | Domain | DED 2 |
Hgene | >CASP8 | chr2:202131514 | chr2:202195556 | ENST00000392259 | + | 3 | 9 | 100_177 | 101 | 751 | Domain | DED 2 |
Hgene | >CASP8 | chr2:202131514 | chr2:202195556 | ENST00000392266 | + | 3 | 8 | 100_177 | 101 | 736 | Domain | DED 2 |
Hgene | >CASP8 | chr2:202131514 | chr2:202195556 | ENST00000432109 | + | 3 | 10 | 100_177 | 101 | 480 | Domain | DED 2 |
Tgene | ALS2CR12 | chr2:202131514 | chr2:202195556 | ENST00000286190 | - | 5 | 14 | 122_226 | 174 | 446 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | ALS2CR12 | chr2:202131514 | chr2:202195556 | ENST00000392257 | - | 6 | 15 | 122_226 | 174 | 423 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | ALS2CR12 | chr2:202131514 | chr2:202195556 | ENST00000405148 | - | 6 | 15 | 122_226 | 174 | 446 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | ALS2CR12 | chr2:202131514 | chr2:202195556 | ENST00000439709 | - | 6 | 15 | 122_226 | 174 | 423 | Coiled coil | Ontology_term=ECO:0000255 |
Top |
FusionGeneSequence for CASP8_ALS2CR12 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CASP8_ALS2CR12 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CASP8 | TNFRSF10B, FADD, FASLG, BID, EZR, FAS, MAPK8, MSN, CASP10, RHOA, ARHGDIA, TNFRSF1A, RALBP1, TRADD, TRAF1, TRAF2, BIRC2, CFLAR, CASP8, CHD3, TFCP2, VIM, BCAP31, TNFRSF10A, APAF1, NR1H4, NOD1, PEA15, BCL2, HIP1, IFT57, CASP6, CASP3, CASP7, CASP9, CASP2, BCL2L1, XIAP, RIPK1, MAP3K14, CHUK, IKBKB, NOL3, DEDD2, DEDD, CASP4, CASP1, CASP8AP2, CASP14, TNFAIP3, HDAC7, FAF1, RALGDS, NLRC4, PTEN, KHDRBS1, MAP1LC3B, USP2, TSC22D3, MAP1LC3A, SQSTM1, TNFSF10, SORBS1, CEBPB, TRAF6, COPS6, CLIP3, BIRC6, BFAR, RNF34, MAPK1, TOPORS, TP53, LRRK2, FIS1, UBC, CUL3, CARD11, PARK7, RIPK3, RB1, PLA2G4B, PRKCI, SNRPD3, PDIA6, PLIN4, GZMB, HECTD3, CRYAB, TNF, PRDX6, BAX, ERLIN2, TICAM1, BIRC3, ATG4D, PARP1, AGR3, ANGPTL4, ATAD2, BAP1, BEX1, BLID, CASC3, CDH13, EPSTI1, ERRFI1, GLCE, GREB1, IL13RA2, IL24, KLK5, KLK9, LYPD3, PRDM14, PSMC3IP, S100A14, SCGB2A2, SERPINB5, ST14, PRSS50, VPS45, WHSC1L1, ATP1A3, BCL2L10, CNBP, HBP1, QDPR, SOX2, UMPS, YBX1, BLM, GMNN, MLKL, TLR3, OPTN, RYBP, CHEK1, CDK9, MTOR, VHL, CDKN1B, SERPINB9, MAPK14 | ALS2CR12 | SULT2B1, TCL1A, STK16, TXNDC5 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CASP8_ALS2CR12 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CASP8_ALS2CR12 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CASP8 | C1458155 | Mammary Neoplasms | 3 | CTD_human |
Hgene | CASP8 | C0014859 | Esophageal Neoplasms | 2 | CTD_human |
Hgene | CASP8 | C0025202 | melanoma | 2 | CTD_human |
Hgene | CASP8 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Hgene | CASP8 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | CASP8 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Hgene | CASP8 | C0007873 | Uterine Cervical Neoplasm | 1 | CTD_human |
Hgene | CASP8 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | CASP8 | C0011616 | Contact Dermatitis | 1 | CTD_human |
Hgene | CASP8 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Hgene | CASP8 | C0013604 | Edema | 1 | CTD_human |
Hgene | CASP8 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | CASP8 | C0027055 | Myocardial Reperfusion Injury | 1 | CTD_human |
Hgene | CASP8 | C0035126 | Reperfusion Injury | 1 | CTD_human |
Hgene | CASP8 | C0037286 | Skin Neoplasms | 1 | CTD_human |
Hgene | CASP8 | C0038220 | Status Epilepticus | 1 | CTD_human |
Hgene | CASP8 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | CASP8 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
Hgene | CASP8 | C0950124 | Papillomavirus Infections | 1 | CTD_human |
Hgene | CASP8 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
Hgene | CASP8 | C1846545 | Autoimmune Lymphoproliferative Syndrome Type 2B | 1 | ORPHANET;UNIPROT |
Hgene | CASP8 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
Hgene | CASP8 | C2937358 | Cerebral Hemorrhage | 1 | CTD_human |