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Fusion gene ID: 5458 |
FusionGeneSummary for CAPN2_LAPTM4A |
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Fusion gene information | Fusion gene name: CAPN2_LAPTM4A | Fusion gene ID: 5458 | Hgene | Tgene | Gene symbol | CAPN2 | LAPTM4A | Gene ID | 824 | 9741 |
Gene name | calpain 2 | lysosomal protein transmembrane 4 alpha | |
Synonyms | CANP2|CANPL2|CANPml|mCANP | HUMORF13|LAPTM4|MBNT|Mtrp | |
Cytomap | 1q41 | 2p24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | calpain-2 catalytic subunitCANP 2M-calpaincalcium-activated neutral proteinase 2calpain 2, (m/II) large subunitcalpain 2, large [catalytic] subunitcalpain 2, large subunitcalpain M-typecalpain, large polypeptide L2millimolar-calpain | lysosomal-associated transmembrane protein 4Agolgi 4-transmembrane-spanning transporter MTPlysosomal-associated protein transmembrane 4 alphamembrane nucleoside transporter | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P17655 | Q15012 | |
Ensembl transtripts involved in fusion gene | ENST00000433674, ENST00000295006, ENST00000474026, | ENST00000175091, | |
Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 3 X 3 X 1=9 |
# samples | 6 | 3 | |
** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CAPN2 [Title/Abstract] AND LAPTM4A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CAPN2 | GO:0051603 | proteolysis involved in cellular protein catabolic process | 12150984 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ308066 | CAPN2 | chr1 | 223940501 | - | LAPTM4A | chr2 | 20240665 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000433674 | ENST00000175091 | CAPN2 | chr1 | 223940501 | - | LAPTM4A | chr2 | 20240665 | + |
intron-3CDS | ENST00000295006 | ENST00000175091 | CAPN2 | chr1 | 223940501 | - | LAPTM4A | chr2 | 20240665 | + |
intron-3CDS | ENST00000474026 | ENST00000175091 | CAPN2 | chr1 | 223940501 | - | LAPTM4A | chr2 | 20240665 | + |
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FusionProtFeatures for CAPN2_LAPTM4A |
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Hgene | Tgene |
CAPN2 | LAPTM4A |
Calcium-regulated non-lysosomal thiol-protease whichcatalyzes limited proteolysis of substrates involved incytoskeletal remodeling and signal transduction. Proteolyticallycleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolyticallycleaves CPEB3 following neuronal stimulation which abolishes CPEB3translational repressor activity, leading to translation of CPEB3target mRNAs (By similarity). {ECO:0000250|UniProtKB:O08529,ECO:0000269|PubMed:17650508}. | May function in the transport of nucleosides and/ornucleoside derivatives between the cytosol and the lumen of anintracellular membrane-bound compartment. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CAPN2_LAPTM4A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CAPN2_LAPTM4A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CAPN2_LAPTM4A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CAPN2_LAPTM4A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CAPN2 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |