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Fusion gene ID: 558 |
FusionGeneSummary for ACTG1_SLC25A44 |
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Fusion gene information | Fusion gene name: ACTG1_SLC25A44 | Fusion gene ID: 558 | Hgene | Tgene | Gene symbol | ACTG1 | SLC25A44 | Gene ID | 71 | 9673 |
Gene name | actin gamma 1 | solute carrier family 25 member 44 | |
Synonyms | ACT|ACTG|DFNA20|DFNA26|HEL-176 | - | |
Cytomap | 17q25.3 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | actin, cytoplasmic 2cytoskeletal gamma-actinepididymis luminal protein 176 | solute carrier family 25 member 44 | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | P63261 | Q96H78 | |
Ensembl transtripts involved in fusion gene | ENST00000331925, ENST00000573283, ENST00000575842, ENST00000575087, | ENST00000359511, ENST00000423538, ENST00000469537, | |
Fusion gene scores | * DoF score | 25 X 19 X 11=5225 | 3 X 3 X 3=27 |
# samples | 34 | 3 | |
** MAII score | log2(34/5225*10)=-3.94182438571791 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ACTG1 [Title/Abstract] AND SLC25A44 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM552360 | ACTG1 | chr17 | 79477706 | + | SLC25A44 | chr1 | 156163920 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000331925 | ENST00000359511 | ACTG1 | chr17 | 79477706 | + | SLC25A44 | chr1 | 156163920 | + |
intron-5UTR | ENST00000331925 | ENST00000423538 | ACTG1 | chr17 | 79477706 | + | SLC25A44 | chr1 | 156163920 | + |
intron-intron | ENST00000331925 | ENST00000469537 | ACTG1 | chr17 | 79477706 | + | SLC25A44 | chr1 | 156163920 | + |
intron-5UTR | ENST00000573283 | ENST00000359511 | ACTG1 | chr17 | 79477706 | + | SLC25A44 | chr1 | 156163920 | + |
intron-5UTR | ENST00000573283 | ENST00000423538 | ACTG1 | chr17 | 79477706 | + | SLC25A44 | chr1 | 156163920 | + |
intron-intron | ENST00000573283 | ENST00000469537 | ACTG1 | chr17 | 79477706 | + | SLC25A44 | chr1 | 156163920 | + |
intron-5UTR | ENST00000575842 | ENST00000359511 | ACTG1 | chr17 | 79477706 | + | SLC25A44 | chr1 | 156163920 | + |
intron-5UTR | ENST00000575842 | ENST00000423538 | ACTG1 | chr17 | 79477706 | + | SLC25A44 | chr1 | 156163920 | + |
intron-intron | ENST00000575842 | ENST00000469537 | ACTG1 | chr17 | 79477706 | + | SLC25A44 | chr1 | 156163920 | + |
intron-5UTR | ENST00000575087 | ENST00000359511 | ACTG1 | chr17 | 79477706 | + | SLC25A44 | chr1 | 156163920 | + |
intron-5UTR | ENST00000575087 | ENST00000423538 | ACTG1 | chr17 | 79477706 | + | SLC25A44 | chr1 | 156163920 | + |
intron-intron | ENST00000575087 | ENST00000469537 | ACTG1 | chr17 | 79477706 | + | SLC25A44 | chr1 | 156163920 | + |
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FusionProtFeatures for ACTG1_SLC25A44 |
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Hgene | Tgene |
ACTG1 | SLC25A44 |
Actins are highly conserved proteins that are involvedin various types of cell motility and are ubiquitously expressedin all eukaryotic cells. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACTG1_SLC25A44 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACTG1_SLC25A44 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACTG1_SLC25A44 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ACTG1 | P63261 | DB11638 | Artenimol | Actin, cytoplasmic 2 | small molecule | approved|investigational |
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RelatedDiseases for ACTG1_SLC25A44 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACTG1 | C1858172 | Deafness, Autosomal Dominant 20 | 5 | CTD_human;UNIPROT |
Hgene | ACTG1 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | ACTG1 | C0009363 | Congenital ocular coloboma (disorder) | 1 | CTD_human |
Hgene | ACTG1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | ACTG1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | ACTG1 | C0029456 | Osteoporosis | 1 | CTD_human |
Hgene | ACTG1 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Hgene | ACTG1 | C0497552 | Congenital neurologic anomalies | 1 | CTD_human |
Hgene | ACTG1 | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
Hgene | ACTG1 | C3281235 | BARAITSER-WINTER SYNDROME 2 | 1 | UNIPROT |