FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 5508

FusionGeneSummary for CAPZA2_MET

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPZA2_MET
Fusion gene ID: 5508
HgeneTgene
Gene symbol

CAPZA2

MET

Gene ID

830

8731

Gene namecapping actin protein of muscle Z-line subunit alpha 2RNA guanine-7 methyltransferase
SynonymsCAPPA2|CAPZCMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMet
Cytomap

7q31.2

18p11.21

Type of geneprotein-codingprotein-coding
DescriptionF-actin-capping protein subunit alpha-2F-actin capping protein alpha-2 subunitcapZ alpha-2capping actin protein of muscle Z-line alpha subunit 2capping protein (actin filament) muscle Z-line, alpha 2mRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferase
Modification date2018052320180523
UniProtAcc

P47755

P08581

Ensembl transtripts involved in fusion geneENST00000361183, ENST00000458284, 
ENST00000490693, ENST00000466023, 
ENST00000397752, ENST00000318493, 
ENST00000436117, ENST00000495962, 
ENST00000539704, 
Fusion gene scores* DoF score5 X 4 X 7=14011 X 10 X 9=990
# samples 720
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/990*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAPZA2 [Title/Abstract] AND MET [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMET

GO:0006370

7-methylguanosine mRNA capping

27422871


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AR-A1AN-01ACAPZA2chr7

116550365

+METchr7

116409699

+
TCGARVKIRPTCGA-G7-6793-01ACAPZA2chr7

116528244

+METchr7

116395409

+
TCGARVLUADTCGA-78-7220-01ACAPZA2chr7

116528244

+METchr7

116414935

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000361183ENST00000397752CAPZA2chr7

116550365

+METchr7

116409699

+
In-frameENST00000361183ENST00000318493CAPZA2chr7

116550365

+METchr7

116409699

+
5CDS-intronENST00000361183ENST00000436117CAPZA2chr7

116550365

+METchr7

116409699

+
5CDS-intronENST00000361183ENST00000495962CAPZA2chr7

116550365

+METchr7

116409699

+
5CDS-intronENST00000361183ENST00000539704CAPZA2chr7

116550365

+METchr7

116409699

+
Frame-shiftENST00000458284ENST00000397752CAPZA2chr7

116550365

+METchr7

116409699

+
Frame-shiftENST00000458284ENST00000318493CAPZA2chr7

116550365

+METchr7

116409699

+
5CDS-intronENST00000458284ENST00000436117CAPZA2chr7

116550365

+METchr7

116409699

+
5CDS-intronENST00000458284ENST00000495962CAPZA2chr7

116550365

+METchr7

116409699

+
5CDS-intronENST00000458284ENST00000539704CAPZA2chr7

116550365

+METchr7

116409699

+
intron-3CDSENST00000490693ENST00000397752CAPZA2chr7

116550365

+METchr7

116409699

+
intron-3CDSENST00000490693ENST00000318493CAPZA2chr7

116550365

+METchr7

116409699

+
intron-intronENST00000490693ENST00000436117CAPZA2chr7

116550365

+METchr7

116409699

+
intron-intronENST00000490693ENST00000495962CAPZA2chr7

116550365

+METchr7

116409699

+
intron-intronENST00000490693ENST00000539704CAPZA2chr7

116550365

+METchr7

116409699

+
intron-3CDSENST00000466023ENST00000397752CAPZA2chr7

116550365

+METchr7

116409699

+
intron-3CDSENST00000466023ENST00000318493CAPZA2chr7

116550365

+METchr7

116409699

+
intron-intronENST00000466023ENST00000436117CAPZA2chr7

116550365

+METchr7

116409699

+
intron-intronENST00000466023ENST00000495962CAPZA2chr7

116550365

+METchr7

116409699

+
intron-intronENST00000466023ENST00000539704CAPZA2chr7

116550365

+METchr7

116409699

+
Frame-shiftENST00000361183ENST00000397752CAPZA2chr7

116528244

+METchr7

116395409

+
Frame-shiftENST00000361183ENST00000318493CAPZA2chr7

116528244

+METchr7

116395409

+
Frame-shiftENST00000361183ENST00000436117CAPZA2chr7

116528244

+METchr7

116395409

+
5CDS-3UTRENST00000361183ENST00000495962CAPZA2chr7

116528244

+METchr7

116395409

+
5CDS-intronENST00000361183ENST00000539704CAPZA2chr7

116528244

+METchr7

116395409

+
Frame-shiftENST00000458284ENST00000397752CAPZA2chr7

116528244

+METchr7

116395409

+
Frame-shiftENST00000458284ENST00000318493CAPZA2chr7

116528244

+METchr7

116395409

+
Frame-shiftENST00000458284ENST00000436117CAPZA2chr7

116528244

+METchr7

116395409

+
5CDS-3UTRENST00000458284ENST00000495962CAPZA2chr7

116528244

+METchr7

116395409

+
5CDS-intronENST00000458284ENST00000539704CAPZA2chr7

116528244

+METchr7

116395409

+
Frame-shiftENST00000490693ENST00000397752CAPZA2chr7

116528244

+METchr7

116395409

+
Frame-shiftENST00000490693ENST00000318493CAPZA2chr7

116528244

+METchr7

116395409

+
Frame-shiftENST00000490693ENST00000436117CAPZA2chr7

116528244

+METchr7

116395409

+
5CDS-3UTRENST00000490693ENST00000495962CAPZA2chr7

116528244

+METchr7

116395409

+
5CDS-intronENST00000490693ENST00000539704CAPZA2chr7

116528244

+METchr7

116395409

+
intron-3CDSENST00000466023ENST00000397752CAPZA2chr7

116528244

+METchr7

116395409

+
intron-3CDSENST00000466023ENST00000318493CAPZA2chr7

116528244

+METchr7

116395409

+
intron-3CDSENST00000466023ENST00000436117CAPZA2chr7

116528244

+METchr7

116395409

+
intron-3UTRENST00000466023ENST00000495962CAPZA2chr7

116528244

+METchr7

116395409

+
intron-intronENST00000466023ENST00000539704CAPZA2chr7

116528244

+METchr7

116395409

+
In-frameENST00000361183ENST00000397752CAPZA2chr7

116528244

+METchr7

116414935

+
In-frameENST00000361183ENST00000318493CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000361183ENST00000436117CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000361183ENST00000495962CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000361183ENST00000539704CAPZA2chr7

116528244

+METchr7

116414935

+
In-frameENST00000458284ENST00000397752CAPZA2chr7

116528244

+METchr7

116414935

+
In-frameENST00000458284ENST00000318493CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000458284ENST00000436117CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000458284ENST00000495962CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000458284ENST00000539704CAPZA2chr7

116528244

+METchr7

116414935

+
In-frameENST00000490693ENST00000397752CAPZA2chr7

116528244

+METchr7

116414935

+
In-frameENST00000490693ENST00000318493CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000490693ENST00000436117CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000490693ENST00000495962CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000490693ENST00000539704CAPZA2chr7

116528244

+METchr7

116414935

+
intron-3CDSENST00000466023ENST00000397752CAPZA2chr7

116528244

+METchr7

116414935

+
intron-3CDSENST00000466023ENST00000318493CAPZA2chr7

116528244

+METchr7

116414935

+
intron-intronENST00000466023ENST00000436117CAPZA2chr7

116528244

+METchr7

116414935

+
intron-intronENST00000466023ENST00000495962CAPZA2chr7

116528244

+METchr7

116414935

+
intron-intronENST00000466023ENST00000539704CAPZA2chr7

116528244

+METchr7

116414935

+

Top

FusionProtFeatures for CAPZA2_MET


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAPZA2

P47755

MET

P08581

F-actin-capping proteins bind in a Ca(2+)-independentmanner to the fast growing ends of actin filaments (barbed end)thereby blocking the exchange of subunits at these ends. Unlikeother capping proteins (such as gelsolin and severin), theseproteins do not sever actin filaments. Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding tohepatocyte growth factor/HGF ligand. Regulates many physiologicalprocesses including proliferation, scattering, morphogenesis andsurvival. Ligand binding at the cell surface inducesautophosphorylation of MET on its intracellular domain thatprovides docking sites for downstream signaling molecules.Following activation by ligand, interacts with the PI3-kinasesubunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.Recruitment of these downstream effectors by MET leads to theactivation of several signaling cascades including the RAS-ERK,PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation isassociated with the morphogenetic effects while PI3K/AKTcoordinates prosurvival effects. During embryonic development, METsignaling plays a role in gastrulation, development and migrationof muscles and neuronal precursors, angiogenesis and kidneyformation. In adults, participates in wound healing as well asorgan regeneration and tissue remodeling. Promotes alsodifferentiation and proliferation of hematopoietic cells. Mayregulate cortical bone osteogenesis (By similarity).{ECO:0000250|UniProtKB:P16056}. Acts as a receptor for Listeria internalin inlB,mediating entry of the pathogen into cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMETchr7:116528244chr7:116414935ENST00000318493+13211078_134510271409DomainProtein kinase
TgeneMETchr7:116528244chr7:116414935ENST00000397752+13211078_134510091391DomainProtein kinase
TgeneMETchr7:116528244chr7:116414935ENST00000436117+091078_13450765DomainProtein kinase
TgeneMETchr7:116528244chr7:116414935ENST00000436117+0927_5150765DomainSema
TgeneMETchr7:116528244chr7:116414935ENST00000436117+09563_6550765DomainNote=IPT/TIG 1
TgeneMETchr7:116528244chr7:116414935ENST00000436117+09657_7390765DomainNote=IPT/TIG 2
TgeneMETchr7:116528244chr7:116414935ENST00000436117+09742_8360765DomainNote=IPT/TIG 3
TgeneMETchr7:116550365chr7:116409699ENST00000318493+10211078_13458791409DomainProtein kinase
TgeneMETchr7:116550365chr7:116409699ENST00000397752+10211078_13458611391DomainProtein kinase
TgeneMETchr7:116550365chr7:116409699ENST00000436117+091078_13450765DomainProtein kinase
TgeneMETchr7:116550365chr7:116409699ENST00000436117+0927_5150765DomainSema
TgeneMETchr7:116550365chr7:116409699ENST00000436117+09563_6550765DomainNote=IPT/TIG 1
TgeneMETchr7:116550365chr7:116409699ENST00000436117+09657_7390765DomainNote=IPT/TIG 2
TgeneMETchr7:116550365chr7:116409699ENST00000436117+09742_8360765DomainNote=IPT/TIG 3
TgeneMETchr7:116528244chr7:116414935ENST00000318493+13211084_109210271409Nucleotide bindingATP
TgeneMETchr7:116528244chr7:116414935ENST00000397752+13211084_109210091391Nucleotide bindingATP
TgeneMETchr7:116528244chr7:116414935ENST00000436117+091084_10920765Nucleotide bindingATP
TgeneMETchr7:116550365chr7:116409699ENST00000318493+10211084_10928791409Nucleotide bindingATP
TgeneMETchr7:116550365chr7:116409699ENST00000397752+10211084_10928611391Nucleotide bindingATP
TgeneMETchr7:116550365chr7:116409699ENST00000436117+091084_10920765Nucleotide bindingATP
TgeneMETchr7:116528244chr7:116414935ENST00000436117+0925_9320765Topological domainExtracellular
TgeneMETchr7:116528244chr7:116414935ENST00000436117+09956_13900765Topological domainCytoplasmic
TgeneMETchr7:116550365chr7:116409699ENST00000318493+1021956_13908791409Topological domainCytoplasmic
TgeneMETchr7:116550365chr7:116409699ENST00000397752+1021956_13908611391Topological domainCytoplasmic
TgeneMETchr7:116550365chr7:116409699ENST00000436117+0925_9320765Topological domainExtracellular
TgeneMETchr7:116550365chr7:116409699ENST00000436117+09956_13900765Topological domainCytoplasmic
TgeneMETchr7:116528244chr7:116414935ENST00000436117+09933_9550765TransmembraneHelical
TgeneMETchr7:116550365chr7:116409699ENST00000318493+1021933_9558791409TransmembraneHelical
TgeneMETchr7:116550365chr7:116409699ENST00000397752+1021933_9558611391TransmembraneHelical
TgeneMETchr7:116550365chr7:116409699ENST00000436117+09933_9550765TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMETchr7:116528244chr7:116414935ENST00000318493+132127_51510271409DomainSema
TgeneMETchr7:116528244chr7:116414935ENST00000318493+1321563_65510271409DomainNote=IPT/TIG 1
TgeneMETchr7:116528244chr7:116414935ENST00000318493+1321657_73910271409DomainNote=IPT/TIG 2
TgeneMETchr7:116528244chr7:116414935ENST00000318493+1321742_83610271409DomainNote=IPT/TIG 3
TgeneMETchr7:116528244chr7:116414935ENST00000397752+132127_51510091391DomainSema
TgeneMETchr7:116528244chr7:116414935ENST00000397752+1321563_65510091391DomainNote=IPT/TIG 1
TgeneMETchr7:116528244chr7:116414935ENST00000397752+1321657_73910091391DomainNote=IPT/TIG 2
TgeneMETchr7:116528244chr7:116414935ENST00000397752+1321742_83610091391DomainNote=IPT/TIG 3
TgeneMETchr7:116550365chr7:116409699ENST00000318493+102127_5158791409DomainSema
TgeneMETchr7:116550365chr7:116409699ENST00000318493+1021563_6558791409DomainNote=IPT/TIG 1
TgeneMETchr7:116550365chr7:116409699ENST00000318493+1021657_7398791409DomainNote=IPT/TIG 2
TgeneMETchr7:116550365chr7:116409699ENST00000318493+1021742_8368791409DomainNote=IPT/TIG 3
TgeneMETchr7:116550365chr7:116409699ENST00000397752+102127_5158611391DomainSema
TgeneMETchr7:116550365chr7:116409699ENST00000397752+1021563_6558611391DomainNote=IPT/TIG 1
TgeneMETchr7:116550365chr7:116409699ENST00000397752+1021657_7398611391DomainNote=IPT/TIG 2
TgeneMETchr7:116550365chr7:116409699ENST00000397752+1021742_8368611391DomainNote=IPT/TIG 3
TgeneMETchr7:116528244chr7:116414935ENST00000318493+132125_93210271409Topological domainExtracellular
TgeneMETchr7:116528244chr7:116414935ENST00000318493+1321956_139010271409Topological domainCytoplasmic
TgeneMETchr7:116528244chr7:116414935ENST00000397752+132125_93210091391Topological domainExtracellular
TgeneMETchr7:116528244chr7:116414935ENST00000397752+1321956_139010091391Topological domainCytoplasmic
TgeneMETchr7:116550365chr7:116409699ENST00000318493+102125_9328791409Topological domainExtracellular
TgeneMETchr7:116550365chr7:116409699ENST00000397752+102125_9328611391Topological domainExtracellular
TgeneMETchr7:116528244chr7:116414935ENST00000318493+1321933_95510271409TransmembraneHelical
TgeneMETchr7:116528244chr7:116414935ENST00000397752+1321933_95510091391TransmembraneHelical


Top

FusionGeneSequence for CAPZA2_MET


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CAPZA2_ENST00000361183_chr7_116550365_+_MET_ENST00000397752_chr7_116409699_+_725aa
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDP
KNRICFKFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFT
ITPSTTQVVGILKIQGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIA
GVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQY
PLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRIT
DIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLA
ARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYL
LQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASF

>In-frame_CAPZA2_ENST00000361183_chr7_116550365_+_MET_ENST00000318493_chr7_116409699_+_725aa
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDP
KNRICFKFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFT
ITPSTTQVVGILKIQGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIA
GVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQY
PLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRIT
DIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLA
ARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYL
LQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASF

>In-frame_CAPZA2_ENST00000361183_chr7_116528244_+_MET_ENST00000397752_chr7_116414935_+_416aa
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQA
VQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLV
VLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL
PVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVS

>In-frame_CAPZA2_ENST00000361183_chr7_116528244_+_MET_ENST00000318493_chr7_116414935_+_416aa
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQA
VQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLV
VLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL
PVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVS

>In-frame_CAPZA2_ENST00000458284_chr7_116528244_+_MET_ENST00000397752_chr7_116414935_+_416aa
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQA
VQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLV
VLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL
PVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVS

>In-frame_CAPZA2_ENST00000458284_chr7_116528244_+_MET_ENST00000318493_chr7_116414935_+_416aa
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQA
VQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLV
VLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL
PVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVS

>In-frame_CAPZA2_ENST00000490693_chr7_116528244_+_MET_ENST00000397752_chr7_116414935_+_416aa
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQA
VQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLV
VLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL
PVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVS

>In-frame_CAPZA2_ENST00000490693_chr7_116528244_+_MET_ENST00000318493_chr7_116414935_+_416aa
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQA
VQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLV
VLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL
PVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CAPZA2_ENST00000361183_chr7_116550365_+_MET_ENST00000397752_chr7_116409699_+_2175nt
ATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAAT
GAGGTTTTCAATGATGTTCGGTTACTGCTTAATAATGACAATCTTCTCAGGGAAGGAGCAGCCCATGCATTTGCACAGTATAACTTGGAC
CAGTTTACTCCAGTAAAAATTGAAGGTTATGAAGATCAGGTATTGATAACAGAACATGGCGACTTGGGAAATGGAAAGTTTTTGGATCCA
AAGAACAGAATCTGTTTTAAATTTGATCACTTAAGGAAGGAGGCAACTGATCCAAGACCCTGTGAAGTAGAAAATGCAGTTGAATCATGG
AGAACTTCAGTAGAAACTGCTCTGAGAGCTTACGTAAAAGAACATTACCCGAATGGAGTCTGCACTGTGTATGGCAAAAAAATAGATGGA
CAGCAAACCATTATTGCATGCATAGAAAGCCATCAGTTCCAAGCAAAAAATTTTTGGAATGGTCGTTGGAGGTCAGAATGGAAGTTTACA
ATCACTCCTTCAACCACTCAAGTGGTTGGCATCTTGAAAATTCAGGGAAATGATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAA
GTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTATGCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAG
CTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAATAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCT
GGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGT
GAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTT
TCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTAT
CCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGT
GCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGA
GGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACT
GACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGC
CTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCA
ACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCT
GCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGT
GTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTG
TGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTG
TTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATG
CGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTAT
GTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATGAGGTGGACACACGACCAGCCTCCTTC

>In-frame_CAPZA2_ENST00000361183_chr7_116550365_+_MET_ENST00000318493_chr7_116409699_+_2175nt
ATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAAT
GAGGTTTTCAATGATGTTCGGTTACTGCTTAATAATGACAATCTTCTCAGGGAAGGAGCAGCCCATGCATTTGCACAGTATAACTTGGAC
CAGTTTACTCCAGTAAAAATTGAAGGTTATGAAGATCAGGTATTGATAACAGAACATGGCGACTTGGGAAATGGAAAGTTTTTGGATCCA
AAGAACAGAATCTGTTTTAAATTTGATCACTTAAGGAAGGAGGCAACTGATCCAAGACCCTGTGAAGTAGAAAATGCAGTTGAATCATGG
AGAACTTCAGTAGAAACTGCTCTGAGAGCTTACGTAAAAGAACATTACCCGAATGGAGTCTGCACTGTGTATGGCAAAAAAATAGATGGA
CAGCAAACCATTATTGCATGCATAGAAAGCCATCAGTTCCAAGCAAAAAATTTTTGGAATGGTCGTTGGAGGTCAGAATGGAAGTTTACA
ATCACTCCTTCAACCACTCAAGTGGTTGGCATCTTGAAAATTCAGGGAAATGATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAA
GTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTATGCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAG
CTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAATAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCT
GGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGT
GAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTT
TCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTAT
CCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGT
GCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGA
GGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACT
GACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGC
CTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCA
ACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCT
GCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGT
GTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTG
TGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTG
TTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATG
CGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTAT
GTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATGAGGTGGACACACGACCAGCCTCCTTC

>In-frame_CAPZA2_ENST00000361183_chr7_116528244_+_MET_ENST00000397752_chr7_116414935_+_1248nt
ATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAAT
GAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTA
ACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCA
GTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGG
ACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTG
ACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTG
GTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGT
CTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAA
TTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTG
CCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAG
CTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCC
GAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCC
CGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTAT

>In-frame_CAPZA2_ENST00000361183_chr7_116528244_+_MET_ENST00000318493_chr7_116414935_+_1248nt
ATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAAT
GAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTA
ACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCA
GTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGG
ACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTG
ACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTG
GTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGT
CTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAA
TTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTG
CCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAG
CTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCC
GAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCC
CGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTAT

>In-frame_CAPZA2_ENST00000458284_chr7_116528244_+_MET_ENST00000397752_chr7_116414935_+_1248nt
ATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAAT
GAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTA
ACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCA
GTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGG
ACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTG
ACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTG
GTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGT
CTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAA
TTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTG
CCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAG
CTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCC
GAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCC
CGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTAT

>In-frame_CAPZA2_ENST00000458284_chr7_116528244_+_MET_ENST00000318493_chr7_116414935_+_1248nt
ATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAAT
GAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTA
ACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCA
GTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGG
ACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTG
ACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTG
GTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGT
CTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAA
TTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTG
CCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAG
CTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCC
GAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCC
CGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTAT

>In-frame_CAPZA2_ENST00000490693_chr7_116528244_+_MET_ENST00000397752_chr7_116414935_+_1248nt
ATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAAT
GAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTA
ACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCA
GTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGG
ACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTG
ACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTG
GTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGT
CTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAA
TTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTG
CCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAG
CTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCC
GAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCC
CGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTAT

>In-frame_CAPZA2_ENST00000490693_chr7_116528244_+_MET_ENST00000318493_chr7_116414935_+_1248nt
ATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAAT
GAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTA
ACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCA
GTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGG
ACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTG
ACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTG
GTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGT
CTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAA
TTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTG
CCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAG
CTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCC
GAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCC
CGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_CAPZA2_ENST00000361183_chr7_116550365_+_MET_ENST00000397752_chr7_116409699_+_4576nt
CCCGGGGTGCGCGTGCGCGGCGGCCTGAGCGGCGGGCCCCTCCCTTAGCGGGGGCGCGCGGCGCTGAGGACCGCACGGAAACGGGGAAGT
CAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGT
GCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATGTTCGGTTACTGCTTAATAATGACAA
TCTTCTCAGGGAAGGAGCAGCCCATGCATTTGCACAGTATAACTTGGACCAGTTTACTCCAGTAAAAATTGAAGGTTATGAAGATCAGGT
ATTGATAACAGAACATGGCGACTTGGGAAATGGAAAGTTTTTGGATCCAAAGAACAGAATCTGTTTTAAATTTGATCACTTAAGGAAGGA
GGCAACTGATCCAAGACCCTGTGAAGTAGAAAATGCAGTTGAATCATGGAGAACTTCAGTAGAAACTGCTCTGAGAGCTTACGTAAAAGA
ACATTACCCGAATGGAGTCTGCACTGTGTATGGCAAAAAAATAGATGGACAGCAAACCATTATTGCATGCATAGAAAGCCATCAGTTCCA
AGCAAAAAATTTTTGGAATGGTCGTTGGAGGTCAGAATGGAAGTTTACAATCACTCCTTCAACCACTCAAGTGGTTGGCATCTTGAAAAT
TCAGGGAAATGATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTGA
AGCCGTTTTATGCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCCT
TGGAAAAGTAATAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTGG
GTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATTT
GGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAGA
TCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTC
TGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGT
GATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAA
TGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCAT
CATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACAT
GAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAA
AGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGT
TGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGAT
GGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGG
AGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGA
CCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGAT
CTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTC
ATCAGAAGATAACGCTGATGATGAGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAGT
CCACACTTTGTCCAATGGTTTTTTCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGAC
TTGTATTGTTATTTAAATTACTGGATTCTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAGAGGCTTGGTCCCACAGGCCACGGACC
AATGGCCTGCAGCCGTGACAACACTCCTGTCATATTGGAGTCCAAAACTTGAATTCTGGGTTGAATTTTTTAAAAATCAGGTACCACTTG
ATTTCATATGGGAAATTGAAGCAGGAAATATTGAGGGCTTCTTGATCACAGAAAACTCAGAAGAGATAGTAATGCTCAGGACAGGAGCGG
CAGCCCCAGAACAGGCCACTCATTTAGAATTCTAGTGTTTCAAAACACTTTTGTGTGTTGTATGGTCAATAACATTTTTCATTACTGATG
GTGTCATTCACCCATTAGGTAAACATTCCCTTTTAAATGTTTGTTTGTTTTTTGAGACAGGATCTCACTCTGTTGCCAGGGCTGTAGTGC
AGTGGTGTGATCATAGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCCTCCCGAATAGCTGGGACTACAGGCGCACACCACCATCCCCG
GCTAATTTTTGTATTTTTTGTAGAGACGGGGTTTTGCCATGTTGCCAAGGCTGGTTTCAAACTCCTGGACTCAAGAAATCCACCCACCTC
AGCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACTGCGCCCAGCCCTTATAAATTTTTGTATAGACATTCCTTTGGTTGGAAGAATA
TTTATAGGCAATACAGTCAAAGTTTCAAAATAGCATCACACAAAACATGTTTATAAATGAACAGGATGTAATGTACATAGATGACATTAA
GAAAATTTGTATGAAATAATTTAGTCATCATGAAATATTTAGTTGTCATATAAAAACCCACTGTTTGAGAATGATGCTACTCTGATCTAA
TGAATGTGAACATGTAGATGTTTTGTGTGTATTTTTTTAAATGAAAACTCAAAATAAGACAAGTAATTTGTTGATAAATATTTTTAAAGA
TAACTCAGCATGTTTGTAAAGCAGGATACATTTTACTAAAAGGTTCATTGGTTCCAATCACAGCTCATAGGTAGAGCAAAGAAAGGGTGG
ATGGATTGAAAAGATTAGCCTCTGTCTCGGTGGCAGGTTCCCACCTCGCAAGCAATTGGAAACAAAACTTTTGGGGAGTTTTATTTTGCA
TTAGGGTGTGTTTTATGTTAAGCAAAACATACTTTAGAAACAAATGAAAAAGGCAATTGAAAATCCCAGCTATTTCACCTAGATGGAATA
GCCACCCTGAGCAGAACTTTGTGATGCTTCATTCTGTGGAATTTTGTGCTTGCTACTGTATAGTGCATGTGGTGTAGGTTACTCTAACTG
GTTTTGTCGACGTAAACATTTAAAGTGTTATATTTTTTATAAAAATGTTTATTTTTAATGATATGAGAAAAATTTTGTTAGGCCACAAAA
ACACTGCACTGTGAACATTTTAGAAAAGGTATGTCAGACTGGGATTAATGACAGCATGATTTTCAATGACTGTAAATTGCGATAAGGAAA
TGTACTGATTGCCAATACACCCCACCCTCATTACATCATCAGGACTTGAAGCCAAGGGTTAACCCAGCAAGCTACAAAGAGGGTGTGTCA
CACTGAAACTCAATAGTTGAGTTTGGCTGTTGTTGCAGGAAAATGATTATAACTAAAAGCTCTCTGATAGTGCAGAGACTTACCAGAAGA
CACAAGGAATTGTACTGAAGAGCTATTACAATCCAAATATTGCCGTTTCATAAATGTAATAAGTAATACTAATTCACAGAGTATTGTAAA
TGGTGGATGACAAAAGAAAATCTGCTCTGTGGAAAGAAAGAACTGTCTCTACCAGGGTCAAGAGCATGAACGCATCAATAGAAAGAACTC
GGGGAAACATCCCATCAACAGGACTACACACTTGTATATACATTCTTGAGAACACTGCAATGTGAAAATCACGTTTGCTATTTATAAACT
TGTCCTTAGATTAATGTGTCTGGACAGATTGTGGGAGTAAGTGATTCTTCTAAGAATTAGATACTTGTCACTGCCTATACCTGCAGCTGA

>In-frame_CAPZA2_ENST00000361183_chr7_116550365_+_MET_ENST00000318493_chr7_116409699_+_2532nt
CCCGGGGTGCGCGTGCGCGGCGGCCTGAGCGGCGGGCCCCTCCCTTAGCGGGGGCGCGCGGCGCTGAGGACCGCACGGAAACGGGGAAGT
CAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGT
GCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATGTTCGGTTACTGCTTAATAATGACAA
TCTTCTCAGGGAAGGAGCAGCCCATGCATTTGCACAGTATAACTTGGACCAGTTTACTCCAGTAAAAATTGAAGGTTATGAAGATCAGGT
ATTGATAACAGAACATGGCGACTTGGGAAATGGAAAGTTTTTGGATCCAAAGAACAGAATCTGTTTTAAATTTGATCACTTAAGGAAGGA
GGCAACTGATCCAAGACCCTGTGAAGTAGAAAATGCAGTTGAATCATGGAGAACTTCAGTAGAAACTGCTCTGAGAGCTTACGTAAAAGA
ACATTACCCGAATGGAGTCTGCACTGTGTATGGCAAAAAAATAGATGGACAGCAAACCATTATTGCATGCATAGAAAGCCATCAGTTCCA
AGCAAAAAATTTTTGGAATGGTCGTTGGAGGTCAGAATGGAAGTTTACAATCACTCCTTCAACCACTCAAGTGGTTGGCATCTTGAAAAT
TCAGGGAAATGATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTGA
AGCCGTTTTATGCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCCT
TGGAAAAGTAATAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTGG
GTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATTT
GGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAGA
TCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTC
TGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGT
GATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAA
TGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCAT
CATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACAT
GAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAA
AGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGT
TGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGAT
GGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGG
AGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGA
CCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGAT
CTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTC
ATCAGAAGATAACGCTGATGATGAGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAGT
CCACACTTTGTCCAATGGTTTTTTCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGAC
TTGTATTGTTATTTAAATTACTGGATTCTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAGAGGCTTGGTCCCACAGGCCACGGACC

>In-frame_CAPZA2_ENST00000361183_chr7_116528244_+_MET_ENST00000397752_chr7_116414935_+_3649nt
CCCGGGGTGCGCGTGCGCGGCGGCCTGAGCGGCGGGCCCCTCCCTTAGCGGGGGCGCGCGGCGCTGAGGACCGCACGGAAACGGGGAAGT
CAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGT
GCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGAACGG
TTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAA
TACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCA
TTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGT
GAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGT
CCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCAT
TCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAA
GTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACAT
GTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAA
GTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACAC
CTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATG
CTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTA
TGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATGAGGT
GGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAGTCCACACTTTGTCCAATGGTTTTTTCAC
TGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGACTTGTATTGTTATTTAAATTACTGGATT
CTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAGAGGCTTGGTCCCACAGGCCACGGACCAATGGCCTGCAGCCGTGACAACACTCC
TGTCATATTGGAGTCCAAAACTTGAATTCTGGGTTGAATTTTTTAAAAATCAGGTACCACTTGATTTCATATGGGAAATTGAAGCAGGAA
ATATTGAGGGCTTCTTGATCACAGAAAACTCAGAAGAGATAGTAATGCTCAGGACAGGAGCGGCAGCCCCAGAACAGGCCACTCATTTAG
AATTCTAGTGTTTCAAAACACTTTTGTGTGTTGTATGGTCAATAACATTTTTCATTACTGATGGTGTCATTCACCCATTAGGTAAACATT
CCCTTTTAAATGTTTGTTTGTTTTTTGAGACAGGATCTCACTCTGTTGCCAGGGCTGTAGTGCAGTGGTGTGATCATAGCTCACTGCAAC
CTCCACCTCCCAGGCTCAAGCCTCCCGAATAGCTGGGACTACAGGCGCACACCACCATCCCCGGCTAATTTTTGTATTTTTTGTAGAGAC
GGGGTTTTGCCATGTTGCCAAGGCTGGTTTCAAACTCCTGGACTCAAGAAATCCACCCACCTCAGCCTCCCAAAGTGCTAGGATTACAGG
CATGAGCCACTGCGCCCAGCCCTTATAAATTTTTGTATAGACATTCCTTTGGTTGGAAGAATATTTATAGGCAATACAGTCAAAGTTTCA
AAATAGCATCACACAAAACATGTTTATAAATGAACAGGATGTAATGTACATAGATGACATTAAGAAAATTTGTATGAAATAATTTAGTCA
TCATGAAATATTTAGTTGTCATATAAAAACCCACTGTTTGAGAATGATGCTACTCTGATCTAATGAATGTGAACATGTAGATGTTTTGTG
TGTATTTTTTTAAATGAAAACTCAAAATAAGACAAGTAATTTGTTGATAAATATTTTTAAAGATAACTCAGCATGTTTGTAAAGCAGGAT
ACATTTTACTAAAAGGTTCATTGGTTCCAATCACAGCTCATAGGTAGAGCAAAGAAAGGGTGGATGGATTGAAAAGATTAGCCTCTGTCT
CGGTGGCAGGTTCCCACCTCGCAAGCAATTGGAAACAAAACTTTTGGGGAGTTTTATTTTGCATTAGGGTGTGTTTTATGTTAAGCAAAA
CATACTTTAGAAACAAATGAAAAAGGCAATTGAAAATCCCAGCTATTTCACCTAGATGGAATAGCCACCCTGAGCAGAACTTTGTGATGC
TTCATTCTGTGGAATTTTGTGCTTGCTACTGTATAGTGCATGTGGTGTAGGTTACTCTAACTGGTTTTGTCGACGTAAACATTTAAAGTG
TTATATTTTTTATAAAAATGTTTATTTTTAATGATATGAGAAAAATTTTGTTAGGCCACAAAAACACTGCACTGTGAACATTTTAGAAAA
GGTATGTCAGACTGGGATTAATGACAGCATGATTTTCAATGACTGTAAATTGCGATAAGGAAATGTACTGATTGCCAATACACCCCACCC
TCATTACATCATCAGGACTTGAAGCCAAGGGTTAACCCAGCAAGCTACAAAGAGGGTGTGTCACACTGAAACTCAATAGTTGAGTTTGGC
TGTTGTTGCAGGAAAATGATTATAACTAAAAGCTCTCTGATAGTGCAGAGACTTACCAGAAGACACAAGGAATTGTACTGAAGAGCTATT
ACAATCCAAATATTGCCGTTTCATAAATGTAATAAGTAATACTAATTCACAGAGTATTGTAAATGGTGGATGACAAAAGAAAATCTGCTC
TGTGGAAAGAAAGAACTGTCTCTACCAGGGTCAAGAGCATGAACGCATCAATAGAAAGAACTCGGGGAAACATCCCATCAACAGGACTAC
ACACTTGTATATACATTCTTGAGAACACTGCAATGTGAAAATCACGTTTGCTATTTATAAACTTGTCCTTAGATTAATGTGTCTGGACAG
ATTGTGGGAGTAAGTGATTCTTCTAAGAATTAGATACTTGTCACTGCCTATACCTGCAGCTGAACTGAATGGTACTTCGTATGTTAATAG

>In-frame_CAPZA2_ENST00000361183_chr7_116528244_+_MET_ENST00000318493_chr7_116414935_+_1605nt
CCCGGGGTGCGCGTGCGCGGCGGCCTGAGCGGCGGGCCCCTCCCTTAGCGGGGGCGCGCGGCGCTGAGGACCGCACGGAAACGGGGAAGT
CAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGT
GCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGAACGG
TTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAA
TACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCA
TTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGT
GAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGT
CCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCAT
TCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAA
GTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACAT
GTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAA
GTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACAC
CTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATG
CTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTA
TGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATGAGGT
GGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAGTCCACACTTTGTCCAATGGTTTTTTCAC
TGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGACTTGTATTGTTATTTAAATTACTGGATT

>In-frame_CAPZA2_ENST00000458284_chr7_116528244_+_MET_ENST00000397752_chr7_116414935_+_3563nt
AAGTCAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGA
AGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGA
ACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGC
AAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTG
TGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTG
CTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCA
ATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATT
TCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCA
AAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAG
ACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTC
AAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAA
ACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAA
AATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGC
ACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATG
AGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAGTCCACACTTTGTCCAATGGTTTTT
TCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGACTTGTATTGTTATTTAAATTACTG
GATTCTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAGAGGCTTGGTCCCACAGGCCACGGACCAATGGCCTGCAGCCGTGACAACA
CTCCTGTCATATTGGAGTCCAAAACTTGAATTCTGGGTTGAATTTTTTAAAAATCAGGTACCACTTGATTTCATATGGGAAATTGAAGCA
GGAAATATTGAGGGCTTCTTGATCACAGAAAACTCAGAAGAGATAGTAATGCTCAGGACAGGAGCGGCAGCCCCAGAACAGGCCACTCAT
TTAGAATTCTAGTGTTTCAAAACACTTTTGTGTGTTGTATGGTCAATAACATTTTTCATTACTGATGGTGTCATTCACCCATTAGGTAAA
CATTCCCTTTTAAATGTTTGTTTGTTTTTTGAGACAGGATCTCACTCTGTTGCCAGGGCTGTAGTGCAGTGGTGTGATCATAGCTCACTG
CAACCTCCACCTCCCAGGCTCAAGCCTCCCGAATAGCTGGGACTACAGGCGCACACCACCATCCCCGGCTAATTTTTGTATTTTTTGTAG
AGACGGGGTTTTGCCATGTTGCCAAGGCTGGTTTCAAACTCCTGGACTCAAGAAATCCACCCACCTCAGCCTCCCAAAGTGCTAGGATTA
CAGGCATGAGCCACTGCGCCCAGCCCTTATAAATTTTTGTATAGACATTCCTTTGGTTGGAAGAATATTTATAGGCAATACAGTCAAAGT
TTCAAAATAGCATCACACAAAACATGTTTATAAATGAACAGGATGTAATGTACATAGATGACATTAAGAAAATTTGTATGAAATAATTTA
GTCATCATGAAATATTTAGTTGTCATATAAAAACCCACTGTTTGAGAATGATGCTACTCTGATCTAATGAATGTGAACATGTAGATGTTT
TGTGTGTATTTTTTTAAATGAAAACTCAAAATAAGACAAGTAATTTGTTGATAAATATTTTTAAAGATAACTCAGCATGTTTGTAAAGCA
GGATACATTTTACTAAAAGGTTCATTGGTTCCAATCACAGCTCATAGGTAGAGCAAAGAAAGGGTGGATGGATTGAAAAGATTAGCCTCT
GTCTCGGTGGCAGGTTCCCACCTCGCAAGCAATTGGAAACAAAACTTTTGGGGAGTTTTATTTTGCATTAGGGTGTGTTTTATGTTAAGC
AAAACATACTTTAGAAACAAATGAAAAAGGCAATTGAAAATCCCAGCTATTTCACCTAGATGGAATAGCCACCCTGAGCAGAACTTTGTG
ATGCTTCATTCTGTGGAATTTTGTGCTTGCTACTGTATAGTGCATGTGGTGTAGGTTACTCTAACTGGTTTTGTCGACGTAAACATTTAA
AGTGTTATATTTTTTATAAAAATGTTTATTTTTAATGATATGAGAAAAATTTTGTTAGGCCACAAAAACACTGCACTGTGAACATTTTAG
AAAAGGTATGTCAGACTGGGATTAATGACAGCATGATTTTCAATGACTGTAAATTGCGATAAGGAAATGTACTGATTGCCAATACACCCC
ACCCTCATTACATCATCAGGACTTGAAGCCAAGGGTTAACCCAGCAAGCTACAAAGAGGGTGTGTCACACTGAAACTCAATAGTTGAGTT
TGGCTGTTGTTGCAGGAAAATGATTATAACTAAAAGCTCTCTGATAGTGCAGAGACTTACCAGAAGACACAAGGAATTGTACTGAAGAGC
TATTACAATCCAAATATTGCCGTTTCATAAATGTAATAAGTAATACTAATTCACAGAGTATTGTAAATGGTGGATGACAAAAGAAAATCT
GCTCTGTGGAAAGAAAGAACTGTCTCTACCAGGGTCAAGAGCATGAACGCATCAATAGAAAGAACTCGGGGAAACATCCCATCAACAGGA
CTACACACTTGTATATACATTCTTGAGAACACTGCAATGTGAAAATCACGTTTGCTATTTATAAACTTGTCCTTAGATTAATGTGTCTGG
ACAGATTGTGGGAGTAAGTGATTCTTCTAAGAATTAGATACTTGTCACTGCCTATACCTGCAGCTGAACTGAATGGTACTTCGTATGTTA

>In-frame_CAPZA2_ENST00000458284_chr7_116528244_+_MET_ENST00000318493_chr7_116414935_+_1519nt
AAGTCAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGA
AGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGA
ACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGC
AAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTG
TGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTG
CTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCA
ATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATT
TCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCA
AAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAG
ACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTC
AAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAA
ACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAA
AATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGC
ACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATG
AGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAGTCCACACTTTGTCCAATGGTTTTT
TCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGACTTGTATTGTTATTTAAATTACTG

>In-frame_CAPZA2_ENST00000490693_chr7_116528244_+_MET_ENST00000397752_chr7_116414935_+_3522nt
GCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCT
GGAGAATTTAATGAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATG
TCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAG
CTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGT
GTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTT
TCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGG
TCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTT
ATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATG
CTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACA
GGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTG
CTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGA
CTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCT
GAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGT
GTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATGAGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAG
TGCTAGTACTATGTCAAAGCAACAGTCCACACTTTGTCCAATGGTTTTTTCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTC
TTGCCAAAATTGCACTATTATAGGACTTGTATTGTTATTTAAATTACTGGATTCTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAG
AGGCTTGGTCCCACAGGCCACGGACCAATGGCCTGCAGCCGTGACAACACTCCTGTCATATTGGAGTCCAAAACTTGAATTCTGGGTTGA
ATTTTTTAAAAATCAGGTACCACTTGATTTCATATGGGAAATTGAAGCAGGAAATATTGAGGGCTTCTTGATCACAGAAAACTCAGAAGA
GATAGTAATGCTCAGGACAGGAGCGGCAGCCCCAGAACAGGCCACTCATTTAGAATTCTAGTGTTTCAAAACACTTTTGTGTGTTGTATG
GTCAATAACATTTTTCATTACTGATGGTGTCATTCACCCATTAGGTAAACATTCCCTTTTAAATGTTTGTTTGTTTTTTGAGACAGGATC
TCACTCTGTTGCCAGGGCTGTAGTGCAGTGGTGTGATCATAGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCCTCCCGAATAGCTGGG
ACTACAGGCGCACACCACCATCCCCGGCTAATTTTTGTATTTTTTGTAGAGACGGGGTTTTGCCATGTTGCCAAGGCTGGTTTCAAACTC
CTGGACTCAAGAAATCCACCCACCTCAGCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACTGCGCCCAGCCCTTATAAATTTTTGTA
TAGACATTCCTTTGGTTGGAAGAATATTTATAGGCAATACAGTCAAAGTTTCAAAATAGCATCACACAAAACATGTTTATAAATGAACAG
GATGTAATGTACATAGATGACATTAAGAAAATTTGTATGAAATAATTTAGTCATCATGAAATATTTAGTTGTCATATAAAAACCCACTGT
TTGAGAATGATGCTACTCTGATCTAATGAATGTGAACATGTAGATGTTTTGTGTGTATTTTTTTAAATGAAAACTCAAAATAAGACAAGT
AATTTGTTGATAAATATTTTTAAAGATAACTCAGCATGTTTGTAAAGCAGGATACATTTTACTAAAAGGTTCATTGGTTCCAATCACAGC
TCATAGGTAGAGCAAAGAAAGGGTGGATGGATTGAAAAGATTAGCCTCTGTCTCGGTGGCAGGTTCCCACCTCGCAAGCAATTGGAAACA
AAACTTTTGGGGAGTTTTATTTTGCATTAGGGTGTGTTTTATGTTAAGCAAAACATACTTTAGAAACAAATGAAAAAGGCAATTGAAAAT
CCCAGCTATTTCACCTAGATGGAATAGCCACCCTGAGCAGAACTTTGTGATGCTTCATTCTGTGGAATTTTGTGCTTGCTACTGTATAGT
GCATGTGGTGTAGGTTACTCTAACTGGTTTTGTCGACGTAAACATTTAAAGTGTTATATTTTTTATAAAAATGTTTATTTTTAATGATAT
GAGAAAAATTTTGTTAGGCCACAAAAACACTGCACTGTGAACATTTTAGAAAAGGTATGTCAGACTGGGATTAATGACAGCATGATTTTC
AATGACTGTAAATTGCGATAAGGAAATGTACTGATTGCCAATACACCCCACCCTCATTACATCATCAGGACTTGAAGCCAAGGGTTAACC
CAGCAAGCTACAAAGAGGGTGTGTCACACTGAAACTCAATAGTTGAGTTTGGCTGTTGTTGCAGGAAAATGATTATAACTAAAAGCTCTC
TGATAGTGCAGAGACTTACCAGAAGACACAAGGAATTGTACTGAAGAGCTATTACAATCCAAATATTGCCGTTTCATAAATGTAATAAGT
AATACTAATTCACAGAGTATTGTAAATGGTGGATGACAAAAGAAAATCTGCTCTGTGGAAAGAAAGAACTGTCTCTACCAGGGTCAAGAG
CATGAACGCATCAATAGAAAGAACTCGGGGAAACATCCCATCAACAGGACTACACACTTGTATATACATTCTTGAGAACACTGCAATGTG
AAAATCACGTTTGCTATTTATAAACTTGTCCTTAGATTAATGTGTCTGGACAGATTGTGGGAGTAAGTGATTCTTCTAAGAATTAGATAC
TTGTCACTGCCTATACCTGCAGCTGAACTGAATGGTACTTCGTATGTTAATAGTTGTTCTGATAAATCATGCAATTAAAGTAAAGTGATG

>In-frame_CAPZA2_ENST00000490693_chr7_116528244_+_MET_ENST00000318493_chr7_116414935_+_1478nt
GCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCT
GGAGAATTTAATGAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATG
TCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAG
CTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGT
GTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTT
TCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGG
TCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTT
ATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATG
CTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACA
GGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTG
CTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGA
CTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCT
GAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGT
GTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATGAGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAG
TGCTAGTACTATGTCAAAGCAACAGTCCACACTTTGTCCAATGGTTTTTTCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTC
TTGCCAAAATTGCACTATTATAGGACTTGTATTGTTATTTAAATTACTGGATTCTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAG


Top

FusionGenePPI for CAPZA2_MET


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CAPZA2TWF2, RBBP6, ELAVL1, ARRB2, BLNK, CD2AP, LRRK2, PAN2, AASDHPPT, CAPZA1, PTMA, PSMG1, RPL18A, SGTA, STRAP, CAPZB, PKM, CUL7, OBSL1, CCDC8, DAPK1, CSPP1, STAP1, ACTR1B, ACTR1A, ARAP1, CNOT3, KIAA1671, MTCL1, CNOT10, CNOT1, FAM21C, FAM21A, RLTPR, KIAA1033, DCTN1, LRRC16A, KIAA0196, DCTN3, PLEKHO2, TNKS1BP1, SVIL, SH3KBP1, KIAA1211, DCTN2, DCTN4, CNOT2, RQCD1, SH3BP1, ACTR10, CNOT8, PLEKHO1, CNOT11, DCTN5, CNOT7, CCS, CNOT6, CNOT6L, WASH6P, WASH3P, RAVER1, PPP1R9A, DCTN6, FHL2, CCDC53, RBM18, ARPC2, ACTR2, ARPC3, PSMB6, MYO5A, MYO5C, HSPB2, RPGRIP1L, ACTA1, ACTG1, ACTN4, ACTN1, ADD1, ADD3, AP2A1, ALDH3A2, DST, BST2, CAMK2G, DBN1, MARK2, FLNA, MLH1, MYH9, MYO1C, PCDH7, PPP1CB, IQGAP1, PDLIM7, SYNPO, ANLN, MYO19, MYO18A, CFL1, CFL2, AP2M1, CLIC1, CLTA, CLTB, CLTC, COX6C, CPM, DAB2, DAPK3, CTTN, EPS15, FDX1, FLII, FLNB, GNAI2, GSN, HADHA, ITPR1, ITPR2, ITPR3, ABLIM1, LMO7, MLLT4, MYO1B, MYH10, MYO1E, MYO5B, MYO6, PPP1R12A, NAP1L1, NAP1L4, OGDH, ORC4, PFKM, PIK3C2A, PLEC, PPP1CA, PSMC5, PSMD4, TWF1, RAB1A, SIPA1, SPTAN1, SPTBN1, SPTBN2, SSFA2, TMOD1, TNFAIP1, TPM1, TPM2, TPM3, TPM4, CORO2A, LUZP1, CLTCL1, PICALM, SORBS2, PKP4, NUMB, HIP1R, LRRFIP2, MTFR1, CLINT1, ARHGAP11A, ARHGEF17, SEC16A, WDR1, ARPC5, ARPC4, ARPC1B, ACTR3, LRPPRC, FARP1, FLOT1, CDIPT, IPO7, SMC2, MYL12A, GAS2L1, TRIOBP, AKAP2, LIMCH1, SIPA1L3, N4BP3, MPRIP, COBL, SPECC1L, FBXO46, MACF1, CORO1C, PLEKHG3, RAI14, TIMM13, RACGAP1, PACSIN3, TMOD3, CARD10, LIMA1, GTSE1, NCKIPSD, LIN7C, BMP2K, UNC45A, CORO1B, CGN, MICAL3, STAMBPL1, ARHGAP21, AFAP1, ZNF106, INF2, INTS3, AHNAK, TANGO6, WDR76, BICC1, ARPC5L, KCTD10, FAM161A, TUBB6, MYPN, PPP1R9B, LRCH3, STON2, DOCK7, DIXDC1, SSH2, PHLDB2, NEXN, SPECC1, FCHO2, FGD4, MISP, CHMP4B, MYL6B, ARHGAP42, AMOTL1, PPP1R18, GAS2L3, TPRN, MCM2, GLI1, DUSP8, RCSD1, STYX, DLST, TRIM25, G3BP1METGLMN, CDH1, CTNNB1, HGF, RANBP9, GRB2, CBL, SH3KBP1, RANBP10, SRC, SHC1, SOS1, STAT3, GAB1, GAB2, LRIG1, INPPL1, DCN, SPSB1, SPSB2, SPSB3, SPSB4, CBLC, STUB1, HSPA4, HSP90AA1, GGA3, GNG12, FBXO6, HGS, CRK, CEACAM21, LGALS9, PCBP1, CASP3, SOCS1, HSP90AB1, EGFR, ERBB3, MET, CHEK1, PTEN, SCGB1D1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMETchr7:116528244chr7:116414935ENST00000318493+13211320_135910271409MUC20
TgeneMETchr7:116528244chr7:116414935ENST00000397752+13211320_135910091391MUC20
TgeneMETchr7:116528244chr7:116414935ENST00000436117+091320_13590765MUC20
TgeneMETchr7:116550365chr7:116409699ENST00000318493+10211320_13598791409MUC20
TgeneMETchr7:116550365chr7:116409699ENST00000397752+10211320_13598611391MUC20
TgeneMETchr7:116550365chr7:116409699ENST00000436117+091320_13590765MUC20
TgeneMETchr7:116528244chr7:116414935ENST00000318493+13211212_139010271409RANBP9
TgeneMETchr7:116528244chr7:116414935ENST00000397752+13211212_139010091391RANBP9
TgeneMETchr7:116528244chr7:116414935ENST00000436117+091212_13900765RANBP9
TgeneMETchr7:116550365chr7:116409699ENST00000318493+10211212_13908791409RANBP9
TgeneMETchr7:116550365chr7:116409699ENST00000397752+10211212_13908611391RANBP9
TgeneMETchr7:116550365chr7:116409699ENST00000436117+091212_13900765RANBP9


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CAPZA2_MET


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMETP08581DB08865CrizotinibHepatocyte growth factor receptorsmall moleculeapproved
TgeneMETP08581DB08875CabozantinibHepatocyte growth factor receptorsmall moleculeapproved|investigational

Top

RelatedDiseases for CAPZA2_MET


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMETC1336839Type 1 Papillary Renal Cell Carcinoma5UNIPROT
TgeneMETC0007131Non-Small Cell Lung Carcinoma4CTD_human
TgeneMETC0001418Adenocarcinoma2CTD_human
TgeneMETC0004352Autistic Disorder2CTD_human
TgeneMETC0027627Neoplasm Metastasis2CTD_human
TgeneMETC0038356Stomach Neoplasms2CTD_human
TgeneMETC0004114Astrocytoma1CTD_human
TgeneMETC0007134Renal Cell Carcinoma1CTD_human
TgeneMETC0007137Squamous cell carcinoma1CTD_human
TgeneMETC0009241Cognition Disorders1CTD_human
TgeneMETC0014859Esophageal Neoplasms1CTD_human
TgeneMETC0017636Glioblastoma1CTD_human
TgeneMETC0019189Hepatitis, Chronic1CTD_human
TgeneMETC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneMETC0023904Liver Neoplasms, Experimental1CTD_human
TgeneMETC0024121Lung Neoplasms1CTD_human
TgeneMETC0027626Neoplasm Invasiveness1CTD_human
TgeneMETC0027819Neuroblastoma1CTD_human
TgeneMETC0029463Osteosarcoma1CTD_human
TgeneMETC0036341Schizophrenia1CTD_human
TgeneMETC0037199Sinusitis1CTD_human
TgeneMETC0345967Malignant mesothelioma1CTD_human
TgeneMETC0919267ovarian neoplasm1CTD_human
TgeneMETC1876165Copper-Overload Cirrhosis1CTD_human
TgeneMETC2239176Liver carcinoma1CTD_human;HPO;UNIPROT
TgeneMETC4084709DEAFNESS, AUTOSOMAL RECESSIVE 971UNIPROT