![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 5446 |
FusionGeneSummary for CAPN14_HERC3 |
![]() |
Fusion gene information | Fusion gene name: CAPN14_HERC3 | Fusion gene ID: 5446 | Hgene | Tgene | Gene symbol | CAPN14 | HERC3 | Gene ID | 440854 | 8916 |
Gene name | calpain 14 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | |
Synonyms | - | - | |
Cytomap | 2p23.1 | 4q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | calpain-14CANP 14calcium-activated neutral proteinase 14 | probable E3 ubiquitin-protein ligase HERC3HECT domain and RCC1-like domain-containing protein 3HECT-type E3 ubiquitin transferase HERC3hect domain and RLD 3 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | A8MX76 | Q15034 | |
Ensembl transtripts involved in fusion gene | ENST00000444918, ENST00000403897, | ENST00000402738, ENST00000407637, ENST00000601319, ENST00000264345, ENST00000543130, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: CAPN14 [Title/Abstract] AND HERC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI908960 | CAPN14 | chr2 | 31397364 | + | HERC3 | chr4 | 89629028 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000444918 | ENST00000402738 | CAPN14 | chr2 | 31397364 | + | HERC3 | chr4 | 89629028 | + |
intron-intron | ENST00000444918 | ENST00000407637 | CAPN14 | chr2 | 31397364 | + | HERC3 | chr4 | 89629028 | + |
intron-intron | ENST00000444918 | ENST00000601319 | CAPN14 | chr2 | 31397364 | + | HERC3 | chr4 | 89629028 | + |
intron-3UTR | ENST00000444918 | ENST00000264345 | CAPN14 | chr2 | 31397364 | + | HERC3 | chr4 | 89629028 | + |
intron-intron | ENST00000444918 | ENST00000543130 | CAPN14 | chr2 | 31397364 | + | HERC3 | chr4 | 89629028 | + |
intron-3UTR | ENST00000403897 | ENST00000402738 | CAPN14 | chr2 | 31397364 | + | HERC3 | chr4 | 89629028 | + |
intron-intron | ENST00000403897 | ENST00000407637 | CAPN14 | chr2 | 31397364 | + | HERC3 | chr4 | 89629028 | + |
intron-intron | ENST00000403897 | ENST00000601319 | CAPN14 | chr2 | 31397364 | + | HERC3 | chr4 | 89629028 | + |
intron-3UTR | ENST00000403897 | ENST00000264345 | CAPN14 | chr2 | 31397364 | + | HERC3 | chr4 | 89629028 | + |
intron-intron | ENST00000403897 | ENST00000543130 | CAPN14 | chr2 | 31397364 | + | HERC3 | chr4 | 89629028 | + |
Top |
FusionProtFeatures for CAPN14_HERC3 |
![]() |
Hgene | Tgene |
CAPN14 | HERC3 |
Calcium-regulated non-lysosomal thiol-protease.{ECO:0000250}. | E3 ubiquitin-protein ligase which accepts ubiquitin froman E2 ubiquitin-conjugating enzyme in the form of a thioester andthen directly transfers the ubiquitin to targeted substrates.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CAPN14_HERC3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CAPN14_HERC3 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CAPN14_HERC3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CAPN14_HERC3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CAPN14 | C0341106 | Eosinophilic esophagitis | 1 | CTD_human |
Tgene | HERC3 | C0023903 | Liver neoplasms | 1 | CTD_human |