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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5474

FusionGeneSummary for CAPNS1_CCDC149

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPNS1_CCDC149
Fusion gene ID: 5474
HgeneTgene
Gene symbol

CAPNS1

CCDC149

Gene ID

826

91050

Gene namecalpain small subunit 1coiled-coil domain containing 149
SynonymsCALPAIN4|CANP|CANPS|CAPN4|CDPS|CSS1-
Cytomap

19q13.12

4p15.2

Type of geneprotein-codingprotein-coding
Descriptioncalpain small subunit 1CANP small subunitcalcium-activated neutral proteinase small subunitcalcium-dependent protease small subunit 1calcium-dependent protease, small subunitcalpain 4, small subunit (30K)calpain regulatory subunitcalpain, small polcoiled-coil domain-containing protein 149
Modification date2018052220180519
UniProtAcc

P04632

Q6ZUS6

Ensembl transtripts involved in fusion geneENST00000246533, ENST00000589146, 
ENST00000587718, ENST00000590874, 
ENST00000588815, ENST00000588780, 
ENST00000504487, ENST00000428116, 
ENST00000389609, ENST00000502801, 
ENST00000508236, 
Fusion gene scores* DoF score13 X 12 X 5=7805 X 5 X 4=100
# samples 145
** MAII scorelog2(14/780*10)=-2.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAPNS1 [Title/Abstract] AND CCDC149 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-H9-A6BY-01ACAPNS1chr19

36641254

+CCDC149chr4

24981770

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000246533ENST00000504487CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
5CDS-intronENST00000246533ENST00000428116CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
5CDS-intronENST00000246533ENST00000389609CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
5CDS-intronENST00000246533ENST00000502801CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
5CDS-intronENST00000246533ENST00000508236CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
intron-intronENST00000589146ENST00000504487CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
intron-intronENST00000589146ENST00000428116CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
intron-intronENST00000589146ENST00000389609CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
intron-intronENST00000589146ENST00000502801CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
intron-intronENST00000589146ENST00000508236CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
5CDS-intronENST00000587718ENST00000504487CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
5CDS-intronENST00000587718ENST00000428116CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
5CDS-intronENST00000587718ENST00000389609CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
5CDS-intronENST00000587718ENST00000502801CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
5CDS-intronENST00000587718ENST00000508236CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
intron-intronENST00000590874ENST00000504487CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
intron-intronENST00000590874ENST00000428116CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
intron-intronENST00000590874ENST00000389609CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
intron-intronENST00000590874ENST00000502801CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
intron-intronENST00000590874ENST00000508236CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
5CDS-intronENST00000588815ENST00000504487CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
5CDS-intronENST00000588815ENST00000428116CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
5CDS-intronENST00000588815ENST00000389609CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
5CDS-intronENST00000588815ENST00000502801CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
5CDS-intronENST00000588815ENST00000508236CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
intron-intronENST00000588780ENST00000504487CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
intron-intronENST00000588780ENST00000428116CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
intron-intronENST00000588780ENST00000389609CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
intron-intronENST00000588780ENST00000502801CAPNS1chr19

36641254

+CCDC149chr4

24981770

-
intron-intronENST00000588780ENST00000508236CAPNS1chr19

36641254

+CCDC149chr4

24981770

-

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FusionProtFeatures for CAPNS1_CCDC149


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAPNS1

P04632

CCDC149

Q6ZUS6

Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis ofsubstrates involved in cytoskeletal remodeling and signaltransduction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CAPNS1_CCDC149


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CAPNS1_CCDC149


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CAPNS1ARR3, ATP5J2, DRG1, RAB1A, TERF1, GET4, GNB2, CDK4, CAPN2, IL2RG, RUVBL1, MEPCE, POU5F1, CSPG4, FN1, VCAM1, ITGA4, ADRB2, TRAF5, STAT3, PPARGC1A, ALDH7A1, APEX1, ASNS, EIF5, FERMT2, GAPDH, GNAI3, STK26, MYO1E, OGFOD1, PTMA, TBCB, DCPS, ISOC1, MAT2A, MAT2B, PAFAH1B1, PAK2, PDIA4, PPP1CA, PROSC, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ, CDC20, NEDD1, TUBGCP2, TUBGCP3, HUWE1, AGTRAP, USP1, KNG1, FNTB, TNF, CAPNS2, CAPN1, DUSP19, C8orf37CCDC149PRNP, APP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CAPNS1_CCDC149


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CAPNS1_CCDC149


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCAPNS1C0033578Prostatic Neoplasms1CTD_human